Diagnosis and Management Diagnosis and Management of Syncope of Syncope Robert Helm, M.D. Robert Helm, M.D. Assistant Professor of Medicine Assistant Professor of Medicine Boston University School of Boston University School of Medicine Medicine August 2013 August 2013
Diagnosis and Management of Syncope. Robert Helm, M.D. Assistant Professor of Medicine Boston University School of Medicine August 2013. Case 1. - PowerPoint PPT Presentation
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Diagnosis and Management of Diagnosis and Management of SyncopeSyncope
Robert Helm, M.D.Robert Helm, M.D.Assistant Professor of MedicineAssistant Professor of Medicine
Boston University School of MedicineBoston University School of Medicine
August 2013August 2013
Case 1Case 1
53 year-old obese gentleman with diabetes, hypertension and 53 year-old obese gentleman with diabetes, hypertension and
hyperlipidemia who presented with syncope. This occurred after working hyperlipidemia who presented with syncope. This occurred after working
at the boat yard on a very hot day. He was taking a break and drinking at the boat yard on a very hot day. He was taking a break and drinking
a cold slurpee, when he suddenly felt pins and needles in his neck, peri-a cold slurpee, when he suddenly felt pins and needles in his neck, peri-
oral numbness, and tingling of his forehead. As he was calling for wife, oral numbness, and tingling of his forehead. As he was calling for wife,
he lost consciousness and fell to the ground. According to his wife, he he lost consciousness and fell to the ground. According to his wife, he
was unconscious for about a minute and his entire body was quivering. was unconscious for about a minute and his entire body was quivering.
Upon regaining consciousness, he was confused and disoriented. His Upon regaining consciousness, he was confused and disoriented. His
wife reports that he was cold, clammy, and very diaphoretic. He wife reports that he was cold, clammy, and very diaphoretic. He
sustained some minor bruising of left shoulder but no head injuries.sustained some minor bruising of left shoulder but no head injuries.
No prior syncope but two weeks ago he did a “pirouette” No prior syncope but two weeks ago he did a “pirouette”
due to sudden brief episode of lightheadedness and loss of due to sudden brief episode of lightheadedness and loss of
balance. He did not lose consciousness. He consulted balance. He did not lose consciousness. He consulted
with his internist, who found relative low blood pressure with his internist, who found relative low blood pressure
(100/54 mmHg) and reduced his Lisinopril by half (40 to 20 (100/54 mmHg) and reduced his Lisinopril by half (40 to 20
mg daily). His blood sugars have been well controlled. mg daily). His blood sugars have been well controlled.
Case 1Case 1
Past Medical HistoryPast Medical HistoryDiabetes (HgBA1C 5.8)Diabetes (HgBA1C 5.8)HypertensionHypertensionHyperlipidemiaHyperlipidemia? myocardial infarction? myocardial infarctionObstructive sleep apneaObstructive sleep apnea
Social HistorySocial History Non-smokerNon-smoker No alcohol or drugsNo alcohol or drugs
Family HistoryFamily History Mother had MI at 60Mother had MI at 60 Brother died suddenly at 48Brother died suddenly at 48
Review of systemReview of system Negative. Good functional Negative. Good functional capacity.capacity.
AllergiesAllergies NoneNone
MedicationsMedications Cardizem cd 120 mg dailyCardizem cd 120 mg daily Lisinopril 20 mg dailyLisinopril 20 mg daily Lantus 40 units at nightLantus 40 units at night Novalog 12 units with mealsNovalog 12 units with meals Aspirin 81 mg dailyAspirin 81 mg daily Lasix 80 mg dailyLasix 80 mg daily Simvastatin 80 mg at nightSimvastatin 80 mg at night Fenofibrate 134 mg dailyFenofibrate 134 mg daily Percocet 5/325 mg as needed for painPercocet 5/325 mg as needed for pain Viagra 100 mg – last used 2 days priorViagra 100 mg – last used 2 days prior Nitroglycerin 0.4 mg SL – never usedNitroglycerin 0.4 mg SL – never used
Case 1Case 1
PPhysical examinationhysical examination
BP 124/62 mmHg. Not orthostatic. Normal carotid palpation and BP 124/62 mmHg. Not orthostatic. Normal carotid palpation and
auscultation. Normal cardiovascular exam. Bruised right hip. auscultation. Normal cardiovascular exam. Bruised right hip.
