DNA structure & Replication • DNA • Composition of DNA • Evidence for genetic material • Structure • Implications of the structure • DNA replication
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DNA structure & Replication
• DNA• Composition of DNA • Evidence for genetic material • Structure • Implications of the structure• DNA replication
DNA & Nucleotides
Evidence for genetic material: Griffith transformation
Evidence for genetic material
Avery, McCarty & Macleod
Hershey- Chase expt
Structure
Chargaff’s rules
Base Pairing Rules
Watson-Crick Model
• The double helix • base pairing rules • anti-parallel strands • bases/turn • major and minor
groove
Implications of the structure
• DNA replication
• Genetic Information stored in DNA molecule
DNA replication • DNA replication• Process of Replication
in E. coli• Origin of replication• Role of Primase: RNA
Primer • Elongation • Lagging strand
synthesis: Okazaki fragments
• Error rate of DNA synthesis
• Eukaryotic Replication
Meselson-Stahl Experiment: Semi-conservative replication
Origin of Replication
Initiation
Elongation
Replication Fork
Telomeres
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