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Dietary diversity, global change, Dietary diversity, global change,
and human healthand human healthTimothy JohnsTimothy Johns
CentreCentre for Indigenous Peoples’for Indigenous Peoples’Nutrition and Environment (CINE)Nutrition and Environment (CINE)
andandSchool of Dietetics and Human Nutrition,School of Dietetics and Human Nutrition,
McGill University, McGill University, MontréalMontréal, Canada, Canada
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Dietary Diversity = HealthDietary Diversity = Health
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Dietary Diversity & HealthDietary Diversity & Health--MortalityMortality--
Variety ScoreVariety Score OddsOdds(median) (median) RatioRatio
7.07.0 1110.010.0 0.820.8212.012.0 0.710.7115.015.0 0.690.69
P for trend <0.001P for trend <0.001Kant et al. Kant et al. 2000. JAMA 283:21092000. JAMA 283:2109--21152115
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Dietary Diversity & Gastric CancerDietary Diversity & Gastric CancerLa La Vecchia Vecchia et al. 1997. et al. 1997. Int. J. CancerInt. J. Cancer 72:25572:255--257257
VegetableVegetable Percentage of Cases OddsPercentage of Cases Oddsdiversitydiversity RatioRatio# of items# of items Stomach ControlsStomach Controls
cancercancer<5<5 39.939.9 29.429.4 1155 18.018.0 18.118.1 0.80.866 19.419.4 19.319.3 0.80.8≥≥77 22.722.7 33.233.2 0.50.5
P for trend <0.001P for trend <0.001
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Mediterrean diets / french paradox
Fresh fruits and vegetables
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Urinary tract
infections
Vaccinium spp. blueberry, bluet
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Lepidium meyeniimaca
Johns 1981. Johns 1981. Journal of Journal of EthnobiologyEthnobiology 1:2081:208--212.212.
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Lepidium meyeniimaca
(“Peruvian ginseng”)
Johns 1981. Johns 1981. Journal ofJournal of EthnobiologyEthnobiology 1:208-212.
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Opuntia Opuntia ficusficus--indicaindica
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Food Functionality for Developing Areas
?
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Food Functionality for Developing Areas
CONSIDERATIONS• traditional ecology
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Food Functionality for Developing Areas
CONSIDERATIONS• traditional ecology
• urbanization
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Food Functionality for Developing Areas
CONSIDERATIONS• traditional ecology
dietary transitiondietary transition• urbanization
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Population growth
Industrialization
UrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
Malnutrition
Toxicants &Xenobiotics
Immunity & Infection
HEALTHCHALLENGES
Oxidative status
Biodiversity loss
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DIET / NUTRITIONInadequacyInadequacy
Population growth
Industrialization
UrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
Malnutrition
Toxicants &Xenobiotics
Immunity & Infection
HEALTHCHALLENGES
Oxidative status
Biodiversity loss
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DIET / NUTRITIONInadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
Malnutrition
Toxicants &Xenobiotics
Immunity & Infection
HEALTHCHALLENGES
Oxidative status
Biodiversity lossBiodiversity loss
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DIET / NUTRITIONInadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
MalnutritionMalnutrition
Toxicants &Xenobiotics
Immunity & Immunity & InfectionInfection
HEALTHCHALLENGES
Oxidative Oxidative statusstatus
Biodiversity lossBiodiversity loss
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Premature Mortality Rates Premature Mortality Rates (45(45--64 years of age/1000)64 years of age/1000)
Ratios Relative to CanadaRatios Relative to CanadaCountry CVD DiabetesCountry CVD Diabetes
ChileChile 2.92.9 1.51.5
ArgentinaArgentina 4.44.4 2.02.0
MexicoMexico 1.91.9 8.28.2
NicaraguaNicaragua 4.64.6 4.74.7
Albala et al. 2001. Nutrition Reviews 59:170-176
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DIET / NUTRITIONInadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
MalnutritionMalnutrition
Toxicants &Xenobiotics
Immunity & Immunity & InfectionInfection
HEALTHCHALLENGES
Oxidative Oxidative statusstatus
Biodiversity lossBiodiversity loss
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DIET / NUTRITIONInadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
MalnutritionMalnutrition
Toxicants &Xenobiotics
Immunity & Immunity & InfectionInfection
HEALTHCHALLENGES
ADAPTATION
Oxidative Oxidative statusstatus
Biodiversity lossBiodiversity loss
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DIET / NUTRITION
OptimizationOptimization
Inadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
MalnutritionMalnutrition
Toxicants &Xenobiotics
Immunity & Immunity & InfectionInfection
HEALTHCHALLENGES
ADAPTATION
Oxidative Oxidative statusstatus
Biodiversity lossBiodiversity loss
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DIET / NUTRITION
OptimizationOptimization
Inadequacy
Population growth
Industrialization
UrbanizationUrbanizationClimate change
ENVIRONMENTAL DISTURBANCE
MalnutritionMalnutrition
Toxicants &Xenobiotics
Immunity & Immunity & InfectionInfection
HEALTHCHALLENGES
ADAPTATION
Oxidative Oxidative statusstatus
Biodiversity lossBiodiversity loss
BIOCULTURALDIVERSITY
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Functionality of Ingested Phytochemicals
•• NutritionNutrition• Gastrointestional
function• Antioxidants• Glycemic control
• Antibiotic• Immunostimulant• Nervous system• Detoxification• Anti-inflammatory /
anti-gout
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Dietary Variety and Nutritional Adequacy in Mali
Hatløy et al. 1998. European J. Clinical Nutrition 52:891-898.