LaboratoryLaboratory
BUN 27 ng/dl Creatinine 1.47 ng/dl. Electrolytes and blood count BUN 27 ng/dl Creatinine 1.47 ng/dl. Electrolytes and blood count
normal.normal.
EchocardiogramEchocardiogram – normal 1 month ago. – normal 1 month ago.
Case 1Case 1
Case 1
Case 1Case 1
Admitted for 24 hour observation and hydration. Admitted for 24 hour observation and hydration.
PollThe correct statement is:The correct statement is:
A.A. The patient has been correctly diagnosed.The patient has been correctly diagnosed.
B.B. The patient should be referred for urgent pacemaker.The patient should be referred for urgent pacemaker.
C.C. The patient should be referred for electrophysiologic study.The patient should be referred for electrophysiologic study.
D.D. The patient should be referred for 30 day event recorder.The patient should be referred for 30 day event recorder.
E.E. The patient should be referred for tilt-table study.The patient should be referred for tilt-table study.
61 year old gentleman with history of cocaine use who 61 year old gentleman with history of cocaine use who
presented with syncope. “He was in kitchen making presented with syncope. “He was in kitchen making
Thanksgiving dinner and developed lightheadedness. He Thanksgiving dinner and developed lightheadedness. He
sat on a step stool and the next thing he remember is being sat on a step stool and the next thing he remember is being
on the floor and his son calling his name. He felt like he on the floor and his son calling his name. He felt like he
couldn’t move. The kitchen was really hot and and he had couldn’t move. The kitchen was really hot and and he had
missed lunch. He reports using cocaine “months ago”.missed lunch. He reports using cocaine “months ago”.
Case 2Case 2
Past Medical HistoryPast Medical Historynonenone
Social HistorySocial History history of cocainehistory of cocaine
Family HistoryFamily History no premature CAD or SCDno premature CAD or SCD
Review of systemReview of system Negative. Negative.
AllergiesAllergies NoneNone
MedicationsMedications NoneNone
Case 2Case 2
PPhysical examinationhysical examination
BP 145/91 mmHg. Not orthostatic. Normal carotid BP 145/91 mmHg. Not orthostatic. Normal carotid
palpation and auscultation. Normal cardiovascular exam. palpation and auscultation. Normal cardiovascular exam.
Minor bruise on elbow.Minor bruise on elbow.
LaboratoryLaboratory
BUN 26 ng/dl Creatinine 1.1 ng/dl. Electrolytes and blood BUN 26 ng/dl Creatinine 1.1 ng/dl. Electrolytes and blood
count normal.count normal.
Case 2Case 2
Case 2Case 2
a. Check toxicology screen. If positive then a. Check toxicology screen. If positive then attribute syncope to cocaine use. attribute syncope to cocaine use.
b. Continuous-loop event monitoring.b. Continuous-loop event monitoring.c. Increase fluid intake and reassure patient.c. Increase fluid intake and reassure patient.d. Electrophysiology study to assess for inducible d. Electrophysiology study to assess for inducible
VTVTe. Tilt-table study. e. Tilt-table study.
f. Implant loop recorder (ILR).f. Implant loop recorder (ILR). g. Echocardiogram.g. Echocardiogram.
h. B and then D if event monitoring is negative.h. B and then D if event monitoring is negative. i. B and then F if event monitoring is negative.i. B and then F if event monitoring is negative. j. G and if ejection fraction is < 35% then Dj. G and if ejection fraction is < 35% then D
PollPoll
The correct next step is:The correct next step is:
Why is syncope a difficult problem?Why is syncope a difficult problem?
• Physiologic response to a wide variety of medical conditions Physiologic response to a wide variety of medical conditions
• By definition it is a transient conditionBy definition it is a transient condition
• Occurs with unpredictable and random pattern Occurs with unpredictable and random pattern
• Difficult to establish definitive “diagnosis”Difficult to establish definitive “diagnosis”
• ““Another patient with syncope….”Another patient with syncope….”
• History from patient may not be reliable.History from patient may not be reliable.
