Material Safety Data Sheet Diethyl ether sc-239731 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Diethyl ether STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA SUPPLIER Company: Santa Cruz Biotechnology, Inc. 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE As a solvent and for solvent extraction of waxes, fats, oils, perfumes, alkaloids, gums. Ether / alcohol mix is a good solvent for nitrocellulose. Used in the manufacture of gun powder and organic products, as a primer in gasoline engines. Obsolescent use as a medical anaesthetic by inhalation. SYNONYMS C4-H10-O, anaesthetic, "anaesthesia ether", "ethyl oxide", "diethyl oxide", ether, "ethoxy ethane", "solvent ether", "1, 1-oxybisethane", "sulfuric ether", "inhibited diethyl ether" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 4 Toxicity: 2 Body Contact: 2 Reactivity: 2 Chronic: 2 Min/Nil=0 Low=1 Moderate=2 High=3 Extreme=4 CANADIAN WHMIS SYMBOLS FLAMMABILITY 4 HEALTH HAZARD 1 INSTABILITY 1 1 of 17
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Material Safety Data Sheet
Diethyl ether
sc-239731
Hazard Alert Code Key: EXTREME HIGH MODERATE LOW
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAMEDiethyl ether
STATEMENT OF HAZARDOUS NATURE
CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200.
NFPA
SUPPLIERCompany: Santa Cruz Biotechnology, Inc.
2145 Delaware Ave
Santa Cruz, CA 95060
Telephone: 800.457.3801 or 831.457.3800
Emergency Tel: CHEMWATCH: From within the US and Canada:
877-715-9305
Emergency Tel: From outside the US and Canada: +800 2436 2255
(1-800-CHEMCALL) or call +613 9573 3112
PRODUCT USEAs a solvent and for solvent extraction of waxes, fats, oils, perfumes, alkaloids, gums. Ether / alcohol mix is a good solvent for nitrocellulose.
Used in the manufacture of gun powder and organic products, as a primer in gasoline engines. Obsolescent use as a medical anaesthetic by
Laboratory analysis of complete blood count, serum electrolytes, BUN, creatinine, glucose, urinalysis, baseline for serum
aminotransferases (ALT and AST), calcium, phosphorus and magnesium, may assist in establishing a treatment regime. Other useful
analyses include anion and osmolar gaps, arterial blood gases (ABGs), chest radiographs and electrocardiograph.
Ethers may produce anion gap acidosis. Hyperventilation and bicarbonate therapy might be indicated.
Hemodialysis might be considered in patients with impaired renal function.
Consult a toxicologist as necessary.
BRONSTEIN, A.C. and CURRANCE, P.L. EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994.
Section 5 - FIRE FIGHTING MEASURES
Vapor Pressure (mmHg): 439.836 at 20 C.
Upper Explosive Limit (%): 48
Specific Gravity (water=1): 0.714 at 20 C.
Lower Explosive Limit (%): 1.85
EXTINGUISHING MEDIA!
Foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.
Water spray or fog - Large fires only.
FIRE FIGHTING!
Alert Emergency Responders and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
Consider evacuation (or protect in place).
Fight fire from a safe distance, with adequate cover.
If safe, switch off electrical equipment until vapor fire hazard removed.
Use water delivered as a fine spray to control the fire and cool adjacent area.
Avoid spraying water onto liquid pools.
DO NOT approach containers suspected to be hot.
Cool fire exposed containers with water spray from a protective location.
If safe to do so, remove containers from path of fire.
GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS!
Liquid and vapor are highly flammable.
Severe fire hazard when exposed to heat, flame and/or oxidizers.
Vapor forms an explosive mixture with air.
Severe explosion hazard, in the form of vapor, when exposed to flame or spark.
Vapor may travel a considerable distance to source of ignition.
Heating may cause expansion / decomposition with violent rupture of containers.
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On combustion, may emit toxic fumes of carbon monoxide (CO)
Combustion products include: carbon dioxide (CO2), other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
WARNING: Long standing in contact with air and light may result in the formation
of potentially explosive peroxides.
FIRE INCOMPATIBILITY! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result.
PERSONAL PROTECTIONGlasses:
Chemical goggles.
Gloves:
1.PE/EVAL/PE 2.PVA 3.TEFLON
Respirator:
Type AX Filter of sufficient capacity
Section 6 - ACCIDENTAL RELEASE MEASURES
MINOR SPILLS
!
Remove all ignition sources.
Clean up all spills immediately.
Avoid breathing vapors and contact with skin and eyes.
Control personal contact by using protective equipment.
Contain and absorb small quantities with vermiculite or other absorbent material.
Wipe up.
Collect residues in a flammable waste container.
MAJOR SPILLS
! Chemical Class: phenols and cresols
For release onto land: recommended sorbents listed in order of priority.
SORBENT TYPE RANK APPLICATION COLLECTION LIMITATIONS
SS: Not for use within environmentally sensitive sites
W: Effectiveness reduced when windy
Reference: Sorbents for Liquid Hazardous Substance Cleanup and Control;
R.W Melvold et al: Pollution Technology Review No. 150: Noyes Data Corporation 1988.
