1 2 pôles d’excellence Chimie du vivant BIO Chimie des surfaces et nanomatériaux MATERIAUX Département de Chimie des FUNDP Chimie du vivant BIO § Chimie des surfaces et nanomatériaux MATERIAUX * Groupe de Chimie Physique Théorique et Structurale(GCPTS) D.Vercauteren § , J.Wouters § , JM.André * Groupe de Chimie Organique et Bio-organique supramoléculaire (GCOBS) S.Vincent § , D.Bonifazi *, A.Krief § (successeur) Groupe de Chimie des nanomatériaux (GCNM) BL.Su *, L.BNagy * (successeur) Groupe de Chimie et d’Electrochimie des Surfaces (GCES) Z.Mekhalif *, J.Delhalle *
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1
2 pôles d’excellence
Chimie du vivant
BIO
Chimie des surfaces et
nanomatériaux
MATERIAUX
Département de Chimie des FUNDP
Chimie du vivant
BIO§
Chimie des surfaces et
nanomatériaux
MATERIAUX*
Groupe de Chimie Physique Théorique et Structurale(GCPTS)D.Vercauteren§, J.Wouters§, JM.André*
Groupe de Chimie Organique et Bio-organiquesupramoléculaire (GCOBS)
S.Vincent§, D.Bonifazi*, A.Krief§ (successeur)
Groupe de Chimie des nanomatériaux (GCNM)BL.Su*, L.BNagy* (successeur)
Groupe de Chimie et d’Electrochimie des Surfaces (GCES)Z.Mekhalif*, J.Delhalle*
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BIO MATERIAUX
Structural Biological ChemistryLaboratory
J.WOUTERS et al.
BIO MAT
Competences- Organic Synthesis- Carbohydrate Chemistry- Rational Design of Inhibitors- Enzyme kinetics- Binding constants measurements- Use of enzymes for preparative chemistry
Competences- crystallography- protein purification- physico-chemistry of proteins- structure-based drug design
Scientific area- structural chemistry and biochemistry- structure-function relationships- medicinal chemistry
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Structural Biological ChemistryLaboratory
J.WOUTERS et al.
BIO MAT
0,1 mm
Structural Biological ChemistryLaboratory
J.WOUTERS et al.
BIO MAT
R6R97
W219 FMN
IPP
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Structural Biology : mechanisms ofenzymes
Ligand-Based and Target-Based Drud Design
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Structure-Based Drud Design
Physico-chemical phenomena in life sciences using quantum
chemistry approaches
Example of research project in progress :
Analyzing the nonlinear optical (NLO) responses of Green Fluorescent Protein as a function of the protonation state in comparison with their absorption and emission spectra.
Chromophore in protonated form
Proposal : unraveling the behavior and properties of “active molecules” in living environments (in particular, chromophores, radicals, and chiral species).
B.Champagne et al.
