This presentation is intended for educational use only, and does not in any way constitute medical consultation or advice related to any specific patient. Mountain West AIDS Education and Training Center Do Integrase Inhibitors Cause Weight Gain? Brian R. Wood, MD Associate Professor of Medicine, University of Washington Medical Director, MW AETC ECHO Last Updated: 11/9/17
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This presentation is intended for educational use only, and does not in any way constitute medical consultation or advice
related to any specific patient.
Mountain West AIDS Education and Training Center
Do Integrase Inhibitors Cause Weight Gain?
Brian R. Wood, MD
Associate Professor of Medicine, University of Washington
Medical Director, MW AETC ECHO
Last Updated: 11/9/17
Antiretroviral Therapy and Weight Gain
• Weight gain is frequent in the year following ART initiation1,2
• May be associated with lower mortality for those who are not
initially overweight3
• However, may lead to higher rates of DM and CVD4,5
• May be more likely with a PI,2 though change in lean mass or
regional fat similar b/w RAL, DRV/r, & ATV/r after 96 weeks6
1. Koethe JR et al. AIDS Res Hum Retroviruses, Jan 2016 2. Lakey W et al. AIDS Res Hum
Retroviruses, March 2013. 3. Yuh B et al. CID, June 2015. 4. Achhra AC et al. HIV Med, April 2016.
5. Herrin M et al. JAIDS, Oct 2016. 6. McComsey GA et al. CID, April 2016.
Guidelines-Based Regimens for Initial ART
Recommended Regimens
Sources:
2017 HHS Antiretroviral Therapy Guidelines. AIDS Info (www.aidsinfo.nih.gov)