Clear area of personnel and move upwind.
Alert Emergency Responders and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
Consider evacuation (or protect in place).
No smoking, naked lights or ignition sources.
Increase ventilation.
Stop leak if safe to do so.
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Water spray or fog may be used to disperse / absorb vapor.
Contain spill with sand, earth or vermiculite.
Use only spark-free shovels and explosion proof equipment.
Collect recoverable product into labeled containers for recycling.
Absorb remaining product with sand, earth or vermiculite.
Collect solid residues and seal in labeled drums for disposal.
Wash area and prevent runoff into drains.
If contamination of drains or waterways occurs, advise emergency services.
Cover spill with foam blanket to reduce fire risk.
PROTECTIVE ACTIONS FOR SPILL
From US Emergency Response Guide 2000 Guide 127
From IERG (Canada/Australia)
Isolation Distance 25 meters
Downwind Protection Distance 300 meters
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone assumes that random changes in wind direction confines the
vapour plume to an area within 30 degrees on either side of the predominant wind direction, resulting in a crosswind protective action distance equal to the downwind protective
action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill and working away from the site in the downwind direction. Within
the protective action zone a level of vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and unable to take protective action
and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high probability of localised wind reversal may expose nearly all persons
without appropriate protection to life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or box with inner containers). Larger packages leaking less than 200
litres and compressed gas leaking from a small cylinder are also considered "small spills". LARGE SPILLS involve many small leaking packages or a leaking package of greater
than 200 litres, such as a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 127 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
ACUTE EXPOSURE GUIDELINE LEVELS (AEGL) (in ppm)AEGL 1: The airborne concentration of a substance above which it is predicted
that the general population, including susceptible individuals, could
experience notable discomfort, irritation, or certain asymptomatic nonsensory
effects. However, the effects are not disabling and are transient and
reversible upon cessation of exposure.
AEGL 2: The airborne concentration of a substance above which it is predicted
that the general population, including susceptible individuals, could
experience irreversible or other serious, long-lasting adverse health effects
or an impaired ability to escape.
AEGL 3: The airborne concentration of a substance above which it is predicted
that the general population, including susceptible individuals, could
experience life-threatening health effects or death.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING!
Containers, even those that have been emptied, may contain explosive vapors.
Do NOT cut, drill, grind, weld or perform similar operations on or near containers.
The tendency of many ethers to form explosive peroxides is well documented. Ethers lacking non-methyl hydrogen atoms adjacent to the
ether link are thought to be relatively safe
DO NOT concentrate by evaporation, or evaporate extracts to dryness, as residues may contain explosive peroxides with DETONATION
potential.
Any static discharge is also a source of hazard.
Before any distillation process remove trace peroxides by shaking with excess 5% aqueous ferrous sulfate solution or by percolation
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through a column of activated alumina.
Distillation results in uninhibited ether distillate with considerably increased hazard because of risk of peroxide formation on storage.
Add inhibitor to any distillate as required.
When solvents have been freed from peroxides by percolation through columns of activated alumina, the absorbed peroxides must
promptly be desorbed by treatment with polar solvents such as methanol or water, which should then be disposed of safely.
Contains low boiling substance:
Storage in sealed containers may result in pressure buildup causing violent rupture of containers not rated appropriately.
Check for bulging containers.
Vent periodically
Always release caps or seals slowly to ensure slow dissipation of vapors
DO NOT allow clothing wet with material to stay in contact with skin
The substance accumulates peroxides which may become hazardous only if it evaporates or is distilled or otherwise treated to concentrate
the peroxides. The substance may concentrate around the container opening for example.
Purchases of peroxidizable chemicals should be restricted to ensure that the chemical is used completely before it can become peroxidized.
A responsible person should maintain an inventory of peroxidizable chemicals or annotate the general chemical inventory to indicate
which chemicals are subject to peroxidation. An expiration date should be determined. The chemical should either be treated to remove
peroxides or disposed of before this date.
The person or laboratory receiving the chemical should record a receipt date on the bottle. The individual opening the container should
add an opening date.
Unopened containers received from the supplier should be safe to store for 18 months.
Opened containers should not be stored for more than 12 months.
Avoid all personal contact, including inhalation.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Prevent concentration in hollows and sumps.
DO NOT enter confined spaces until atmosphere has been checked.
Avoid smoking, naked lights, heat or ignition sources.
When handling, DO NOT eat, drink or smoke.
Vapor may ignite on pumping or pouring due to static electricity.
DO NOT use plastic buckets.
Earth and secure metal containers when dispensing or pouring product.
Use spark-free tools when handling.
Avoid contact with incompatible materials.
Keep containers securely sealed.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately.
Use good occupational work practice.
Observe manufacturer's storing and handling recommendations.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions.
RECOMMENDED STORAGE METHODS! Packing as supplied by manufacturer. Plastic containers may only be used if approved for flammable liquid. Check that containers are
clearly labeled and free from leaks.
