DAFTAR PUSTAKA Abdennadher I, Abdelmaksoud-Damak R, Ayadi ...

DAFTAR PUSTAKA

Abdennadher I, Abdelmaksoud-Damak R, Ayadi L, Khabir A, Frikha F,

Kallel L, Amouri A, Frikha M, Sellami-Boudawara T, Gargouri A,

Mokdad-Gargouri R, 2010. Hypermethylation of RARβ2 correlates with

high COX-2 expression and poor prognosis in patients with

colorectalcarcinoma. International Society of Oncology and BioMarkers

(ISOBM) 31:503–11. Adham M, Kurniawan A, Muhtadi A, Roezin A, Hermani B, Gondhowiardjo

S, Tan I, Middeldorp J, 2012. Nasopharyngeal Carcinoma in Indonesia:

epidemiology, incidence, sign and symptoms at presentation. Chin J

Cancer ; Vol. 31 Issue 4:185-96.

Aggarwal, B.B., Shishodia, S., Sandur, S.K., Pandey, M.K. and Sethi, G.

2006. Inflammation and cancer: how hot is the link? Biochemical

Pharmacology 72 (11): 1605-21.

Agulnik, M. and Siu, L.L. 2005. State-of-the-art management of

nasopharyngeal carcinoma: current and future directions. Brit J

Cancer. 92: 799-806.

Amalinei, C., Caruntu, I.D., Giusca, S.E. and Balan, R.A. 2010. Matrix

metalloproteinases involvement in pathologic conditions. Romanian

Journal of Morphology and Embryology 51 (2): 215-28.

Andrianto, Y. 2008. Peranan pemeriksaan immunohistokimia COX-2 pada

karsinoma nasofaring [Tesis]. Medan: Fakultas Kedokteran Universitas

Sumatera Utara, Bagian Patologi Anatomi.

Baas, P., Belderbos, J.S.A., Senan, S., Kwa, H.B., Van Bochove, A., Van

Tinteren, H., Burgers, J.A. and Van Meerbeeck, J.P. 2006. Concurrent

chemotherapy (carboplatin, paclitaxel, etoposide) and involved-field

radiotherapy in limited stage small cell lung cancer: a Dutch multicenter

phase II study. British Journal of Cancer 94: 625-30.

Bingham III, C.O., Sebba, A.I., Rubin, B.R., Ruoff, G.E., Kremer, J., Bird,

S., Smugar, S.S., Fitzgerald, B.J., O’Brien, K. and Tershakove, A.M.

2006. Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in

Universitas Sumatera Utara

the treatment of osteoarthritis in two identically designed, randomized,

placebo-controlled, non-inferiority studies. Rheumatology 46: 496-507.

Blachley, J.D. and Hill, J.B. 1981. Renal and electrolyte disturbances

associated with cisplatin. Ann Intern Med. 95 (5): 628-32.

Brennan, B. 2006. Nasopharyngeal carcinoma. Orphanet Journal of Rare

Diseases 1 (23): 1-5.

Brooks, P. and Kubler, P. 2006. Etoricoxib for arthritis and pain

management. Therapeutics and Clinical Risk Management. 2(1):

45– 57.

Cao, X., He, L.R., Xie, F.Y., Chen, Y.F. and Wen, Z.S.

Cao, X, Luo R, He L.R, Li Y, Lin WQ, Chen Y.F, Wen Z.S. 2011.

Prognosticators And Risk Grouping Inpatients With Lung Metastasis

From Nasopharyngeal Carcinoma: A More Accurate And Appropriate

Assessement Of Prognosis. Radition Oncology 2011, 6: 104: 1-10.

2011. Factors

determining the survival of nasopharyngeal carcinoma with lung

metastasis alone: does combined modality treatment benefit ? BMC

Cancer 11 (370): 1-9.

Cao S., Liu Z., Jia W, Huang Q, Liu Q, Guo X, Huang TB, Ye W, Hong M,

2011. Fluctuations of Epstein-Barr Virus Serological Antibodies and

Risk for Nasopharyngeal Carcinoma: A Prospective Screening Study

with a 20-Year Follow-Up. Plos One, Vol 6; 1-10.

Cao S, Simons M, Qian C, 2011. The prevalence and prevention of

nasopharyngeal carcinoma in China. Chinese Anti-Cancer Assosiation.

Vol 30; 114-9.

Chang, E.T. and Adami, H.O. 2006. The enigmatic epidemiology of NPC.

Cancer Epidemiol Biomarkers Prev 15: 1765-77.

Chen, P.S., Shih, Y.W., Huang, H.C. and Cheng, H.W. 2011. Diosgenin, a

steroid saponin, inhibits migration and invasion of human prostate

cancer PC-3 cells by reducing matrix metalloproteinases expression.

Plos One 6 (5): 1-9.

Chen M, Jiang R, Guo L, Zou X, Liu Q, Qiu F, Xia Z, Huang H, Zhang L,

Hong M, Mai H, Qian C, 2013. Locoregional radiotherapy in patients

Universitas Sumatera Utara

with distant metastases of nasopharyngeal carcinoma at diagnosis.

Chinese Anti-Cancer Assosiation. Vol 32; 604-13.

