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Dr Adam Watson Eye Institute 16:30 - 17:25 WS #188: Identifying and Managing Problems With the Surface of the Eye 17:35 - 18:30 WS #200: Identifying and Managing Problems With the Surface of the Eye (Repeated) Dr Shanu Subbiah Ophthalmologist Eye Surgeon Eye Institute
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Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Sep 06, 2019

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Page 1: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Dr Adam WatsonEye Institute

16:30 - 17:25 WS #188: Identifying and Managing Problems With the Surface of the Eye

17:35 - 18:30 WS #200: Identifying and Managing Problems With the Surface of the Eye

(Repeated)

Dr Shanu SubbiahOphthalmologist

Eye Surgeon

Eye Institute

Page 2: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Copyright 2017 Eye Institute. Confidential.

Surface of the Eye-Identifying and Handling Problems

Dr Adam WatsonCataract, Cornea, Refractive,

Oculoplastic Surgery

Dr Shanu SubbiahCataract, Refractive Surgery,

Medical Retina, Cornea

Page 3: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Central - Remuera

South - Manukau

North - Northcote

West – New Lynn

Dr Adam Watson [email protected]

Page 4: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Copyright 2017 Eye Institute. Confidential.

Pterygium

Page 5: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Pterygium. What’s with the name?

from Greek “little wing”

Dr Adam Watson [email protected]

Page 6: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

What causes pterygium?

Dr Adam Watson [email protected]

Page 7: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium - cause

•p53 protein overexpressed without

apoptosis

•indicates probable p53 gene mutations

•damaged p53-dependent programmed

cell death mechanism allows

progressive accumulation of other

mutations

•allow the multi-step development of

pterygia and limbal tumours

Dr Adam Watson [email protected]

Page 8: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Does everyone with pterygium need surgery?

No

Dr Adam Watson [email protected]

Page 9: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium – who needs surgery?

• Vision

• Symptoms

• Appearance

Dr Adam Watson [email protected]

Page 10: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium – who needs surgery?

small but prominent

• Vision

• Symptoms

• Appearance

Dr Adam Watson [email protected]

Page 11: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium – who needs surgery?

• Vision

• Symptoms

• Appearance

Dr Adam Watson [email protected]

Page 12: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Do you just scrape it off?

Dr Adam Watson [email protected]

Page 13: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable
Page 14: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium post-op

3 months (different eye!)2 weeks

Dr Adam Watson [email protected]

Page 15: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

If you remove them, they just come back don’t they?

Dr Adam Watson [email protected]

Page 16: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium - recurrence

Technique

bare sclera 50%

conjunctival flap 10%

conjunctival autograft <5%

beta radiation

Dr Adam Watson [email protected]

Page 17: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Is there a season for pterygium surgery?

No

Dr Adam Watson [email protected]

Page 18: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Do pingueculae become pterygia?

Dr Adam Watson [email protected]

Page 19: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium – from pinguecula?

Probably not, most of the time

Dr Adam Watson [email protected]

Page 20: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium

Should I be worried it could be something else?

Dr Adam Watson [email protected]

Page 21: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium – other possible pathologies

• pseudopterygium

• squamous neoplasia

(OSSN/CIN)

• peripheral degenerative

conditions

• trauma, scars etc.

localised chemical burnOSSNperipheral degeneration

Dr Adam Watson [email protected]

Page 22: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Pterygium - Summary

• prevalence 3%1

• sun exposure aetiology

• surgery remarkably safe

and effective

• be aware of atypical

pterygium mimickers

Dr Adam Watson [email protected]. Taylor Br J Ophthalmol 2000;84:289 Victoria, Australia

Page 23: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Copyright 2017 Eye Institute. Confidential.

Meibomian glands and the

ocular surface

Page 24: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Glands

What are Meibomian glands?

Dr Adam Watson [email protected]

Heinrich Meibom (1638-1700)German physician and poet

Page 25: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Glands

• oil secreting glands

• upper and lower eyelids

infra red meibography

Dr Adam Watson [email protected]

Page 26: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Glands

Dr Adam Watson [email protected]

MG Dysfunction

Page 27: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Dr Adam Watson [email protected]

“classic” tear film modeltear film model updated

tear film instability

Page 28: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

Why dysfunction?

No good answer

Dr Adam Watson [email protected]

Page 29: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction - associations

• age

• rosacea

• genetic

• diet?

Dr Adam Watson [email protected]

Page 30: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

Is this the same as blepharitis?

Dr Adam Watson [email protected]

It’s a subset of blepharitis

Page 31: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

Dr Adam Watson [email protected]

anterior blepharitisposterior blepharitis

Page 32: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

How do I identify it in my practice?

Dr Adam Watson [email protected]

Page 33: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Identifying MGD

Symptoms:

• dry, irritated eyes

• stinging, burning

• intermittent watering

• variable vision

• morning predominance

Dr Adam Watson [email protected]

approx 70% of dry eye patients have MGD

Rabensteiner. Acta Ophthalmol 2018;96:e707

30 to 60% of people have signs of MGD

Page 34: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Identifying MGD

Signs:

• redness

• thickened lid margins, blunted architecture

• congested glands

• thickened or frothy secretions

• eyelash misdirection

• chalazia

• rosacea

• MG “dropout”

Dr Adam Watson [email protected]

Page 35: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

Can you cure MGD?

No

Dr Adam Watson [email protected]

Page 36: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

So what should I tell people to do?

Dr Adam Watson [email protected]

Ongoing control

Page 37: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

MGD treatment

• heat treatments

Dr Adam Watson [email protected]

2 to 10 minutes every morning

Page 38: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

MGD treatment

• heat treatments

• Omega 3 supplement

Dr Adam Watson [email protected]

3000 mg daily

Page 39: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

MGD treatment

• heat treatments

• Omega 3 supplement

• lubricant drops

Dr Adam Watson [email protected]

restore lipid layer

Page 40: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

MGD treatment

• heat treatments

• Omega 3 supplement

• lubricant drops

• disease modifying

antibiotic

Dr Adam Watson [email protected]

Doxycycline 50mg daily 6 to 12 weeks

Azithromycin 500mg daily 3 days

Page 41: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

Who needs referral?

Dr Adam Watson [email protected]

Unsatisfactory outcome with basic treatments

Page 42: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction

• detailed tear film, MG and dry

eye assessment

• intense pulsed light therapy

• gland expression

• topical anti-inflammatories

Dr Adam Watson [email protected]

Page 43: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

Meibomian Gland Dysfunction - Summary

• it’s common

• think of it as a cause for

your patients’ low grade

dryness, watering and

redness symptoms

Page 44: Dr Adam Watson Dr Shanu Subbiah - gpcme.co.nz north/Sat_Room5_1630_Watson - Ocular surface... · Pterygium - cause •p53 protein overexpressed without apoptosis •indicates probable

And now, Dr Shanu Subbiah