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Good afternoon!
JI Balamban, Fabros, Pati
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THE CASE
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This is a case of a 2 ear old
female "ho came in d#e to
fe$er and abdominal %ain
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&o histor of tra$el to other %ro$inces
&o "adin' in (ood "aters
Constant e)%os#re to rodents and li$esnear a (ooded area for the %astmonths*
+- .no"n cases of $ector relatedinfection in her ho#sehold, as hercommon la" %artner and child "eredia'nosed "ith the illness 2 ears a'o*
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Patient "as a%%arentl "ell #ntil/
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0 das PTA
Patient "o1e #% "ith#ndoc#mented fe$er
"ith associated sm%toms of s#dden onset headache, frontal
to tem%oral in location, throbbin'in character, non radiatin',
described as 345 in se$erit mal'ia and arthral'ia
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0 das PTA
She too14* Phenle%hrine HCl Chlor%henamine
maleate Paracetamol +Bio(#- 55m'3 tab e$er 6 ho#rs for the fe$er
and headache2* Ib#%rofen Paracetamol
255m'372m' +Ala)an F8- formal'ia and arthral'ia
A9orded no relief
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&o co#'hs, colds, chills, throat %ain,ear %ain, ear dischar'e, abdominal%ain, $omitin', diarrhea, ds#ria,hemat#ria, $a'inal dischar'e noted
&o cons#lt done
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2 das PTA
Still "ith abo$e sm%toms no"di::iness ; s#dden onset of Abdominal%ain, b#rnin' in
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2 das PTA
7 e%isodes of $omitin'of %re$io#sl in'ested food, non>bilio#s,
non>blood, "ater, and a%%ro)imatel
455 cc in $ol#me* Self>medicated Simethicone +.remil S- )
4 dose a9orded no relief of abdominal%ain
There "as no chan'e in bo"el mo$ement,melena, hematoche:ia, hematemesis
&o cons#lt done
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4 da PTA
Fe$er s#bsided, b#t %ersistence ofabdominal %ain and headache noted"hich %ro'resses from =345 to 45345
Persistence of sm%toms %rom%ted
cons#lt
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Past ?edical Histor
S3P sal%in'o>oo%horectom, leftsecondar to ecto%ic %re'nanc+2540, PGH-
&o h%ertension
&o diabetes mellit#s
&o 1idne, li$er, or throid diseases
&o aller'ies to food or dr#'s &o %re$io#s PTB treatment
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FAMILY HISTORY
&o h%ertension, no @?,Bronchial asthma
&o 1idne, li$er, or throid
disease &o Cancer
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PERSONAL AND SOCIALHISTORY
Smo1er, %ac1 ears
ccasional alcoholic be$era'edrin1er
?ari#ana ) 4 #se +7 monthsa'o-
Ho#se"ife
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OB History
G2P4 4>5>4>4 4 li$in' child deli$ered $ia &S@
+??C,255-
S3P sal%in'o>oo%horectom, left,secondar to ecto%ic %re'nanc+2540, PGH-
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?enstr#al Histor
?enarche at = ears old A$era'e of 0 na%1ins a da,
soa1ed
&o histor of dsmenorrhea
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SEDA HIST8
Had 7 heterose)#al male %artner
First coit#s at 40 3o
C#rrentl ha$e 4 heterose)#al male%artner
&o histor of articial contrace%ti$e
method #se
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F#nctional Health Pattern
@iet 7 c#%s of rice3meal, $arieties of
meal
8e'#larl #ses condiments onfood salt, so sa#ce, sh sa#ce,%e%%er, s%ic %o"der
Fl#id inta1e 55ml of ater3da +2 c#%s-
7 bottles of Co1e
+o#nces3bottle- >
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F#nctional Health Pattern
