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Camchong, Endres, Fein 1
Decision Making, Risky Behavior, and Alcoholism
Chapter 13 - Section 5
To appear in: HANDBOOK OF CLINICAL NEUROLOGY, 3rd Series
Authors: Jazmin Camchong, PhD Michael J. Endres, PhD George
Fein, PhD 3rd Series Co-Editors: Edith V. Sullivan, Ph.D. Adolf
Pfefferbaum, M.D.
Series Editors: Michael Aminoff, M.D, D.Sc., FRCP Francois
Boller, M.D., Ph.D. Dick Swaab Publisher: Elsevier (in press
2013)
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Camchong, Endres, Fein 2
Decision making, risky behavior and alcoholism
A hallmark symptom of alcoholism is the continual engagement in
dangerous or risky
drinking behavior despite recurring social or personal
difficulties such as alienation from friends
and family, trouble with the law and at work, or problems with
physical and emotional well-
being. It has been suggested that the alcoholic’s propensity for
such risky behavior is
manifested by impulsive decision-making processes, wherein
potential short-term appetitive
outcomes of drinking (e.g. intoxication) are deemed more
important than potential long-term
aversive consequences of drinking (e.g., drunk driving arrests).
Dual process models of
alcoholism hold that separate but interrelated neurocognitive
pathways to impulsive decision
making exist. One reflected by weak “top-down” executive control
over impulsive and
compulsive urges to consume alcohol. The other reflected by a
strong “bottom-up” appetitive
drive in impulsive and compulsive urges to consume alcohol. The
current chapter surveys
evidence that functional and organizational patterns in brain
executive control and appetitive
drive networks characterize impulsive decision making and risky
behavior in alcoholics, and
that these patterns differ at different stages of alcoholism
dependence and recovery.
POOR EXECUTIVE CONTROL leads to poor decision making
Impairments in executive cognitive ability have been
consistently noted in alcoholics at
various stages of alcohol dependence and recovery. Actively
drinking alcoholics typically
perform more poorly than non-substance abusing controls in a
variety of neurocognitive
domains related to attention, memory, and contingency learning
(Finn and Hall, 2004, Finn et
al., 2009, Bechara and Martin, 2004, Bogg and Finn, 2010). Finn
et al. (2009) showed that
severity of alcoholism and other related externalizing problems
predicted poor short-term and
working memory capacity, with the greatest impairments exhibited
by those with other co-
occurring externalizing behavior problems. Alcoholics’ poor
cognitive capacity also has been
linked with a broad constellation of personality traits related
to impulsiveness, poor-harm
avoidance, and antisocial behavior tendencies (Bogg and Finn,
2010). In the same vein,
laboratory evidence has suggested that poor executive cognitive
capacity is partially
responsible for impulsive decision making in alcoholics and
related externalizing syndromes
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Camchong, Endres, Fein 3
(Finn, 2002, Endres et al., 2011, Bogg et al., 2012). Recent
evidence also shows that, when
combined with highly impulsive trait dispositions, poor
executive cognitive capacity predicts
more heavy and dangerous drinking behavior in active alcoholics
(Gunn and Finn, 2013). In
summary, the evidence suggests that impaired or weak executive
cognitive control processes
are at least partially responsible for the impulsive
decision-making tendencies and risky
behaviors of actively drinking alcoholics.
Alcoholics who stop drinking, and remain sober, experience
recovery in some, but not
all, domains of neuropsychological functioning. Studies have
shown that while
neuropsychological impairments in executive cognitive ability
are present in recently detoxified
and short-term abstinent alcoholics, such impairments may
resolve with extended abstinence;
nonetheless, the major recovery is observed in the first year of
abstinence (Fein et al., 2006,
Mann et al., 1999, Sullivan et al., 2000, Nixon and Glenn, 1995,
Stavro et al., 2012). A recent
meta-analysis by Stavro et al. (2012) found widespread deficits
in executive cognitive ability
characterized recently detoxified and short-term abstinent
alcoholics; but, such impairments
were dramatically attenuated in long-term abstinent alcoholics.
