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Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health
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Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Mar 28, 2015

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Page 1: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Dr S Saxena1 Dr G Ambler2

Prof. TJ Cole3 Prof A. Majeed1

1Imperial College London, 2UCLH Trust, 3Institute of Child Health

Page 2: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

England and Scotland have one of the fastest growing obesity rates in the world….more than doubled between 1980 and the early nineties...(2001 figures) show 21% of men and 23.5% of women over 16 years have a Body Mass Index of 30 or more in England.

Page 3: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Background

• Obesity epidemic world wide

• US rising faster in African-Americans

• British South Asians & Afro-Caribbean adults at risk of cardiac disease

• British South Asian children have worse biochemical risk profiles for cardiac disease

Page 4: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Interrelationships

Diabetes

Cardiovascular disease

Black Caribbean

S. Asian ethnicity

Obesity

Page 5: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Aims

To compare the percentage of obese or overweight children within different ethnic and socio-economic groups

Page 6: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Health Survey for England1999

• Annual cross sectional survey

• Focus on ethnic minority groups

• Random sampling of private households

• Interview & nurse visit for measurements

Page 7: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Sampling

Ethnic boostn=3891

Ethnic groupsn=4857

General Populationn=6552

“Core”general

pop n=2061

Chinese n=342

Ethnicgroupsn=354

postcode sectors

household

screening

Systematic samplingRandom sampling

Page 8: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Ethnic group categories in HSE99

‘Chinese’

‘Bangladeshi’

‘Pakistani’

‘Indian’

‘Afro-Caribbean’

‘General population’

ETHNIC GROUPS COMPARED

‘Irish’

Page 9: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

height 2weight /BMI =(kg) (m)(kg/m2)

Body Mass Index

Measure

Page 10: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

*US reference population # UK growth reference charts (1991)

Defining obesity in children

Adults overweight: BMI 25 kg/m2

obese: BMI 30 kg/m2*

• In children, BMI rapidly changes with age• In US,85th and 95th centile for OW and OB*• UK growth reference charts adopt this#

Page 11: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

IOTF standard 2000

Overweight Obesity

Page 12: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

% Response rates

Gen Pop Ethnic boost

Household 76 71

Interview 97 92-96

Nurse visit 89 86

Page 13: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Results : Socio-economic status of ethnic groups

Social Ethnicity

class

G.PopAC Ind Pak Bang Chin Irish

I+II 34 22 28 18 9 37 39

IIIn 13 22 10 6 7 16 15

IIIm 31 22 30 40 35 31 29

IV+V 20 28 28 23 33 10 16

Page 14: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Results : Socio-economic status of ethnic groups

Social Ethnicity

class

G.PopAC Ind Pak Bang Chin Irish

I+II 34 22 28 18 9 37 39

IIIn 13 22 10 6 7 16 15

IIIm 31 22 30 40 35 31 29

IV+V 20 28 28 23 33 10 16

Page 15: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk of being overweight in girls by social class

0

0.4

0.8

1.2

1.6

I & II IIIn IIIm IV&V

Ad

just

ed o

dd

s ra

tios

Social class

Page 16: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk of being overweight in boys by social class

0

0.4

0.8

1.2

1.6

I & II IIIn IIIm IV&V

Ad

just

ed o

dd

s ra

tio

Social class

Page 17: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk overweight in boys by ethnic group

0

0.5

1

1.5

2

2.5

3

Genpopn

Afro-Carib

Indian Pakistani Bangla Chinese Irish

Ethnic group

Ad

just

ed

od

ds

rat

io

Page 18: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk overweight in girls by ethnic group

Ethnic group

0

0.5

1

1.5

2

2.5

Genpopn

Afro-Carib

Indian Pakistani Bangla Chinese Irish

Ad

just

ed

od

ds

rat

io

Page 19: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk of obesity in boys by ethnic group

0

0.5

1

1.5

2

2.5

3

Genpopn

Afro-Carib

Indian Pakistani Bangla Chinese Irish

Ethnic group

Ad

just

ed

od

ds

rat

io

Page 20: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Risk of obesity in girls by ethnic group

00.5

11.5

22.5

33.5

4

4.55

Genpopn

Afro-Carib

Indian Pakistani Bangla Chinese Irish

Ethnic group

Ad

just

ed

od

ds

rat

io

Page 21: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Strengths of study

Power: Large

Representative:Population based study

Measure: Objective (BMI)

Page 22: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Ethnic group comparisons: limitations

• Different heights for same BMI

• Different fat composition for same BMI

• Ethnic group reported by parent

• Data cross sectional

Page 23: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Conclusions

• Ethnicity strong determinant of obesity in children

• British Afro-Caribbean & Pakistani girls at increased risk of obesity

• Indian and Pakistani boys more likely to be overweight

• Social class differences do not contribute to obesity in children

Page 24: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Possible explanations

Biologicalgenetic

susceptibility

Behaviouraldiet

exercise patterns

Factors related to ethnic group

ENERG Y REG ULATIO N

Body fat stores

Page 25: Dr S Saxena 1 Dr G Ambler 2 Prof. TJ Cole 3 Prof A. Majeed 1 1 Imperial College London, 2 UCLH Trust, 3 Institute of Child Health.

Future studies

• Longitudinal studies for cumulative risk

• Develop standards for child obesity

• Include ethnicity in assessing cardiac risk