Do Now 1.Turn in Alien Invasion (staple sheets together) 2.Get out Protein Synthesis HW 3.Explain the difference between transcription and translation. (Hint: Think about what is made) 4.Explain difference between codon and anticodon. After answering the above questions get out a piece of scratch paper.
Do Now
Dec 31, 2015
Do Now. Turn in Alien Invasion (staple sheets together) Get out Protein Synthesis HW Explain the difference between transcription and translation. (Hint: Think about what is made) Explain difference between codon and anticodon . - PowerPoint PPT Presentation
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Do Now1. Turn in Alien Invasion (staple sheets together)2. Get out Protein Synthesis HW3. Explain the difference between transcription and
translation. (Hint: Think about what is made)4. Explain difference between codon and
anticodon.After answering the above questions get out a piece
of scratch paper.
What is the protein for the DNA strand below?
TAATACAGGTTGCGTACT
AUUAUGUCCAACGCAUGA
MET SER ASN ALA STOP
TRANSCRIPTION
TRANSLATION
DNA
RNA
Protein Synthesis ReviewVideo
MutationsMutations
What is a mutation?
Change in the DNA nitrogen base
sequence of a gene
How do Mutations Occur?
Errors in DNA Replication
Replication
How do Mutations Occur?
Damaged DNA caused by
agents such as sunlight, smoke,
radiation
How do we get mutations????
Two ways to classify mutations
Acquired mutation
Get a mutation at some point in life.
Hint: Think of it like getting sick, but you
can’t get rid of it.
Two ways to classify mutations
Inherited mutation
Get a mutation from your
parents
Let’s practice protein synthesis with normal DNA
DNA: TAC AAC GTC ACC ATT
mRNA: AUG UUG CAG UGG UAA
Amino acid: Met Leu Gln Trp STOP
Category of Mutation: Point Change in one base of the DNA sequence.
Original: The fat cat ate the wee rat
Point mutation: The fat hat ate the wee rat
Example of Point Mutation: Sickle Cell Anemia
Sickle Cell Anemia: Point Mutation
Sickle Cell Anemia Story(Beginning to 3:00)
Category of Mutation: Frameshift Addition or deletion of a DNA base resulting
in a different sequence of DNA.
Original: The fat cat ate the wee rat
Frameshift mutation: The fat ata tet hew eer at
Example of Frameshift Mutation: Tay Sachs
Tay Sachs Disease: Frameshift Mutation
Type of Mutations: Missense Change in one base of the DNA sequence
which causes a change in amino acid.
Mutated Example of Missense
DNA: TAC AAG GTC ACC ATT
mRNA: AUG UUC CAG UGG UAA
Amino acid: Met Phe Gln Trp STOP
Type of Mutations: Nonsense Change in one base of the DNA sequence
which codes for a STOP codon
Mutated Example of Nonsense
DNA: TAC AAC GTC ACT ATT
mRNA: AUG UUG CAG UGA UAA
Amino acid: Met Phe Gln STOP
Type of Mutations: SilentChange in one base of the DNA sequence which
has no effect on the amino acid sequence
Mutated Example of Silent
DNA: TAC AAT GTC ACC ATT
mRNA: AUG UUA CAG UGG UAA
Amino acid: Met Leu Gln Trp STOP
Type of Mutations: InsertionAddition of one or more bases into a DNA
sequence
Mutated Example of Insertion
DNA: TAC AAC CGT CAC CAT T
mRNA: AUG UUG GCA GUG GUA A
Amino acid: Met Leu Gly Val Val
Type of Mutations: DeletionThe removal of one or more bases in DNA
Mutated Example of Deletion
DNA: TAC AAC GCA CCA TT
mRNA: AUG UUG CGA GGU AA
Amino acid: Met Leu Arg Gly
Blame it on DNA: Review Song
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