Elimination Pattern rination )3da, li'ht ello"
and clear , +>- hemat#ria
@efecation 2)3da, 'olden bro"n,
+>- consti%ation +>- 'ross blood
Acti$it> E)ercise PatternSedentar lifestle
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REVIEW OF SYSTEMS
&o "ei'ht chan'es, no anore)ia
&o a#ndice
&o co#'hs, colds, ds%nea
&o chest %ain, no %al%itations, no ortho%nea,no P&@
&o ds#ria, oli'#ria, hemat#ria
&o diarrhea, consti%ation
&o %ol#ria, %ol%ha'ia, %old%sia, heatintolerance
&o calf tenderness ,rashes, ecchmosis,%#r%#ra, edema
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PHYSICAL EXAM
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GENERAL SURVEY
J*@* "as a"a1e, alert andcoherent and oriented to 7s%heres
Calm, no si'ns ofcardiores%irator distress
Amb#lator
Ectomor%hic
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VITAL SIGNST 7*0KC +a)illar-
P8 63?I& 88 4c%m
BP 4453L5 mmH' +sittin'-
ANTHROPOMETRIC
Hei'ht 4*0 meters
ei'ht061'
B?I 4=*7= +&ormal-
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SKIN
i'ht bro"n in color "ith s%arsehair, e$enl distrib#ted on alle)tremities
&o noticeable chan'e in s1in color &o rash, erthema, %#r%#ra,
ecchmosis
"arm to to#ch %in1ish nail beds
To#rni
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HEAD
&ormoce%halic atra#matic+&C3AT-
Hair "as nat#rall blac1 incolor M te)t#re is ne and "ithnormal hair distrib#tion
&o %al%able lesions, masses ortenderness
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EYES
&o %rotr#sions, retraction, droo%in'or edema in the eelids*
+>- lesions, masses and %eriorbitaledema and tenderness
Nis#al ac#it @ 25325 S 25325
$is#al elds intact
Sclerae "hite in color, +>- abrasions Pale and moist Pal%ebral
con#ncti$ae
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P#%ils e
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Bilateral 1idne>sha%e %inna
&o deformities, lesions, masses
Intact tm%anic membrane, cone of
li'ht %ointin' antero>inferiorl* &o %ain on t#'>test
+- "his%ered $oice hearin' test
8O
EARS
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&ose and nasal se%t#m midline
Patent nostrils
Frontal and ma)illar sin#ses non>tender
NOSE
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Pin1ish i%s
ith dental caries , incom%lete set ofteeth
Pin1ish b#ccal m#cosa and '#ms ,&obleedin'
&o #lcerations, in(ammation orbleedin'
&on>in(ammed Tonsils
Ton'#e and #$#la midline
THROAT
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&o asmmetries or masses
&on>%al%able throid 'land
&o nec1 $ein distention
&on %al%able cer$ical lm%h nodes
NECK
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&o deformities Smmetric chest e)%ansion "ith 'ood
l#n' e)c#rsion
&o $isible and %al%able masses
E
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Adnamic %recordi#m
&o thrills, lifts or hea$es
P?I thleft ICS ?C 4*diameter
Base S4 S2
A%e) S2 S4
S7 and S0 absent
&o m#rm#rs, no e)tra so#nds
HEART
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Breasts are e
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Sha%e 'lob#lar
In$erted #mbilic#s
Smmetrical, "ith $ertical s#r'ical
scar belo" the #mbilic#s,healed
&o dilated $eins
&o $isible %eristalsis or %#lsations
Bo"el so#nds normoacti$e +273min-
&o br#it, thrills
ABDOMEN
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Tm%anitic on all fo#r %al%able
&o CNA tenderness
ABDOMEN
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Arms and le's smmetrical, "arm,no edema
&o hematoma
Ca%illar rell 2sec #%%er andlo"er
Peri%heral %#lses smmetric arms
and le's +2 brachial, radial,%o%liteal and dorsalis %edis-
&o limitation 8?