However, Stavro et al. (2012)
also noted a dearth of research on the persistence of inhibitory
control/impulsive decision-
making deficits in those with multi-year abstinence. A
longitudinal study by Sullivan et al. (2000)
found similar evidence of recovery, demonstrating alcoholics
with sustained abstinence
improved in short-term memory, visuospatial processing,
attention, and gait and balance
abilities. Likewise, Fein et al. (2006) showed that long-term
abstinent (LTA) alcoholics with an
average of 6.7 years abstinence did not differ from
non-substance abusing controls in
numerous executive cognitive domains, including cognitive
abstraction/flexibility, attention,
short-term/working memory, psychomotor function/reaction time,
and verbal skills. For
example, Fein et al. (2006) showed spatial processing deficits
were present in LTAs. Thus,
evidence suggests that executive cognitive impairments in
attention, memory, and motor
control to a large extent normalize with extended abstinence.
However, as reviewed below,
evidence also suggests that cognitive impairments related to the
processing of appetitive
and/or emotional information remain present in multi-year
abstinent alcoholics.
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Camchong, Endres, Fein 4
STRONG APPETITIVE DRIVE leads to poor decision making
Psychometric evidence has suggested that impulsive
decision-making in alcoholism and related
externalizing syndromes comprises three independent domains:
myopia to the future,
unwillingness to delay gratification, and difficulties with
passive avoidance (Dom et al., 2007).
Myopic decision-making reflects insensitivity to the long-term
aversive consequences of
appetitive goal-directed behavior and has been assessed with
simulated gambling tasks such as
the Iowa Gambling Task ) (Bechara et al., 1994). Preference for
immediate gratification reflects
a tendency to choose smaller immediate appetitive outcomes over
larger delayed appetitive
outcomes and has been assessed with intertemporal choice
paradigms such as the delay
discounting task (DDT)(Rachlin et al., 1991). Poor passive
avoidance refers to difficulty stopping
or withholding proponent or appetitive behavior so as to avoid
sub-optimal or aversive
outcomes and has been assessed with measures of inhibitory
control, such as the stop-signal
(SST)(Logan et al., 1997), go/no-go (GNG) (Newman et al., 1985),
or balloon analog risk task
(BART) (Lejuez et al., 2002).
Acute alcohol use has disinhibiting effects on behavior control,
impairing rational
decision making and fueling such risky behavior as gambling,
getting a tattoo, or having
unprotected sex (Lin et al., 2005, Purdie et al., 2011,
Tzambazis and Stough, 2000). Separate
studies have shown active alcoholics typically make more
impulsive or disinhibited decisions
than non-substance abusing controls, with those presenting other
co-occurring externalizing
symptoms exhibiting the poorest performances on the Iowa
Gambling Task, DDT, and GNG
(Cantrell et al., 2008, Finn et al., 2002, Mazas et al., 2000,
Endres et al., 2011, Bobova et al.,
2009). Evidence also suggests that impaired processing of
aversive feedback leads to impulsive
decision-making in alcoholism and related externalizing
syndromes, and this information
processing impairment is associated with factors that predate
the onset of clinical problems,
such as a family history of alcoholism (Finn et al., 1994, Fein
and Chang, 2008).
Impulsive decision-making tendencies also have been observed in
abstinent alcoholics,
and unlike impairments in executive cognitive ability, evidence
has suggested that impulsive
decision-making tendencies persist for weeks, months, and even
years of abstinence. Research
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Camchong, Endres, Fein 5
has shown abstinent alcoholics to be less willing to delay
gratification in the DDT relative to
non-substance abusing controls, and this effect was still
present after controlling for impulsive
personality traits (Mitchell et al., 2005). Evidence also has
suggested recently detoxified
alcoholics make more myopic decisions in the Iowa Gambling Task
than controls with little to
no improvement in this capacity at 1 month follow (Dom et al.,
2007). Similar myopic decision-
making tendencies have also been found in short-term and
long-term abstinent alcoholics (Fein
et al., 2010b), with short-term and long-term abstainers showing
comparable impulsive
decision-making during the Iowa Gambling Task relative to
non-substance abusing controls
(Ando et al., 2012). Long-term abstinent alcoholics also are
known to have persistent difficulties
with emotion perception and affective decision-making (Fein et
al., 2010b, Foisy et al., 2007,
Philippot et al., 1999, Kornreich et al., 2001, Endres and Fein,
2012). Endres and Fein (2012)
recently showed that LTA’s persistent difficulties with passive
avoidance in an affective GNG
task were largely due to a history of externalizing problems and
independent of more general
difficulties in lexical decision-making. However, research has
suggested a disassociation
between antisocial symptoms and traits in LTA, suggesting that
antisocial behaviors return to
normal levels in the face of elevated antisocial and
reward-seeking trait dispositions (Fein and
Fein, 2012). In light of the fact that alcoholics can remain
sober in spite of elevated levels of
impulsive traits and decision-making tendencies, researchers
have suggested that other
compensatory mechanisms come into play, such as heighted
executive control and
conscientiousness aid in abstinence maintenance (Ando et al.,
2012, Camchong et al., 2013a).
