CVN - Cristina Vilaplana Massaguer · PDF file2b24b79a2c491916ba3c7b7d9602b69e 6 Education University education 1st and 2nd cycle studies and pre-Bologna degrees 1 University degree:

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Summary of CV

This section describes briefly a summary of your career in science, academic and research; themain scientific and technological achievements and goals in your line of research in the medium-and long- term. It also includes other important aspects or peculiarities.

Multidisciplinary profile covering all aspects of research: physician (MD, PhD), MIR specialistin microbiology and parasitology, a researcher at full time contract with Miguel Servet 1; authorof more than 40 scientific articles; 13 participation in competitive R & D projects, of which 6 aremultipartner, international and funded by the European Commission (5) and one by the Bill &Melinda Gates Foundation; as well as numerous contracts with industry. 15 years experiencein design and evaluation of new therapeutic strategies in animal experimental models; co-inventor of 2 patents; founding partner of a spin-off and technology transfer experience andknowledge, teaching and scientific dissemination.Leader of the newly created line of research on the role of inflammation in tuberculosis (TB)and their modulation by drugs with anti-inflammatory effect, thanks to a contract Miguel ServetI (CP13 / 00174) and the project awarded associated. This line has been created withinthe Unit Tuberculosis Experimental, whose head is the Pr. Pere-Joan Cardona. My job isto demonstrate in humans the results obtained in basic studies conducted in our Unit. Forthis, I count on two valuable collaborators: the Perinatal Center HIV Unit in Johannesburg,South Africa (PHRU), and the National Center for Tuberculosis and Lung Diseases (NCTLD)of Tblisi, Georgia. Furthermore, I actively participate in the the Africa-Europe HDT-Network(http://www.unza-uclms.org/hdt-net), led by Pr A. Zumla (UCL, London) and Pr M. Maeurer(Stockholm, Sweden)) precisely to evaluate Host-Directed Therapies (HDT) in randomizedcontrolled trials. In my daily activities, I continue working in all the studies conducted in the Unit,specially on the evaluation of new prophylactic and therapeutic strategies in animal models.

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General quality indicators of scientific research

This section describes briefly the main quality indicators of scientific production (periods ofresearch activity, experience in supervising doctoral theses, total citations, articles in journals ofthe first quartile, H index...). It also includes other important aspects or peculiarities.

Number of presidential terms: From 09/2001 to the present (2 presidential terms);Total citations: 837Average citations / year (during the last 5 years not including the current year: 107.2;)Total publications in the first quartile (Q1): 22;ResearchGate Code: http://www.researchgate.net/profile/Cris_Vilaplana

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Cristina Vilaplana Massaguer

Surname(s): Vilaplana MassaguerName: CristinaDNI: 40340126NDate of birth: 28/09/1975Gender: FemaleLand line phone: 934978677Email: [email protected] web page: www.unitatdetuberculosiexperimental.wordpress.com

Current professional situation

Employing entity: Universidad Carlos III deMadrid

Type of entity: University

Department: Unitat de Tuberculosi Experimental, Fundació Institut Germans Trias i PujolProfessional category: Miguel Servet I ResearcherStart date: 01/01/2014Type of contract: Temporary employmentcontract

Dedication regime: Full time

Primary (UNESCO code): 320505 - Infectious diseasesSecondary (UNESCO code): 320103 - Clinical microbiologyTertiary (UNESCO code): 241210 - VaccinesIdentify key words: Therapeutics; Laboratoy animals; Animal tuberculosis

Previous positions and activities

Employing entity Professional category Start date1 CIBER ENFERMEDADES

RESPIRATORIAS (CIBERES)Researcher 01/02/2010

2 Instituto de Salud Carlos III Researcher FIS post-FSE 20073 National Heart and Lung Institute, Imperial

College of LondonVisitant Researcher 2008

4 Archivel Farma SL Responsible of the Evaluation of theImmune Response generated by thevaccine RUTI, Phase I Clinical Trial

2007

5 FUNDACIÓ INSTITUT D'INVESTIGACIÓEN CIÈNCIES DE LA SALUT GERMANSTRIAS I PUJOL

Pre-doctoral Researcher 2005

6 Hospital Universitari Germans Trias i Pujolde Badalona

"Médico Interno Residente MIR" medicaldoctor

2001

1 Employing entity: CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)Professional category: ResearcherStart-End date: 01/02/2010 - 31/12/2013 Duration: 3 years

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2 Employing entity: Instituto de Salud Carlos III Type of entity: Public Research BodyProfessional category: Researcher FIS post-FSEStart-End date: 2007 - 2010 Duration: 3 years

3 Employing entity: National Heart and Lung Institute, Imperial College of LondonProfessional category: Visitant ResearcherStart-End date: 2008 - 2009 Duration: 8 months

4 Employing entity: Archivel Farma SL Type of entity: BusinessProfessional category: Responsible of the Evaluation of the Immune Response generated by thevaccine RUTI, Phase I Clinical TrialStart-End date: 2007 - 2008 Duration: 2 years

5 Employing entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLProfessional category: Pre-doctoral ResearcherStart-End date: 2005 - 2007 Duration: 2 years

6 Employing entity: Hospital Universitari GermansTrias i Pujol de Badalona

Type of entity: Healthcare Institutions

Professional category: "Médico Interno Residente MIR" medical doctorStart-End date: 2001 - 2005 Duration: 4 years

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Education

University education

1st and 2nd cycle studies and pre-Bologna degrees

1 University degree: specialization diplomaName of qualification: Specialization diploma in Research MethodologyDegree awarding entity: Escuela Nacional deSanidad- Instituto Carlos III

Type of entity: Administrative Body of the NationalHealth System

Date of qualification: 2006

2 University degree: Higher degreeName of qualification: Bachelor on Medicine and SurgeryDegree awarding entity: Universitat Autònoma deBarcelona


Date of qualification: 1999

Doctorates

Doctorate programme: PhD in Medicine (Microbiology and Genetic Department)Degree awarding entity: Universitat Autònoma deBarcelona


Date of degree: 11/11/2009

Specialized healthcare studies

Name of the speciality: Specialization FSE MIR in Microbiology and ParasitologyName of the sub-speciality: Medical Doctor - specialist MIR in Microbiology and ParasitologyAwarding entity: Ministerio de Sanidad y Consumo Type of entity: Administrative Body of the National

Health SystemStart-End date: 2001 - 2005 Duration: 4 years

Healthcare studies in R&D

1 Name of the studies: Post-FSE FIS Contract, expedient code: CM0600123Professional category: Pre-doctoral researcherAwarding entity: Instituto de Salud Carlos III Type of entity: Public Research BodyStart-End date: 2007 - 2010

2 Name of the studies: Specialization diploma in Research MethodologyAwarding entity: Escuela Nacional de Sanidad- Instituto Carlos IIIStart-End date: 2004 - 2006

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Language skills

Language Listening skills Reading skills Spoken interaction Speaking skills Writing skillsRussian A1 A1 A1Italian C1 C1 C1 C1 C1English C1 C2 C1 C1 C2French C2 C2 C1 C1 C2Catalan C2 C2 C2 C2 C2Spanish C2 C2 C2 C2 C2