EXTREMITIES
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Mus!" #u!$% smmetrical, 'oodtone both #%%er and lo"er
&o 'ross in$ol#ntar mo$ements
or atro%h Amb#lator, able to stand, slo"
stead 'ait
s#all sittin' #%%er bodleanin' for"ard
Mus!" str"&'t(% 03 #%%er, 3
lo"er
MUSCULOSKELETAL
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NEUROLOGIC EXAMINATION
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Level of Consciousness: Alert
Awareness:riented to %erson, %lace andtime
Behavior:Able to maintain 'ood ee contact,no mannerisms
Speech and language:?oderate rate, (#ent$oice, no hoarseness, dsarthria, able toa%%ro%riatel ans"er
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Object recognition:Can reco'ni:eobects seen3%al%ated +ball%en,noteboo1 and bottle of alcohol-
Aect:A%%ro%riate
P"r")tio&% Good tho#'ht %erce%tion !hought content:&o dist#rbed
tho#'hts*
MENTAL STATUS EXAMINATION
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CRANIAL
NERVE INTERPRETATION
I Able to smell coffee beans on both nostrils.
II
OD:20/20 OS: 20/20
Pupils are equally reactie to li!ht "#
2mm$ %ith &irect an&consensual li!ht refle'( ")$ accommo&ation
III
IV
VI
*'traocular muscle moements of both eyes are intact.
V
+orrectly i&entifie& the areas on the face %here li!ht brush stro,es
%ere applie& in.
+an close mouth an& !rin& teeth.
CRANIAL NERVE
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CRANIAL
NERVE INTERPRETATION
VII
-ilaterally symmetrical face
+an raise eyebro%s( %rin,le forehea&( close eyes ti!htly( an& puff
chee,s.VIII ntact !ross hearin!
IX
X
ntact !a! refle'
o hoarseness in oice
ula is in mi&line.
XIAble to shru! an& eleate shoul&ers( as %ell as rotate hea& a!ainst
resistance.
XII
1on!ue is in mi&line( not atrophie& an& can be moe& freely an&
from si&e to si&e. Patient %as able to stic, out ton!ue an& moe it
from left to ri!ht.
CRANIAL NERVE
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Smmetric m#scle b#l1 of %ro)imal anddistal m#scles of both #%%er and lo"ere)tremities*
&o atro%h of m#scles* &o clon#s, fascic#lations, sei:#res,tremors, and s%asm*
&o in$ol#ntar mo$ements
Arms and le's can be e)tendedthro#'ho#t the ran'e of mo$ement*
&o ri'idit, s%asticit, or (accidit*
MOTOR
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?#scle stren'th on #%%er and lo"ere)tremities are as follo"s
LUE *+* RUE *+*
LLE*+*
RLE *+*
MUSCLE STRENGTH
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Intact %ain, li'ht to#ch, s#%ercialsensation, dee% sensation and $ibratorsensation on both %lantar s#rfaces of feet,n'erti%s and both and e)tremities
mber identication, %oint locali:ation ande)tinction on both 8 and sides "ere intact
LUE,--.
RUE ,--.
LLE,--.
RLE ,--.