When together, research has shown impulsive decision-making
tendencies are present in
alcoholics throughout the recovery process, but such impulsive
personality and decision-making
tendencies do not appear to militate against the ability to
maintain abstinence.
It is still not completely clear whether poor decision making
and risky behavior
contribute to the vulnerability of becoming an alcoholic or
whether they are a consequence of
chronic alcohol use. There is evidence supporting the idea that
poor decision making exists
before alcohol dependence. A longitudinal study on young adults
in college found that poor
decision making (as assessed with the Iowa Gambling Task) at
second year of college is
associated with heavy drinking two years later (Goudriaan et
al., 2009). Poor decision making
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Camchong, Endres, Fein 6
(assessed with the Iowa Gambling and Stroop tasks) has also been
identified in individuals at
risk for alcoholism (with family history of alcoholism) when
compared to healthy controls
(Lovallo et al., 2006). Heavy drinking adolescents have shown
poor decision making and higher
impulsivity than light drinking adolescents (Field et al.,
2007).
There is also evidence suggesting that chronic alcohol
consumption during adolescence,
a period in which decision making brain regions are still
developing, has a long-term effect on
adult decision making. A longitudinal study using a rodent model
of chronic alcohol use found
that rats that were exposed to chronic alcohol use during
adolescence had poor decision
making (did not properly weigh benefits and costs) and preferred
more risky options (chose
large but uncertain rewards over small but certain rewards) when
performing a probability-
discounting instrumental response task in adulthood versus rats
that were exposed to a
placebo (Nasrallah et al., 2009). Further research needs to be
conducted to better determine
whether poor decision making is present before or is a
consequence of alcoholism.
Other aspects of behavior related to poor decision making in
alcoholics
Even though poor decision making has been identified in
alcoholics and individuals at
risk of becoming alcoholics, this behavioral deficit is not
specific to alcoholism. Poor decision
making in alcoholism has been associated with other aspects of
behavior such as antisocial
tendencies, stress, number of detoxifications, and onset of
alcohol dependence.
An individual with antisocial personality disorder does not
adhere to accepted societal
norms and often engages in criminal and other impulsive behavior
(APA, 1994). Antisocial
Personality Disorder is more prevalent in alcoholics than in
healthy controls (Compton et al.,
2005, Goldstein et al., 2007). Previous research has proposed
that poor decision making in
alcohol dependent individuals is increased in those with a
comorbid Antisocial Personality
Disorder. A study by Miranda et al (2009) compared risky
decision making (Iowa Gambling Task
performance) between men with alcohol dependence (abstinent
>30 days) with and without
ASPD comorbidity compared with non-substance abusing control
men. Both alcoholic groups
made significantly more risky decisions (manifested as poorer
Iowa Gambling Task
performance) than the control group. However, while alcoholics
without ASPD comorbidity
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Camchong, Endres, Fein 7
showed a slow and steady improvement in advantageous decision
making during the task,
alcoholics with ASPD comorbidity showed an initial improvement
but were unable to sustain it.
Moreover, authors reported evidence that impulsive behavioral
traits (e.g., propensity for rash
impulsive behavior) mediated disadvantageous decision making in
alcoholics with ASPD
comorbidity. These findings suggest that poor decision making in
alcoholics is closely related to
impulsive antisocial tendencies. Because there is evidence that
alcoholics’ antisocial behavior
resolves with extended periods of abstinence, while antisocial
disposition does not (Fein and
Fein, 2012), findings of poor decision making in long-term
abstinent alcoholics might be related
to a persistent disposition to appetitive drive tendencies.
There is evidence that decision making improves when stress is
induced in actively
heavy drinkers. A study that compared decision making in heavy
and light drinkers reported
that heavy drinkers made significantly more disadvantageous
decisions than light drinkers (with
more attention to gains and less attention to losses). When
anticipatory stress was induced (by
asking them to give a speech), decision making was improved in
both heavy and light drinkers
(by increasing attention to losses) (Gullo and Stieger, 2011).