Teaching experience

General teaching experience

1 Name of the course: Modelling and simulation in sciencesUniversity degree: Bachelor in BiophysicsStart date: 2013End date: 2013Entity: Universitat Politècnica de Catalunya Type of entity: UniversityFaculty, institute or centre: Campus Nord

2 Name of the course: Clinical TB Management CourseUniversity degree: Post-graduate diplomaStart date: 2012End date: 2013Entity: FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYAFaculty, institute or centre: Universitat Oberta de Catalunya, International Graduate Institute

3 Name of the course: Medical MicrobiologyUniversity degree: Bachelor in BiosciencesStart date: 2011Entity: Universitat Autònoma de Barcelona Type of entity: UniversityFaculty, institute or centre: Hospital Universitari Germans Trias i Pujol

4 Name of the course: Clinical MicrobiologyUniversity degree: Bachelor in Medicine and SurgeryStart date: 2001Entity: Universitat Autònoma de Barcelona Type of entity: UniversityFaculty, institute or centre: Hospital Universitari Germans Trias i Pujol

5 University degree: Student tutorialEntity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL

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Experience supervising doctoral thesis and/or final year projects

1 Project title: Evaluation of the effect of vitamins and a nutraceutical in a mouse model of active tuberculosisType of project: Final degree projectEntity: FUNDACIÓ BARCELONA MEDIA UNIVERSITAT POMPEU FABRAStudent: Anna LlopartDate of reading: 22/07/2016

2 Project title: Modelling and simulation of tuberculosis lesions’ dynamics in a minipig bronchial treeType of project: Final Degree ProjectEntity: Universitat Politècnica de Catalunya Type of entity: UniversityStudent: Martí CatalàDate of reading: 2015

3 Project title: Evaluation of synergies between a novel compound and BCG vaccination in a murine experimentalmodel of tuberculosisType of project: Master ThesisEntity: Universitat de Barcelona- Universitat Autònoma de BarcelonaStudent: Noemí TomsenDate of reading: 2015

4 Project title: Estudi en models experimentals animals de la influència de comorbiditats en el curs de la malaltiatuberculosaType of project: Doctoral thesisEntity: Universitat de Barcelona Type of entity: UniversityStudent: Lilibeth Arias

5 Project title: Study of TB by radiology in an experimental model of minipig and its extrapolation to humansType of project: Doctoral thesisEntity: Universitat Autònoma de Barcelona Type of entity: UniversityStudent: Jordi Bechini

6 Project title: Study of TB lesions obtained in surgery: in search of best biomarkers correlating with TB pathology,clinical features,MDR cases and prognosisType of project: Doctoral thesisEntity: Universitat de Barcelona Type of entity: UniversityStudent: Albert Despuig

7 Project title: Tractant la tuberculosi des del punt de vista de l’hostatger: Assaig clínic a Sud-Àfrica per a avaluarl’eficàcia del tractament de la Infecció Tuberculosa Latent amb teràpies dirigides contra l’hostatger.Type of project: Final degree projectEntity: Universitat Autònoma de Barcelona Type of entity: UniversityStudent: Marc Viles

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Student tutorials

1 Name of the programme: Bachelor in Business AdministrationEntity: IES La Pineda Type of entity: Technological CentreNumber of tutored students: 1

2 Name of the programme: Counsellor of the students enroled in the Post-graduate course "Clinical TBManagement Course" during the whole courseEntity: FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYA

3 Name of the programme: Degree in BiotechnologyEntity: Universitat de VicNumber of tutored students: 1

4 Name of the programme: Degree in MedicineEntity: Carl von Ossietzky University Oldenburg

5 Name of the programme: Degree in MicrobiologyEntity: Universitat Autònoma de Barcelona Type of entity: UniversityNumber of tutored students: 2

6 Name of the programme: Degree on Biological SystemsEntity: UNIVERSITAT POLITÈCNICA DE BARCELONANumber of tutored students: 1

7 Name of the programme: Degree on BiomedicineEntity: FUNDACIO UNIVERSITAT DE LLEIDANumber of tutored students: 1

8 Name of the programme: High SchoolEntity: Col·legi Sant Miquels dels Sants Type of entity: InstituteNumber of tutored students: 1

Educational or pedagogical publications, books, articles, etc.

1 Cristina Vilaplana. Tuberculosis and HIV.Name of the materials: Video classesDate of drafting: 01/09/2012Format: Videos

2 Cristina Vilaplana; Pere-Joan Cardona. The hidden history of tuberculin. Understanding Tuberculosis – GlobalExperiences and Innovative Approaches to the Diagnosis. InTech, ISBN 978-953-307-942-4Name of the materials: Book ChapterDate of drafting: 2012Format: Chapters of books

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3 Eduard Mesalles; Cristina Vilaplana. Botulism. Medicina Interna "Farreras-Rozman". II, pp. 2313 - 2315.Name of the materials: Book chapterDate of drafting: 2004Format: Book

Participation in innovative teaching projects

Project title: "Ens apropem a la Recerca"Type of participation: OthersTime of working relationship: For a limited timeFunding entity: Ajuntament de Badalona Type of entity: AyuntamientoStart-End date: 2010 - 2011 Duration: 1 day

Participation in conferences with talks focused on teacher training

1 Name of the event: IX Curs d'Infectologia PediàtricaType of event: WorkshopCity of event: Barcelona, SpainDate of presentation: 2010Organising entity: FUNDACIO INSTITUT DE RECERCA DE L'HOSPITAL UNIV. VALL D'HEBRONCity organizing entity: Barcelona, SpainMillorant el diagnòstic de la infecció tuberculosa latent: fonament i utilitat dels TIGRAs.

2 Name of the event: Actualització en Microbiologia Clínica IIType of event: SeminarCity of event: Badalona, SpainDate of presentation: 2009Organising entity: Hospital Universitari Germans Trias iPujol


City organizing entity: Badalona, Spain

3 Name of the event: Sessions Internes del Pla de FormacióType of event: SeminarCity of event: Badalona, SpainDate of presentation: 2007Organising entity: Hospital Universitari Germans Trias iPujol


City organizing entity: SpainFase 1 d’una vacuna terapèutica.

4 Name of the event: Sessió d’Investigació: Activitat als laboratoris de recerca de la IGTPType of event: SeminarCity of event: Badalona, SpainDate of presentation: 2006Organising entity: Hospital Universitari Germans Trias iPujol


City organizing entity: Badalona, SpainDesenvolupament de la vacuna RUTI.

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City organizing entity: Badalona, SpainEstudi d’un brot nosocomial de Klebsiella pneumoniae.



City organizing entity: Badalona, SpainLeishmaniasis visceral.



City organizing entity: Badalona, SpainAvaluació d’uma tècnica d’hibridació “in situ” per a la identificació de Staphylococcus aureus directament des del’hemocultiu.

