Fertility preservation in patients on cytotoxic therapy Dr Kamini A Rao
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Dr Kamini A Rao. Over 100 000 individuals under 45 years are diagnosed of cancer annually in US. Improved treatment and survival Fertility preservation.
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Slide 1
Dr Kamini A Rao
Slide 2
Over 100 000 individuals under 45 years are diagnosed of cancer
annually in US. Improved treatment and survival Fertility
preservation is a quality-of-life issue.
Slide 3
Factors contributing to ovarian failure: Age at time of
treatment Drug type Cumulative dose Cyclophosphamide: Most
gonado-toxic Cumulative dose strongly influences POF rate Pelvic or
total body irradiation also has high risk of POF
Slide 4
No ideal marker FSH AMH ovarian volume AFC similar to controls
Transient suppression of inhibin B in pre-pubertal girls.
Slide 5
1. Young cancer patients 2. Childhood pelvic tumours: Ewings
sarcoma, osteosarcoma, retroperitoneal sarcoma, anorectal cancer 3.
Wilms tumour, neuroblastoma, rhabdomyosarcoma 4. Autoimmune
disorders SLE, Behcets disease, steroid resistant
glomerulonephritis 5. Chemotherapy for bone marrow transplantation
and stem cell transplantation
Slide 6
15% of all breast cancer cases are estimated to occur in
women