Angioplasty Summit Seoul Sunao Nakamura M.D,Ph.D. New Tokyo Hospital New Tokyo Circulation Research Group Drug Eluting Stent Implantation For Unprotected Left Main Coronary Arteries Drug Eluting Stent Implantation For Unprotected Left Main Coronary Arteries
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Angioplasty Summit Seoul
Sunao Nakamura M.D,Ph.D.New Tokyo Hospital
New Tokyo Circulation Research Group
Drug Eluting Stent Implantation For Unprotected Left Main Coronary
Arteries
Drug Eluting Stent Implantation For Unprotected Left Main Coronary
Arteries
Angioplasty Summit Seoul
1. Park SJ, Kim YH, Lee BK, et al.Sirolimus-eluting stent implantation for unprotected left main coronaryartery stenosis. Comparison with bare metal stent implantation.
J Am Coll Cardiol 2005;45:351-62. Jose Suarez de Lezo, Alfonso Medina, Manuel Pan, et al.
Rapamycin-eluting stents for the treatment of unprotected left main coronary disease.
Am Heart 2004;148:481-53. Marco Valgimigli, Carlos A.G. van Mieghem, Andrew T.L. Ong, et al.
Short- and Long-Term Clinical Outcome After Drug-Eluting Stent Implantation for the Percutaneous Treatment of Left Main Coronary Artery Disease.
Circulation. 2005;111:1383-13894. Alaide Chieffo, Goran Stankovic, Erminio Bonizzoni, et al.
Early and Mid-Term Results of Drug-Eluting Stent Implantation in Unprotected Left Main.
Circulation 2005;111:791-7955. Marco Valgimigli, Patrizia Malagutti, Jiro Aoki, et al.
Sirolimus-Eluting Versus Paclitaxel-Eluting Stent Implantation for the Percutaneous Treatment of Left Main Coronary Artery Disease.
J Am Coll Cardiol 2006;47:507-146. Matthew J. Price, Ecaterina Cristea, Neil Sawhney, et al.
Serial Angiographic Follow-up of Sirolimus-Eluting Stents for Unprotected Left Main Coronary Artery Revascularization.
J Am Coll Cardiol 2006;47:871-7
Drug-Eluting Stent for Left Main Coronary ArteryDrug-Eluting Stent for Left Main Coronary Artery
Angioplasty Summit Seoul
1. S Nakamura, et al. Initial clinical experience of Sirolimus-eluting stent for treatment of left main coronary artery disease.
JSC 2004
2. S Nakamura, et al.Durable clinical benefit following Sirolimus-eluting stent deployment on the outcome of patients with unprotected left main coronary arteries.
TCT 2004, ACC 2005
3. S Nakamura, et al.Comparison of efficacy and safety between Sirolimus-eluting stent and Paclitaxel-eluting stent in unprotected left main coronary.
ACC 2005, ESC 2005
Drug-Eluting Stent for Left Main Coronary ArteryDrug-Eluting Stent for Left Main Coronary Artery
Angioplasty Summit Seoul
Saint Louis Hospital
Siriaj Hospital
-Multicenter Registry in Asia--Multicenter Registry in Asia-
Tamil Selvan Muthusamy M.D. (Malaysia)
Jang-Ho Bae M.D. (Korea)
Sudaratana Transapasawasdikul M.D.(Thailand)
Sunao Nakamura M.D., Ph.D. (Japan)
Yeo Hans Cahyadi M.D. (Indonesia)
Damras Tresukosol M.D. (Thailand)
Wasan Udayachalerm M.D. (Thailand)
New Tokyo Hospital
Chest Disease Institute
Konyang University Hospital
Husada Hospital
King ChulalongkornMemorial Hospital
Boonsert Chatlaong M.D. (Thailand)
Damansara Heart Center
Far Eastern Hospital Chao Loun Lai M.D. (Taiwan)
Angioplasty Summit Seoul
20022002 20032003 20042004
MarMar
20052005
Study Patients : LMTStudy Patients : LMT
Patients n=118Patients n=118
FebFeb
Patients n=211Patients n=211
Patients n=89Patients n=89
Patients n=88Patients n=88
TAXUS: Asian Multicenter LMT Registry
FebFeb FebFeb
20062006
FebFeb
Cypher: Asian Multicenter LMT Registry
Patients n=193Patients n=193
Patients n=102Patients n=102
BMS: Japanese Multicenter Registry
Patients n=288Patients n=288
> 2 years
> 1 year
> 3 years
> 3 years
> 2 years
> 2 years
> 1 year
Angioplasty Summit Seoul
Can We Improve Clinical Outcome of LMT PCI ?Can We Improve Clinical Outcome of LMT PCI ?
In hospital outcome
Can reduce restenosis ?
Long term durability ?
Cypher and TAXUS registry
Other DES ?
In hospital outcome
Angioplasty Summit Seoul
Cypher(n=193)
In-Hospital OutcomeIn-Hospital Outcome
Angiographic success (%)
Clinical success (%)
MACE (n)DeathQMIUrgent CABGUrgent PCI
Minor complication (%)Vascular hematoma
100
99.0
0101
4.9
100
100
0000
5.2
BMS(n=102)
(SAT)
(SAT)
p
NS
NS
NSNSNSNS
NS
100
100
0000
6.0
TAXUS(n=118)
Cypher TAXUSvsvs 2years2years
No SAT
Angioplasty Summit Seoul
0
5
10
15
5.55.5 5.95.9
00
10.010.0
00
Valgimigli
Chieffo
NakamuraPark
Price
30 DAYS: MACE30 DAYS: MACE
NO SAT
DES in LMT
(%)
Angioplasty Summit Seoul
Can We Improve Clinical Outcome of LMT PCI ?Can We Improve Clinical Outcome of LMT PCI ?
In hospital outcome
Can reduce restenosis ?
Long term durability ?
Cypher and TAXUS registry
Other DES ?
Can reduce restenosis ?
Angioplasty Summit Seoul
Can We Improve Clinical Outcome of LMT PCI ?Can We Improve Clinical Outcome of LMT PCI ?
Can We Perform LMT PCI in ALL Cases ?Can We Perform LMT PCI in ALL Cases ?
Angioplasty Summit Seoul
Conclusions Conclusions 1. Treatment of unprotected left main trunk coronary artery disease with
Cypher Sirolimus-eluting stent and Paclitaxel-eluting stent are safe and feasible.
2. Implantation of Cypher Sirolimus-eluting stent and Paclitaxel-eluting stent result in a larger MLD at follow-up and dramatically decrease the restenosis rate and target lesion revascularization compared with implantation of bare metal stent.
3. Implantation of Cypher Sirolimus-eluting stent and Paclitaxel-eluting stent with modified T-stenting with mini-crush stenting technique and single stenting technique seems to be able to decrease the restenosis rare at follow-up compared with other stenting techniques.
4. These clinical benefits with Cypher Sirolimus-eluting stent and Paclitaxel-eluting stent are durable at least 2 years.