For low viscosity materials (i): Drums and jerricans must be of the non-removable head type. (ii): Where a can is to be used as an inner
package, the can must have a screwed enclosure.
For materials with a viscosity of at least 2680 cSt. (23 deg. C)
For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
Manufactured product that requires stirring before use and having a viscosity of at least 20 cSt (23 deg. C) - (i): Removable head
packaging; (ii): Cans with friction closures and (iii): low pressure tubes and cartridges may be used.
Where combination packages are used, and the inner packages are of glass, there must be sufficient inert cushioning material in contact
with inner and outer packages
In addition, where inner packagings are glass and contain liquids of packing group I there must be sufficient inert absorbent to absorb any
spillage, unless the outer packaging is a close fitting molded plastic box and the substances are not incompatible with the plastic.
STORAGE REQUIREMENTS! Easily peroxidizable. Products formed as a result of peroxidation are not only safety hazards but may chemically alter the chemical
behavior of the parent compound. Should have a warning label affixed bearing the date of receipt in the laboratory and the date on which the
label was first opened. Store-room items should have the label affixed by the Store-room whilst for non-storeroom items or materials
synthesized in the laboratory, an individual chemist should be responsible for warning labels.
WARNING: This product may form peroxides to a hazardous level by concentration (by distillation, evaporation, etc.) Should be evaluated
every twelve months after opening, redated if safe or else discarded. The oxidation of iodide to iodine or the conversion of colorless
ferrothiocyanate to red ferrithiocyanate by peroxides are simple and convenient tests for most peroxides. Before distilling or evaporating test
for peroxides. Leave at least 10% bottoms. Use a shield when evaporating or distilling mixtures which may contain peroxidizable compounds.
Store away from heat and light. Particular attention should be paid to the adequacy of the closure on storage containers.
Peroxides may be removed by;
passing the material over a column of ordinary activated alumina (care should be taken in disposal of the activated alumina);
shaking with a concentrated solution of ferrous salt (provided the carrier solvent is water-insoluble);
agitation with an approximately equimolar mixture of ferrous sulfate and sodium bisulfate;
commercial quantities may be treated with a 5% solution of aqueous sodium carbonate.
Jackson et al: Control of Peroxizable Compounds; Safety in the Chemical Laboratory, Journal of Chemical Education; Vol 47, 1970, pp
A175-A188
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When solvents have been freed from peroxides by percolation through a column of activated alumina, the adsorbed peroxides must promptly
be desorbed by treatment with polar solvents, methanol or water, which must in turn be discarded safely.
Rotate all stock to prevent ageing. Use on FIFO (First In-First Out) basis.
Store in original containers in approved flame-proof area.
No smoking, naked lights, heat or ignition sources.
DO NOT store in pits, depressions, basements or areas where vapors may be trapped.
Keep containers securely sealed.
Store away from incompatible materials in a cool, dry well ventilated area.
Protect containers against physical damage and check regularly for leaks.
Observe manufacturer's storing and handling recommendations.
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X X X X +
X: Must not be stored together
O: May be stored together with specific preventions
+: May be stored together
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
APPEARANCEClear very highly volatile and very highly flammable liquid; slightly soluble in and floats on water. Pleasant aromatic odour. Burning taste.
Diethyl ether is hygroscopic; i.e. absorbs moisture from the air. Mixes with aliphatic alcohols, benzene, chloroform.
log Kow 0.77-0.89
Material Value
! log Kow (Sangster 1997) 0.89
Section 10 - CHEMICAL STABILITY
CONDITIONS CONTRIBUTING TO INSTABILITY! Presence of a stabilizing inhibitor prevents/retards peroxide formation.
Presence of incompatible materials.
Product is considered stable.
Hazardous polymerization will not occur.
STORAGE INCOMPATIBILITY! Ethers may react violently with strong oxidizing agents and acids.
The tendency of many ethers to form explosive peroxides is well documented.
Ethers lacking non-methyl hydrogen atoms adjacent to the ether link are thought to be relatively safe.
When solvents have been freed from peroxides (by percolation through a column of activated alumina for example), the absorbed
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peroxides must promptly be desorbed by treatment with the polar solvents methanol or water, which should be discarded safely.
Avoid reaction with oxidizing agents.
For incompatible materials - refer to Section 7 - Handling and Storage.
Section 11 - TOXICOLOGICAL INFORMATION
diethyl ether
TOXICITY AND IRRITATION! unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
Hazardous materials descriptions and proper shipping names:
Diethyl ether or Ethyl ether
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1155 Packing Group: I
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Special provisions: None
Shipping Name: DIETHYL ETHER
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1155 Packing Group: I
EMS Number: F-E , S-D Special provisions: None
Limited Quantities: 0
Shipping Name: DIETHYL ETHER (ETHYL ETHER)
Section 15 - REGULATORY INFORMATION
REGULATIONS
diethyl ether (CAS: 60-29-7) is found on the following regulatory lists;"Canada - Alberta Occupational Exposure Limits","Canada - British Columbia Occupational Exposure Limits","Canada - Northwest Territories