SENSORY
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REFLEXES RIGHT LEFT
-iceps )2 )2
1riceps )2 )2
-rachiora&ialis )2 )2
nee)2 )2
An,le )2 )2
REFLEXES
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Fin'er>to>nose test "as%erformed "ith slo" mo$ement
Able to "al1 across the room and
can rise from sittin' %osition "ithassistance
Good balance and 'ait
COORDINATION AND GAIT
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SALIENT FEATURES
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SALIENT FEATURES% PERTINENTPOSITIVE
23 F
ndoc#mented Fe$er for three das sis of fe$er on the fo#rth da
Headache +fronto>tem%oral,throbbin', 345-
?al'ia and arthral'ia
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Abdominal %ain +E%i'astric, B#rnin',45345, radiatin' to 8-
Persistent na#sea and $omitin' +),
in'ested food, non>bilo#s, no relief#%on inta1e of antacids-
oss of a%%etite
&o relief of sm%toms #%on inta1e ofmedications
SALIENT FEATURES% PERTINENTNEGATIVE
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&o histor of tra$el into %ro$inces
&o histor of "adin' into (ood"aters
&o %re$io#s renal, li$er disease
&o "ei'ht chan'es
SALIENT FEATURES% PERTINENTNEGATIVE
S S
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&o rashes
&o chest %ain, ortho%nea, P&@
&o ds#ria, no oli'#ria, no hemat#ria
&o eas br#isalit
SALIENT FEATURES% PERTINENTNEGATIVE
SALIENT FEATURES
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NS 4553L5=7 25 76*0=M B?I O4=* 1'3m2
Abdomen Flat, +- midline incision on
h%o'astri#m, h%o'astric area, 27 bo"el so#nds %er min#te,
i$er s%an 6 ) = cm, +- e%i'astric
tenderness #%on %erc#ssion and %al%ation +>- ?#r%hQs si'n, +>- 8o$sin' si'n, +>-
Psoas si'n, +>- bt#rator si'n
SALIENT FEATURES%PERTINENT POSITIVE FROM PE
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APPROACH TO DIAGNOSIS
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Fe$er
AbdominalPain
Ac#te
Infectio#s
@en'#eFe$er
e%tos%irosisT%hoid
Fe$er
&on>infectio#s
Gastrointestinal
A%%endicitis Cholecstitis Pancreatitis
Genito>#rinar
Pel$icIn(ammator
@isease
Chronic
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DIFFERENTIAL DIAGNOSIS
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Pel$ic In(ammator @isease
RULE IN
Fe$er
Abdominal %ain
RULE OUT
Absence of fo#l>
smellin' $a'inaldischar'e
+>- terine tenderness
@oes not #s#all
%resent "ith mal'iaand arthral'ia
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ACTE APPE&@ICITIS
RULE IN
Fe$er
oss of a%%etite
E%isodes of $omitin'
RULE OUT
+>- 8i'ht lo"er - 8o$sin' si'n +>- bt#rator si'n
+>- Psoas si'n
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ACTE CHECSTITIS
RULE IN
Female
Fe$er E%isodes of $omitin'
E%i'astric %ain+radiates to 8-
8 tenderness
RULE OUT
Pain is not 'enerali:edon the ri'ht #%%er
abdomen Pain does not radiateto the intersca%#lararea, ri'ht sca%#la, orsho#lder
@oes not %resent "ith?al'ia and arthral'ia
+>- ?#r%hQs si'n
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ACTE PA&C8EATITIS
RULE IN
Fe$er
Abdominal %ain
&a#sea and $omitin'
RULE OUT
&o radiation to the bac1
Absent abdominal
distention Absent m#scle ri'idit
Patient has normo>acti$e bo"el so#nds
?al'ia and arthral'ia +>- C#llenQs si'n
+>- T#rnerQs si'n
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EPTSPI8SIS
RULE IN
Fe$er
Abdominal %ain
&a#sea and $omitin'
?al'ia
RULE OUT
&o histor of "adin' into"aters
+>- a#ndice
&o ds#ria, no oli'#ria, nohemat#ria
Absent mac#lo%a%#larrash
Broncho$esic#lar breathso#nds
Pin1 %al%ebral con#ncti$a
+>- He%atos%lenome'al
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TPHI@ FENE8
RULE IN
Fe$er
Abdominal %ain Headache
?al'ia and arthral'ia
Anore)ia
&a#sea and $omitin' Abdominal tenderness
RULE OUT
&o histor of %rolon'edfe$er for #% to 0 "ee1s if#ntreated
Absence ofmac#lo%a%#lar rash +roses%ots-
&o chan'e in bo"el
mo$ement +>- He%atos%lenome'al
&ormal heart rate d#rin'time of fe$er
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@E&GE FENE8
RULE IN
Fe$er
Abdominal %ain
Headache
Persistent na#sea and
$omitin' ?al'ia and arthral'ia
RULE OUT
Cannot be r#led o#t
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APPROACH TO
DIAGNOSIS
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PATHOGENESIS
PATHOGENESIS
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A* ae'%ti
En$ironmental 8is1Factors3 Breedin' sites4* Sta'nant (ood
"ater2* Flo"er $ases3%ots7* Piles tires
PATHOGENESIS
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@E&GE PATHGE&ESIS
A* ae'%ti
E&/iro&0"&t1! Ris$F1tors+ Br""2i&'
sit"s4* Sta'nant (ood
"ater2* Flo"er $ases3%ots7* Piles tires
BITE OF A VIRUS 1rryi&'
0os3uitoSkin
BloodInfect cells
I&4"tio&I00u&" r"s)o&s"
Ati/1tio& T "!! r"s)o&s"50"0ory T "!! i4 r"6"7)osur"
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Ati/1tio& T "!!r"s)o&s" 50"0ory T "!!
