D KE Multi-Modality Imaging Lab Comparison of Scintimammography and Dedicated Emission Mammotomography Martin P. Tornai, Caryl N. Martin P. Tornai, Caryl N. Brzymialkiewicz, Spencer J. Brzymialkiewicz, Spencer J. Cutler, Priti Madhav Cutler, Priti Madhav Multi-Modality Imaging Laboratory Multi-Modality Imaging Laboratory Department of Radiology Department of Radiology Department of Biomedical Engineering Department of Biomedical Engineering Duke University Medical Center, Durham, NC, USA Duke University Medical Center, Durham, NC, USA Supported by NIH Grant Supported by NIH Grant RO1-CA96821 and DAMD 17-03- RO1-CA96821 and DAMD 17-03- 1-0558 1-0558
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D KE Multi-Modality Imaging Lab Comparison of Scintimammography and Dedicated Emission Mammotomography Martin P. Tornai, Caryl N. Brzymialkiewicz, Spencer.
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D KE Multi-Modality Imaging Lab
Comparison of Scintimammography and Dedicated Emission
Mammotomography
Martin P. Tornai, Caryl N. Brzymialkiewicz, Martin P. Tornai, Caryl N. Brzymialkiewicz,
Spencer J. Cutler, Priti MadhavSpencer J. Cutler, Priti Madhav
Multi-Modality Imaging LaboratoryMulti-Modality Imaging LaboratoryDepartment of RadiologyDepartment of Radiology
Department of Biomedical EngineeringDepartment of Biomedical EngineeringDuke University Medical Center, Durham, NC, USADuke University Medical Center, Durham, NC, USA
Supported by NIH Grant Supported by NIH Grant RO1-CA96821 and DAMD 17-03-1-0558RO1-CA96821 and DAMD 17-03-1-0558
D KE Multi-Modality Imaging Lab
OverviewOverview
Develop a “universal” breast phantom for emission and/or Develop a “universal” breast phantom for emission and/or transmission imagingtransmission imaging
Needs to be compressible for uncompressed and partial Needs to be compressible for uncompressed and partial compression imaging comparisonscompression imaging comparisons
Needs to accommodate inserted lesionsNeeds to accommodate inserted lesions
Needs to have physical attributes similar to human torsoNeeds to have physical attributes similar to human torso
Make direct comparison of uncompressed breast SPECT and Make direct comparison of uncompressed breast SPECT and compressed scintimammographycompressed scintimammography
Develop and compare various fillable lesion sizesDevelop and compare various fillable lesion sizes
Compare different activity concentrationsCompare different activity concentrations
D KE Multi-Modality Imaging Lab
Solid State Imaging DetectorSolid State Imaging Detector
6.6 cm
6.6 cm
20.0 cm20.0 cm
16.0 cm16.0 cm
LumaGEM™ 3200-SLumaGEM™ 3200-S
(Gamma Medica Inc.)(Gamma Medica Inc.)
DetectorDetector CdZnTeCdZnTe
DensityDensity 5.78 g/cm5.78 g/cm33
Effective ZEffective Z 4949
ElementsElements 64 x 8064 x 80
Crystal DimensionsCrystal Dimensions 2.3 x 2.3 x 5 mm2.3 x 2.3 x 5 mm33
OSEM reconstruction with 5 iterations, 8 subsets, calculated attenuation OSEM reconstruction with 5 iterations, 8 subsets, calculated attenuation correction, 3D Hann filtration with fcorrection, 3D Hann filtration with fcc = 0.8*Nyquist = 0.8*Nyquist
ROI data from OSEM reconstruction with 3 iterations, 8 subsets, calculated ROI data from OSEM reconstruction with 3 iterations, 8 subsets, calculated attenuation correction, 3D Hann filtration with fattenuation correction, 3D Hann filtration with fcc = 0.8*Nyquist = 0.8*Nyquist
Conclusions Developed a compressible breast+chest phantom useful for Developed a compressible breast+chest phantom useful for
comparative emission breast imaging with physical comparative emission breast imaging with physical limitations more consistent with a human torsolimitations more consistent with a human torso
Measured various lesion sizes, locations (esp. near chest Measured various lesion sizes, locations (esp. near chest wall), and activity concentrations relative to backgroundswall), and activity concentrations relative to backgrounds
Compared compressed breast, planar scintimammography Compared compressed breast, planar scintimammography with uncompressed breast SPECT mammotomographywith uncompressed breast SPECT mammotomography
Scintimammography has limited viewable breast volume Scintimammography has limited viewable breast volume towards the anterior chest walltowards the anterior chest wall
Under a wide range of “low noise” measurement conditions:Under a wide range of “low noise” measurement conditions:
More lesions, lesion sizes, and (3D) lesion locations can be More lesions, lesion sizes, and (3D) lesion locations can be detected (and thus quantitated) with dedicated emission detected (and thus quantitated) with dedicated emission mammotomography than with compressed breast mammotomography than with compressed breast scintimammographyscintimammography