BIO MAT
Ongoing Projects and Synergy within the
'PÔLE MATERIAUX'
Key Words
Chemistry
Surfaces , Materials
COMS Research Areas
Creation of functional molecular architectures characterized by innovating targeted synthesis, physical-organic studies, and material-based
design
Research Areas
COMS
Exploring Weak Interactions
Organic Nanochemistry
Carbon-based Materials
•Molecular organic emitting diodes (OLEDs)
•Organic nanopatteringof surfaces
•Molecular electronics
•Organic modifications of silicon surfaces
•New supramolecular resins for art conservation
•Molecular organic emitting diodes (OLEDs)
•Organic nanopatteringof surfaces
•Molecular electronics
•Organic modifications of silicon surfaces
•New supramolecular resins for art conservation
•Fullerene-based materials
•Carbon nanotubes(molecular imaging and photovoltaic devices)
•Synthetic porphyrinchemistry
•Highly-luminescent polycyclic modules
•Fullerene-based materials
•Carbon nanotubes(molecular imaging and photovoltaic devices)
•Synthetic porphyrinchemistry
•Highly-luminescent polycyclic modules
•Host-guest chemistry (fluorescent capsules)
•Hydrogen-bonding interactions
•Hydrophobic interactions
•Host-guest chemistry (fluorescent capsules)
•Hydrogen-bonding interactions
•Hydrophobic interactions
CES Research Areas
Electrochemistry and Surface Chemistry for Functional Materials
Synthesis and Analysis
CES
Surface ChemistryLarge and Nano surfaces
Electrochemistry for Synthesis and
Analysis
CNTs-based Materials
•Electrochemistry in Ionic liquids
•Materials Synthesis : Composites, Nanowires, Conducting and Insulating Polymers
•ElectrochromicMaterials
Local techniques (SVET, SKP, SECM)
•Functinalization, new methods
•Composites Polymers/CNTs
•Composites Metals/CNTs
•Exploring covalent bonds
•Self-Assembly on active metals
•Biomaterial Surfaces
Research Areas
Synergy and Complementarities between COMS and CES
D. BONIFAZI, J. DELHALLE, Z. MEKHALIF
PÔLE MATERIAUX
Chemistry and Material Synthesis :
Organic Chemistry and Electrochemistry
Surface Chemistry and Self-Assembly :
Monolayer and Multilayers Assembly : Covalent Interactions
Supramolecular Assembly : Non Covalent Interactions
Single-walled Carbon Nanotubes coated with Eu(III) complexes
G. Accorsi, N. Armaroli,* A. Parisini,* M. Meneghetti,* R. Marega, M. Prato, and D. Bonifazi,* Adv. Funct. Mater., 2007, in press.
Z-contrast ADF-STEM micrographs
Cover page, in press.
COMS
Oxidation Single Walled Carbon Nanotubes
R. C. Haddon and co., Chem. Phys. Lett. 2001, 347, 8; R. E. Smalley and co., Chem. Phys. Lett. 2000, 324, 213; A. Hirsch, Angew. Chem. Int. Ed., 2002, 41, 1857; D. Tasis, N. Tagmatarchis, V. Georgakilas, M. Prato, Chem. Eur. J. 2003, 9, 4000.
35nm
STM Investigation of sh-SWNT Functionalized with n-C18H37NH2 (Endcaps)
32nm
123nm
16nm
Substrate: Au(111) deposited on micaT = 298 K (in air); Tip = TiPercentage of functionalization: 78 ± 9 %Linear density of bumps [μm-1]: 16 ± 3
D. Bonifazi, C. Nacci, R. Marega, G. Ceballos, S. Modesti, M. Meneghetti, and M. Prato, Nano Lett., 2006, 6,1408.
COMS
CES
L.VAST et Al‘Chemical functionalization by a fluorinated trichlorosilane of multi-walled carbon nanotubes’Nanotechnology, 15 (2004) 781-785.
L.VAST et Al‘Dispersion of organic functionalized multi-walled carbon nanotubes in silicone base’Composites Science and Technology, 67 (2006) 880-889.
L.VAST et Al‘Note on the dispersion in perfluoropolyether lubricants of multi-walled carbon nanotubes functionalized with (tridecafluoro-1,1,2,2-tetrahydrooctyl)trichlorosilane’Journal of Nanoscience and Nanotechnology (2007) in press
L. VAST et Al ‘Formation of an adherent polyacrylonitrile/carbon nanotubes composite film onto a polyacrylonitrile brush electrografted on copper’Nanoscience and Nanotechnology (2007), in press
SiO
O
OY x
SiO
O
OSi
O
O
Y
Y
x
x
Fomblin®/pMWNTs(0.5 wt.%)
CES
PAN/pMWNTs(4 wt.%)
CES
Silicone/pMWNTs(0.5 wt.%)
CES
CES Covalent Covalent FunctionalizedFunctionalized MWNTs (f MWNTs)MWNTs (f MWNTs)
Silicone
PANFomblin®
10 nm 5 nm10 nm
SiO
O
OY x
SiO
O
OSi
O
O
Y
Y
x
x
continuous organic coating on carbon nanotubes walls and ends (~2nm)