Drug Carrier Systems Targeted to Widely Dispersed Cells Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Department of Pharmaceutics KLE University College of Pharmacy, BELGAUM-590010, Karnataka, India. Cell No.: 0091-9742431000 E-mail: [email protected]05 March 2013 1 DDSEC, Prince of Songkla University, Hat Yai, Thailand.
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Drug Carrier Systems Targeted to Widely Dispersed Cells
Drug Carrier Systems Targeted to Widely Dispersed Cells. Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Department of Pharmaceutics KLE University College of Pharmacy, BELGAUM-590010, Karnataka, India. Cell No.: 0091-9742431000 E-mail: [email protected]. CONTENT. - PowerPoint PPT Presentation
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Drug Carrier Systems Targeted to Widely
Dispersed Cells
Prof. Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D
Department of PharmaceuticsKLE University College of Pharmacy,BELGAUM-590010, Karnataka, India.
• Polymers: Dendrimers, Polymeric Micelles, Natural and Synthetic Polymeric Nanoparticles
05 March 2013 DDSEC, Prince of Songkla University, Hat Yai, Thailand. 27
Targeting to macrophages
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Delivery to lymphoid cells of Immune
network
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Lymphoid cell • Lymphoid cells lack granules, have a compact
nucleus, and a transparent cytoplasm. • They are involved in producing immunity.
Two main divisions:• Cell mediated immunity (T cell)
• Antibody mediated immunity (B cell)
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Human lymphocyte
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Cell membrane
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B Cells• Responsible for antibody-mediated
immunity• Defends against antigens and pathogens
in body fluids • Attack antigens by producing specific
antibodies• Corresponding antigens in interstitial fluids
bind to B cell receptors• B cell prepares for activation
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T Cells • Provide cell-mediated immunity
• Defends against abnormal cells and pathogens inside cells
• T cells only recognize antigens that are bound to glycoproteins in cell membranes
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Virosomes /Drug Carrier
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Drug Delivery to Tumours
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Immune surveillance
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Delivery to Lysosomal
Storage Diseases
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Lysosomal Storage Diseases
• Lysosomes are the cell's waste disposal system.
• Lysosomes Helps in repair damage to the plasma membrane by serving as a membrane patch, sealing the wound.
• LSDs occur with incidences of less than 1:100,000
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Lysosomal Storage Diseases
• Lysosomes break down unwanted matter via enzymes, highly specialized proteins essential for survival.
• A genetic defect in a protein responsible for maintaining the lysosomal system results in the accumulation within lysosomes of partially degraded molecules, the initial step in the process leading to a lysosomal storage disease.
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Causes for LSD’S1. Defects in the lysosomal function
2. Defects in the hydrolytic enzymes
3. Defects in post translational processing of
lysosomal enzymes.
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Lysosomal targeting of a Cell
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Therapies for Lysosomal Storage Diseases
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