Chen M, Mai H, Sun R, Guo X, Zhao C, Hong M, Hua Y, 2013. Clinical

findings and imaging features of nasopharyngeal carcinoma with

postradiation nasopharyngeal necrosis. Chinese Anti-Cancer

Assosiation, vol 32; 533-8.

Chen S, Yang Q, Wang C, Zhang L, Fang Y, Lei F, Wu S, Song L, Guo X,

2014. Transducin β-like 1 X-linked receptor 1 suppresses cisplatin

sensitivity in Nasopharyngeal Carcinoma via activation of NF-κB

pathway. Molecular Cancer, 13:195.

Chen, Q.Y., Wen, Y.F., Guo, L., Liu, H., Huang, P.Y., Mo, H.Y., Li, N.W.,

Xiang, Y.Q., Luo, D.H., Qiu, F., Sun, R., Deng, M.Q., Chen, M.Y., Hua,

Y.J., Guo, X., Cao, K.J., Hong, M.H., Qian, C.N. and Mai, H.Q, 2011.

Concurrent chemoradiotherapy vs radiotherapy alone in stage II

nasopharyngeal carcinoma: Phase III randomized trial. J Natl Cancer

Inst. 103 (23): 1-10.

Chew, C.T. 1997. Nasopharynx (the post nasal space). Di dalam: Kerr,

A.G., editor. Scott-Brown’s Otolaryngology. Volume ke-5, Ed ke-6.

Oxford: Butterworth Heinemann. hlm. 5/13/1-22.

Cho W, 2007. Nasopharyngeal carcinoma: molecular biomarker discovery

and progress. Molecular Cancer 6;1. BioMed Central Ltd. 1-9.

Chou J, Lin Y, Kim J, You L, Xu Z, PhD1, Biao He, Jablons D, Nasopharyngeal Carcinoma—review of the Molecular Mechanisms of

Tumorigenesis. NIH Public Access Author Manuscript, 30(7): 946–963.

Chow D, Fellow R,Sung J. 2009. Non-NSAID non-H. pylori ulcer disease.

Best Practice & Research Clinical Gastroenterology.

Choy, H. And Milas, L. 2003. Enhancing radiotherapy with

cyclooxygenase-2 enzym inhibitors: a rational advance ? J Natl Cancer

Inst. 95 (15): 1440-52.

Cormack P, 2011. Celecoxib; A Review of its Use for Symptomatic Relief

in the Treatment of Osteoarthritis, Rheumatoid Arthritis and Ankylosing

Spondylitis. Adis Drug Evaluation : 2457-89.

Universitas Sumatera Utara

Demizu, Y., Sasaki, R., Soejima, T., Maruta, T., Okamoto, Y., Yamada, K.,

Yoden, E., Ejima, Y., Ota, Y., Ishida, H., Nibu, K. and Sugimura, K.

2006. Efficacy and feasibility of cisplatin-based concurrent

chemoradiotherapy for nasopharyngeal carcinoma. Jpn J Clin Oncol.

36 (10): 620-5.

Delektorskaya, V.V., Perevoshchikov, A.G., Golovkov, D.A. and

Kushlinskii, N.E. 2007. Prognostic significance of expression of matrix

metalloproteinase in colorectal adenocarcinomas and their metastases.

Bull Exp Biol Med. 143 (4): 455-8.

Egeblad, M. And Werb, Z. 2002. New function for the matrix

metalloproteinases in cancer progression. Nat Rev Cancer. 2 (3): 161-

74.

Gao, J., Hu, J.Y., Xia, Y.F., Yi, W., Tao, Y.L. and Li, G. 2009. Continuous

fall in hemoglobin level is a poor prognostic factor in patients with

nasopharyngeal carcinoma treated with radiotherapy. Chinese Journal

of Cancer 29 (5): 561-6.

Gao Y, Liu J, Zhu S, Yi X, 2014. The Diagnostic Accuracy of

Ultrasonography versus endoscopy for Primary Nasopharingeal

Carcinoma. Plos One March 2014,vol 9; 1-6.

Goh, J. and Lim, K. 2009. Imaging of nasopharyngeal carcinoma. Ann

Acad Med Singapore. 38 (9): 809-16.

Gallo, O., Franchi, A., Magnelli, L., Sardi, L., vannacci, A., Boddi, V.,

chiarugi, V. and Masini, E. 2001. Cyclooxygenase-2 pathway correlates

with VEGF expression in head and neck cancer, implications for tumor

angiogenesis and metastasis. Neoplasia 3 (1): 55-61.

Galusca, B., Dumollard, J.M., Chambonniere, M.L., Germain, N., Prades,

J.M., Peoch, M. and Estour B. 2004. Peroxisome proliferator activated

receptor gamma immunohistochemical expression in human papillary

thyroid carcinoma tissues. Possible relationship to lymph node

metastasis. Anticancer Res. 24 (3b): 1993-7.

Universitas Sumatera Utara

Gandamihardja, S., Wrakusumah, F.F., Shahib, N., Sastramiharja, H.S.

dan Aziz, M.F. 2010. Peran siklooksigenase dalam pertumbuhan

kanker leher rahim. MKB. 42 (4): 169-74

Gramke, H.F., Petry, J.J.J., Durieux, M.E., Mustaki, J.P., Vercauteren,

M., Verheecke, G. and Marcus, M.A.E. 2006. Sublingual piroxicam for

postoperative analgesia; preoperative versus postoperative

administration: a randomized, double-blind study. Anesth Analg. 102:

755-8.

