Delivering clinical research to make patients, and the NHS, better NIHR CRN: North Thames Prof Lyn Chitty – Clinical Director
Dec 22, 2015
Delivering clinical research to make patients, and the NHS, better
NIHR CRN: North Thames
Prof Lyn Chitty – Clinical Director
Clinical Research Network
Provide research support in clinical teams to facilitate recruitment to portfolio studies
Research nursesData managersVariety of other posts
Develop systems to identify and recruit participants
CSP – gaining NHS permissions for research studies
PERFORMANCE MANAGEMENT of DELIVERY
Launch of National Cancer Research
Network
Creation of Mental Health Research
Network
UKCRN established along with four
additional Research Networks, making up the 6 therapy areas recognised today
National Institute for Health Research created to implement Government
Health Strategy “Best Research for Best Health”
Primary Care and Comprehensive
Research Networks created
NIHR CRN is formed to deliver clinical research
in England
2001 2003 2006/7 20092005 2010
Dr Jonathan Sheffield joins NIHR CRN as
Chief Executive OfficerHigh Level Objectives
and Performance Management
Framework introduced
2012
Health and Social Care Act comes into effect bringing new
NHS structures
2012 - 15
Time for the National Institute
for Health Research Clinical Research Network
to evolve
Our journey so far…
2007/8 2008/9 2009/10 2010/11 2011/12 2012/130
100,000
200,000
300,000
400,000
500,000
600,000
700,000
208,200
331,226
454,138
564,698
595,540637,974
Patients recruited
We have tripled the annual number of patients into studies in six years
Ensure patients will benefit from a consistent approach to clinical research with key specialties being available in all geographies
Provide transparent, consistent governance and clear accountability
Ensure funders (including industry) will benefit from a consistent integrated approach to research delivery
Be platform to share best practice in research delivery and improve learning opportunities and career development
A simplified structure will
High Level Objectives
1. Increase the number of participants recruited into NIHR CRN Portfolio studies
Number of participants recruited in a reporting year into NIHR CRN Portfolio studies
650,000
2. Increase the proportion of studies in the NIHR CRN Portfolio delivering to recruitment target and time
A: Proportion of commercial contract studies achieving or surpassing their recruitment target during their planned recruitment period, at confirmed Network sites
80%
B: Proportion of non-commercial studies achieving or surpassing their recruitment target during their planned recruitment period
80%
3. Increase the number of commercial contract studies delivered through the NIHR CRN
A: Number of new commercial contract studies entering the NIHR CRN Portfolio
600
B: Number of new commercial contract studies entering the NIHR CRN Portfolio as a percentage of the total commercial MHRA CTA approvals for Phase II–IV studies
75%
4. Reduce the time taken for NIHR studies to achieve NHS Permission through CSP
Proportion of studies obtaining NHS Permission at all sites within 40 calendar days (from receipt of a valid complete application by NIHR CRN)
80%
5. Reduce the time taken to recruit first participant into NIHR CRN Portfolio studies
A: Proportion of commercial contract studies achieving first participant recruited within 30 calendar days of NHS Permission being issued or First Network Site Initiation Visit, at confirmed Network sites
80%
B: Proportion of non-commercial studies achieving first participant recruited within 30 calendar days of NHS Permission being issued
80%
6. Increase NHS participation in NIHR CRN Portfolio Studies A: Proportion of NHS Trusts recruiting each year into NIHR CRN Portfolio studies
99%
B: Proportion of NHS Trusts recruiting each year into NIHR CRN Portfolio commercial contract studies
70%
C: Proportion of General Medical Practices recruiting each year into NIHR CRN Portfolio studies
25%
7. Increase the number of participants recruited into Dementias and Neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio
Number of participants recruited into Dementias and Neurodegeneration (DeNDRoN) studies on the NIHR CRN Portfolio
13,500
CRN: North Thames
North Central London, Essex & HertsFormed by merging 11 networksHosted by Barts Health
17 Acute Trusts7 Community & Mental Health Trusts20 CCGs4 HEIs [2 medical schools]
Population 5.7M (10% NHS)Budget £29.4M (+£0.93M RCF)>10% of NIHR portfolio leadfrom North Thames
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London
Guildford
Maidstone
Basildon
High Wycombe
Slough
Reigate
Dartford
Watford
Dunstable Stevenage
Brentwood
Chelmsford
Chief Operating
Officer
Communications Officer & Office
Manager
Admin Officer
Head of RM&G
CSP Co-ordinator
2.0WTEPharmacy/Medical Exposure Manager
Permissions Centre Co-
ordinator
1.0WTE per centre