Correlation Between Nutrient Adequacy Ratio (NAR) and Food Variety
NAR Food Variety Score Correlation Energy (MJ/d) 0.01Fat Energy (%) 0.29*iron (mg/d) -0.15vitamin C 0.38**vitamin A 0.27*Mean Adequacy Ratio (MAR) 0.33**
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Adansonia digitata
baobab
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CaCa FeFe ßß--car.car. Vit Vit CC kcalkcal ProteinProtein
Per 100 g edible Per 100 g edible mgmg mgmg ugug mgmg gg
baobab, ripe, rawbaobab, ripe, raw 285285 7.47.4 6363 270270 280280 2.22.2
orange, raworange, raw 2828 0.10.1 730730 4646 4444 0.60.6
cowpea leaves, rawcowpea leaves, raw 255255 5.75.7 700700 5656 4545 4.74.7
maize, white, driedmaize, white, dried 1616 3.6 3.6 00 00 345345 9.49.4
cassava, freshcassava, fresh 6868 1.91.9 1515 3131 140140 1.2 1.2
beans, driedbeans, dried 120120 8.28.2 00 11 320320 22.022.0
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CaCa FeFe ßß--car.car. Vit Vit CC kcalkcal ProteinProtein
Per 100 g edible Per 100 g edible mgmg mgmg ugug mgmg gg
baobab, ripe, rawbaobab, ripe, raw 285285 7.47.4 6363 270270 280280 2.22.2
orange, raworange, raw 2828 0.10.1 730730 4646 4444 0.60.6
cowpea leaves, rawcowpea leaves, raw 255255 5.75.7 700700 5656 4545 4.74.7
maize, white, driedmaize, white, dried 1616 3.6 3.6 00 00 345345 9.49.4
cassava, freshcassava, fresh 6868 1.91.9 1515 3131 140140 1.2 1.2
beans, driedbeans, dried 120120 8.28.2 00 11 320320 22.022.0
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Crotalaria brevidens
> 4900 µg β-carotene per 100 g d edible portionUiso and Johns, 1996. Ecology of Food and Nutrition, 35:59-69.
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Crotalaria brevidens
Solanum nigrum
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provitaminprovitamin A, vitamin A, vitamin C, C, folatefolate
iron, calcium, iron, calcium, fibrefibre, , proteinprotein
Gynandropsis Gynandropsis gynandragynandra
Solanum nigrum
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Functionality of Ingested Phytochemicals
• Nutrition• Gastrointestional
function• Antioxidants• Glycemic control• Hypolipidemic
• Antibiotic• Immunostimulant• Nervous system• Detoxification• Anti-inflammatory /
anti-gout
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AntiAnti--giardial giardial activityactivity
Johns et al 1995. Johns et al 1995.
Journal ofJournal of Ethnopharmacology Ethnopharmacology 6:176:17--23.23.
Solanum nigrum
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Functionality of Ingested Phytochemicals
• Nutrition• Gastrointestional
function• Antioxidants• Glycemic control• Hypolipidemic
• Antibiotic• Immunostimulant• Nervous system• Detoxification• Anti-inflammatory /
anti-gout
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Acacia nilotica “olkiloriti”
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Inhibition of LDL oxidation by Maasai soup additives
Conjugated dienes
Lindhorst and Johns
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Functionality of Ingested Phytochemicals
• Nutrition• Gastrointestional
function• Antioxidants• Glycemic control• Hypolipidemic
• Antibiotic• Immunostimulant• Nervous system• Detoxification• Anti-inflammatory /
anti-gout
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Functionality of Ingested Phytochemicals
• Nutrition• Gastrointestional
function• Antioxidants• Glycemic control• Hypolipidemic
• Antibiotic• Immunostimulant• Nervous system• Detoxification• Anti-inflammatory /
anti-gout
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Commiphora mukul
“guggul” Indian Bdellium
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RESIN 0.03 %
CHEWED RESIN 0.006%
RELEASED BYMASTICATION: 80% 0.24mg/g
E- Guggulsterone content
RESIN OF COMMIPHORA AFRICANA
Johns et al. 2000. Current Anthropology 41:453-459.
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Xanthine oxidase inhibition-Maasai milk & soup additives
0102030405060708090
100allopurinolAcacia niloticaBridelia micranthaOlinia usambarensisOsyris lanceolataMyrisine africanaRhamnus prinoidesHarrisonia abyssinicaMaytenus senegalensisXimenia americana
Guertin and Johns, 2001
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Xanthine oxidase inhibition-Maasai milk & soup additives
0102030405060708090
100allopurinolAcacia niloticaBridelia micranthaOlinia usambarensisOsyris lanceolataMyrisine africanaRhamnus prinoidesHarrisonia abyssinicaMaytenus senegalensisXimenia americana
Guertin and Johns, 2001
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Xanthine oxidase inhibition-Maasai milk & soup additives
% Inhibition (S.D.)Remedies for 60.6 (13.6)
joint disease (n=5)
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Xanthine oxidase inhibition-Maasai milk & soup additives
% Inhibition (S.D.)Remedies for 60.6 (13.6)
joint disease (n=5)
Other indications 38.2 (28.9)
(n=18)
Student’s t-test p = 0.03
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CONCLUSIONS CONCLUSIONS •• Biodiversity Biodiversity ⇒⇒ Dietary Dietary
Diversity Diversity ⇒⇒ HealthHealth
•• Global change impacts Global change impacts traditional ecologytraditional ecology
••Health rationale for Health rationale for managing biodiversitymanaging biodiversity
••Health not simply absence Health not simply absence of of diseasedisease
•• Rural / Urban linkages are keyRural / Urban linkages are key