Other activities/achievements not included above

1 Description of the activity: Responsible of the dissemination activities of the Unitat de Tuberculosi ExperimentalOrganising entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS IPUJOL

2 Description of the activity: Training activities on research I+D in the tuberculosis field for predoctoral studentsOrganising entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS IPUJOL

3 Description of the activity: Training activities on research I+D in the tuberculosis field for techniciansOrganising entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS IPUJOL

4 Description of the activity: training activities on research I+D in the tuberculosis field for college studentsOrganising entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS IPUJOL

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Most relevant contributions of your teaching CV

Description: Co-organizator of the postdoctoral course "Clinical TB Management"Organising entity: FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYA

Healthcare experience

Healthcare innovation projects

Name of the project: Clinical development of the antituberculous vaccine RUTI. Design and performance of aPhase 1 Clinical Trial. Design of a Phase 2 clinical trial.Type of project: ClinicalEntity where project took place: Archivel Farma SL Type of entity: BusinessStart date: 2007

Projects for planning/improving healthcare

1 Name of the project: Estudio de Prevalencia de las Infecciones Nosocomiales en los Hospitales Españoles(EPINE) 2005Entity where project took place: Hospital UniversitariGermans Trias i Pujol


Start date: 2005



Start date: 2004



Start date: 2003



Start date: 2002

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Scientific and technological experience

Scientific or technological activities

R&D projects funded through competitive calls of public or private entities

1 Name of the project: PI16/01511 Estudio de las lesiones tuberculosas obtenidas mediante cirugía torácica:en búsqueda de los biomarcadores que mejor correlacionan con la patología, la clínica y la epidemiologíaEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLName principal investigator (PI, Co-PI....): Cristina VilaplanaNº of researchers: 7Funding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain

Start-End date: 2016 - 2019Total amount: 86.515 €

2 Name of the project: Estudio de las lesiones tuberculosas obtenidas mediante cirugía torácica: enbúsqueda de los biomarcadores que mejor correlacionen con la patología tuberculosa, las característicasclínicas, los casos de tuberculosis multi-resistentes a drogas y con el pronóstico.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLNº of researchers: 2Funding entity or bodies:Sociedad Española de Neumología y CirugíaTorácica

Type of entity: Associations and Groups

City funding entity: Barcelona, Catalonia, Spain


3 Name of the project: Advancing novel and promising TB vaccine candidates from discovery to preclinicaland early clinical development- Grant nº: SEP-210138189. (TBVAC2020)Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainName principal investigator (PI, Co-PI....): Pere-Joan CardonaNº of researchers: 12Funding entity or bodies:European community H2020 programme


4 Name of the project: Eliciting Mucosal Immunity in Tuberculosis - Grant nº 643558Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOL

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City of entity: SpainNº of researchers: 12Funding entity or bodies:European community H2020 programme


5 Name of the project: Estudio de los mecanismos implicados en la protección contra la tuberculosisgenerada por la administración oral de dosis bajas de micobacterias inactivadasEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainNº of researchers: 5Start-End date: 2015 - 29/03/2016 Duration: 3 yearsTotal amount: 221.127,5 €

6 Name of the project: Evaluation of the effect of common anti-inflammatories when used as coadjuvants totreat active tuberculosisEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLName principal investigator (PI, Co-PI....): Cristina VilaplanaNº of researchers: 1Funding entity or bodies:Instituto de Salud Carlos III


7 Name of the project: Elaboración de una nueva propuesta profiláctica y/o terapéutica contra la tuberculosisbasada en la inducción de una tolerancia de baja dosisEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainNº of researchers: 5Funding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain

Start-End date: 2011 - 2014Total amount: 210.650,11 €

8 Name of the project: NEWTBVAC: Discovery and preclinical development of new generation tuberculosisvaccines.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainFunding entity or bodies:7th Framework Programme, European Community


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9 Name of the project: NOPERSIST: Novel strategies for the prevention and control of persistent infections.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainNº of researchers: 6Funding entity or bodies:7th Framework Programme, European Community


10 Name of the project: Demostración de la hipótesis dinámica de la infección tuberculosa latenteEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainNº of researchers: 7Funding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain


11 Name of the project: LATENT TUBERCULOSIS: New tools for the detection and clearance of dormantMycobacterium tuberculosis. (StopLATENT-TB)Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: SpainNº of researchers: 6Funding entity or bodies:7th Framework Programme, European Community


12 Name of the project: GC#12: Preclinical and clinical evaluation of a post-exposure TB vaccine.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLNº of researchers: 7Funding entity or bodies:Bill and Melinda Gates Foundation Type of entity: Foundation


13 Name of the project: BIO2005-07949-C02-02: Estudios de atenuación y protección en modelos de ratón,cobayo y cerdo de los candidatos a vacunas preventivas y terapeuticas basados en la inactivación de phoP.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: Badalona, SpainFunding entity or bodies:MINISTERIO DE EDUCACION Y CIENCIACity funding entity: Spain

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14 Name of the project: Caracterización de la expresión genética de Mycobacterium Tuberculosis en fase delatencia en modelos experimentales en animales e "in vitro". Bases para la optimización del tratamiento dela tuberculosisEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: Badalona, SpainFunding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain


15 Name of the project: Estudio, en un modelo experimental murino, de los distintos grados de virulencia delas cepas de Mycobacterium tuberculosis resistentes a la isoniazida y su correlación con la composiciónglicolipídica de la pared celular, el tipo de respuesta inflamatoria pulmonar y las bases genéticasresponsables de la resistenciaEntity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLCity of entity: Badalona, SpainFunding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain


16 Name of the project: Ayuda de iniciación a la Investigación al doctorando Albert Despuig.Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLName principal investigator (PI, Co-PI....): Cristina VilaplanaFunding entity or bodies:CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)City funding entity: Spain

Start date: 2016Total amount: 15.600 €

17 Name of the project: Programa Corporativo en Tuberculosis.Enfermedades Respiratorias. CB06//06/0031Entity where project took place: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLFunding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research Body

Start date: 2007

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R&D non-competitive contracts, agreements or projects with public or private entities

1 Name of the project: Collaboration ContractDegree of contribution: ResearcherName principal investigator (PI, Co-PI....): Julià BlancoFunding entity or bodies:AlbaJuna Therapeutics Type of entity: Business

Start date: 2016Total amount: 50.617,93 €

2 Name of the project: Collaboration Contract: Project EPISTEMName principal investigator (PI, Co-PI....): Javier Martínez PicadoParticipating entity/entities: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUTGERMANS TRIAS I PUJOLFunding entity or bodies:FUNDACIÓN IRSICAIXA


3 Name of the project: EVALUATION OF SYNERGIES BETWEEN IND-02 AND BCG VACCINATION IN AMURINE EXPERIMENTAL MODEL OF TBName principal investigator (PI, Co-PI....): Cristina VilaplanaFunding entity or bodies:Indusbiotech


4 Name of the project: Evaluation of the in vitro and in vivo effect os the product IND02Name principal investigator (PI, Co-PI....): María Rosa Sarrías; Pere-Joan Cardona; Cristina VilaplanaFunding entity or bodies:Indusbiotech, IdtCity funding entity: India