Guigay, J., Temam, S., Bourhis, J., Pignon, J.P. and Armand, J.P. 2006.

Nasopharyngeal carcinoma and therapeutic management: the place of

chemotherapy. Annals of Oncology 17 (10): 304-7.

Guo S, Huang P, Chen Q, Liu H, Tang L, Zhang L, Liu L, Cao K, Guo L,

Mo H, Guo X, Hong M, Mai H, 2014. The impact of smoking on the

clinical outcome of locoregionally advanced nasopharyngeal carcinoma

after chemoradiotherapy. Radiation Oncology 2014, 9:246: 1-9.

Guo S, Wu S, Zhou J, Feng H, Li F, Wu Y, Sun J, He Z, 2014.

Transdermal Fentanyl for paindue to chemoradiotherapy-induced oral

mucocitis in nasopharyngeal cancer patients: evaluating efficacy,

safety, and improvement in quality of life. Dove Press: 497-503.

Guo X, Winkler C, Guan L, Tang M, Liao J, Deng H, The G, Zeng Y,

O’Brien S, 2014. Evaluation and Integration of Genetic Signature for

Prediction Risk of Nasopharyngeal Carcinoma in Southern China.

BioMed Research International. Volume 2014;1-7.

Harahap, M.P.H. 2009. Ekspresi vascular endothelial growth factor pada

karsinoma nasofaring [Tesis]. Medan: Fakultas Kedokteran

Universitas Sumatera Utara, Departemen Ilmu Kesehatan THT-KL.

Henny F. 2006. Ekspresi protein mutan p53 pada karsinoma nasofaring

[Tesis]. Medan: Fakultas Kedokteran Universitas Sumatera Utara,

Departemen Ilmu Kesehatan THT-KL.

Her, C. 2001. Nasopharyngeal cancer and the Southeast Asian patient.

American Family Physician 63 (9): 1776-80.

Universitas Sumatera Utara

Hillman, R.S., Ault, K.A., and Rinder, H.M. 2005. Marrow damage anemia.

Di dalam: Hematology in Clinical Practice. Connecticut: Mc Graw Hill.

hlm: 1-20.

Horikawa, T., Yoshizaki, T., Sheen, T. S., Lee, S. Y. and Furukawa, M.

2000. Association of latent membrane protein 1 and matrix

metalloproteinase 9 with metastasis in nasopharyngeal carcinoma.

American Cancer Society 89(4): 715-23.

Horvai, E.A., Schaefer, T.J., Nakakura, K.E., and Odonnell, R.J. 2008.

Immunostaining for peroxisome proliferator gamma distinguishes

dedidefferentiated liposarcoma from other retroperitoneal sarcomas.

Modern Pathology 21: 517-24.

Ignace W, 2003. Cancer of the Nasopharynx: Functional Surgical Salvage.

University of Hong Kong Medical Centre.

Jayaprakash V., Rigual, N.R., Moysich, K.B., Nasca, M.A., Menezes,

R.J. and Reid, M.E. 2006. Chemoprevention of head and neck cancer

with aspirin: a case-control study. Arch Otolaryngol Head Neck Surg.

132 (11): 1231-6.

Jeyakumar, A., Brickman, T.M., Jeyakumar, A. and Doerr, T. 2006.

Review of nasopharyngeal carcinoma. Ear, Nose and Throat Journal

85 (3): 168-84.

Katzung, B.G. dan Furst, D.E. 1998. Nonsteroidal Anti-inflamatory Drugs;

Disease-Modifying Antirheumatic drugs; Nonopioid analgesics; Drugs

used in Gout. In : Katzung, B.G. ed. Basic & Clinical Pharmacology. 7

th edition. Connecticut : Appleton & Lange. p. 588.

Kaul, R., Verma, S.C., Murakami, M., Lan, K., Choudhuri, T. and

Robertson, E.S. 2006. Epstein-Barr virus protein can upregulate

cyclooxygenase-2 expression through association with the suppresor

of metastasis Nm23-H1. Journal of Virology 8 (3): 1321-31.

Kaye. 1992. Cisplatin IM 132. Tasmania: Tasmanian Poison Information

Centre. hlm: 1-31.

Universitas Sumatera Utara

Kayl, A.E. and Meyers, C.A. 2006. Side-effects of chemotherapy and

quality of life in ovarian and breast cancer patients. Curr Opin Obstet

Gynecol. 18 (1): 24-8.

Keles, G.T., Topçu, I., Ekici, Z. and Yentür, A. 2010 Evaluation of

piroxicam-β-cyclodextrin as a preemptive analgesic in functional

endoscopic sinus surgery. Braz J Med Biol Res. 43 (8): 806-11.

Kim, J.H., Jung, J.Y., Shim, J.H., Kim, J., Choi, K.H., Shin, J.A., Choi,

E.S., Lee, S.O., Chintharlapalli, S., Kwon, K.H., Leem, D.H., Cho, N.P.

and Cho, S.D. 2010. Apoptotic effect of tolfenamic acid in KB human

oral cancer cells: possible involvement of the p38 MAPK Pathway. J.

