Designed, tested, FDA approved and proven to perform in all angles up to 90˚ Pre-Operative Post-Operative 2 year Ref: 120-210 0-90º The 1st and only AAA stent graft approved by the FDA for use with 0 – 90˚ angles Why compromise? Choose AORFIX ™ for all neck angulations from 0˚–90˚ 1. AbuRahma, A. F., Campbell, J., Stone, P. A., Nanjundappa, A., Scott Dean, L., Keiffer, T., & Emmett, M. (2010). Early and late clinical outcomes of endovascular aneurysm repair in patients with an angulated neck. Vascular, 18(2), 93-101. 2. Bench test data on file. Secure fixation 8 cat’s claw hooks placed at the proximal edge of 4 closely spaced stent rings that cover 8mm in the proximal seal zone Supreme flexibility in neck angles up to 90° with ring stent structure Effective sealing Aorfix™ shown to reduce type 1 endoleaks in high angulations¹ Highly flexible limbs Positioning Tantalum radiopaque markers aid positioning² Interlocking modular connections minimize dislocations Inter- locking helical design SIZING COMPONENT GUIDE 1. Refer to product specific IFUs for full indications. For further details please refer to the Aorfix™ IFU. 2. Aorfix™ US IDE trial results, see Aorfix™ IFU for full details. 3. Competitor data from Summaries of Safety and Effectiveness filed with FDA. SSE Ref: Aorfix™: P110032 Feb 14, 2013. Talent: P070027 April 15, 2008. Endurant: P100021 Dec 16, 2010. EndoLogix: P040002 Oct 29, 2004. Excluder: P020004 Nov 6, 2002. Zenith: P020018 May 23, 2003. Zenith Hi Risk: P020018 May 23, 2003. • Only Pythagoras low angle data <60° can be compared with competitors’ FDA results as there are no other high angle FDA trials. • Aorfix™ demonstrates better or comparable performance and results when compared with competitor AAA stent grafts in angulation <60°. UnrivAlleD clinicAl PerFOrmAnce bAseD On eviDence ² AOrFix™ resUlts vs Other AAA stent grAFts ³ Overall Pythagoras results Freedom from SVS MAE (30 d) Mortality (30 d) Mortality (1 yr) Sac shrinkage (5mm 1yr) Sac expansion (5mm 1yr) Type I/III leak (1yr) Migration (10mm 1yr) Aorfix™ Aorfix™ Aorfix™ <60° 60-133° All SVS control group N=67 N=151 N=218 N=323 92.5% 81.5% 84.9% 56.4% 1.5% 2.0% 1.8% 2.8% 4.5% 7.9% 6.9% 6.5% 36.7% 44.1 % 41.9% • 0% 1.8% 1.2% • 0% 1.9% 1.3% • 0% 1.7% 1.2% • Performance of Aorfix™ reduces only slightly in angles from 60° to 90° UniqUe inDicAtiOn 0º – 60º 60º – 90º Comparison of IFU indications for neck angulations 1 AAA stent graft Aorfix™ 3 3 Endurant 3 7 Zenith 3 7 Excluder 3 7 Freedom from SVS MAE (30 d) Mortality (30 d) Mortality (1 yr) Sac shrinkage (5mm 1yr) Sac expansion (5mm 1yr) Type I/III leak (1yr) Migration (10mm 1yr) % Different definitions used, not comparable Aorfix™ <60° Talent Endurant Endologix Gore Cook Cook N=67 Excluder Zenith Zenith (Hi Risk) 92.5% 96% 89% 1.5% 1.8% 0% 1% 1.3% 0.5% 2% 4.5% 6.5% 4% 6.8% 7.2% 3.5% 9% 36.7% 33.6 % 49.6% 35.7% 14.3% 67.5% 62.9% 0% 2.3% 0% 2% 7.1% 1.3% 1.6% 0% 2.5% 0% 0% 1.3% 1.4% 1.8% 0% 0.8% 0% 0.7% 2.3% 2.5% 2.8% Different definitions used, not comparable Different definitions used, not comparable Different definitions used, not comparable 1 year For further details please refer to the Aorfix™ AAA Flexible Stent Graft System IFU.