Definition : Definition Hyperlipidemia, hyperlipoproteinemia or dyslipidemia is the presence of raised or abnormal levels of lipids and/or lipoproteins.

ANTIHYPERLIPIDEMIA

Definition : Definition Hyperlipidemia, hyperlipoproteinemia or

dyslipidemia is the presence of raised or abnormal levels of lipids and/or lipoproteins in the blood

Lipids are insoluble in aqueous solution.

Lipids (fatty molecules) are transported in a protein capsule, and the density of the lipids and type of protein determines the fate of the particle and its influence on metabolism.

Lipid and lipoprotein abnormalities are extremely common in the general population, and are regarded as a highly modifiable risk factor for cardiovascular disease due to the influence of cholesterol, one of the most clinically relevant lipid substances, on atherosclerosis.

Pathobiology of Atherosclerosis

When excess cholesterol deposits on cells

and on the inside walls of blood vessels

it forms an atherosclerotic plaque

The first step of atherosclerosis is

injury to the endothelium which results

in atherosclerotic lesion formation

When the plaque ruptures, blood clots

form which lead to decreased blood

flow, resulting in cardiovascular events

Complications of Hyperlipidemia Macrovascular complications:

Unstable Angina (chest pain) Myocardial Infarction (heart attack)Ischemic Cerebrovascular Disease (stroke)Coronary Artery Disease (heart disease)

Microvascular complications: Retinopathy (vision loss) Nephropathy (kidney disease)Neuropathy (loss of sensation in the feet and

legs)

Risk Factors for Hyperlipidemia

Obesity Type 2 diabetes mellitus Advanced age Hypothyroidism Obstructive liver disease Genetics Drug induced:

(e.g. glucocorticoids, thiazide diuretics, beta blockers, protease inhibitors, sirolimus, cyclosporine, progestins and alcohol)

Treatment Goals :Reduce total cholesterol and LDL (bad)

cholesterol

Prevent the formation of atherosclerotic

plaques and stop the progression of

established plaques

Prevent heart disease

Prevent morbidity and mortality

Non-Pharmacological Treatment :1. Lipid lowering therapy should be started with lifestyle

modification for at least 12 weeks

2. Increase physical activity

3. Weight reduction

4. Diet modification: ○ Total fat 25-35% of total calories ○ Saturated fat <7% of total calories ○ Polyunsaturated fat up to 10% total calories○ Monounsaturated fat up to 20% total calories○ Carbohydrates 50-60% total calories ○ Fiber 20-30 g/ day total calories ○ Protein 15% total calories ○ Cholesterol <200 mg/day

Pharmacological Treatment :Pharmacological Treatment If non-pharmacological treatment is not successful, a

lipid-lowering drug should be started, especially in high risk populations

1st step: ○ Initiate LDL-lowering drug therapy .○ Start with statins, bile acid sequestrants, or nicotinic acid.○ Evaluate after 6 weeks .

2nd step: ○ If goal was not reached, intensive lipid-lowering treatment should be started .○ Increase dose of statins .○ Bile acid sequestrants or nicotinic acid should be added.○ Evaluate after 6 weeks .

3rd step: ○ If goal is not reached, intensive lipid lowering should be continued or individual should be

referred to a lipid specialist .○ If goal was reached, other lipid risk factors should be treated .

4th step:○ Monitor response and compliance.

Pharmacological TreatmentPharmacological Treatment

1. Statins (HMG CoA Reductase Inhibitors)○ Atorvastatin (Lipitor® ) ○ Simvastatin (Zocor®) ○ Lovastatin (Mevacor®): extended release ○ Pravastatin (Pravachol®) ○ Fluvastatin (Lescol®) ○ Lescol XL: 80 mg tablets .○ Rosuvastatin (Crestor®): tablets

Statins (HMG CoA Reductase Inhibitors)

Effectiveness of statins:1. Reduce LDL cholesterol by 18-55%

2. Decrease TG by 7-30%

3. Raise HDL cholesterol by 5-15%

4. Statins are the most effective in lowering LDL cholesterol

5. Statins are the most effective in patient who has low HDL and high LDL

Statins (HMG CoA Reductase Inhibitors)

Mechanism of action:

Statins inhibit HMG-CoA reductase (enzyme involved in cholesterol synthesis) thus decreasing mevalonic acid production and stimulating LDL breakdown.

