Disease systems biology

Lars Juhl Jensen

Disease Systems Biology

protein networks

cellular signaling

Horn, Schoof et al., in preparation, 2012

sequence motif atlas

functional associations

Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011

computational predictions

experimental data

curated knowledge

confidence scores

orthology-based transfer

Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013

functional modules

Palleja et al., in preparation, 2012

literature mining

~22 million abstracts

~4 million full-text articles

comprehensive lexicon

co-mentioning

proteins

compartments

compartments.jensenlab.org

tissues

tissues.jensenlab.org

diseases

diseases.jensenlab.org

diseases.jensenlab.org

behavioral phenotypes

diseases.jensenlab.org

medical data mining

electronic health records

Jensen et al., Nature Reviews Genetics, 2012

structured data

Jensen et al., Nature Reviews Genetics, 2012

unstructured data

patient stratification

Roque et al., PLoS Computational Biology, 2011

comorbidity

Roque et al., PLoS Computational Biology, 2011

disease trajectories

Jensen et al., in preparation, 2012

pharmacovigilance

Eriksson et al., in preparation, 2012

conferences

questions?