i4 r"6"7)osur"
Sti0u!1t"s r"!"1s" o4yto$i&"s
P!1t"!"t s(i"!2s /irus4ro0 "7)osur" 1&2
#i&2i&'
N"utr1!i8" )r"6"7isti&'1&ti#o2y
P(1'oytosis
V1su!o)1t(y5P!1s01!"1$1'"9
Co1'u!o)1t(y5PTT+APTT9
T1r'"ts !i/"r 1&2s)!""& )1r"&(y01!
"!!s
HEPATOSPLENOME
GALY
Virus61&ti#o2y o0)!"7
AB "&(1&" u)t1$"
Cyto!ysis
Dir"t "!!u!1r 2"strutio&1&2 i&4"tio& o4 Bo&"
M1rro: )r"ursor "!!s ;s(ort"&"2 )!1t"!"t sur/i/1!
1usi&' )!1t"!"t !ys"s
THROMBOCYTOPENIA
DENGUE HEMORRHAGIC
High fever,body
weakness,headache anddizziness
Cyto$i&"s 2"stroy "!!0"0#r1&" 1&2 :1!! 5/ir1!
1&ti'"& i& 0o&oyt"9
Co0)!"0"&t syst"01ti/1tio&
V1su!1r "&2ot("!i1!
1ti/1tio&
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The In$esti'ation
aborator and @ia'nostic Proced#res
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THE INVESTIGATION%LABORATORY ANDDIAGNOSTICS
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< PHASES OF DENGUE
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asts 2>L das ?onitorin' for "arnin'
si'ns is cr#cial
?ild hemorrha'icmanifestations
Pro'ressi$e decrease inBC earliestabnormalit
To#rni
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@efer$escence on da 7C
Patient can either im%ro$e or deteriorate
e#1o%enia, thrombocto%enia, increase in Hct
,> D"&'u" :it(out :1r&i&' si'&s
?> D"&'u" :it( :1r&i&' si'&s
S"/"r" 2"&'u"
Clinical %roblems enco#ntered Shoc1 from the %lasma lea1a'e Se$ere hemorrha'e r'an im%airment
CRITICAL PHASE
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W1r&i&' si'&s% Increase in ca%illar
fra'ilit
Be'innin' of critical%hase
S"/"r" D"&'u"%4* Plasma lea1a'e and3or
(#id acc#m#lation
res%irator distress2* Se$ere bleedin'
7* Se$ere or'anim%airment
Clinical %roblems enco#ntered Shoc1 from the %lasma lea1a'e Se$ere hemorrha'e r'an im%airment
CRITICAL PHASE
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D"&'u" s(o$% critical $ol#me of %lasma is lost thro#'h
lea1a'e
Preceded b "arnin' si'nsTem% s#bnormal
Prolon'ed shoc1 or'an h%o%erf#sion
or'an im%airment, metabolic acidosis,@IC se$ere hemorrha'e dec Hct,inc BCClinical %roblems enco#ntered
Shoc1 from the %lasma lea1a'e Se$ere hemorrha'e r'an im%airment
CRITICAL PHASE
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Grad#al re>absor%tion of e)tra$asated (#id+0>L2 ho#rs-
PatientsQ 'eneral "ellbein' im%ro$es,
hemodnamic stat#s stabili:es anddi#resis ens#es*
