Direct Cross-Coupling Reaction of Simple Alkenes with Acrylates Catalyzed by Palladium Catalyst Yun-He Xu, Jun Lu, and Teck-Peng Loh J. Am. Chem. Soc., Article ASAP Current Literature Chenbo Wang @ Wipf Group Jan 17, 2009 Chenbo Wang @ Wipf Group Page 1 of 12 1/18/2009
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Direct Cross-Coupling Reaction of Simple Alkenes
with Acrylates Catalyzed by Palladium Catalyst
Yun-He Xu, Jun Lu, and Teck-Peng LohJ. Am. Chem. Soc., Article ASAP
Current LiteratureChenbo Wang @ Wipf GroupJan 17, 2009
Chenbo Wang @ Wipf Group Page 1 of 12 1/18/2009
Preparation of Diene Units with Cross-coupling Reactions: Classical Cross-coupling Reactions vs. Direct Cross-Coupling Reaction of Simple Alkenes
The challenge: •Chemoselectivity: dimerization•Stereoselectivity: cis/trans•Difficulty in activating alkene C-H without a directing group•Product stability
Chenbo Wang @ Wipf Group Page 2 of 12 1/18/2009
Construction of Diene Units in Natural Product Synthesis: Suzuki Reaction