Evidence from this study suggests
that stress is needed to better focus attention on negative
consequences and hence better
decision making. It should be noted, however, that the effect of
stress on decision making may
be different in individuals that have been diagnosed with
alcohol dependence or substance
dependence (Zhang et al., 2011). In addition, the level of
stress induced by requesting
participants to give a speech may not be severe, chronic, or
realistic enough to negatively affect
drinkers’ decision making.
Another aspect that has been found to affect decision making in
individuals with alcohol
dependence is the number of detoxifications an individual has
been through. A study that
compared a group with fewer than 2 detoxifications (low-detox
group) versus a group with >2
detoxifications (high-detox group) reported that the low-detox
group had a significantly greater
rate of improvement in choices throughout the Iowa Gambling Task
than the high-detox group
(Loeber et al., 2009). This evidence suggests that individuals
with repeated withdrawal
episodes lack the ability to make proper decisions and to adapt
behavior to newly learned rules.
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Camchong, Endres, Fein 8
More research needs to be conducted to find out whether poor
decision making leads to
repeated relapse episodes or whether the negative effects of
repeated withdrawals affect
decision making.
Higher levels of impulsive decision making have been associated
with early-onset
alcoholism (Dom et al., 2006). Early-onset alcoholics have shown
higher levels of impulsive
decision making during a delayed discounting task than
late-onset alcoholics and controls (Dom
et al., 2006). This claim, however, needs to be further examined
considering other factors
related to poor decision making in early-onset alcoholism such
as fewer years of education,
potentially higher genetic load, or longer lifetime alcohol
use.
Neural correlates of decision making and risky behavior in
alcoholism
Behavioral aspects of alcoholism such as poor decision making
and risky behavior have
been associated with corresponding brain functional differences
from non-substance abusing
individuals. The executive control (principally mediated by
cortical regions particularly in
frontal cortex) and appetitive drive (principally mediated by
striatal regions) brain networks
have prominent roles in decision making and risky behavior in
alcoholism. During its early
stages, alcohol consumption is a goal-directed behavior,
initiated and executed by regions
within the executive control network (such as dorsolateral
prefrontal cortex and anterior
cingulate cortex) with its rewarding effects processed by
appetitive drive regions (such as
nucleus accumbens). After alcohol is repeatedly consumed,
evidence for or consistent with
poor decision making, consumption becomes more automatic (with
more involvement of
appetitive drive regions such as caudate and putamen) and less
voluntary (with less
involvement of executive control regions) (Everitt and Robbins,
2005). Alcohol consumption
shifts to a more habitual mode, particularly as a response to
avoid withdrawal symptoms. An
individual with alcohol dependence seeks alcohol compulsively, a
behavior that has been
associated with increased activity of appetitive drive regions
when presented with an alcohol
cue, and a lack of engagement of prefrontal regions when
required to stop a prepotent,
maladaptive behavior such as alcohol consumption. The quality of
interaction between and
within these functional networks (frontal executive and striatal
appetitive networks) is
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Camchong, Endres, Fein 9
becoming an increasingly relevant topic in alcoholism and
addiction in general. Both the
attenuation of the executive control and the enhancement of the
appetitive drive networks are
closely related to behavioral aspects of alcoholism such as poor
decision making and
subsequently risky behavior.
To examine functional brain activity and synchrony associated
with poor decision
making in alcoholics, participants are required to perform tasks
while functional magnetic
resonance imaging (fMRI) data are collected. Numerous
neuroimaging studies have used
specific tasks to tap into functional brain differences
associated with poor decision making and
risky behavior during alcohol use, abuse and dependence.
Brain function associated with decision making in
binge-drinking
A study by Xiao et al (2012) compared brain functional activity
of 14 binge-drinking
adolescents while they made decisions during the Iowa Gambling
Task compared with 14
adolescents who had never consumed alcohol. Binge drinkers had
both behavioral and brain
functional differences manifested as inflexible poor decision
making (kept making
disadvantageous decision) together with higher activity than
non-drinkers in limbic brain
regions known to play a role in the emotional aspects of
decision making (amygdala and insula).
