Cyclins and Cell Cycle Regulation Cell decides whether to continue Cell prepares to divide Cell division (mitosis) Cycle begins Cell grows Replication of DNA Cyclin E CDK2 Rb dephosphorylation Rb phosphorylation G2 M G1 S Cyclin B/A CDK1/ CDC2 Cyclin A CDK2 Cyclin D CDK4,6 Cdk2 antibody (ab7954) ATM (phospho S1981) antibody (ab2888) p21 antibody (ab18209) p57 Kip2 antibody (ab4058) Abcam in Japan Abcam K.K. 1-16-8 Nihonbashi Kak igaracho Chuo-ku,T okyo 103-0014 Japan T el: +81-(0)3-6231-0940 Fax: +81-(0)3-6231-0941 www.abcam.co.jp Abcam in Europe Abcam plc, 330 Cambridge Science Park Milton Road, Cambridge. CB4 0FL UK T el: +44 1223 696000 Fax: +44 1223 771600 Abcam in the USA Abcam Inc. 1 Kendall Square,Ste 341 Cambridge .MA 02139-1517 US A T el: 1-617-225-2272 T oll free: 1-888-77- ABCAM T oll free F ax: 1-866-739-9884 www.abcam.com Copyright © 2009 Abcam, All Rights Reserved.The Abcam logo is a registered trademark. All information/detail is correct at time of going to print.