Disability-Adjusted Life Year (DALY) combines premature deaths and loss of healthy life resulting from illness or disability. (1.4 billion a year) 90% of DALY occur in developing countries For most of human history, the greatest health threats have been pathogenic organisms, accidents, and violence.
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Disability-Adjusted Life Year (DALY) combines premature deaths and loss of healthy life resulting from illness or disability. (1.4 billion a year) 90%
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Disability-Adjusted Life Year (DALY) combines premature deaths and loss of
healthy life resulting from illness or disability. (1.4 billion a year)
90% of DALY occur in developing countries WHO reports 50% due to communicable disease
For most of human history, the greatest health threats have been
pathogenic organisms, accidents, and violence.
EMERGENT DISEASE – Never known before or has been absent for 20 years or more
Spreads Rapidly – modern travel means
Example – FOOT & MOUTH DISEASE
Infectious diseases are still responsible for about 24% of all disease-related deaths.
Majority of these deaths in poorer countries with poor nutrition, sanitation, and vaccination programs.
AIDS now largest single cause of communicable death in the world.
Risk Assessment & ManagementRisk = probability of exposure x probability of harm
Risk Assessment1) ID potential hazard
2) Probability of occurrence
3) Determine how much damage
(social; env; economic)
Controversy over assessments – WHY?
Disputes over variables such as - # exposed, level of exposure, and impact due to age/health/sex of organism
1) How Serious?
2) Can it be reduced?
3) How can it be reduced?
4) $$ to clean it up?
Risk Management
After Assessment
4 Main Types of Hazards smoking (case study), unsafe working
conditions, diet, drinking, driving, poverty!
Cultural
Chemical
synthetic chemicals from water & air pollution – human body contains over 500 syn.chemicals not known prior to 1920
pathogens (bacteria, viruses, parasites), pollen and other allergens; animals (bees, snakes)
Physical
Biological
Biological HazardsEpidemiology – the study of factors affecting the health and illness Epidemiology – the study of factors affecting the health and illness
of a populationof a population
Dose Response Curve
Non-Transmittable Disease – – not caused by living organisms and does not spread from person to personCardiovascular disease,
obesity, diabetes, most cancers, bronchitis
Transmissible Disease – – caused by living organisms (bacteria, protozoa, and parasites) and virusesPathogens (disease causing organisms) spread through water, air, food, insects, & body fluids - VECTORS
TRANSMISSIBLE TRANSMISSIBLE DISEASEDISEASEAccording to the WHO & UNICEF 2 million children in developing According to the WHO & UNICEF 2 million children in developing
countries die each year due to preventable infectious disease.countries die each year due to preventable infectious disease.
80% of the infectious disease is spread through waterborne infections (diarrhea, hepatitis, typhoid fever, and cholera)
Endocrine – glands and hormones that regulate body functions
Disruptors – (HAA’s – hormonally active agents) = can Disruptors – (HAA’s – hormonally active agents) = can mimic or block natural hormone responses – many mimic or block natural hormone responses – many synthetic chemicals such as atrazine, DDT, PCB’ssynthetic chemicals such as atrazine, DDT, PCB’s
Endocrine disruptors have major impacts on reproductive systems
1) Size of the dose over time
2) How often exposure occurs
3) Who is exposed
4) How well the body’s detox system works
5) Genetic make-up of organism
Factors affecting Toxicity
Toxicity – measure of how harmful a substance is.
Dosage – the amount inhaled, absorbed, or
ingested
EXAMPLES: DDT (synthetic organic pesticide), PCB’s (oils used in
electrical equipment); Mercury (heavy metal)
Many chemicals are used because of their long Many chemicals are used because of their long persistence or resistance to breakdown: plastics, persistence or resistance to breakdown: plastics,
-Organophosphates inhibit signal transmission between nerve cells. (malathion)
Insecticides
•Mutagens - Agents that damage or alter genetic material.
Radiation (x-ray equipment)
•Teratogens - Specifically cause abnormalities during embryonic growth and development.
Alcohol - Fetal Alcohol Syndrome
PCB’s, steroids, lead & mercury
•Carcinogens - Substances that cause cancer.
Cigarette smoke, dioxins, radon gas, asbestos
100 million Antibiotic doses prescribed each year in the US – many unnecessary
ANTIBIOTICS More than ½ of the antibiotics manufactured in the US are fed to farm animals to stimulate weight gain
RESISTANCEMany protozoans and insects are now immune to most antibiotics & pesticides (rapid evolution)
Humans overuse and therefore add pressure to adapt and change.
•Solubility - One of most important characteristics in determining the movement of a toxin.
•Chemicals are divided into two major groups:
-Those that dissolve more readily in water.
-Those that dissolve more readily in oil.
Water soluble compounds move rapidly through the environment, and have ready access to most human cells.
RATE OF MOVEMENT & DISTRIBUTION
•Animal Testing
Most commonly used and widely accepted toxicity test is to expose a population of laboratory animals to measured doses of specific toxins.
-Sensitivity differences pose a problem.
Dose Response Curves
LD50 - Dose at which 50% of the test population is sensitive.
LD50 = median lethal dose: the amount of a chemical received in one dose that kills exactly 50% of the organisms in a population (typically in a 2 week period of time)
Animal Testing
Takes 2-5 years – costs between 200,000 – 2 mil
Threshold = dosage amount at which no negative effects are seen