5 Name of the project: Immunogenicity and cytokine profile evaluation of the Nyaditum resae within theclinical trial NYADATREG (ClinicalTrials.gov Identifier: NCT02076139)Funding entity or bodies:Manresana de Micobacteriologia SL (Manremyc) Type of entity: BusinessCity funding entity: Spain

Start date: 2013 Duration: 3 yearsTotal amount: 32.043,08 €

6 Name of the project: Production of 3 batches of Nyaditum resaeFunding entity or bodies:Manresana de Micobacteriologia (Manremyc) Type of entity: Business

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7 Name of the project: Collaboration Contract: Evaluation of Vaccine CandidatesDegree of contribution: Managing coordinatorFunding entity or bodies:Fundació IRSICaixa Type of entity: Foundation


8 Name of the project: Collaboration Contract: Evaluation of Vaccine CandidatesDegree of contribution: ResearcherFunding entity or bodies:Fundació IRSICaixa Type of entity: Foundation


9 Name of the project: Collaboration Contract: Evaluation of the Virulence of several M.kansasii strains in aexperimental animal modelDegree of contribution: ResearcherFunding entity or bodies:Hospital Universitari de Bellvitge Type of entity: Healthcare InstitutionsCity funding entity: Barcelona, Catalonia, Spain


10 Name of the project: Collaboration Contract: Evaluation of the Virulence of several M.tuberculosis mutantstrains in a experimental animal modelDegree of contribution: Scientific coordinatorFunding entity or bodies:Universidad de Zaragoza Type of entity: UniversityCity funding entity: Zaragoza, Aragon, Spain


11 Name of the project: Collaboration Contract: Development of the vaccine RUTIDegree of contribution: ResearcherFunding entity or bodies:Archivel Farma SL Type of entity: BusinessCity funding entity: Spain


12 Name of the project: Collaboration Contract-Evaluation of Drug CandidatesDegree of contribution: ResearcherFunding entity or bodies:GLAXOSMITHKLLINE (GSK)City funding entity: Spain

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13 Name of the project: Phase I Clinical Trial: “Estudio de Fase I, doble ciego, aleatorizado, controlado conplacebo para estudiar la tolerabilidad e inmunogenicidad de cuatro distintas dosis (5, 25, 100 y 200µg) devacuna antituberculosa RUTI en voluntarios sanos”Degree of contribution: Scientific coordinatorFunding entity or bodies:Archivel Farma SL Type of entity: BusinessCity funding entity: Spain

Start date: 2007 Duration: 2 yearsTotal amount: 18.000 €

14 Name of the project: Collaboration Contract-Evaluation of Drug CandidatesDegree of contribution: ResearcherFunding entity or bodies:GLAXOSMITHKLLINE (GSK)City funding entity: Spain


15 Name of the project: Estudio de los mecanismos de protección generados por RUTI en el control de lainfección tuberculosa latenteDegree of contribution: ResearcherFunding entity or bodies:Archivel Farma SL Type of entity: BusinessCity funding entity: Spain


16 Name of the project: Diseño de una vacuna contra la tuberculosis basada en antígenos estructurales enmodelos de tuberculosisDegree of contribution: Current university studentFunding entity or bodies:Archivel Farma SL Type of entity: BusinessCity funding entity: Spain


17 Name of the project: Pilot Study to estimate the potential efficacy and safety of using Adjunctive Ibuprofenfor the Treatment of XDR TuberculosisDegree of contribution: Coordinator of total project, network or consortiumNº of researchers: 7Funding entity or bodies:Instituto de Salud Carlos III Type of entity: Public Research BodyCity funding entity: Majadahonda, Community of Madrid, Spain

Duration: 3 years

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18 Name of the project: Transferència cel·lular a una soca de ratolí immunodeficient per a la deteccióultrasensible de persistència viral en pacients infectats pel VIH-1 que han estat sotmesos a novesestratègies terapèutiques per a la remissió de la infeccióDegree of contribution: Researcher, collaborator in experimental animal modellingParticipating entity/entities: Obra Social Fundación la Caixa

Results

Industrial and intellectual property

1 Title registered industrial property: MICOBACTERIAS INACTIVADAS PARA SU USO POR VÍA ORALEN LA PREVENCIÓN DE LA TUBERCULOSISInventors/authors/obtainers: Pere-Joan Cardona; Cristina Vilaplana; Elena MarzoEntity holder of rights: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANSTRIAS I PUJOL and CIBERESNº of application: P201200640Country of inscription: SpainDate of register: 2012Conferral date: 2012PCT patent: YesLicences: YesExclusive use: YesCreating an innovative enterprise: Yes Results: Success

2 Title registered industrial property: MÉTODO DE VALORACIÓN DE VIRULENCIA DE CEPAS DEMYCOBACTEIUM TUBERCULOSIS COMPLEX Y USO DE LOS AGREGADOS BACILARES DE CEPASDE MYCOBACTERIUM TUBERCULOSIS COMPLEX EN CULTIVO LÍQUIDO PARA DICHA VALORACIONInventors/authors/obtainers: Pere-Joan Cardona; Clara Prats; Isaac Llopis; Daniel López-Codina; NeusCaceres; Cristina VilaplanaEntity holder of rights: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANSTRIAS I PUJOL, CIBERES & Universitat Politècnica de CatalunyaNº of application: P201100734Country of inscription: SpainDate of register: 2011

Technological results derived from specialized and transfer activities, not included in previoussections

1 Description: Transferece of know-how on design and evaluation of new antituberculous vaccine candidatesboth in vitro and in experimental animal modelsName of the principal Investigator (PI): Pere-Joan CardonaName of the Co-principal investigator (Co-PI): Cristina VilaplanaDegree of contribution: Training activitiesCollaborating entity or bodies:Archivel Farma SL Type of entity: BusinessCity collaborating entity: Badalona, Spain

Start date: 2001 Duration: 13 years

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2 Description: Founding partner of the spin-off Manresana de Micobacteriologia SLCollaborating entity or bodies:CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)City collaborating entity: Spain

FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOLCity collaborating entity: Spain

Duration: 2012 years

Scientific and technological activities

Scientific production

H index: 18Date of application: 27/06/2016

Publications, scientific and technical documents

1 Alimuddin Zumla; Martin Rao; Robert S Wallis; Stefan H E Kaufmann; Roxana Rustomjee; Peter Mwaba; CrisVilaplana; Dorothy Yeboah Manu; Jeremiah Chakaya; Giuseppe Ippolito; Esam Azhar; Michael Hoelscher; MarkusMaeurer. Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.TheLancet. Infectious diseases. 16 - 4, pp. e47 - e63. 04/2016. ISSN 1474-4457Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Infectious DiseasesImpact index in year of publication: 22,433 Journal in the top 25%: YesPosition of publication: 1 No. of journals in the cat.: 78

2 Clara Prats; Cristina Vilaplana; Joaquim Valls; Elena Marzo; Pere-Joan Cardona; Daniel López. LocalInflammation, Dissemination and Coalescence of Lesions Are Key for the Progression toward Active Tuberculosis:The Bubble Model.Frontiers in microbiology. 7, pp. 33. (Switzerland): 2016. ISSN 1664-302XType of production: Scientific paper Format: JournalImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,989 Journal in the top 25%: YesPosition of publication: 27 No. of journals in the cat.: 119