Clin. Biochem. Nutr. 47: 74-80.

King, P.D. and Perry, M.C. 2001. Hepatotoxicity of chemotherapy. The

Oncologist 6: 162-76.

Knauer, S.K. 2009. Prognostik and therapeutic potential of Nuclear

Receptors in Head and Neck squamous cell carsinomas. Journal of

Ancology : 1-9.

Koeffler, H. P. 2003. Peroxisome Proliferator-Activated Reseptor Gamma

And Cancers. Clin Cancer Res. 9: 1-9.

Kong F, Cai B, Chen X, Zhang J, Wang Y, 2012. Prognostic factors for

survival of patients with nasopharyngeal carcinoma following

conventional fractionation radiotherapy. Ekperimental and Therapeutic

Medicine 6: 57-60.

Konturek, P.C., Kania, J., Burnat, G., Hahn, E.G. and Konturek, S.J. 2005.

Prostaglandins as mediators of cox-2 derived carcinogenesis in

gastrointestinal tract. J Physiol Pharmacol. 5:57-73.

Koontongkaewand, K. and Leelahavanichkul, K. 2012. Arachidonic acid

metabolism and its implication on head and neck cancer. Head and

Neck Cancer Intech: 167-84.

Krizkova, S., Zitka, O., Masarik, M., Adam, V., Stiborova, M., Eckschlager,

T., Hubalek, J. and Kizek, R. 2011. Clinical importance of matrix

metalloproteinases. Bratisl Lek Listy 112 (8): 435-40.

Universitas Sumatera Utara

Kumar, S. 2003. Epidemiological and etiological factors associated with

nasopharyngeal carcinoma. ICMR Bulletin 33 (9): 1-9.

Kurnianda, J., Hardianti, M.S., Harijadi, Taroeno-Hariadi, K.W., Purwanto,

I., Haryana, S.M. and Tjokronagoro, M.S. 2009. Elevation of vascular

endothelial growth factor in indonesian advanced stage

nasopharyngeal carcinoma. Kobe J Med Sci. 55 (2): 36-44.

Kuwano, T., Nakao, S., Yamamoto, H., Tsuneyoshi, M., Yamamoto, T.,

Kuwano, M. and Ono, M. 2004. Cyclooxygenase 2 is a key enzyme for

inflammatory cytokine-induced angiogenesis. The FASEB Journal 18:

300-10.

Kyzas, P.A., Stefanou, D. and Agnantis, N.J. 2005. COX-2 expression

correlates with VEGF-C and lymph node metastases in patients with

head and neck squamous cell carcinoma. Modern Pathology 18: 153-

60.

Lau, K.Y., Kan, W.K., Sze, W.M., Lee, A.W.M., Chan, J.K.W., Yau, T.K.,

Yeung, R.M., Tan, L.T.H., Chan, P.O. and Lee, A.S.L. 2000. Magnetic

resonance for T-staging of nasopharyngeal carcinoma-the most

informative pair of sequences. Jpn J Clin Oncol. 34 (4): 171-5.

Leahy, K.M., Koki, A.T. and Masferrer, J.L. 2000. Role of cyclooxygenases

in angiogenesis. Medicinal Chemistry 7: 1163-70.

Lelo A, Hidayat DS, Juli S, 2004. Penggunaan Anti-Inflamasi Non-Steroid

Yang Rasional Pada Penanggulangan Nyeri Rematik, Bagian

Farmakologi dan Terapeutik Fakultas Kedokteran Universitas

Sumatera Utara, e-Repository USU,1-9.

Levita, J., Istyastono, E.P., Nawawi, A., Mutholib, A., de Esch, I.J.P and

Ibrahim, S. 2009. Analyzing the interaction of andrographolide and

neoandrographolide, diterpenoid compounds from andrographis

paniculata (Burm.F) nees to cyclooxygenase-2 enzyme by docking

simulation. ITB J Sci. 41 A (2): 110-9.

Licitra, L., Bernier, J., Cvitkovic, E., Grandi, C., Spinazze, S., Bruzzi, P.,

Gatta, G. and Molinari, R. 2003. Cancer of the nasopharynx. Critical

Reviews in Oncology/Hematology 45: 199-214.

Universitas Sumatera Utara

Li J, Lu T, Huang Y, Han F, 2012. Clinical Characteristics of Recurrent

Nasopharyngeal Carcinoma. The Scientific World Journal. Volume

2012; 1-8.

Lin, J.C., Jan, J.S., Hsu, C.Y., Liang, W.M., Jiang, R.S. and Wang, W.Y.

2003. Phase III study of concurrent chemoradiotherapy versus

radiotherapy alone for advanced nasopharyngeal carcinoma: positive

effect on overall and progression-free survival. Journal of clinical

oncology 21 (4): 631-7.

Li, M.Y., Deng, H., Zhao, J.M., Dai, D. and Tan, X.Y. 2003. Peroxisome

proliferator-activated receptor gamma ligands inhibit cell growth and

induce apoptosis in human liver cancer BEL-7402 cells. Word J

Gastroenterol. 9 (8): 1683-8.

Liu H, Chen Q, Guo L, Tang L, Mo H, Zhong Z, Huang P, Luo D, Sun R,

Guo X, Cao K, Hong M, Mai H, 2013. Feacibility and efficacy of

chemoradiotherapy for elderly patients with locoregionally advanced

nasopharyngeal carcinoma: result from a matched cohort analisys.