Hct stabili:es or ma be lo"er +dil#tione9ect of reabsorbed (#id-
After defer$escence rise in BC then%lateletClinical %roblems enco#ntered
H%er$olemia
RECOVERY PHASE
COURSE OF DENGUE ILLNESS
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COURSE OF DENGUE ILLNESS
CBC@+ @+
AM@+ PM @+,-
AM@+,- PM @+,, AM
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AM AMBC 2*2 2* 7*2 0*7 0* 6*=&e#t 62*7 *7 24 70*7 20*6 4*Lm 22*2 2L*2 L0 0 60*7 6=*7
?ono 4* 4L* 25*L 44* 4*5Eosi 5 5 5 5 5 5Baso 5 5 5 5 5 58BC 0*L 0*4 0*7L 0*0 0*46 0*5H'b 4*2 40*0 40*4 47* 47*2 47*4Hct 04*4 05*4 7L*L 7*7 7*= 7*6
?CN L*0 6*L 6*7 L 6*7 L*=?CH 72*7 74*= 72*7 74*0 74*L 72*7?CHC 7L*5 76* 7L*0 76 76* 76*8@ 42*= 47*4 42* 42* 42* 42*Plt 226 46= =0 426 =L 4LBT c 8h
PT 42*Control 40*6
Act 440*5
6
I&8 5*
PTT 2*0
7/26/2019 Dengue Fever Case Reporting
81/101
, ? < @ 5@+9 * 5@+9120it
5@+,-9 = 5@+,,9 5@+,?9
STAGE Febrile Critical 8eco$er @ISCHA8GE@
TE?P* ndoc#mented 76*576*076*
76*L
FENE8
76*L76*
SS) Fe$erHeadache?al'iaArthral'ia
Fe$erHeadache?al'iaArthral'ia
Fe$erHeadache?al'iaArthral'iaA#2o0i&1! )1i&Vo0iti&'
sis offe$erHeadacheAbdominal %ain
E%i'astric %ainHeadache
&o ab%ain
E%i'astric %ain
Ab %ain
BC+inc-
2*2 2* 7*2 0*7 0* 6*=
PTC&T
226 46=
=0 426
=L 4L
HCT+dec-
04*4 05*4
7L*L
7*7
7*=
7*6
Serolo' I'G
7/26/2019 Dengue Fever Case Reporting
82/101
CBC "ith Platelet co#nt dail #ntilthe critical %hase is o$er Hematocrit +earl %hase- baseline
BC decreasin' M Platelet co#nt
7/26/2019 Dengue Fever Case Reporting
83/101
MANAGEMENT
r"su0) /" 1'&os s% Li/" i&+tr1/"! to "&2"0i1r"1
7/26/2019 Dengue Fever Case Reporting
84/101
ASSESSM
ENT
F"/"r 1&2 ? o4 t(" % A&or"7i1 1&2 N1us"1 R1s(
A("s 1&2 )1i&s50y1!'i1 1rt(r1!'i19
W1r&i&' si'&s L"uo)"&i1 Tour&i3u"t t"st
)ositi/"
W1r&i&' Si'&s% A#2o0i&1! )1i&+t"&2"r&"ss P"rsist"&t /o0iti&' C!i&i1! ui2 1u0u!1tio&
Muos1! #!""2 L"t(1r'y 1&2 r"st!"ss&"ss Li/"r "&!1r'"0"&t ?0 L1#% i& Ht o&urr"&t :it(
r1)i2 2"> o4 Pt ou&t
7/26/2019 Dengue Fever Case Reporting
85/101
7/26/2019 Dengue Fever Case Reporting
86/101
W1r&i&' Si'&s6
o"7isti&' o&2itio&soi1! iru0st1&"
Co6"7isti&' o&2itio&st(1t 01y 01$" 2"&'u"
Soi1!iru0st1&"s
7/26/2019 Dengue Fever Case Reporting
87/101
t(1t 01y 01$" 2"&'u"or its 01&1'"0"&t
0or" o0)!i1t"2
iru0st1&"s
Pre'nanc infanc ld a'e
besit @iabetes mellit#s H%ertension Heart fail#re
8enal fail#re Chronic hemoltic
diseases s#ch as sic1le>cell disease and
a#toimm#ne diseases
