Presentation by: Bharat Kumar Cytoskeleton Friday October 11
Jun 03, 2015
Presentation by: Bharat Kumar
Cytoskeleton
FridayOctober 11
Introduction Types of protein
filaments Function of protein
filaments
Overview
The cytoskeleton extends throughout the cytoplasm and is a complex network of protein filaments.
Providing structural support to the cell, the cytoskeleton also functions in cell motility and regulation.
The existence of an organized fibrous array or cytoskeleton in the structure of the protoplasm was postulated in 1928 by Koltzoff.
What is Cytoskeleton?
Types of protein filaments
There are three main types of Protein fibers in the cytoskeleton:
A. MICROTUBULES
B. MICROFILAMENTS
C. INTERMEDIATE FILAMENTS
Microtubules
A microtubule consists of a long, unbranched, hollow tubules 24–25 nm in diameter and with 6 nm thick wall having 13 subunits or protofilaments.
A protofilament of microtubule is made of a protein called tubulin. It occurs in two different forms, called α-tubulin and β-tubulin.
Functions of Microtubules
Microtubules are the central structural supports in cilia and flagella.
During cell differentiation, the mechanical function of microtubules is used to determine the shape of the developing cells.
Microtubules play a role in the contraction of the spindle and movement of chromosomes and centrioles as well as in ciliary and flagellar motion.
Microfilaments
Microfilaments are the thinnest class of the cytoskeletal fibers, approximately 8 nm in diameter.
Thicker filaments, composed of a motor protein, myosin, interdigitate with the thinner actin fibers.
An actin microfilament consists of a twisted double chain of actin subunits.
Function of microfilaments
Microfilaments are found to be involved in movement associated with furrow formation in cell division.
In plant cells(and others), actin-myosin interactions and sol-gel transformations drive cytoplasmic streaming.
This creates a circular flow of cytoplasm in the cell.
This speeds the distribution of materials within the cell.
Intermediate filaments
Constructed like woven ropes, they are typically between 8 nm to 12 nm in diameter, which is “intermediate” between the thin and thick filaments.
Intermediate filaments are built from a diverse class of subunits from a family of proteins called keratins.
Function of Intermediate filaments
They are very stable structures provide reinforce cell shape and fix organelle location.
Intermediate filaments can be anchored between the membrane to provide extra support
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