3 Alimuddin Zumla; Markus Maeurer. Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis:Learning From the Pasteur-Bechamp Debates.Clinical infectious diseases : an official publication of the InfectiousDiseases Society of America. 61 - 9, pp. 1432 - 1440. 01/11/2015. ISSN 1537-6591Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 8,886 Journal in the top 25%: YesPosition of publication: 9 No. of journals in the cat.: 148

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4 Marco Schito; Giovanni Battista Migliori; Helen A Fletcher; Ruth McNerney; Rosella Centis; Lia D'Ambrosio;Matthew Bates; Gibson Kibiki; Nathan Kapata; Tumena Corrah; Jamshed Bomanji; Cris Vilaplana; Daniel Johnson;Peter Mwaba; Markus Maeurer; Alimuddin Zumla. Perspectives on Advances in Tuberculosis Diagnostics, Drugs,and Vaccines.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.61Suppl 3, pp. S102. 15/10/2015. ISSN 1537-6591Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 8,886 Journal in the top 25%: YesPosition of publication: 9 No. of journals in the cat.: 148

5 Peter Sander; Simon Clark; Agnese Petrera; Cristina Vilaplana; Michael Meuli; Petra Selchow; Andrea Zelmer;Deepa Mohanan; Nuria Andreu; Emma Rayner; Michael Dal Molin; Gregory J Bancroft; Pål Johansen; Pere-JoanCardona; Ann Williams; Erik C Böttger. Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protectionin a guinea pig model of tuberculosis.Vaccine. 33 - 11, pp. 1353 - 1362. 10/03/2015. ISSN 1873-2518Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MEDICINE, RESEARCH &

EXPERIMENTALImpact index in year of publication: 3,624 Journal in the top 25%: NoPosition of publication: 32 No. of journals in the cat.: 123

6 Gabriel Rech; Cristina Vilaplana; Juan Velasco; Raquel Pluvinet; Sheila Santín; Cristina Prat; Esther Julián;Fernando Alcaide; Iñaki Comas; Lauro Sumoy; Pere-Joan Cardona. Draft Genome Sequences of Mycobacteriumsetense Type Strain DSM-45070 and the Nonpathogenic Strain Manresensis, Isolated from the Bank of theCardener River in Manresa, Catalonia, Spain.Genome announcements. 3 - 1, 2015. ISSN 2169-8287Type of production: Scientific paper Format: JournalCorresponding author: No

7 Clara Prats; Cristina Montañola Sales; Joan F Gilabert Navarro; Joaquim Valls; Josep Casanovas Garcia; CristinaVilaplana; Pere-Joan Cardona; Daniel López. Individual-Based Modeling of Tuberculosis in a User-FriendlyInterface: Understanding the Epidemiological Role of Population Heterogeneity in a City.Frontiers in microbiology.6, pp. 1564. (Switzerland): 2015. ISSN 1664-302XType of production: Scientific paper Format: JournalImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,989 Journal in the top 25%: YesPosition of publication: 27 No. of journals in the cat.: 119

8 Paula Cardona; Elena Marzo Escartín; Gustavo Tapia; Jorge Díaz; Vanessa García; Ismael Varela; CristinaVilaplana; Pere-Joan Cardona. Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progressiontoward Active Tuberculosis in C3HeB/FeJ Mice.Frontiers in microbiology. 6, pp. 1482. (Switzerland): 2015. ISSN1664-302XType of production: Scientific paper Format: JournalCorresponding author: YesImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,989 Journal in the top 25%: YesPosition of publication: 27 No. of journals in the cat.: 119

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9 Juan Ruiz Manzano; Cristina Vilaplana. Will we be treating tuberculosis with vaccines in the XXI century?. Archivosde bronconeumologia. 50 - 9, pp. 373 - 377. (Spain): 09/2014. ISSN 1579-2129Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - RESPIRATORY SYSTEMImpact index in year of publication: 1,823 Journal in the top 25%: NoPosition of publication: 40 No. of journals in the cat.: 58

10 Elena Marzo; Cristina Vilaplana; Gustavo Tapia; Jorge Diaz; Vanessa Garcia; Pere-Joan Cardona. Damaging roleof neutrophilic infiltration in a mouse model of progressive tuberculosis.Tuberculosis (Edinburgh, Scotland). 94 - 1,pp. 55 - 119. 01/2014. ISSN 1873-281XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 2,711 Journal in the top 25%: NoPosition of publication: 53 No. of journals in the cat.: 119

11 Pere-Joan Cardona; Cristina Vilaplana. Multiple consecutive infections might explain the lack of protection byBCG.PloS one. 9 - 4, pp. e94736. 2014. ISSN 1932-6203Type of production: Scientific paper Format: JournalCorresponding author: YesImpact source: ISI Category: Science Edition - MULTIDISCIPLINARY

SCIENCESImpact index in year of publication: 3,234 Journal in the top 25%: YesPosition of publication: 9 No. of journals in the cat.: 57

12 Cristina Vilaplana; Pere-Joan Cardona. The lack of a big picture in tuberculosis: the clinical point of view, theproblems of experimental modeling and immunomodulation. The factors we should consider when designing noveltreatment strategies.Frontiers in microbiology. 5, pp. 55. (Switzerland): 2014. ISSN 1664-302XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,989 Journal in the top 25%: YesPosition of publication: 27 No. of journals in the cat.: 119

13 Cristina Vilaplana; Clara Prats; Elena Marzo; Carles Barril; Marina Vegué; Jorge Diaz; Joaquim Valls; DanielLópez; Pere-Joan Cardona. To achieve an earlier IFN-γ response is not sufficient to control Mycobacteriumtuberculosis infection in mice.PloS one. 9 - 6, pp. e100830. 2014. ISSN 1932-6203Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MULTIDISCIPLINARY


14 Neus Caceres; Cristina Vilaplana; Clara Prats; Elena Marzo; Isaac Llopis; Joaquim Valls; Daniel Lopez; Pere-JoanCardona. Evolution and role of corded cell aggregation in Mycobacterium tuberculosis cultures.Tuberculosis(Edinburgh, Scotland). 93 - 6, pp. 690 - 698. 11/2013. ISSN 1873-281XType of production: Scientific paper Format: Journal

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Corresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 2,711 Journal in the top 25%: NoPosition of publication: 53 No. of journals in the cat.: 119

15 Ainhoa Arbues; Juan I Aguilo; Jesus Gonzalo Asensio; Dessislava Marinova; Santiago Uranga; Eugenia Puentes;Conchita Fernandez; Alberto Parra; Pere Joan Cardona; Cristina Vilaplana; Vicente Ausina; Ann Williams;Simon Clark; Wladimir Malaga; Christophe Guilhot; Brigitte Gicquel; Carlos Martin. Construction, characterizationand preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinicaltrials.Vaccine. 31 - 42, pp. 4867 - 4940. 01/10/2013. ISSN 1873-2518Type of production: Scientific paper Format: JournalImpact source: ISI Category: Science Edition - MEDICINE, RESEARCH &