Radiation oncology; 1-10.

Liu, Z., Li, L., Yang, Z., Luo, W., Li, X., Yang, H., Yao, K., Wu, B. and

Fang, W. 2010. Increased expression of MMP is correlated with poor

prognosis of nasopharyngeal carcinoma. BMC Cancer Journal 10: 1-7.

Lutan, R. 2003. Diagnosis dan penatalaksanaan karsinoma nasofaring. Di

dalam: Kumpulan Naskah KONAS XIII PERHATI, Bali: hlm.16.

Luthi F, Stupp R, 2010. Chemotherapy in Head and Neck Cancer. Di

dalam: Head and Neck Surgery, Volume 2, jaypee brother medical

Publisher; hlm 795-811.

Lutzky, V.P., Moss, D.J., Chin, D., Coman, W.B., Parsons, P.G. and Boyle,

G.M. 2008. Biomarkers for Cancers of the head and neck. Clinical

Medicine: Ear, Nose and Throat 1: 5-15.

Lu J, Tang Y, Yu H, Zhou J, Fu X, Zeng X, Yu Z, Yin MH, Wu , Zhang J, Li

X, Li G, 2010. Epstein–Barr virus facilitates the malignant potential

ofimmortalized epithelial cells: from latent genome to viral production

and maintenance. Laboratory Investigation Volume 90.

Universitas Sumatera Utara

Lu X , Wang FL, Guo X, Wang L, Zhang H, Xia W, Li S, Li N, Qian C,

Xiang Y, 2013. Pavorable prognosis of female patients with

nasopharyngeal carcinoma. Chin J Cancer; Vol. 32 Issue 5. 283-8.

Wildeman M, Fles R, Herdini C, Indrasari R, Vincent A, Tjokronagoro M,

Stoker S, Kurnianda J, Karakullukcu B, Kartika W. Hariadi T,

Hamming-Vrieze O, Jaap M. Middeldorp, Hariwiyanto B,. Haryana S,

Tan I, 2013. Primary Treatment Results of Nasopharyngeal

Carcinoma(NPC) in Yogyakarta, Indonesia. Plos One Volume 8.

Marur S, Forastiere A, 2008. Head and Neck Cancer : Changing

Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc; 489-501.

Morris, M.A., Dawson, C.W. and Young, L.S. 2009. Role of the EBV-

encoded latent membrane protein-1, LMP-1, in the pathogenesis of

nasopharyngeal carcinoma. Future Oncol. 5 (6): 811-25.

Morita, Y., Hata, K., Nakanishi, M., Nishisho, T., Yura, Y. and Yoneda,

T. 2012. Cyclooxygenase-2 promotes tumor lymphangiogenesis and

lymph node metastasis in oral squamous cell carcinoma. International

Journal of Oncology 41 (3): 885-92.

Mould, R.F. and Tai, T.H.P. 2002. Nasopharyngeal carcinoma: treatments

and outcomes in the 20th century. The British Journal of Radiology 75:

307-39.

Mukunyadzi, P., Ai, L., Portilla, D., Barnes, L. and Fan, C.Y. 2003.

Expression Of peroxisome proliferator activated receptor gamma in

salivary duct carcinoma: immunohistochemical analysis of 15 cases.

Med Pathol. 16 (12): 1218-23.

Mulyarjo. 2002. Diagnosis dan penatalaksanaan karsinoma nasofaring. Di

dalam: Mulyarjo, Soedjak, S., Wisnubroto, Harmadji, S., Hasanusi, R.,

Artono., editor. Perkembangan Terkini Diagnosis dan Penatalaksanaan

Tumor Ganas THT-KL. Surabaya: FK-UNAIR. hlm. 149-55.

Munir, D. 2007. Asosiasi antara alel gen HLA-DRB1 dan HLA-DQB1

dengan kerentanan timbulnya karsinoma nasofaring pada suku batak

[Disertasi]. Medan: Universitas Sumatera Utara, Program

Pascasarjana.

Universitas Sumatera Utara

Munir, D. 2009. Karsinoma nasofaring (kanker tenggorok). USU Press

Medan

Murono S., Inouue, H., Tanabe, T., Joab, I., Yoshizaki, T., Furukawa, M.

and Pagano, J. S. 2001. Induction of cyclooxygenase-2 by Epstein-

Barr virus latent membrane protein 1 is involved in vascular endothelial

growth factor production in nasopharyngeal carcinoma cells. PNAS. 98

(12): 6905-10.

Nasr H, Chahed K, Bouaouina N, Chouchane L, 2009 .TGS2 (COX-2) -

765 GC functional promoter polymorphismand its association with risk

and lymph node metastasisin nasopharyngeal carcinoma. MolBiol Rep

(36:193–200).

Nasution, I.I. 2007. Hubungan merokok dengan karsinoma nasofaring

[Tesis]. Medan: Fakultas Kedokteran Universitas Sumatera Utara,

Departemen Ilmu Kesehatan THT-KL.

National Comprehensive Cancer Network (NCCN). 2010. Practice

Guideline in Oncology.Version 1.

