CYCLOTRON AND RADIOPHARMACEUTICAL CORE HOUSTON METHODIST RESEARCH INSTITUTE Cyclotron and Radiopharmaceutical Core Director: Meixiang (Max) Yu, Ph.D. Email: [email protected]713.441.2921 houstonmethodist.org/cyclotron Houston Methodist Research Institute 6670 Bertner Avenue Houston, TX 77030 houstonmethodist.org/research HMRI Communications & External Relations | RICORE-008 | MM | DH | 08.2014 The Houston Methodist Research Institute Cyclotron and Radiopharmaceutical Core facility can produce Positron Emission Tomography or PET tracers with half lives ranging from 2 to 110 minutes, including tracers that are not commercially available. In addition to the commercially available [ 18 F]FDG compound, the Houston Methodist cyclotron facility can produce rare 15 O, 13 N, 11 C, 64 Cu, and other compounds such as [ 11 C]PIB, [ 18 F]FLT, and [ 18 F]FDOPA. M.D. ANDERSON BLVD. MOURSUND ST. M.D. Anderson Cancer Center BERTNER AVE. BATES ST. McGovern Commons & Trevisio UNIVERSITY BLVD. DRYDEN RD. JOHN FREEMAN BLVD. St. Luke’s Hospital Texas Children’s Hospital Texas Heart Institute WILKINS ST. E. CULLEN ST. ROSS STERLING AVE. Garage 1 Baylor College of Medicine Marriot Garage 7 University of Texas Health & Science P P P P Jones Tower Outpatient Center P P FANNIN ST. RICE UNIVERSITY SOUTH MAIN ST. N R Smith Tower Scurlock Tower Mary Gibb Jones Building Rice Bioscience Research Collaberative Texas Children’s Neurological Research Institute A Research Institute Houston Methodist METRORAIL DRYDEN/TMC METRORAIL STATION P PARKING MAP LEGEND HOUSTON METHODIST RESEARCH INSTITUTE ACCOMODATIONS R A
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The Houston Methodist Research Institute Cyclotron and Radiopharmaceutical Core facility can produce Positron Emission Tomography or PET tracers with half lives ranging from 2 to 110 minutes, including tracers that are not commercially available. In addition to the commercially available [18F]FDG compound, the Houston Methodist cyclotron facility can produce rare 15O,13N, 11C, 64Cu, and other compounds such as [11C]PIB, [18F]FLT, and [18F]FDOPA.
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CAMBRIDGE ST.
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SON
BLV
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MOURSUND ST.
M.D. AndersonCancer Center
BERT
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JOH
NSO
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McGovernCommons & Trevisio
UNIVERSITY BLVD.
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JOHN FREEMAN BLVD.
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MemorialHermannHospital
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Ben TaubGeneralHospital
BaylorCollege
of Medicine
Marriot
Garage7
Universityof TexasHealth &Science
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BRAESWOOD BLVD.
SOUTHLOOP610
TAUB
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HOUSTON METHODIST RESEARCH INSTITUTE
ACCOMODATIONS
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Houston Methodist
Cyclotron and Radiopharmaceutical Core
The Houston Methodist Research Institute Cyclotron and Radiopharmaceutical Core produces radiopharmaceuticals for research and medical applications. The facility operates a GE PETrace cyclotron that produces tracers for Positron Imaging Tomography or PET. These clinical grade tracers are available to customers throughout the Texas Medical Center.
PET APPLICATIONS
The on-site cyclotron facility enables Houston Methodist to engage in research studies that require rare custom tracers. The facility can produce multiple doses for a patient in a single day, and can offer cutting-edge PET imaging for patients that is not available elsewhere in the Texas Medical Center such as:
•Oncology:PETimagingoftypesofcancerthatare not possible with traditional [18F]FDG-based imaging, including imaging of prostate, renal, and certain types of brain cancers.
•Neurology:PETisthemostsensitivetoolforspecific diagnosis of Alzheimer’s disease and other dementias, and is used for locating epilepsy seizure foci prior to surgery.
•Cardiology:Thecyclotronfacilityproducestracers containing 15O and 13N that are the leading tools for PET detection of coronary artery disease and diseased tissuethatwillbenefitfromrevascularization.
•Newdrugdevelopment:PETcanfacilitatethespeed of drug development with noninvasive measurement ofinvivobiodistributionandpharmacokineticprofiles.With PET, only very low amounts of the experimental drug are administered, far below toxicity levels, enabling clinical human studies that expedite FDA approval pathways.
PET RADIOPHARMACEUTICALS
The facility produces [18F]FDG and other compounds:
[13N]AmmoniaCardiac perfusion
[11C]AcetateCardiac perfusion
[11C]Palmitate
Fatty acid, beta-oxidation
[11C]CholineProstate cancer imaging
[11C]WAY-100,635
5-HT1A receptor imaging, for depression, anxiety, and
schizophrenia
6-[18F]Fluoro-L-DOPA
Brain tumor imaging, over 96% sensitivity
Our Specialized Services
• cGMP production
• Nuclear pharmacy
• 18F, 15O, 13N, 11C, 64Cu compounds
• GE PETrace 16.5 MeV negative ion isochronous cyclotron
• 9 hot cells
• Rapid transport system to PET scanner and research floors
• GE automated production and quality control procedures
• GE radiopharmaceuticals preparation and distribution equipment
[18F]FHBGGene therapy imaging
[11C]PIB
Beta-amyloid plaque imaging for Alzheimer’s disease
[11C]Raclopride
Dopamine D2 receptor-imaging for age and mental disease-related