Department of Chemical Engineering University of California, Los Angeles 2003 AIChE Annual Meeting San Francisco, CA November 17, 2003 Nael H. El-Farra Panagiotis D. Christofides James C. Liao Computational Modeling & Computational Modeling & Simulation of Nitric Oxide Simulation of Nitric Oxide Transport-Reaction in the Blood Transport-Reaction in the Blood
23
Embed
Department of Chemical Engineering University of California, Los Angeles 2003 AIChE Annual Meeting San Francisco, CA November 17, 2003 Nael H. El-Farra.
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Department of Chemical EngineeringUniversity of California, Los Angeles
2003 AIChE Annual Meeting
San Francisco, CANovember 17, 2003
Nael H. El-FarraPanagiotis D. Christofides
James C. Liao
Computational Modeling & Simulation Computational Modeling & Simulation of Nitric Oxide Transport-Reaction in of Nitric Oxide Transport-Reaction in
the Bloodthe Blood
• Nitric oxide (NO) : active free radical
Immune response
Neuronal signal transduction
Inhibition of platelet adhesion & aggregation
Regulation of vascular tone and permeability
• Versatility as a biological signaling molecule
Molecule of the year (Science, 1993)
Nobel Prize (Dr. Ignarro, UCLA, 1998)
• Need for fundamental understanding of NO regulation
Distributed modeling
IntroductionIntroduction
• Complex mechanism:
Release in blood vessel wall
Diffusion into surrounding tissue
Blood pressure regulation
Diffusion into vessel interior
Scavenging by hemoglobin
Trace amounts can abolish NO
• Paradox: how can NO maintain its biological how can NO maintain its biological
function ?function ?
Barriers for NO uptake
NO Transport-Reactions in BloodNO Transport-Reactions in Blood
Vessel wall
Barriers for NO Uptake in the Blood
(1)(2)
(3)(4)
Previous Work on Modeling NO Transport
• Homogenous models:
Blood treated as a continuum
e.g., Lancaster, 1994; Vaughn et al., 1998
• Single-cell models:
Neglects inter-cellular diffusion
e.g., Vaughn et al., 2000; Liu et al., 2002
• Survey of previous modeling works (Buerk, 2001)
• Limitations:
Population of red blood cells (RBC) unaccounted for
Cannot quantify relative significance of barriers
Present Work
• Objectives:
Develop a detailed multi-particle model to describe NO transport-reactions in the blood
Use the developed model to investigate sources for NO transport resistance