Niibe, Y., Karasawa, K., Mitsuhashi, T., Miyashita, H. and Tanaka, Y.

2004. Hyperfractionated radiation therapy for oropharyngeal carcinoma

in a Japanese population. Jpn J Clin Oncol. 34 (6): 312–5.

Nikitakis, N.G., Siavash, H., Hebert, C., Reynolds, M.A., Hamburger, A.W.

and Sauk, J.J. 2002. 15-PGJ2, but not thiazolidinediones, inhibits cell

growth, induces apoptosis and causes downregulation of stat3 in

human oral SCC a cells. British Journal of Cancer 87: 1396-403.

Nishida, N., Yano, H., Nishida, T., Kamura, T. and Kojiro, M. 2006.

Angiogenesis in cancer. Vascular Health and Risk Management 2 (3):

213-9.

Nix, P., Lind, M., Greenman, J., Stafford, N. and Cawkwell, L. 2004.

Expression of Cox-2 protein in radioresistant laryngeal cancer. Annals

of Oncology 15: 797–801.

Olivier, S., Robe, P. and Bours, V. 2006. Can NF-kB be a target for novel

and efficient anti-cancer agents? Biochemical pharmacology 72 (9):

1054-68.

Universitas Sumatera Utara

Pang, R.W.C. and Poon, R.T.P. 2006. Clinical implications of

angiogenesis in cancers. Vascular Health and Risk Management 2 (2):

97-108.

Poon, R.T.P, Ng, I.O.L., Lau, C., Yu, W.C., Yang, Z.P., Fan, S.T. and

Wong, J. 2002. Tumor microvessel density as a predictor recurrence

after resection of hepatocellular carcinoma: aprospective study. Journal

of Clinical Oncology 20 (7): 1775-85.

Pua, K.C., Khoo., A.S., Yap, Y.Y., Subramanian, S.K., Ong, C.A., Gopala,

K.G. and Shahid, H. 2008. Nasopharyngeal carcinoma database. Med

J Malaysia. 63: 59-62.

Puspitasari, D. 2011. Gambaran penderita karsinoma nasofaring di RSUP.

H. Adam Malik Medan tahun 2006-2010. [Tesis]. Medan: Fakultas

Kedokteran Universitas Sumatera Utara, Departemen Ilmu Kesehatan

THT-KL.

Qadri, S.S.A., Wang,bJ.H., Redmond, K.C., O’ Donnell, A.F., Aherne, T.

and Redmond, H.P. 2002. The role of COX-2 inhibitors in lung cancer.

Ann Thorac Surg. 74: 1648-52.

Qing, H., Chen, J., Lin, H.L., Hu, P.J. and Chen, M.H. 2009. Expression Of

peroxisome proliferator-activated receptor g, E-cadherin and matrix

metalloproteinases-2 in gastric carcinoma and lymph node metastases.

Chin Med J. 120 (17): 1498-504.

Roezin, A. 1995. Deteksi dan pencegahan karsinoma nasofaring. Di

dalam: Susworo, R., Tjarta, A., Boedina, S., Poetiray, E.D.C.,

Kurniawan, A.N., Djoerban, Z. dan Aziz, M.F., editor. Pencegahan dan

Deteksi Dini Penyakit Kanker. Jakarta: Perhimpunan Onkologi

Indonesia. hlm. 274-88.

Roezin, A. 1996. Faktor predisposisi kanker nasofaring. Di dalam:

Kumpulan Naskah Ilmiah PIT PERHATI. Malang: hlm. 833-9.

Saragih A. 2012. Deteksi mikrometastase sel kanker di darah tepi

melalui pemeriksaan mRNA CK-19 penderita karsinoma nasofaring

dengan LMP-1 positif maupun negatif pada stadium dini dan lanjut.

Universitas Sumatera Utara

[Disertasi]. Medan: Universitas Sumatera Utara, Program

Pascasarjana.

Sari, V.A. 2004. Korelasi tingkat ekspresi cyclooxygenase-2 dan

gambaran angiogenesis pada karsinoma nasofaring tak berdiferensiasi

[Tesis]. Jakarta: Fakultas Kedokteran Universitas Indonesia, Bagian

Ilmu penyakit THT.

Schweitzer, A., Knauer, S.K. Stauberg, R.H. 2009. Nuklear reseptor in

head and neck cancer current knowledge and perspective. Int J of

Cancer. 126: 801-9.

Schetter, A.J., Heegaard, H.H.N. and Harris, C.C. 2009. Inflammation and

cancer: interviewing microRNA, free radical, cytokine and p53

pathways. Carcinogenesis 31 (1): 37-49.

Sivanandan R, Fee W.E, 2005. Beningn And Malignant Tumors Of The

Nasopharynx. Di dalam: Cummings Otolaryngology, Vol 3, Fourth

Edition, Elsivier Mosby, Philadelphia; hlm.1669-82.

Sobolewski, C., Cerella, C., Dicato, M., Ghibelli, L. and Diederich, M.

2010. The role of cyclooxygenase-2 in cell proliferation and cell death

in human malignancies. International Journal of Cell Biology:1-21.

Soehartono, Rahaju, P., dan Kentjono, W.A. 2007. Hubungan antara

ekspresi latent membrane protein-1 dengan peningkatan ekspresi

epidermal growth factor receptor pada karsinoma nasofaring jenis

undifferentiated. Otorhinolaryngologica Indonesia 31(3): 1-35.

