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Clinical decision modeling for n00bs: The absolute minimum you NEED to know Suranga Nath Kasthurirathne
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Decision Modelling for n00bs

Jan 28, 2018

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Page 1: Decision Modelling for n00bs

Clinical decision modeling for n00bs: The absolute

minimum you NEED to know

Suranga Nath Kasthurirathne

Page 2: Decision Modelling for n00bs

What is a Decision Model?

An intellectual template for perceiving, organizing, and managing the business logic

behind a business decision [1].

When applied to Computer science, and explained in plain English,

A computer based system that predicts an outcome or makes a decision

[1] Gottinger, H. W., & Weimann, P. (1992). Intelligent decision support systems. Decision Support Systems, 8(4), 317-332.

Page 3: Decision Modelling for n00bs

Why do we care?

Decision models:

• Allow us to leverage existing silos of information for valuable purposes

• Saves time

• Lets the computer (and not a human) do extremely complicated thinking

• Is very cool and science-y.

Page 4: Decision Modelling for n00bs

Data

Decision

Decision

Data

Flaws, mistakes, Individual perspectives

Page 5: Decision Modelling for n00bs

Decision models

Classification

J48

Logistic Regression

Etc. etc.

Clustering

EM

Simple Kmeans

Classification Vs. Clustering

Page 6: Decision Modelling for n00bs

Decision models

Classification

J48

Logistic Regression

Etc. etc.

Clustering

EM

Simple Kmeans

Classification Vs. Clustering

Page 7: Decision Modelling for n00bs

What we wont cover

• Clustering / unsupervised approaches

• How algorithms work

• How modeling tools work

Page 8: Decision Modelling for n00bs

How does a human being do it?

Case study: Dr. Jones selects students for the masters program

Page 9: Decision Modelling for n00bs

What happens inside the reviewers brain?

Criteria 1 Criteria 2 Criteria 3 Outcome

Mark TRUE FALSE FALSE Reject

Alex TRUE TRUE FALSE Accept

Sarah TRUE TRUE TRUE Accept

The reviewers brain is trained to watch out for specific criteria.So basically….

Page 10: Decision Modelling for n00bs

What can Dr. Jones do wrong?

• Selects wrong criteria

• Places emphasis on the wrong criteria

• Forgets

• Makes mistakes

• And what if Dr. Jones is doing this for the first time?

Page 11: Decision Modelling for n00bs

How does a computer replicate this?

The computer;

• Obtains a data vector, just like our brain does

• ‘Trains’ itself on this vector (just like our brains do)

• Delivers decisions based on this knowledge (just like we do!)

Page 12: Decision Modelling for n00bs

Weka, R project etc.

Page 13: Decision Modelling for n00bs

Computers also share our weakness

• Over fitting

– An applicant has won 10 Nobel prizes

• Imbalance

– Applications for a postdoc position are mistakenly sent to Dr. Jones

• Missing data

– A blank doesn’t mean zero. It means, “I don’t know”

Page 14: Decision Modelling for n00bs

Computers have their advantages

• Feature selection

• Boosting unbalanced data

• Being very very impartial and unbiased

Page 15: Decision Modelling for n00bs

Since real life is always more complicated…

• No binary outcome

– Accept, reject, waitlist, no scholarship, small scholarship

• No binary criteria

– Excellent track record

– Meh track record

– Slightly impressed track record

– Incomplete

Page 16: Decision Modelling for n00bs

Performing decision modeling: guidelines

• Know thyself, know thy data

• Have an ‘unquestionable’ gold standard (outcome variable)

• Use an existing tool

• Get a statistician involved, EARLY

Page 17: Decision Modelling for n00bs

USE A TOOL

No, really…..

Page 18: Decision Modelling for n00bs

Thank you