Statins (HMG CoA Reductase Inhibitors)

Side effects:Muscle break down (rhabdomyolysis) Increased liver enzymes leading to renal failure Fatigue, mild stomach disturbances,

headache, or rash

Statins (HMG CoA Reductase Inhibitors)Avoid use in: Active or chronic liver disease and pregnancy

Use with caution with: Concomitant use of cyclosporine, macrolide

antibiotics, antifungal agents. For example: Itraconazole, ketoconazole, erythromycin, clarithromycin, cyclosporine, nefazodone, HIV antiretrovirals

When statins are used with fibric acids and niacin, appropriate caution should be taken because of increasing incidence of muscle breakdown

Statins (HMG CoA Reductase Inhibitors)

Drug- food interaction: Grapefruit juice increases concentration of statins Pravastatin, rosuvastatin & fluvastatin

concentrations are not affected by grapefruit juice.

Monitoring: Muscle soreness, tenderness, or pain.Liver function tests : baseline, 4-6 weeks after

starting therapy, and then annually.Muscle enzyme levels when individual has muscle

pain

Pharmacological Treatment:

2. Bile Acid Sequestrants Mechanism of action:

Bile acid sequestrants bind to bile acids in the intestine, thus inhibits uptake of intestinal bile salts into the blood and increases the fecal loss of bile salt-bound LDL

Bile Acid Sequestrants:1) Cholestyramine (Questran®):

Usual dose: 4 g by mouth 1-2 times a day with meal to a maximum of 24 g per day.

2) Colesevelam (Welchol®):

Usual dose: 3 tablets by mouth twice daily with meals or 6 tablets once daily with a meal.

3) Colestipol (Colestid®)

Usual dose: ○ Granules: 5-30 g by mouth daily given once or 2-4 times a day

with meal ○ Tablets: 2-16 g by mouth daily.

Bile Acid Sequestrants:

Effectiveness: ○ Reduces LDL cholesterol by 15-30% ○ Increases HDL cholesterol by 3-5% ○ Increases TG.

Drug interaction: ○ Decreased absorption of fat soluble Vitamins:

A, D, E, K, C and folic acid ○ Decreased absorption of other drugs:

tetracycline, thiazide diuretics, aspirin, phenobarbital, pravastatin, digoxin

Bile Acid Sequestrants:Side effects:

Stomach upset, constipation accompanied by heart burn, nausea, and bloating

Avoid use in: A disease called dysbetalipoproteinemia Triglycerides >400 mg/dL

Use caution if: Triglycerides >200 mg/dL. Colesevalam is much better tolerated than cholestyramine or

colestipol Statins and other drugs should be taken 1-2 hours before and 4-5

hours after bile acid sequestrants

Pharmacological Treatment:3) Nicotinic Acid:Mechanism of action:

Nicotinic acid decreases the clearance of ApoA1 to increase HDL; it inhibits the synthesis of VLDL

Effectiveness: Decreases LDL cholesterol by 5-25 % Increases HDL cholesterol by 15-35% Decreases TG by 20-50% Nicotinic acid is the most potent drug that increases

HDL cholesterol

Nicotinic Acid:Side effects:

○ Flushing (taking aspirin or ibuprofen can reduce symptoms) ○ Increases blood glucose due to impaired insulin sensitivity ○ Gout ○ Liver toxicity associates with sustained release form (Niaspan) ○ Upper stomach distress and muscle weaknes

Avoid use in: ○ Chronic liver disease ○ Severe gout

Use with caution in: ○ Type 2 diabetes (high dose) ○ Gout ○ Peptic ulcer disease

Pharmacological Treatment:4) Fibric Acids :Mechanism of action:

Fibric acid up-regulates fatty acid transport protein and fatty acid

oxidation; thus it reduces the formation of VLDL, increases

formation of HDL, and enhances the breakdown of TG

Agents:

○ Gemfibrozil (Lopid®)

○ Fenofibrate (Tricor®)

Fibric Acids:

Effectiveness:

○ Reduces LDL cholesterol by 20-50% with normal TG

○ Increases LDL cholesterol with high TG

○ Reduces TG by 20-50%

○ Increases HDL cholesterol by 10-20%

○ Fibric acids are very effective in lowering TG and

preventing pancreatitis

○ Fibric acids reduce VLDL, but fibric acids might

increase LDL and total cholesterol

Fibric Acids:

Side effects: Dyspepsia, gallstones, muscle ache, rash Unexplained non-coronary heart disease deathsWeakness, tiredness, elevations in muscle enzyme

Avoid use in: Severe renal disease Severe hepatic disease

Drug interaction: Fibric acids bind to albumin and increase the effect of

anticoagulants

Pharmacological Treatment:5) Ezetimibe (Zetia) Mechanism of action:

Inhibits absorption of cholesterol in the small intestine; thus it decreases the delivery of cholesterol to the liver and increases the clearance of cholesterol from the blood

Side effects:

chest pain, dizziness, diarrhea, abdominal pain

Drug interaction: Bile acid sequestrants decrease ezetimibe concentrations

○ Ezetimibe should be spaced 2 hours before or 4 hours after bile acid sequestrants administration

Fibric acids increase ezetimibe concentrations