Deathstalker

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Fig. Area of Sahara Desert 6

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The venom is 83 times as powerful as a king cobra's!

(L/D50=0.1-0.01 mg kg-1 body wt.)8

Fig. A computer model of scorpion venom.

Fig. Structure of CLTX

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Example of how long the paralysis of CLTX will be working

0.5 mg kg-1 body wt.

Recover after 2 hours.

1.23-2.23 mg kg-1 body wt.

Within 90 sec. : paralysis can be

observed gradually.

After 6 hours : no recovery was noted.

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Therapeutic use

Example

Tumor paint

CLTX + Cy5.5

Fig. Example of the tumor paint. 11

A 37-amino acid peptide.

Blocks calcium-activated potassium channels.

→ Causes hyperexcitability of the nervous system.

Close homoloque of agitoxin.

Fig. Structure of CTX.12

• Blocks of small-conductance Ca2+ activated K+ channels.

• Induces spoutaneous contractions in guinea pig taenia

coli muscle cells.

• A 38-amino acids.

• Three types of agitoxin can be distinguished

• Highly homologious, differing only in

the identify of the residues at positions 7, 15, 29 and 31.

Fig. Structure of agitoxin.

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Muscle cells

Outside cell

Inside cell

Ions

Channel

Fig. How a nerve works in our body.14

Venom (CLTX)

Outside cell

Inside cell

Ions

Channel

Fig. How venom works in our body.15

Fig. Gram-negative bacteria 16

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Can bacteria be associated to the deathstalker’s venom?

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Scorpion has the cuticle in its

outer layer of skin.

The Cuticle will react to black

light and will be illuminated in

the green colour.

Fig. Illuminated scorpion under black light.

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Why Painting Tumors Could Make Brain Surgeons Better

http://www.npr.org/blogs/health/2013/09/12/221060071/why-painting-

tumors-could-make-brain-surgeons-better

Poison (Japanese)

http://www.geocities.jp/scubadive21/sub/mame/poison.htm

Scorpion Poison –Point of View from Neurotoxin- (Japanese)

http://ameblo.jp/plus-science/entry-11635039977.html

Chlorotoxin

http://en.wikipedia.org/wiki/Chlorotoxin

Deathstalker

http://en.wikipedia.org/wiki/Deathstalker

Scorpion Venom

http://askabiologist.asu.edu/venom/scorpion_venom

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