7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
1/23
Alterna(velicensingmodelstos(mulate
innova(on
ThomasKrohn,RPh,MBADirector,ClinicalOpenInnova(on
EliLillyandCompany
WorldDrugReposi(oningCongressWashington,DC
5December2012Pleasenotethatsomeoftheviewspresented
donotnecessarilyreflectthoseofEliLillyand
Company
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
2/23
3GoalsToday
Caseforalterna(velicensing/businessmodel Lessonsfromotherindustries Examplealterna(vemodel
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
3/23
DrugDevelopmentToday
TargetedConfirma.on
Closed
Exploratory
Collabora.ve
patent
Innova(on Process
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
4/23
LicensingToday
patent
PorNolioAri(on
BusinessDevelopmentDeal
PorNolioGaps
Patentclock(cking
Asymmetricinforma(onInconsistentRepresenta(on
CustomDeals
Effortand(me
Priori(za(on/OppCost
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
5/23
BackupCompounds:LicensingConcerns
Cannibaliza(onofleadcompound Class-effectsafetyconcerns Partnerdoesbadscience Lossofownershipandcontrol Intellectualpropertyissues
RedHerringsorMi(gableRisks
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
6/23
IncrementalImprovement
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
7/23
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
8/23
Weneedabolderalterna(ve
to S1'
to S2
S1
Time
Performance
Disruptive
Change
SimplerFaster Cheaper
SustainingInnova?onEfficiencyInnova?onEmpoweringInnova/on
ClaytonChris(ansenYT,11/4/12
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
9/23
Learningfromotherindustries
Accesstoop(ons-buy&sell Standardcontentrepresenta(on Streamlinedtransac(ons Licensingtoenableexternalinnova(on
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
10/23
Accesstoop(ons-buy&sell
MusicIndustry
PhysicalPurchase
MP3Download
Subscrip(onAnymusic,any(me,anywhere
Collec(bles
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
11/23
Standardcontentrepresenta(on
AmazonSearch
ClinicalCollec(ons
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
12/23
Streamlinedtransac(ons
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
13/23
Enablingexternalinnova(on
Opensourceso^wareLicensing
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
14/23
Crea(veCommonsLicenses
Exclusivity
Permissionrequired
Crea(vity
Predefinedpermission
Absolute Flavors
Copyright Copyle^
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
15/23
Enablingexternalinnova(on
Opensourceso^ware
Copyle^Licensing
Collabora(veDevelopment
Fulltransparency
LinuxForks
$1B
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
16/23
Learningfromotherindustries
Accesstoop(ons-buy&sell StandardRepresenta(on Streamlinedtransac(ons Enablingexternalinnova(on
RemovedBarrierstoMarketInnova(on
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
17/23
LicensingToday
patent
PorNolioAri(on
BusinessDevelopmentDeal
PorNolioGaps
Patentclock(cking
Asymmetricinforma(onInconsistentRepresenta(on
CustomDeals
Effortand(me
Priori(za(on/OppCost
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
18/23
Whatif?
patent
PorNolioAri(on
BusinessDevelopmentDeal
PorNolioGaps
Patentclock(cking
Access/ClearingHouseSymmetricinforma(on
StandardizedRepresenta(on
StandardizedDeals
Innova(onEnablingLicensing
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
19/23
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
20/23
CommonsDrugDevelopment
Pharma Biotechs Academics Foundations Individuals
standardrulesofentry standardlegaltools standarddataformats mustcontributedatatoaccessdata voluntarycommitment
selectedcrea(onof
precompe((vedataspaces
preferredstrategicpartners samerulesandformats:interoperability crea(onofadatacommonsover(me2
decayofdataintopublicdomain founda(onfundingandcrowdtalent encouragetooldevelopmentbycrowd
3
1
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
21/23
EmpoweringInnova(on
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
22/23
MoreInforma(on
www.crea(vecommons.org www.lillycoi.com
7/30/2019 Drug Repositioning Conf - Krohn Dec 2102
23/23