Soetjipto, D. 1989. Karsinoma nasofaring. Di dalam: Tumor Telinga

Hidung dan Tenggorok, Diagnosis dan Penatalaksanaan. Jakarta: FK-

UI. hlm. 71-84

Soo, R., Putti, T., Tao, Q., Goh, B.C., Lee, K.H., Seng, L.K., Tan, L. and

Hsieh, W.S. 2005. Overexpression of cyclooxygenase-2 in

nasopharyngeal carcinoma and association with epidermal growth

factor receptor expression. Arch Otolaryngology Head Neck Surgery

131: 147-52.

Soylu, L., Ozcan, C., Cetik, F., Paydaş, S., Kiroğlu, M., Aydoğan, B.,

Sargin, O., Ozşahinoglu, C. and Seyrek, E. 1994. Serum levels of

Universitas Sumatera Utara

tumor necrosis factor in squamous cell carcinoma of the head and

neck. Am J Otolaryngol. 15:281-5.

Steinbach, G., Lynch, P.M., Phillips, R.K.S., Wallace, M.H., Hawk, E.,

Gordon, G.B., Wakabayashi, N., Saunders, B., Shen, Y., Fujimura, T.,

Su, L.K. and Levin, B. 2000. The effect of celecoxib, a cyclooxygenase-

2 inhibitor, in familial adenomatous polyposis. The New England

Journal of medicine 342 (26): 1946-52.

Stevens, S.J., Verkuijlen, S.A., Hariwiyanto, B., Harijadi, Paramita, D.K.,

Fachiroh, J., Adham, M., Tan, I.B., Haryana, S.M. and Middeldorp, J.M.

2006. Noninvasive diagnosis of nasopharyngeal carcinoma:

nasopharyngeal brushings reveal high Epstein-barr virus DNA load and

carcinoma-specific Viral BARF1 mRNA. Int J Cancer. 119 (3): 608-14.

Sudyartono, T., Wiratno. 1996. Manifestasi klinik sebagai dasar diagnosis

karsinoma nasofaring. Di dalam: Kumpulan Naskah Ilmiah PIT

PERHATI. Malang: hlm. 841-59.

Susworo, R. 2010. Radioterapi pada penderita karsinoma nasofaring.

Departemen Radioterapi FK UI Jakarta [In press].

Tabuchi K, Nakayama M, Nishimura B, Hayashi K, Hara A, Early Detection

of Nasopharyngeal Carcinoma. Internnational Journal of

Otolaryngology, Volume 2011; 1-6.

Takemoto, J.K., Reynolds, J.K., Remsberg, C.M., Vega, K.R. and Davies,

N.M. 2008. Clinical pharmacokinetic and pharmacodynamic profile of

etoricoxib. Clinical Pharmacokinetic 47 (11): 703-20.

Tan, K.B. and Putti, T.C. 2005. Cyclooxygenase-2 expression in

nasopharyngeal carcinoma: immunohistochemical findings and

potential implications. J Clin Pathol. 58: 535-8.

Tang, J.G., Li, X. and Chen, P. 2004. Expression of matrix

metalloproteinase-9 in NPC and association with Epstein-Barr virus

infection. J Zhejiang Univ Sci. 5 (10): 1304-12.

Tang L, Guo R, Zhou G, Sun Y, Liu L, Lin A, Mai H, Shao J, Li L, Ma J,

2014. Prognostic Value and Staging Classification of Retropharyngeal

Lymph Node Metastasis in Nasopharyngeal Carcinoma Patients

Universitas Sumatera Utara

Treated with Intensity-modulated Radiotherapy. Plos One, volume 9;

1-8.

Tracey, L.B., Farver, C.F., Barna, B.P., Malur, A., Abraham, S.,

Raychaudhuri, B., Kavuru, M.S. and Thomassen, M.J.

Turkoz, F.P., Celenkoqlu, G., Dogu, G.G., Kalender, M.E., Coskun, U.,

Alkis, N., Ozkan, M., Turk, H.M. and Arslan, U.Y. 2011. Risk factors of

nasopharyngeal carcinoma in turkey-an epidemiological survey of the

anatolian society of medical oncology. Asian Pac J Cancer Prev. 12

(11): 3017-21

2003.

Peroxisome proliferator-activated receptor gamma is deficient in

alveolar macrophages from patients with alveolar proteinosis.

American Journal of Respiratory Cell and Molecular Biology 29 (6):

677-82.

Umar M, Upadhyay R, Kumar S, Ghoshal U, Mittal B, 2013. Association of

Common Polymorphisms inTNFA, NFkB1and NFKBIA with Risk and

Prognosis of Esophageal Squamous Cell Carcinoma,Volume 8

Vasala, K. 2008. Matrix metalloproteinase MMP-2 and MMP-9 and their

inhibitors TIMP-1 and TIMP-2 in bladder carcinoma. OULU University

Press. hlm. 22-53.

