Vsevolod Peshkov Wipf Group Current Literature 10/12/2013 Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel- Catalyzed Hydrocarbamoylations of Alkenes Pavel A. Donets and Nicolai Cramer* Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland J. Am. Chem. Soc. 2013, 135, 11772 Vsevolod Peshkov @ Wipf Group Page 1 of 14 11/9/2013
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Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel ...ccc.chem.pitt.edu/wipf/current literature/Seb_1.pdfAcid/Ligand SPO5-Al 1a 2a N P N OH tBu tBu Np Np 1-1-nBuLi N P N OLi tBu
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Vsevolod Peshkov
Wipf Group Current Literature
10/12/2013
Diaminophosphine Oxide Ligand Enabled Asymmetric Nickel-Catalyzed Hydrocarbamoylations of Alkenes
Pavel A. Donets and Nicolai Cramer*
Laboratory of Asymmetric Catalysis and Synthesis, Institute of Chemical
Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne
(EPFL), Lausanne, Switzerland
J. Am. Chem. Soc. 2013, 135, 11772
Vsevolod Peshkov @ Wipf Group Page 1 of 14 11/9/2013
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The secondary phosphine oxide (SPO) concept:
For review on SPO, see: Ackermann, L. Synthesis 2006, 1557
Vsevolod Peshkov @ Wipf Group Page 2 of 14 11/9/2013
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SPO early/late heterobimetallic intermediates in catalysis
Ackermann, L.; Born, R.; Spatz, J. H.; Meyer, D. Angew. Chem., Int. Ed. 2005, 44, 7216
Ackermann, L.; Althammer, A. Chem. Unserer Zeit 2009, 43, 74