16 Cristina Vilaplana; Elena Marzo; Gustavo Tapia; Jorge Diaz; Vanesa Garcia; Pere-Joan Cardona. Ibuprofentherapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murineexperimental model of active tuberculosis.The Journal of infectious diseases. 208 - 2, pp. 199 - 401. 15/07/2013.ISSN 1537-6613Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Infectious DiseasesImpact index in year of publication: 5,997 Journal in the top 25%: YesPosition of publication: 4 No. of journals in the cat.: 119

17 Alda Lisa Concia; Livia Gómez; Jordi Bujons; Teodor Parella; Cristina Vilaplana; Pere Joan Cardona; JesúsJoglar; Pere Clapés. Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LABderivatives.Organic & biomolecular chemistry. 11 - 12, pp. 2005 - 2026. 28/03/2013. ISSN 1477-0539Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - CHEMISTRY, ORGANICImpact index in year of publication: 3,562 Journal in the top 25%: YesPosition of publication: 12 No. of journals in the cat.: 58

18 Lucía Sanjurjo; Núria Amézaga; Cristina Vilaplana; Neus Cáceres; Elena Marzo; Marta Valeri; Pere-Joan Cardona;Maria-Rosa Sarrias. The scavenger protein apoptosis inhibitor of macrophages (AIM) potentiates the antimicrobialresponse against Mycobacterium tuberculosis by enhancing autophagy.PloS one. 8 - 11, pp. e79670. 2013. ISSN1932-6203Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MULTIDISCIPLINARY


19 Livia Gómez; Xavier Garrabou; Jesús Joglar; Jordi Bujons; Teodor Parella; Cristina Vilaplana; Pere JoanCardona; Pere Clapés. Chemoenzymatic synthesis, structural study and biological activity of novel indolizidineand quinolizidine iminocyclitols.Organic & biomolecular chemistry. 10 - 31, pp. 6309 - 6330. 21/08/2012. ISSN1477-0539

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Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - CHEMISTRY, ORGANICImpact index in year of publication: 3,562 Journal in the top 25%: YesPosition of publication: 12 No. of journals in the cat.: 58

20 Cristina Vilaplana; Clara Prats; Elena Marzo; Carles Barril; Isaac Llopis; Jorge Diaz; Joaquim Valls; Daniel López;Pere-Joan Cardona. A two-compartment system allows lymphatic tissues to control M. tuberculosis infection in theperipheral organs. Immunology. 137 - 1, pp. 595 - 596. 2012.Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 3,795 Journal in the top 25%: NoPosition of publication: 45 No. of journals in the cat.: 148

21 Neus Caceres; Isaac Llopis; Elena Marzo; Clara Prats; Cristina Vilaplana; Dario Garcia de Viedma; Sofía Samper;Daniel Lopez; Pere-Joan Cardona. Low dose aerosol fitness at the innate phase of murine infection betterpredicts virulence amongst clinical strains of Mycobacterium tuberculosis.PloS one. 7 - 1, pp. e29010. 2012. ISSN1932-6203Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MULTIDISCIPLINARY


22 Lucía Sanjurjo; Núria Amézaga; Cristina Vilaplana; Neus Cáceres; Elena Marzo; Maria-Rosa Sarrias. TheScavenger protein Spalpha modulates the macrophage response to Mycobacterium tuberculosis.Immunology. 137- 1, pp. 149 - 149. 2012. ISSN 0019-2805Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 3,795 Journal in the top 25%: NoPosition of publication: 45 No. of journals in the cat.: 148

23 Heinner Guio; Cristina Vilaplana; Pere-Joan Cardona. [Immunodiagnosis and biomarkers in tuberculosis].Medicinaclinica. 137 - 9, pp. 408 - 421. (Spain): 08/10/2011. ISSN 0025-7753Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MEDICINE, GENERAL &

INTERNALImpact index in year of publication: 1,417 Journal in the top 25%: NoPosition of publication: 69 No. of journals in the cat.: 154

24 Cristina Vilaplana; Olga Gil; Neus Cáceres; Sergio Pinto; Jorge Díaz; Pere-Joan Cardona. Prophylactic effect ofa therapeutic vaccine against TB based on fragments of Mycobacterium tuberculosis.PloS one. 6 - 5, pp. e20404.2011. ISSN 1932-6203Type of production: Scientific paper Format: JournalCorresponding author: No

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Impact source: ISI Category: Science Edition - MULTIDISCIPLINARYSCIENCES

Impact index in year of publication: 3,234 Journal in the top 25%: YesPosition of publication: 9 No. of journals in the cat.: 57

25 Cristina Vilaplana; Pere-Joan Cardona. Tuberculin immunotherapy: its history and lessons to be learned.Microbesand infection / Institut Pasteur. 12 - 2, pp. 99 - 204. (France): 02/2010. ISSN 1769-714XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 2,861 Journal in the top 25%: NoPosition of publication: 44 No. of journals in the cat.: 119

26 Cristina Vilaplana; Eva Montané; Sergio Pinto; Ana-María Barriocanal; Gema Domenech; Ferran Torres;Pere-Joan Cardona; Joan Costa. Double-blind, randomized, placebo-controlled Phase I Clinical Trial of thetherapeutical antituberculous vaccine RUTI.Vaccine. 28 - 4, pp. 1106 - 1122. 22/01/2010. ISSN 1873-2518Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MEDICINE, RESEARCH &


27 Olga Gil; Ivan Díaz; Cristina Vilaplana; Gustavo Tapia; Jorge Díaz; María Fort; Neus Cáceres; Sergio Pinto;Joan Caylà; Leigh Corner; Mariano Domingo; Pere-Joan Cardona. Granuloma encapsulation is a key factor forcontaining tuberculosis infection in minipigs.PloS one. 5 - 4, pp. e10030. 2010. ISSN 1932-6203Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - MULTIDISCIPLINARY


28 Mariano Domingo; Olga Gil; Erika Serrano; Evelyn Guirado; Miguel Nofrarias; M Grassa; Neus Cáceres; BernatPérez; Cristina Vilaplana; Pere-Joan Cardona. Effectiveness and safety of a treatment regimen based on isoniazidplus vaccination with Mycobacterium tuberculosis cells' fragments: field-study with naturally Mycobacteriumcaprae-infected goats.Scandinavian journal of immunology. 69 - 6, pp. 500 - 507. 06/2009. ISSN 1365-3083Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 1,739 Journal in the top 25%: NoPosition of publication: 123 No. of journals in the cat.: 148

29 Neus Cáceres; Gustavo Tapia; Isabel Ojanguren; Frederic Altare; Olga Gil; Sergio Pinto; Cristina Vilaplana;Pere-Joan Cardona. Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosismodels.Tuberculosis (Edinburgh, Scotland). 89 - 2, pp. 175 - 257. 03/2009. ISSN 1873-281XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - RESPIRATORY SYSTEM

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Impact index in year of publication: 2,711 Journal in the top 25%: NoPosition of publication: 24 No. of journals in the cat.: 58