li$in' alone li$in' far from a
health facilit
"itho#t reliablemeans of trans%ort
Warning Signs
6 Coeisting conditionsSocial circ!mstance
DENGUEWITHOUT
G8P A?A BE
7/26/2019 Dengue Fever Case Reporting
88/101
Grou) Crit"ri1 L1#or1toryT"sts
Tr"1t0"&t Mo&itori&'
Patients "ho donot ha$e "arnin'si'ns
AND"ho are able To tolerate
adeAd $ice for immediateret#rn to
hos%ital ifde$elo%ment of an"arnin' si'ns3 ritten ad$ice of
mana'ement +e*'*home care card forden'#e-
WITHOUTWARNING
SIGNS
SE&TH?E
8A 8EH@8ATI&
7/26/2019 Dengue Fever Case Reporting
89/101
8A 8EH@8ATI&&TES
Or1! r"(y2r1tio& so!utio& 5
7/26/2019 Dengue Fever Case Reporting
90/101
Coeisting conditionsSocial circ!mstance
Grou) Crit"ri1 L1#or1tory T"sts
Tr"1t0"&t5without
warning sign"
Tr"1t0"&t5:it(
W1r&i&'
si'&s9
Coe)istin' conditons3socialcirc#mstance
OR E)istin' "arnin' si'ns
Abdominal %ain or
tenderness Persistent $omitin' Clinical (#id
acc#m#lation ?#cosal bleedin' ethar'3 restlessness i$er enlar'ement
2cm
F#llbloodCo#nt+FBC-
Haemat
ocrit+Hct -
Enco#ra'ementfor oral (#ids
If nottolerated,startintra$eno#s
(#id thera%5,= saline or8in'er actateat maintenancerate
S"" &"7ts!i2"
NGUE WITHOUT WARNING SIGNS DENGUE WITH WARNING SIGN
G8P B8EFE88E@ F8
I&>HSPITACA8E
7/26/2019 Dengue Fever Case Reporting
91/101
Tr"1t0"&t 5:it( :1r&i&'
si'&s9 btain reference Hct before(#id thera%
Gi$e isotonic sol#tions s#ch as
5,= saline, 8in'er lactate,start "ith >L ml31'3hr for 4>2 ho#rs
Then red#ce to 7> ml31'3hrfor 2>0 hr
red#ce to 2>7 ml31'3hr or less
accordin' to clinical res%onse
7/26/2019 Dengue Fever Case Reporting
92/101
R"1ss"ss !i&i1! st1tus
1&2 r")"1t Ht If Hct remains the same orrises onl minimall >contin#e "ith 2>7 ml31'3hr
for another 2>0 ho#rs If "orsenin' of $ital si'ns
and ra%idl risin' Hct >
increase rate to >45ml31'3hr for 4>2 ho#rs
R"1ss"ss !i&i1! st1tus
7/26/2019 Dengue Fever Case Reporting
93/101
R"1ss"ss !i&i1! st1tusr")"1t Ht 1&2 r"/i": ui2
i&4usio& r1t"s 1or2i&'!y % 8ed#ce intra$eno#s (#ids'rad#all "hen the rate of%lasma lea1a'e decreasesto"ards the end of the critical%hase*
T(is is i&2i1t"2 #y%
Ade
7/26/2019 Dengue Fever Case Reporting
94/101
5:it(out :1r&i&'si'&s9
5:it( :1r&i&' si'&s9
Tem%erat#re %atternNol#me of (#id inta1eand
osses rine o#t%#t W
$ol#me and fre
7/26/2019 Dengue Fever Case Reporting
95/101
Grou) Crit"ri1 L1#or1tory T"sts Tr"1t0"&t Mo&itori&'
Patients "ith an ofthe follo"in'