Because they also found that adolescents that had higher limbic
activity while performing the
decision making task had more self-reported drinking problems,
Xiao et al. (2012) proposed
that a hyperactive bottom-up affective network may be a good
candidate for a biological
marker that can be used to identify individuals at risk of
alcohol dependence. A previous
behavioral study used the original Iowa Gambling Task and a
variant of the Iowa Gambling Task
to dissect whether poor decision- making found in binge-drinkers
is attributable to insensitivity
to long-term consequences (lack of executive control, planning)
or to hypersensitivity to reward
(enhanced appetitive drive) (Johnson et al., 2008). After
comparing Iowa Gambling Task
performance between adolescent binge-drinkers to adolescent
never-drinkers, Johnson et al
(2008) found that poor decision making in binge-drinkers is
associated to hypersensitivity to
reward. Results from these studies provide evidence that at
early stages of alcohol abuse there
is enhanced behavior ruled by appetitive drive together with a
hyperactive bottom-up network.
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Camchong, Endres, Fein 10
Brain function associated with decision making in active
drinkers with alcohol dependence
The neural correlates of decision making have been examined in
active drinkers with a
diagnosis of alcohol dependence (Amlung et al., 2012). Amlung et
al (2012) compared brain
activity during delayed reward discounting between active
drinkers with an alcohol dependence
diagnosis (AUD+; n = 13) versus active drinkers without an
alcohol dependence diagnosis (AUD-;
n = 12). AUD+ showed more impulsive decision making and higher
activity in executive control
(dorsolateral prefrontal cortex) and attention (precuneus)
regions than AUD- during delayed
reward decisions. Although the study has a small sample size,
was limited to men, but did
compare drinkers with a control (non-drinking) group, this study
provides important evidence
of greater brain activity in executive control regions when
alcoholics are required to delay
gratifications, a finding that may reflect alcoholics’ increased
demand of executive control
when required to make decisions on behavior ruled by appetitive
drive. These neural
differences need to be explored further in larger samples that
include a comparison to control
groups.
Brain function associated with decision making in short-term
abstinent alcoholics
Although it is important to understand the neural network
differences in active drinkers,
findings from these studies may be affected by the acute effects
of alcohol and caution needs
to be taken when comparing such results with those in abstinent
treated samples. Active
drinking samples may comprise a different population from
treated samples - they may not
have an alcohol use disorder (AUD) or have less severe AUDs than
treatment samples (Fein and
Landman, 2005, Di Sclafani et al., 2008, Fein et al., 2010a).
The neural substrates of decision
making have been extensively investigated in short-term
abstinent alcoholics (STAA).
Park et al (2010) compared brain activity during reward-guided
decision making
between 20 STAA with at least 7 days of abstinence (mean = 16.9
days of abstinence) and 16
healthy controls. Subjects performed a task that required them
to make a choice between two
abstract stimuli to be allocated a probabilistically
pre-determined reward. This task measured
learning rates and outcome because subjects needed to update the
reward values associated
with the stimuli to guide their future responses. While STAA did
not differ from controls in
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Camchong, Endres, Fein 11
striatal activity associated with predicting errors during task
performance, they did show
significantly lower fronto-striatal synchrony (i.e., ventral
striatum and right dorsolateral
prefrontal cortex) when presented with feedback of wins versus
losses. Park et al (2010)
suggest that while STAA do not have impaired brain activity
associated with the representation
of prediction error in the ventral striatum (nucleus accumbens),
they do not seem to relay this
information to brain regions that mediate higher executive
control processes (dorsolateral
prefrontal cortex - DLPFC) and are not able to integrate
reward-related information for proper
control of behavior following a reward (Park et al., 2010).
While this study was limited to only
men and to the examination of functional synchrony of the
ventral striatum, it provides
valuable evidence pointing to differences in functional
synchrony between brain regions that
mediate appetitive drive and regions that guide decision making
in STAA versus healthy
controls. The lack of interaction between these executive
control and appetitive drive regions
may underlie alcoholics’ difficulty in guiding future
reward-related choices and goal-directed
behavior. Furthermore, results from this study suggest that
these neural network differences
are evident after short periods of abstinence.