Vlantis AC, Hasselt CA, Anatomi of the Nasopharynx, in : Scott-Brown’s

Otorhinolaryngologi, Head And Neck Surgery, 7th

Wan, X.B., Long, Z.J., Yan, M., Xu, J., Xia, L.P., Liu, L., Zhao, Y., Huang,

X.F., Wang, X.R., Zhu, X.F., Hong, M.H. and Liu, Q. 2008. Inhibition of

aurora-A suppresses epithelial-mesenchymal transition and invasion by

downregulating MAPK in nasopharyngeal carcinoma cells.

Carcinogenesis 29 (10): 1930-7.

edition, volume 2,

Great Britain,2008 ; p.2107-14

Wang Y, Zhang Y, Ma S, 2013. Racial differences in nasopharyngeal

carcinoma in the United States, The International Journal of Cancer

Epidemiology, Detection, and Prevention. 37:793-802.

We, W.I. 2003. Cancer of the nasopharynx: functional surgical salvage.

World J. Surg. 27: 844-8.

Universitas Sumatera Utara

Wei, W.I. 2006. Nasopharyngeal cancer. Di dalam: Bailey, B.J., Johnson,

J.T. and Newlands, S.D., editor. Head and Neck Surgery

Otolaryngology. Ed ke-4. Philadelphia: Lippincot Williams and Wilkins.

hlm. 1657-71.

Wei W.I, Chua D, 2014. Nasopharyngeal Carcinoma. Di dalam : Bailey

Head and Neck Surgery Otolaryngology. Volume two, Fifth Edition,

Philadelphia: Lippincot Williams and Wilkins. Hlm 1875-98.

Wei W.I, Kwong DL, 2010. Current Management Strategy of

Nasopharyngeal Carcinoma. Clinical and Experimental

Otorhinolaryngology Vol. 3, No. 1: 1-12,

Wei, K.R., Xu, Y., Liu, J., Zhang, W.J. and Liang, Z.H. 2011.

Histopathological classification of nasopharyngeal carcinoma. Asian

Pac J Cancer Prev. 12 (5): 1141-7.

Weissman, J.L. and Hirsch, B.E. 2000. Imaging of tinnitus: a review.

Radiology. 216: 342-9.

Xi S.H, Yu I.T, Tse L.A, Mang O.W, Yue L, 2013. Sex different in the

incidence of nasophharyngal in hongkong 1983-2008; suggestion of a

potencial protective role of oestrogen. Elsivier European Journal of

Cancer; 150-5.

Wu, Y. and Zhou, B.P. 2010. TNF-α/NF-κB/Snail Pathway in cancer cell

migration and invasion. Br J Cancer. 102 (4): 639-44.

Wu, M., Li, X., Li, X. and Li, G. 2009. Signaling transduction network

mediated by tumor suppressor/susceptibility genes in NPC. Current

Genomics 10: 216-22.

Xu T, Tang J, Gu M, Liu L, Wei W, Yang H, 2013. Recurrent

nasopharyngeal carcinoma: a clinical dilemma and challenge. Current

Oncology, vol 20; 406-19.

Yang, W.L., Roland, I.H., Godwin, A.K. and Xu, X.X. 2005. Loss of TNFα-

regulated COX-2 expression in ovarian cancer cells. Oncogene 24

(54): 7991-8002.

Universitas Sumatera Utara

Yeh, A.S., Tang, Y., Lui, C.C., Huang, E.Y. 2006. Treatment outcomes of

patients with AJCC Stage IVC nasopharyngeal carcinoma: benefits of

primary radiotherapy. Jpn J Clin Oncol. 36 (3): 132-6.

Yenita, dan Asri, A. 2008. Studi retrospektif karsinoma nasofaring di

Sumatera Barat: reevaluasi subtype histopatologi berdasarkan

klasifikasi WHO [Penelitian pendahuluan]. Padang: FK UNAND.

Yeon S, An J,Park S. 2013. Detection of Epstein–Barr virus-infected

lymphoid cellsin nasal mucosa or nasopharynx: appearances canbe

deceptive. Virchows Arch 462:391–7.

Yuan, Y. and Hunt, R.H. 2003. Assesment of the safety of selective

cyclo-oxygenase-2 inhibitors: where are we in 2003?

Inflammopharmacology 11 (4): 337-54.

Yu, H.S., Wang, X., Song, A.Q., Liu, N., Zhang, W. and Yu, L. 2012.

Concurrent chemoradiotherapy vs radiotherapy alone for locoregional

advanced nasopharyngeal carcinoma. Asia Pacific Journal of Cancer

Prevention 13: 3961-65.

Zhang, S., Li, L., Lin, J.Y. and Lin, H. 2003. Imbalance between

expression of matrix metalloproteinase-9 and tissue inhibitor of

metalloproteinase-1 in invasiveness and metastasis of human gastric

carcinoma. W J Gastroenterol. 9 (5): 899-904.

Zimmermann, M., Zouhair, A., Azria, D. and Ozsahin, M. 2006. The

epidermal growth factor receptor (EGFR) in head and neck cancer: its

role and treatment implication. Radiation Oncology 1:11-6.

Zhang N, Liang S, Deng Y, Lu R, Chen H, Zhao H, Qian Z, Liang S, Yang

L, Liu B, Chen Y, 2014. Primary tumor regression speed after

radiotherapy and its prognostic significance in nasopharyngeal

carcinoma: a retrospective study. BMC Cancer 2014, 14:136. 1-8.

Universitas Sumatera Utara