30 Olga Gil; Cristina Vilaplana; Evelyn Guirado; Jorge Díaz; Neus Cáceres; Mahavir Singh; Pere-Joan Cardona.Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosisrelapse.Clinical and vaccine immunology : CVI. 15 - 11, pp. 1742 - 1746. 11/2008. ISSN 1556-679XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Infectious DiseasesImpact index in year of publication: 2,470 Journal in the top 25%: NoPosition of publication: 43 No. of journals in the cat.: 78

31 Evelyn Guirado; Olga Gil; Neus Cáceres; Mahavir Singh; Cristina Vilaplana; Pere-Joan Cardona. Inductionof a specific strong polyantigenic cellular immune response after short-term chemotherapy controls bacillaryreactivation in murine and guinea pig experimental models of tuberculosis.Clinical and vaccine immunology : CVI.15 - 8, pp. 1229 - 1266. 08/2008. ISSN 1556-679XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - INFECTIOUS DISEASESImpact index in year of publication: 2,470 Journal in the top 25%: NoPosition of publication: 43 No. of journals in the cat.: 78

32 Cristina Vilaplana; Juan Ruiz Manzano; Olga Gil; Federico Cuchillo; Eva Montané; Mahavir Singh; Ralph Spallek;Vicenç Ausina; Pere-Joan Cardona. The tuberculin skin test increases the responses measured by T cellinterferon-gamma release assays.Scandinavian journal of immunology. 67 - 6, pp. 610 - 617. 06/2008. ISSN1365-3083Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 1,739 Journal in the top 25%: NoPosition of publication: 123 No. of journals in the cat.: 148

33 Silvia Blanco; Cristina Prat; María-Dolores Sánchez; D Ferrer; T Pellicer; L Haba; I Latorre; Cristina Vilaplana;Vicente Ausina; J Domínguez. Evaluation of a Legionella urinary antigen enzyme immunoassay for rapid detectionof Legionella pneumophila in water samples.International journal of hygiene and environmental health. 211 - 1-2,pp. 168 - 239. (Germany): 03/2008. ISSN 1438-4639Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - PUBLIC,

ENVIRONMENTAL & OCCUPATIONAL HEALTHImpact index in year of publication: 3,829 Journal in the top 25%: YesPosition of publication: 18 No. of journals in the cat.: 165

34 Sergi Gordillo; Evelyn Guirado; Olga Gil; Jorge Díaz; Isabel Amat; Sonia Molinos; Cristina Vilaplana; VicenteAusina; Pere-Joan Cardona. Usefulness of acr expression for monitoring latent Mycobacterium tuberculosis bacilliin 'in vitro' and 'in vivo' experimental models.Scandinavian journal of immunology. 64 - 1, pp. 30 - 39. 07/2006.ISSN 0300-9475Type of production: Scientific paper Format: JournalCorresponding author: No

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Impact source: ISI Category: Science Edition - IMMUNOLOGYImpact index in year of publication: 1,739 Journal in the top 25%: NoPosition of publication: 123 No. of journals in the cat.: 148

35 Olga Gil; Evelyn Guirado; Sergi Gordillo; Jorge Díaz; Gustavo Tapia; Cristina Vilaplana; Aurelio Ariza; VicençAusina; Pere-Joan Cardona. Intragranulomatous necrosis in lungs of mice infected by aerosol with Mycobacteriumtuberculosis is related to bacterial load rather than to any one cytokine or T cell type.Microbes and infection /Institut Pasteur. 8 - 3, pp. 628 - 664. (France): 03/2006. ISSN 1286-4579Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - INFECTIOUS DISEASESImpact index in year of publication: 2,861 Journal in the top 25%: NoPosition of publication: 31 No. of journals in the cat.: 78

36 Pere-Joan Cardona; Isabel Amat; Sergi Gordillo; Virginia Arcos; Evelyn Guirado; Jorge Díaz; Cristina Vilaplana;Gustavo Tapia; Vicente Ausina. Immunotherapy with fragmented Mycobacterium tuberculosis cells increases theeffectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis.Vaccine. 23 - 11, pp.1393 - 1401. 03/02/2005. ISSN 0264-410XType of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - IMMUNOLOGYImpact index in year of publication: 3,624 Journal in the top 25%: NoPosition of publication: 51 No. of journals in the cat.: 148

37 Eduardo Padilla; Victoria González; Jose María Manterola; Andrés Pérez; María Dolores Quesada; SergioGordillo; Cristina Vilaplana; María Angeles Pallarés; Sonia Molinos; María Dolores Sánchez; Vicente Ausina.Comparative evaluation of the new version of the INNO-LiPA Mycobacteria and genotype Mycobacterium assaysfor identification of Mycobacterium species from MB/BacT liquid cultures artificially inoculated with Mycobacterialstrains.Journal of clinical microbiology. 42 - 7, pp. 3083 - 3091. 07/2004. ISSN 0095-1137Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,993 Journal in the top 25%: YesPosition of publication: 26 No. of journals in the cat.: 119

38 Victoria González; Eduardo Padilla; M Giménez; Cristina Vilaplana; Andrés Pérez; G Fernández; M D Quesada;María Angeles Pallarés; Vicente Ausina. Rapid diagnosis of Staphylococcus aureus bacteremia using S. aureusPNA FISH.European journal of clinical microbiology & infectious diseases : official publication of the EuropeanSociety of Clinical Microbiology. 23 - 5, pp. 396 - 404. (Germany): 05/2004. ISSN 0934-9723Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: Infectious DiseasesImpact index in year of publication: 2,668 Journal in the top 25%: NoPosition of publication: 36 No. of journals in the cat.: 78

39 Cristina Vilaplana; S Blanco; J Domínguez; M Giménez; Vicente Ausina; Cristina Tural; Carme Muñoz.Noninvasive method for diagnosis of visceral leishmaniasis by a latex agglutination test for detection of antigens inurine samples.Journal of clinical microbiology. 42 - 4, pp. 1853 - 1857. 04/2004. ISSN 0095-1137Type of production: Scientific paper Format: Journal

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Corresponding author: NoImpact source: ISI Category: MicrobiologyImpact index in year of publication: 3,993 Journal in the top 25%: YesPosition of publication: 26 No. of journals in the cat.: 119

40 Pere-Joan Cardona; Sergi Gordillo; Jorge Díaz; Gustavo Tapia; Isabel Amat; Angeles Pallarés; Cristina Vilaplana;Aurelio Ariza; Vicenç Ausina. Widespread bronchogenic dissemination makes DBA/2 mice more susceptible thanC57BL/6 mice to experimental aerosol infection with Mycobacterium tuberculosis.Infection and immunity. 71 - 10,pp. 5845 - 5899. 10/2003. ISSN 0019-9567Type of production: Scientific paper Format: JournalCorresponding author: NoImpact source: ISI Category: ImmunologyImpact index in year of publication: 3,731 Journal in the top 25%: NoPosition of publication: 47 No. of journals in the cat.: 148