A study by Li et al (2009) investigated differences in brain
activity specifically related to
impulsive control and risk-taking between 24 STAA and 24 healthy
controls using the stop-
signal task (SST). By dissecting the component processes of SST
performance (response
inhibition, error processing, post-error slowing, risk taking)
they could examine neural
differences specific to discrete aspects of impulse control and
risky behavior. Authors reported
that while groups did not differ in overall SST performance,
STAA compared to healthy controls
showed significantly (1) lower left DLPFC activity when
inhibiting a response, (2) lower right
DLPFC activity during post-error slowing (behavioral adjustment
after an error), (3) lower
amygdala, striatal, and posterior cingulate cortex activity
during post-trial speeding
(representing a risk-taking decision), and (4) higher activity
in visual cortex and anterior
cingulate cortex (ACC) when failing to stop a response. Results
from this study showed that
even though overall performance did not differ between groups,
STAA showed differences in
brain activity during individual trials that reflect specific
instances of poor decision making such
as post-trial speeding and failure to stop a response.
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Camchong, Endres, Fein 12
Evidence from studies mentioned above suggest that poor decision
making and risky
behavior in STAA are associated with brain functional
differences in regions within the
executive control (lower activity) and appetitive drive (higher
activity) networks known to be
involved in cognitive and emotional control. Whether these brain
functional differences
predispose to alcohol problems or are a consequence of unhealthy
alcohol use is not clear.
Brain function associated with decision making in individuals at
risk for alcoholism
Neuroimaging studies on adolescents at risk for alcoholism have
identified brain
functional differences associated with poor decision making in
such samples. A study by
Acheson et al (2009) compared brain function between 15
adolescents with a family history of
alcoholism (FHP) and 19 with a negative family history of
alcoholism (FHN) when performing
the Iowa Gambling Task. While groups did not differ in
behavioral performance, the FHP group
showed more activity in left dorsal anterior cingulate cortex
(ACC) and left caudate nucleus
than the FHN group. Because activity in dorsal ACC has been
associated with risk prediction
and activity in caudate nucleus with risky responses, Acheson et
al (2009) suggest that FHP
need to recruit additional brain regions for proper decision
making involving risk-taking when
compared to FHN. A study by Cservenka et al (2012) provided a
different perspective on
predisposing biological markers of alcoholism. They investigated
whether there were
differences in functional activity associated with risk-taking
when FHP versus FHN adolescents
performed the “Wheel of Fortune” decision making task (WOF).
While there were no
behavioral differences in risk-taking, FHP showed significantly
lower activity in right dorsolateral
prefrontal cortex (DLPFC) and right cerebellar tonsil than FHN
in the risky versus safe decision
making contrast. Authors suggest that attenuated DLPFC response
to risk-taking in FHP may be
associated with poorer cognitive control and hence poorer
behavioral regulation in FHP, making
them vulnerable to failure in the decision to avoid risk-taking
and ultimately contributing to out
of control alcohol consumption.
A study by Norman et al (2011) investigated the neural
correlates of another aspect that
contributes to risky behavior in adolescents, the lack of
response inhibition. They examined
brain function in adolescents while they performed a go/no-go
task that measured response
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Camchong, Endres, Fein 13
inhibition and response selection. Based on follow-up interviews
assessing alcohol use
information (after a mean of 4.2 years), the sample was
classified as either heavy alcohol users
(n=21) or healthy controls (n=17). While there were no
behavioral differences in impulse
control during the go/no-go task at baseline, adolescents that
later became heavy alcohol users
showed significantly lower activity during no-go trials than
healthy controls in prefrontal
regions (inferior frontal gyrus, dorsolateral and medial frontal
gyri), striatum (putamen) and
inferior parietal lobules. The authors suggest that when
required to exert control over a
prepotent response, individuals that are at risk of becoming
alcoholics show less responsive
frontal regions even before the onset of drinking problems.
Although these findings are
important, they still do not provide decisive evidence for a
predetermined predisposition
because these may indicate that future problem drinkers have
either (1) a pre-existing
disadvantage (maybe genetic) due to poor engagement of frontal
regions needed to properly
exert executive control on impulsive and risky behaviors or (2)
a delayed cortical maturity, in
which activation in the executive control network is still not
fully specialized yet, but never
reaches its full potential because its development is later
stunted by alcohol use. More studies
need to be conducted to fully address these issues.
