Drug Formulation / Drug Delivery Raj Suryanarayanan (Sury) Department of Pharmaceutics College of Pharmacy [email protected] 1.

Drug Formulation / Drug Delivery

Raj Suryanarayanan (Sury)Department of Pharmaceutics

College of [email protected]

1

Faculty Research AreasBiological Pharmaceutics

(Pharmacokinetics, Pharmacodynamics, Metabolism)

Elmquist, Fairbanks, Sawchuk, Zimmerman

Physical Pharmaceutics (Materials Science)

Suryanarayanan, Sun

Drug Delivery

Kandimalla, Prabha, Panyam, Siegel, Wiedmann

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Center for Translational Drug Delivery

Developing collaborative relationships with pharmaceutical companies in the

area of drug delivery

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Raj Suryanarayanan(Sury), [email protected]

Goals and missions of the CenterBring together faculty with interest in drug

deliveryLeverage our comprehensive expertise in

drug delivery – develop collaborations with pharmaceutical companies

Work with the different administrative units to expedite legal and contractual issues

Serve as a platform for training grants and program project grants that are focused on drug delivery

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AeroCore

Supporting research and product development through inhalation

drug delivery

Core Activities

Aerosol generation Characterization of aerosol particles (output/particle

size distributions) Exposure of rodents to aerosol particles or vapors Measurement of chemicals deposited in the

respiratory tract and accumulation in blood of rodents Gross and microscopic examinations of rodents Disease induction in animal models (e.g. cancer)

1. Drug solubilization through engineering solid form (nanocaging, solid dispersion, cocrystallization, salt formation, etc.)

2. Tablet formulation and manufacturing process understanding and control

3. Structure-mechanical property relationship in organic crystals and powders

The aqueous solubility of poorly soluble drugs is significantly improved by nanocaging.

C.C. Sun

Kandimalla lab drug delivery projects

Design of nanotheranostics for the diagnosis and treatment of cerebrovascular diseases.

Elucidation of biophysical properties of endogenous macromolecules and their transport across the cellular barriers, particularly the blood brain barrier.

Development of novel drug delivery approaches to disrupt bacterial biofilms.

Strategies to evaluate and enhance oxidative stability of natural carrier oils.

Prabha Research Interests

Oral formulations to improve bioavailability of Oral formulations to improve bioavailability of poorly soluble drugspoorly soluble drugs

Anti-angiogenic therapy for ovarian cancerAnti-angiogenic therapy for ovarian cancer

Photodynamic therapy for treating microbial Photodynamic therapy for treating microbial infections in chronic woundsinfections in chronic wounds

Sustained protein/gene delivery for chronic woundsSustained protein/gene delivery for chronic wounds

Panyam Research Interests

Targeted Antibiotic Delivery for Chlamydial InfectionsTargeted Antibiotic Delivery for Chlamydial InfectionsNIAID/NIH NIAID/NIH

Magnetic Hyperthermia for Lung CancerMagnetic Hyperthermia for Lung CancerDepartment of Defense Department of Defense

Targeting Cancer Stem CellsTargeting Cancer Stem CellsRandy Shaver Foundation Randy Shaver Foundation

Polymeric Systems for Cancer Prevention/TreatmentPolymeric Systems for Cancer Prevention/TreatmentNCI/NIHNCI/NIH

SIEGEL LAB• Polymeric Drug Delivery Systems, Hydrogels• Microfabricated Sensors (e.g. temperature, pH,

glucose)• Intranasal Delivery of Low Solubility, Fast Acting

Drugs

Unabsorbed DZP Cleared in Nasopharynx

Diazepam (DZP) prodrug administered with converting enzyme

Absorption Through

Nasal MucosaDZP in

Bloodstream

Crystallization in

Nasal Cavity

Starting Line Finish Line

“Crystallization” Horse “Absorption” Horse

Application:Canine Epilepsy