feat#res* Se$ere %lasma
lea1a'e "ithshoc1 and3or (#idacc#m#lation"ith
res%iratordistress
Se$ere bleedin'
Se$ere or'an
F#ll bloodCo#nt +FBC-
Haematocrit+Hct -
ther or'anf#nctiontests asindicated
See net slide See netslide
DENGUE8EI8EE?E8GE&CT8EAT?E&T
"2
7/26/2019 Dengue Fever Case Reporting
96/101
Start I*N* (#id res#scitation "ithisotonic ryst1!!oi2sol#tions at *6
,- 0!+$'+(r o$er , (r 8eassess %atientQs condition
T
r"1t0"
&to4o0)"&s1t"
s
(o$
I4 )1ti"&t i0)ro/"s% I N (#ids sho#ld be red#ced
'rad#all to *6=ml31'3hr D 4>2 hr
0 hr and> Then red#ced f#rther de%endin'
on hemodnamic stat#s
I N (#ids can be maintained for #%
(o
I4 )1ti"&t sti!! u&st1#!"% Chec1
7/26/2019 Dengue Fever Case Reporting
97/101
1
t0"&to4o0)
"&s1t"
2s( I4 )1ti"&t sti!! u&st1#!"% Chec1
Hct after rst bol#s
I4 Ht i&r"1s"s3 still hi'h +5-re%eat a second bol#s of
crstalloid sol#tion at ,-6?-
0!+$'+(r 4or , (rIf im%ro$ement after secondbol#s, r"2u" r1t" to =6,-0!+$'+(r 4or ,6? (r contin#e to
red#ce as abo$e*
I4 Ht 2"r"1s"sThis indicates #!""2i&'and
need to cross>match and
(o
7/26/2019 Dengue Fever Case Reporting
98/101
Initiate I*N* (#id res#scitation
"ith crstalloid or colloidsol#tion at 25 ml31' as a bol#sfor 4 min*
1
t0"&t
o4(y)ot"&si/"s(
I4 )1ti"&t i0)ro/"s% Gi$e a crstalloid 3 colloid
sol#tion of ,- 0!+$'+(r 4or ,
(r, then red#ce 'rad#all*
o$I4 )1ti"&t sti!! u&st1#!"%
8 i th H t t 1 b f th t
7/26/2019 Dengue Fever Case Reporting
99/101
Tr"1t0"&
to4(y)
ot"&si/"
s(o8 e $ie" the Hct ta1en before the rst
bol#s
I4 Ht :1s !o: 5J@-. i& (i!2r"& 1&212u!t 4"01!"s J @*. i& 12u!t 01!"s9this indicates bleedin', the need to
crossmatch and transf#se
I4 HCT :1s (i'( o0)1r"2 to t("#1s"!i&" /1!u"%Chan'e to IN colloids at ,-6?- 0!+$' as
a second bol#s o$er to 4 ho#rM reassessafter second bol#sIf i0)ro/i&'red#ce the rate to L>45
ml31't3hr for 4>2 ho#rs, then bac1 to INcrstalloids and red#ce rates as abo$e
I f condition still #nstable, re%eat Hct
Tr"1t0"&t o4 (y)ot"&si/" s(o$
7/26/2019 Dengue Fever Case Reporting
100/101
Tr"1t0"&t o4 (y)ot"&si/" s(o$
Tr"1t0"&t o4 (1"0orr(1'io0)!i1tio&s%Gi$e >45 ml31' of fresh %ac1edred cells or 45>25 ml31' fresh "holeblood *
DISCHARGE CRITERIA
7/26/2019 Dengue Fever Case Reporting
101/101
DISCHARGE CRITERIA
A!! o4 t(" 4o!!o:i&'rit"ri1 0ust #")r"s"&t %
&o fe$er for 0 ho#rs
Increasin' trend of %lateletco#nt
Stable hematocrit "itho#tintra$eno#s (#ids