Amnesia for Loss of Consciousness in Amnesia for Loss of Consciousness in Carotid Sinus SyndromeCarotid Sinus Syndrome
FallsFalls (n=34)(n=34)
SyncopeSyncope (n=34)(n=34) P valueP value
Mean max asystole (s)Mean max asystole (s) 5.15.1 5.45.4 0.420.42
LOC during CSMLOC during CSM 22 (64%)22 (64%) 15 (44%)15 (44%) 0.1440.144
Amnesia for LOCAmnesia for LOC 21 (95%)21 (95%) 4 (27%)4 (27%) <0.001<0.001
Perry S, et al: J Am Coll Cardiol 2005;45:1840Perry S, et al: J Am Coll Cardiol 2005;45:1840
Causes of SyncopeCauses of Syncope
Classification of SyncopeClassification of Syncope
Common and benignCommon and benignOrthostaticOrthostaticNeurocardiogenicNeurocardiogenic
Common and not so benignCommon and not so benignSinus node dysfunction, carotid sinus hypersensitivitySinus node dysfunction, carotid sinus hypersensitivityParoxysmal AV blockParoxysmal AV block
Less common, lethalLess common, lethalVentricular tachycardia, ventricular fibrillationVentricular tachycardia, ventricular fibrillationTorsade de pointesTorsade de pointes
Everything elseEverything else
Emergency Visits with SyncopeEmergency Visits with SyncopeEuropean Society of Cardiology GuidelinesEuropean Society of Cardiology Guidelines
CauseCause NumberNumber PercentPercent
Neurally mediated 309 66
Orthostatic Hypotension 46 10
Cardiac Arrhythmias 53 11
Cardiovascular 21 5
Unknown 11 2
Non-syncopal attack 25 5
Brignole M, Brignole M, et al. et al. European Heart Journal 2006;27:76-82European Heart Journal 2006;27:76-82
465 patients465 patients
Neurally - mediatedNeurally - mediated
Reflex syncope Reflex syncope Vasovagal Vasovagal Carotid sinus hypersensitivityCarotid sinus hypersensitivitySituationalSituationalPost-exercise Post-exercise Glossopharyngeal and trigeminal Glossopharyngeal and trigeminal neuralgia neuralgia
Discharged after 24 observation with diagnosis of “Vaso-vagal syncope”Discharged after 24 observation with diagnosis of “Vaso-vagal syncope”
3 month later..3 month later..
Cardiac arrest at home and successfully defibrillated but prolonged down Cardiac arrest at home and successfully defibrillated but prolonged down
time.time.
Had slow neurologic recovery.Had slow neurologic recovery.
ICD implanted for secondary prevention.ICD implanted for secondary prevention.
Case 2Case 2
Which of the following historical findings are useful for Which of the following historical findings are useful for predicting neurally-mediated syncope in patients with heart predicting neurally-mediated syncope in patients with heart disease and recurrent syncope?disease and recurrent syncope?
a. Feeling warm.a. Feeling warm.b. Awareness of being about to faint.b. Awareness of being about to faint.c. Recovery duration lasting longer than 60 minutes.c. Recovery duration lasting longer than 60 minutes.d. Confusion during recovery.d. Confusion during recovery.e. Time (years) between first and last syncopal e. Time (years) between first and last syncopal
episodes.episodes.
Test questionsTest questions
Which of the following historical findings are useful for Which of the following historical findings are useful for predicting neurally-mediated syncope in patients with heart predicting neurally-mediated syncope in patients with heart disease and recurrent syncope?disease and recurrent syncope?
a. Feeling warm.a. Feeling warm.b. Awareness of being about to faint.b. Awareness of being about to faint.c. Recovery duration lasting longer than 60 minutes.c. Recovery duration lasting longer than 60 minutes.d. Confusion during recovery.d. Confusion during recovery.e. Time (years) between first and last syncopal e. Time (years) between first and last syncopal
episodes.episodes.
