Trends in Disease Stage at Presentation to Care and Pre-ART Outcomes: a Six-Year HIV Cohort Data from Southern Ethiopia Degu Jerene MD, PhD , WCO, Ethiopia Zewdie Mullisa MD, Arba Minch Hospital, Ethiopia Bernt Lindtjørn MD, PhD, University of Bergen, Norway
Trends in Disease Stage at Presentation to Care and Pre-ART Outcomes: a Six-Year HIV Cohort Data from Southern Ethiopia. Degu Jerene MD, PhD , WCO, Ethiopia Zewdie Mullisa MD , Arba Minch Hospital, Ethiopia Bernt Lindtj ø rn MD, PhD, University of Bergen, Norway. - PowerPoint PPT Presentation
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Trends in Disease Stage at Presentation to Care and Pre-ART Outcomes: a Six-Year HIV Cohort Data from Southern Ethiopia
Degu Jerene MD, PhD, WCO, EthiopiaZewdie Mullisa MD, Arba Minch Hospital, EthiopiaBernt Lindtjørn MD, PhD, University of Bergen, Norway
Background and objectives• Access to antiretroviral therapy improved• Delayed visit contributes to higher death• Trends in patient presentation unknown• Little data on pre-ART patient outcomes• Our objective was to document;
– If there had been shift in disease stage– Pre-ART patient outcomes including loss
METHODS
Study Setting• Ethiopia, population: 73.9 m
(CSA 2007)• HIV prevalence: 2.4% (FMOH,
2007)• ART started in 2003, free ART
in 2005• Arba Minch Hospital: public
hospital• The first hospital to start ART in
the southern region – University of Bergen, Norway
• Technical support since mid-2006– PEPFAR through Johns Hopkins
University
Study Design• Retrospective cohort, Jan ‘03-Dec 31,’08• Reviewed routine patient records• Eligibility; adults, treatment-naïve• Excluded; child, treatment experienced• Enrolment stratified into 3 phases;
– Jan 2003-Aug 2006 (Early phase)– Sept 2006-Aug 2007 (Rapid scale-up)– Sept 2007-Dec 2008 (Recent phase)(Assefa Y et al 2009. PLoS Med 6: e1000056).
Definitions• Pre-ART loss to follow-up (pLFU): if patient
did not have follow up visit at least 30 days after the date of clinic appointment
• Advanced disease: Those in WHO Clinical Stage III & IV– NB: No CD4 until 2006
Statistical Methods• SPSS used for entry and analysis• Logistic regression method
– Advanced stage vs less advanced• Kaplan Meier and Cox Regression
– Time to pre-ART outcomes (death or loss)• Demographic and clinical characteristics as
co-variates
Ethics• Arba Minch Hospital HIV Cohort has
National clearance• Approval obtained locally for this specific