Dr. David Goldman, MD, MPH Chief Medical Officer, USPHS Assistant Administrator Office of Public Health Science Food Safety & Inspection Service USDA November 13, 2013 Kansas City, MO Antibiotic Residue Testing in Meat and Poultry - Bridging the Gap to Protect Human Health -
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Dr. David Goldman - Meat/Poultry Antibiotic Residue Testing, Protecting Human Health
Meat/Poultry Antibiotic Residue Testing, Protecting Human Health - Dr. David Goldman, Chief Medical Officer, USPHS Office of Public Health Science, Food Safety and Inspection Service, from the 2013 NIAA Symposium Bridging the Gap Between Animal Health and Human Health, November 12-14, 2013, Kansas City, MO, USA.
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Dr. David Goldman, MD, MPHChief Medical Officer, USPHS
Assistant AdministratorOffice of Public Health Science
Food Safety & Inspection Service USDA
November 13, 2013Kansas City, MO
Antibiotic Residue Testing in Meat and Poultry
- Bridging the Gap to Protect Human Health -
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Overview/Changes to the FSIS National Residue Program
Variability in the Level of In-plant Screening
NARMS Participation & FSIS Multi Hazard Project
FSIS Residue Lab Method (Changes)
Chemicals without Tolerances
Presentation Outline
United States Department of AgricultureFood Safety and Inspection Service
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NRP Overview/Changes
United States Department of AgricultureFood Safety and Inspection Service
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Purpose• Provide a structured process for identifying and
evaluating chemical compounds of concern in food animals
• Test for the presence of chemical compounds, including approved (legal) and unapproved (illegal) veterinary drugs, pesticides, hormones, and environmental contaminants in meat, poultry, and egg products.
• Identify need for regulatory follow-up when violative levels of chemicals residues are found
National Residue Program
United States Department of AgricultureFood Safety and Inspection Service
National Residue Program
The domestic sampling includes: (Headquarters) Scheduled Sampling – which consist of the
random sampling of tissue from food animals that have passed ante-mortem inspection.
Inspector Generated Sampling – which is conducted by in-plant personnel (IPP), when the Public Health Veterinarians (PHVs) suspects that an animal may contain violative levels of chemical residues.
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Inspector-generated: Sampling Flow Diagram
IPP identifies a carcass to
test for residue
In-Plant Screen Test
PositiveSend sample to
FSIS Laboratory
Negative
Carcass released for human food
Owner/Producer Information and all
man-made ID recorded
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In-plant screen
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KIS™ test Positive
New Testing Scheme
Aminoglycosides Method
Multi Residue Method
Old Testing Scheme
KIS™ Test Repeat
7-Plate Bioassay
Sulfonamides
Flunixin
Owner/Producer Information and
animal’s ID recorded
Surveillance Targeted Testing Program Process
Sample Flow Diagram - FSIS Laboratory
Confirmation Test Positive
Qualitative Analysis
Completed
NegativeCarcass released for human food
Positive: Quantitation/
Violative LevelsCarcass and/or
Parts Condemned
Positive: Quantitated/Non-Violative Levels
Carcass released for human food
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FSIS announcement of restructuring NRP - July 2012News Release : Congressional and Public Affairs – OPPDUSDA to Enhance Consumer Safeguards with Expanded Testing for Illegal Drug Residues in Meat.
“A new approach to its testing to protect the public from exposure to harmful levels of chemical residues in meat, poultry, and egg products”
New (multi-residue) chemical methods (screens) and samples scheduling algorithms
Impact of implementing new methods - FSIS lab resources conservation b/c
analyzing more chemical compound per sample
Revamping the scheduled sampling program by increasing the annual number of samples per slaughter class from 230/300 to 800 per animal class.
Improving NRP
United States Department of AgricultureFood Safety and Inspection Service
Paired Multi-Analyses
800 samples
Many production
classes
Multiple compounds
1 production class – 300 samples
Single compound
10888888888
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Advantages
United States Department of AgricultureFood Safety and Inspection Service
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3-Tiered Model
Additional testing
Tier 1 – Scheduled Sampling:
Appropriate Methods Violative Residues
Tier 2 – Targeted Sampling:
Violative Residues
Tier 3 – Targeted Flock/Herd:
May direct sample
for Tier 2 Testing
Appropriate Methods
Violative Residues
Appropriate Methods Additional testing
United States Department of AgricultureFood Safety and Inspection Service
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FSIS has published the first quarterly report that summarizes chemical residue results for the NRP
The report will provide chemical residue testing results more frequently to increase program transparency for all stakeholders
The report is NOT intended to replace the annual report known as FSIS Red Book (FSIS will continue publish)
Quarterly Residue Report
United States Department of AgricultureFood Safety and Inspection Service
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2012 NRP Preliminary data*(Unpublished – from PHIS)
United States Department of AgricultureFood Safety and Inspection Service
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FSIS residue workgroup looked at level in-plant screening to evaluate the degree of variability in testing across production classes in relation to slaughter volume, animals identified as suspect and/or condemned.
Variability in in-plant screening for chemical residues
United States Department of AgricultureFood Safety and Inspection Service
Total 3316 799 24.16% 1219 36.77% 636 94.22% 551 96.50%
FSIS has assumed some of the responsibility to continue the animal arm work done since NARMS inception by ARS
All further characterization (molecular serotyping, PFGE and antimicrobial susceptibility testing) for HACCP and other salmonella isolates will be performed by FSIS Eastern Lab
Results will be stored in the FSIS Data Warehouse and results will be uploaded to PN and NARMS Integrated DB
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NARMS HACCP Sampling and Reporting
United States Department of AgricultureFood Safety and Inspection Service
FSIS Multi Hazard ProjectFSIS is conducting an exploratory pilot program to identify unexpected hazards or multiple concurrent hazards in FSIS regulated products by analyzing reserve microbiology samples with several chemistry residue methods.
This sampling program will assist FSIS in defining potential effectiveness of merging microbiology and chemistry sampling programs.
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United States Department of AgricultureFood Safety and Inspection Service