Head of Finance & Information
Information
Systems Officer
Finance & Information
Manager
Finance OfficerPerformance
Reporting Officer
Industry Operations
Manager
Research Delivery Manager 6.0WTE
Deputy Delivery Manager 6.0WTE
Admin Officer
3.0WTE
Divisional Portfolio Officer 12.0 WTE
Clinical Director
Industry Co-ordinator
PCPIE Manager
Pharmacy /Medical Exposure Co-
ordinator
NIHR CRN Co-ordinating Centre
Barts Health NHS Trust Board
CRN: North Thames Partnership Group
CRN: North Thames Executive Group
CRN: North Thames
Operational Management Group
CRN: North Thames
R&D Advisory Group
CRN: North Thames
Clinical Leadership Group
1
CRN: North Thames Governance Structure
Divisional structureDIVISIONS
Division 1 Speciality Leads for 5 different tumour groups
Division 2 Diabetes & metabolic and endocrine disorders, stroke, cardiovascular disease, renal disorders
Division 3 Children, genetics, haematology, reproductive health and childbirth
Division 4Dementias and neurodegeneration, mental health,
neurological disorders
Division 5Primary Care & ageing, oral and dental health, health services and research delivery & public health, musculoskeletal, dermatology
Division 6Anaesthesia/peri-operative medicine, pain management & critical
care, injuries/emergencies, surgery, ENT, infectious diseases/microbiology, ophthalmology, respiratory disorders,
gastroenterology, hepatology, interventional radiology
The studies and the people
Div 1 Div 2 DIV 3 Div 4 Div 5 Div 6
Open studies 228 128 144 154 131 222
(commercial) (47) (23) (29) (24) (24) (56)
Workforce (FTE) 114.5 59 66 83 52 61
Recruitment (2012-13)
5023 10507 9007 9573 10422 8755
Interventional 2392 1631 2927 2236 4141 1271
CCG Recruitment 2013/14 vs 2014/15
Total0
2000
4000
6000
8000
10000
1200011205
10011
2013/14 2014/15
Recruitment by CCG 2013/14 vs. 2014/15
NHS Barking and Dagenham CCG
NHS Barnet CCG
NHS Basildon and Brentwood CCG
NHS Camden CCG
NHS Castle Point and Rochford CCG
NHS City and Hackney CCG
NHS Enfield CCG
NHS Haringey CCG
NHS Havering CCG
NHS Herts Valleys CCG
NHS Islington CCG
NHS Luton CCG
NHS Mid Essex CCG
NHS Newham
CCG
NHS Redbridge CCG
NHS Southend CCG
NHS Thurrock CCG
NHS Tower Ham
lets CCG
NHS Waltham
Forest CCG
NHS West Essex CCG
0
500
1000
1500
2000
2500
3000
2013/14 2014/15
CCG Recruitment by Specialty 2014/15
Primary Care
Infectious diseases and microbiology
Cardiovascular disease
Diabetes
Children
Health services and delivery research
Mental Health
Reproductive health and childbirth
Oral and dental health
Cancer
Stroke
Dementias and neurodegeneration
Renal disorders
Ageing
Respiratory disorders
Metabolic and endocrine disorders
Neurological disorders
0
1000
2000
3000
4000
50005049
2004
12541107
27757 57 44 35 32 32 23 17 10 10 2 1
No. GP Practices by CCG
Barking &
Dagenham
Barnet
Basildon &
Brentw
ood
Camden
Castle Point &
Rochford
City an
d Hackney
Enfield
Haringe
y
Haverin
g
Herts Vall
ey
Islingto
n
Luto
n
Mid Esse
x
Newham
Redbridge
South
end
Thurro
ck
Tower H
amlets
Walt
ham Fo
rest
West
Essex C
CG 0
10
20
30
40
50
60
70
80
Active GP Practices by CCG 2014/15
Barking &
Dagenham
Barnet
Basildon &
Brentwood
Camden
Castle Point &
Rochford
City and Hackn
ey
Enfield
Haringey
Haverin
g
Herts Valle
y
Islington
Luton
Mid Essex
Newham
Redbridge
Southend
Thurrock
Tower Hamlets
Walth
am Forest
West
Essex
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
66 5
10
13
31
85
8
1812 10
30
21
1211
12
16
6
15
3464 39
30
15
14
4445
42
4926 21
18
40
3425
22
20
39
23
2015-16
£30M + £1M RCF
Initially based on workforce pre-April
Creating a flexible workforce
Divisions build business cases with TrustsTo replace departing staffTo fund new positions
Resource allocation model to support current and new workload (not rewarding past activity) but appropriate to needs
Total recruitment target for NIHR ~58,000. We have set local targets with trusts but need to be aiming high (65,000 = 10% of the NHS)
RM&G Changes
National focus on study support service
HRA
Local provision changes
Harmonisation roll-out across entire CRN
CRN-wide coordination
Working in the CRN
Develop career pathwaysWorkforce reviewStandardised/Job Titles JDsDeveloping a graduate training scheme
Flexible working
Induction
Training and GCP
Dissemination events
Divisional Contacts
Clinical Research Lead Research Delivery Manager (Deputy)
Division 1 Adele Fielding/David Chao Dawn Beaumont-JewellAderonke Adebiyi(Jennifer Godwin)
Division 2 David Wheeler Phil Smith(Jill Gallagher)
Division 3 William Van’t Hoff Dawn Beaumont-Jewell(Heidi Chandler)
Division 4 Helen Killaspy Tania Page(Sarah Styles)
Division 5 David Isenbeg/Lynis Lewis Aderonke Adebiyi(Christine Menzies)
Division 6 Margaret Johnson Sharon Barrett(Belinda Theis)
Contact Us
Email and phone contacts:
Office base for core team:
4th Floor,
170 Tottenham Court Rd
London W1T 7HA
http://www.crn.nihr.ac.uk/
Follow us on Twitter @NIHRCRN_nthames