An 80 year-old frail woman presents to you after falling while An 80 year-old frail woman presents to you after falling while ambulating to the bathroom at night. This is the second time ambulating to the bathroom at night. This is the second time she has fallen in the last month. Echocardiogram shows she has fallen in the last month. Echocardiogram shows diastolic dysfunction and moderate mitral annular diastolic dysfunction and moderate mitral annular calcification. ECG is essentially normal with exception of calcification. ECG is essentially normal with exception of first degree AV block. After her first fall one month ago, she first degree AV block. After her first fall one month ago, she was told by her physician that she needs to use a cane and was told by her physician that she needs to use a cane and to rise slowly out of bed. Her daughter is very concerned to rise slowly out of bed. Her daughter is very concerned and wants a second opinion. You recommend which of the and wants a second opinion. You recommend which of the following:following:
a. Discontinuing evening dose of Lasix.a. Discontinuing evening dose of Lasix.b. Tilt-table study to diagnosis the etiology of b. Tilt-table study to diagnosis the etiology of falls and reassure her daughter.falls and reassure her daughter.c. Electrophysiologic test to assess for c. Electrophysiologic test to assess for
bradyarrhythmias.bradyarrhythmias.d. Continuous-loop event monitoring.d. Continuous-loop event monitoring.e. Physical therapy to improve gait stability.e. Physical therapy to improve gait stability.
An 80 year-old frail woman presents to you after falling while An 80 year-old frail woman presents to you after falling while ambulating to the bathroom at night. This is the second time ambulating to the bathroom at night. This is the second time she has fallen in the last month. Echocardiogram shows she has fallen in the last month. Echocardiogram shows diastolic dysfunction and moderate mitral annular diastolic dysfunction and moderate mitral annular calcification. ECG is essentially normal with exception of calcification. ECG is essentially normal with exception of first degree AV block. After her first fall one month ago, she first degree AV block. After her first fall one month ago, she was told by her physician that she needs to use a cane and was told by her physician that she needs to use a cane and to rise slowly out of bed. Her daughter is very concerned to rise slowly out of bed. Her daughter is very concerned and wants a second opinion. You recommend which of the and wants a second opinion. You recommend which of the following:following:
a. Discontinuing evening dose of Lasix.a. Discontinuing evening dose of Lasix.b. Tilt-table study to diagnosis the etiology of b. Tilt-table study to diagnosis the etiology of falls and reassure her daughter.falls and reassure her daughter.c. Electrophysiologic test to assess for c. Electrophysiologic test to assess for
bradyarrhythmias.bradyarrhythmias.d. Continuous-loop event monitoring.d. Continuous-loop event monitoring.e. Physical therapy to improve gait stability.e. Physical therapy to improve gait stability.
A 16 year-old girl presents to you after a syncopal event A 16 year-old girl presents to you after a syncopal event while playing field hockey on an unusually hot day. She while playing field hockey on an unusually hot day. She was running when she developed profound lightheadedness was running when she developed profound lightheadedness just prior to losing consciousness. Upon regaining just prior to losing consciousness. Upon regaining consciousness, she was diaphoretic and confused to consciousness, she was diaphoretic and confused to surroundings. She felt nauseated for the rest of the day. surroundings. She felt nauseated for the rest of the day. She has no cardiac history and her exam is unremarkable She has no cardiac history and her exam is unremarkable except for mild orthostasis. Her EKG is normal. You except for mild orthostasis. Her EKG is normal. You recommend which of the following:recommend which of the following:
a. Genetic testing for long QT channelopathy.a. Genetic testing for long QT channelopathy.b. Continuous-loop event monitoring.b. Continuous-loop event monitoring.c. Increasing fluid intake and reassure parents.c. Increasing fluid intake and reassure parents.d. Refer to electrophysiology. d. Refer to electrophysiology. e. Tilt-table study. e. Tilt-table study.
A 16 year-old girl presents to you after a syncopal event A 16 year-old girl presents to you after a syncopal event while playing field hockey on an unusually hot day. She while playing field hockey on an unusually hot day. She was running when she developed profound lightheadedness was running when she developed profound lightheadedness just prior to losing consciousness. Upon regaining just prior to losing consciousness. Upon regaining consciousness, she was diaphoretic and confused to consciousness, she was diaphoretic and confused to surroundings. She felt nauseated for the rest of the day. surroundings. She felt nauseated for the rest of the day. She has no cardiac history and her exam is unremarkable She has no cardiac history and her exam is unremarkable except for mild orthostasis. Her EKG is normal. You except for mild orthostasis. Her EKG is normal. You recommend which of the following:recommend which of the following:
a. Genetic testing for long QT channelopathy.a. Genetic testing for long QT channelopathy.b. Continuous-loop event monitoring.b. Continuous-loop event monitoring.c. Increasing fluid intake and reassure parents.c. Increasing fluid intake and reassure parents.d. Refer to electrophysiology. d. Refer to electrophysiology. e. Tilt-table study. e. Tilt-table study.