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CONTRIBUTING AUTHORS RODICA POP-BUSUI, MD, PhD, Editor Larry D. Soderquist Professor of Diabetes Professor of Internal Medicine, Metabolism, Endocrinology and Diabetes Director, Clinical Research, Mentoring and Development, Caswell Diabetes Institute University of Michigan Ann Arbor, MI LYNN ANG, MD Assistant Professor of Internal Medicine, Metabolism, Endocrinology and Diabetes University of Michigan Ann Arbor, MI ANDREW J.M. BOULTON, MD, DSc (HON), FRCP, FACP, FICP Professor of Medicine Division of Diabetes, Endocrinology, and Gastroenterology University of Manchester Manchester, UK; Consultant Physician Manchester Royal Infirmary Manchester, UK; and Visiting Professor of Medicine University of Miami Miller School of Medicine Miami, FL EVA L. FELDMAN, MD, PhD Russell N. DeJong Professor of Neurology Department of Neurology University of Michigan Ann Arbor, MI ROBIN L. MARCUS, PT, PhD, FAPTA Professor of Physical Therapy and Athletic Training and Associate Dean for Clinical Affairs, College of Health University of Utah Salt Lake City, UT KARA MIZOKAMI-STOUT, MD, MSc Assistant Professor of Internal Medicine, Metabolism, Endocrinology, and Diabetes University of Michigan Ann Arbor, MI J. ROBINSON SINGLETON, MD Professor and Vice Chair Department of Neurology University of Utah and Chief of Service, Neurology Salt Lake City Veterans Administration Health System Salt Lake City, UT DAN ZIEGLER, MD, FRCPE Professor of Internal Medicine, Vice Director, Research Group Leader, and Consultant Physician Institute for Clinical Diabetology German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Germany; and Co-Head of Complications Academy German Center for Diabetes Research, Partner Düsseldorf Munich-Neuherberg, Germany This publication has been supported by an unrestricted educational grant to the American Diabetes Association from Nevro, Inc. DIAGNOSIS AND TREATMENT OF PAINFUL DIABETIC PERIPHERAL NEUROPATHY 2022 ADA CLINICAL COMPENDIA SERIES
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DIAGNOSIS AND TREATMENT OF PAINFUL DIABETIC PERIPHERAL NEUROPATHY

May 23, 2023

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Diabetic neuropathies are the most common chronic complications of diabetes, with an estimated lifetime prevalence exceeding 50% in people with diabetes. Among various forms of neuropathy, diabetic peripheral neuropathy (DPN) is the most common and has the strongest evidence base regarding therapeutic approaches. This American Diabetes Association clinical compendium summarizes the latest information about screening for, diagnosing, and treating painful DPN in routine clinical practice. It opens with an overview of the epidemiology of DPN, followed by a description of the pathophysiology of the disease and its often severely painful symptoms.
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