1 Noviembre 2005 Dr. Juan Rodríguez-Tafur D. Profesor Asociado de Inmunología y Farmacología Facultad de Medicina Universidad Nacional Mayor de San Marcos. Lima (Perú) Secretario de la Sociedad Peruana de Alergía e Inmunología www.alergomurcia.com The New England Journal of Medicine Vol. 336(15) Apr 10, 1997 pp 1066-1071 Mechanisms of Disease: Nuclear Factor-(kappa)B -- a Pivotal Transcription Factor in Chronic Inflammatory Diseases. Barnes, Peter J.; Karin, Michael. The New England Journal of Medicine Vol. 336(15) Apr 10, 1997 pp 1066-1071 Mechanisms of Disease: Nuclear Factor-(kappa)B -- a Pivotal Transcription Factor in Chronic Inflammatory Diseases. Barnes, Peter J.; Karin, Michael. Noviembre 2005 www.alergomurcia.com
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1
Noviembre 2005
Dr. Juan Rodríguez-Tafur D.Profesor Asociado de Inmunología y Farmacología
Facultad de MedicinaUniversidad Nacional Mayor de San Marcos. Lima (Perú)
Secretario de la Sociedad Peruana de Alergía e Inmunología
www.alergomurcia.com
The New England Journal of Medicine
Vol. 336(15) Apr 10, 1997 pp 1066-1071
Mechanisms of Disease: Nuclear Factor-(kappa)B --a Pivotal Transcription Factor in ChronicInflammatory Diseases. Barnes, Peter J.; Karin, Michael.
The New England Journal of Medicine
Vol. 336(15) Apr 10, 1997 pp 1066-1071
Mechanisms of Disease: Nuclear Factor-(kappa)B --a Pivotal Transcription Factor in ChronicInflammatory Diseases. Barnes, Peter J.; Karin, Michael.
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):380-3.Hypothetical mechanisms of action of an H1-antihistamine in asthma.
Rihoux JP, Michel L, Arnold R, Koning WUCB SA, Chemin du Foriest B-1420 Braine-l'Alleud, Belgium.
Some recent clinical studies carried out with the potent H1-antihistamine cetirizine (CTZ) suggest that this drug could be useful for the treatment of mild to moderate asthma and even for the prevention of the disease. Besides a potent antagonism of H1-receptors at bronchial level, this drug was also shown to exert a large series of anti-inflammatory effects in in vitro, ex vivo and in vivo pharmacological models and also in clinical situations in atopic subjects. All the data collected up to now suggest the possible existence in the molecule of a central key mechanism of action on resident cells especially involved in cell trafficking and bronchial inflammation, i.e a down-regulating effect on the nuclear factorKappaB (NFkappaB). This hypothesis was tested on human endothelial cells and a human epithelial pulmonary cell line using different experimental methods. The results showed that CTZ down-regulates the TNF-alpha-induced hyperactivation of NFKappaB in these two different resident cells at physiological concentrations.
Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):380-3.Hypothetical mechanisms of action of an H1-antihistamine in asthma.
Rihoux JP, Michel L, Arnold R, Koning WUCB SA, Chemin du Foriest B-1420 Braine-l'Alleud, Belgium.
Some recent clinical studies carried out with the potent H1-antihistamine cetirizine (CTZ) suggest that this drug could be useful for the treatment of mild to moderate asthma and even for the prevention of the disease. Besides a potent antagonism of H1-receptors at bronchial level, this drug was also shown to exert a large series of anti-inflammatory effects in in vitro, ex vivo and in vivo pharmacological models and also in clinical situations in atopic subjects. All the data collected up to now suggest the possible existence in the molecule of a central key mechanism of action on resident cells especially involved in cell trafficking and bronchial inflammation, i.e a down-regulating effect on the nuclear factorKappaB (NFkappaB). This hypothesis was tested on human endothelial cells and a human epithelial pulmonary cell line using different experimental methods. The results showed that CTZ down-regulates the TNF-alpha-induced hyperactivation of NFKappaB in these two different resident cells at physiological concentrations.