Brain function associated with decision making in long-term
abstinent alcoholics
To investigate whether brain functional differences identified
in actively drinking or
recently abstinent alcoholics are permanent or can be overcome
with long periods of
abstinence, it is essential to examine long-term abstinent
alcoholics. The examination of
executive and appetitive drive networks during rest in long-term
abstinent alcoholics (LTAA) has
yielded results consistent with an ongoing compensatory
mechanism in LTAA. A study by
Camchong et al (2013a) that compared resting state synchrony of
executive and appetitive
drive networks between 23 LTAA (with more than 18 months of
abstinence from alcohol use)
and 23 healthy controls found that LTAA have (1) lower synchrony
of appetitive drive regions
and (2) greater synchrony of executive control regions than
healthy controls. Moreover, these
resting state synchrony differences were positively correlated
with performance in a task that
measured cognitive flexibility in decision making (e.g., higher
resting state synchrony of
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Camchong, Endres, Fein 14
executive control regions significantly correlated with better
performance). Results from this
study reflect adaptive mechanisms in brain ongoing functional
organization that may support
proper executive control of behavior in long-term abstinent
alcoholics and successfully stop
behavior that may lead to relapse. A follow-up study by Camchong
et al (2013b) that studied
this effect in STAA (6-15 weeks of abstinence) found ordered
effects from STAA to LTAA within
both the executive control and appetitive drive networks: higher
resting state synchrony of the
executive control network (Figure 1) and lower resting state
synchrony of the reward
processing network (Figure 2) than healthy controls. These
results provided further evidence
that this compensatory mechanism follows an adaptive progression
from short- to long-term
abstinence. Longitudinal studies of brain functional
organization need to be conducted to
explore the hypothesis suggesting that synchrony within the
executive control network
progressively increases and synchrony within the appetitive
drive network progressively
decreases with length of abstinence.
Differences in brain function and organization in prefrontal
executive control regions are
not specific to decision making and risky behavior in
alcoholics. Alcoholics have shown similar
differences as described above in neural activity in executive
control regions (dorsolateral
prefrontal cortex and anterior cingulate cortex) during tasks
that hone in on other aspects of
executive function such as spatial working memory (Pfefferbaum
et al., 2001) or verbal working
memory (Desmond et al., 2003, Cservenka and Nagel, 2012).
Moreover, brain activity and
functional organization differences associated with executive
control differences have been
identified in other samples with addiction to other substances
such as cocaine and nicotine
(Camchong et al., 2011, Gu et al., 2010, Janes et al.,
2010).
Although neuroimaging studies have identified brain function and
organization
differences in executive and appetitive drive networks in
alcoholics, these differences vary
depending on whether the alcoholic is actively drinking or has
been abstinent for short or
extended periods of time. A number of studies reviewed in the
sections above do not show
performance differences between alcoholic and comparison groups,
but instead find
differences between groups in brain activation patterns
associated with comparable
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Camchong, Endres, Fein 15
performance. Such findings are often interpreted as indicating
lack of efficiency in alcoholics vs.
controls of specific brain regions in performing some function.
However, it is important to
remember that such a statement is a hypothesis, not a finding.
If an impairment in some
function is present (less efficient processing by a brain region
is an impairment), there should
be experimental challenges that will result in impaired
performance on some task. A recent
paper by Chanraud et al (2013) found that while controls and
recovering alcoholics had similar
performance levels during a spatial working memory task, they
recruited different brain
networks. While controls recruited prefrontal-cerebellar regions
known to mediate working
memory, recovering alcoholics recruited two additional
fronto-cerebellar networks, presumably
to compensate and achieve normal working memory performance
(Chanraud et al., 2013). It is
also important to emphasize that the phenomena discussed above
are not necessarily reflected
in all aspects of behavior. For example, Fein et al. (2004)
found impaired performance on the
Iowa Gambling Task in long-term abstinent alcoholics – they were
able to achieve multi-year
abstinence despite the persistent decision making impairments on
the Iowa Gambling Task. In
contrast, Fein et. al. (2006) found normal Iowa Gambling Task
performance in actively drinking
treatment naïve alcoholics. These individuals drank harmfully (a
poor decision) despite having
normal Iowa Gambling Task performance. These examples point out
that propensities and
inherited vulnerabilities do not fully control behavior. The
research reviewed above suggests
some of the adaptive changes that may take place in the
development of alcoholism and in the
struggle to achieve long-term abstinence.
-
Camchong, Endres, Fein 16
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