41 Pere Joan Cardona; Sergi Gordillo; Isabel Amat; Jorge Díaz; Joan Lonca; Cristina Vilaplana; Angeles Pallarés;Roger Llatjós; Aurelio Ariza; Vicente Ausina. Catalase-peroxidase activity has no influence on virulence in a murinemodel of tuberculosis.Tuberculosis (Edinburgh, Scotland). 83 - 6, pp. 351 - 360. 2003. ISSN 1472-9792Type of production: Scientific paper Format: JournalImpact source: ISI Category: MicrobiologyImpact index in year of publication: 2,711 Journal in the top 25%: NoPosition of publication: 53 No. of journals in the cat.: 119

42 Sebastián Santaeugenia; Mónica Sanmartí; Cristina Vilaplana; Alejandro Olivé. [Morganella morgagnii septicarthritis].Medicina clinica. 118 - 10, pp. 399. (Spain): 23/03/2002. ISSN 0025-7753Type of production: Scientific paper Format: JournalImpact source: ISI Category: Science Edition - MEDICINE, GENERAL &

INTERNALImpact index in year of publication: 1,417 Journal in the top 25%: NoPosition of publication: 69 No. of journals in the cat.: 154

43 Alimuddin Zumla; Markus Maeurer; Jeremiah Chakaya; Michael Hoelscher; Francine Ntoumi; Roxana Rustomjee;Cristina Vilaplana; Dorothy Yeboah Manu; Voahangy Rasolof; Paula Munderi; Nalini Singh; Eleni Aklillu; NesriPadayatchi; Eusebio Macete; Nathan Kapata; Modest Mulenga; Gibson Kibiki; Sayoki Mfinanga; ThomasNyirenda; Leonard Maboko; Alberto Garcia Basteiro; Niaina Rakotosamimanana; Matthew Bates; Peter Mwaba;Klaus Reither; Sebastien Gagneux; Sarah Edwards; Elirehema Mfinanga; Salim Abdulla; Pere-Joan Cardona;James B W Russell; Vanya Gant; Mahdad Noursadeghi; Paul Elkington; Maryline Bonnet; Clara Menendez;Tandakha N Dieye; Bassirou Diarra; Almoustapha Maiga; Abraham Aseffa; Shreemanta Parida; Christian Wejse;Eskild Petersen; Pontiano Kaleebu; Matt Oliver; Gill Craig; Tumena Corrah; Leopold Tientcheu; Martin Antonio;Martin Rao; Timothy D McHugh; Aziz Sheikh; Giuseppe Ippolito; Gita Ramjee; Stefan H E Kaufmann; GavinChurchyard; Andrie Steyn; Martin Grobusch; Ian Sanne; Neil Martinson; Rajhmun Madansein; Robert J Wilkinson;Bongani Mayosi; Marco Schito; Robert S Wallis. Towards host-directed therapies for tuberculosis.Nature reviews.Drug discovery. 14 - 8, pp. 511 - 513. 08/2015. ISSN 1474-1784Type of production: Review Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - PHARMACOLOGY &

PHARMACYImpact index in year of publication: 41,908 Journal in the top 25%: YesPosition of publication: 1 No. of journals in the cat.: 255

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44 Vicente Ausina Ruiz; Gema Fernández Rivas; Cristina Vilaplana Messeguer. Selected culture anddrug-susceptibility testing methods for drug-resistant Mycobacterium tuberculosis screening inresource-constrained settings.Expert review of molecular diagnostics. 13 - 3, pp. 247 - 256. 04/2013. ISSN1744-8352Type of production: Review Format: JournalCorresponding author: NoImpact source: ISI Category: Science Edition - PATHOLOGYImpact index in year of publication: 3,516 Journal in the top 25%: YesPosition of publication: 15 No. of journals in the cat.: 76

Works submitted to national or international conferences

1 Title of the work: Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependetimmunodominant response overlapping the 2F5 binding motifName of the conference: HIV Research for Prevention (HIVR4P)Type of participation: 'Participatory - posterCity of event: Chicago,Date of event: 17/10/2016End date: 21/10/2016Organising entity: HIVR4P

2 Title of the work: Correlating Clinical and Experimental PathologyCity of event: Empúries,Date of event: 08/06/2016End date: 10/06/2016Organising entity: Unitat de Tuberculosi Experimental

3 Title of the work: MODELING TUBERCULOSIS IN BARCELONA. A SOLUTION TO SPEED-UPAGENT-BASED SIMULATIONSName of the conference: Proceedings of the 2015 Winter Simulation ConferenceType of event: ConferenceCity of event: Huntington Beach, California,Date of event: 06/12/2015End date: 09/12/2015Organising entity: SOCIAL AND BEHAVORIAL SIMULATION

4 Title of the work: PHASE I, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIALWITH THE PROBIOTIC NYADITUM RESAE® IN ADULTS WITH OR WITHOUT LATENT TUBERCULOSISINFECTION.Name of the conference: 12º Congreso de la EACPTCity of event: Madrid, Community of Madrid, SpainDate of event: 27/06/2015End date: 30/06/2015Organising entity: European Association for clinicalpharmatology and therapeutics


Ana Mº Barriocanal; Ana Lucia Arellano; Yolanda Sanz; Angélica Valderrama; Pere-Joan Cardona; CristinaVilaplana; Eva Montané.

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5 Title of the work: From Latent Infection to Active Disease: new experimental and mathematical approachesin tuberculosis researchName of the conference: MYCOMADType of event: ConferenceCity of event: Madrid, SpainDate of event: 19/06/2015Organising entity: Meeting MycoClub 2015Cristina Vilaplana; Carla Prats.

6 Title of the work: Ongoing/Planned HDT trials: repurposed drugs and immunomodulatory agents with ananti-inflammatory componentName of the conference: Africa-Europe HDT TB Clinical Trials Network ConferenceCity of event: Cape Town, South African RepublicDate of event: 07/04/2015End date: 07/04/2015Organising entity: MRC South Africa Type of entity: Administrative Body of the National

Health SystemCity organizing entity: Badalona, SpainCristina Vilaplana Massaguer.

7 Title of the work: Mathematical approaches to better understand and tackle tuberculosisName of the conference: 45th Union World Conference on Lung HealthType of participation: Participatory - oral communicationCity of event: Barcelona, SpainDate of event: 10/2014Organising entity: International Union Against Tuberculosis and Lung DiseaseCristina Vilaplana; Pere-Joan Cardona.

8 Title of the work: Clinical trial with the food supplement Nyaditum resae®: a new tool to reduce the risk ofdeveloping active tuberculosisName of the conference: 45Th Union World Conference on Lung HealthType of participation: 'Participatory - posterCity of event: Barcelona, SpainDate of event: 09/2014Organising entity: International Union Against Tuberculosis and Lung HealthE Montané; AM Barriocanal; AL Arellano; A Valderrama; Y Sanz; P Cardona; C Vilaplana; PJ Cardona.

9 Title of the work: Adjunct host-directed therapies: low-dose aspirin to treat tuberculosis (TB)Name of the conference: 9th International Conference on the Pathogenesis of Mycobacterial InfectionType of event: ConferenceType of participation: 'Participatory - posterCity of event: Saltsjobaden, SwedenDate of event: 26/06/2014End date: 29/06/2014Elena Marzo; Paula Cardona; Jorge Diaz; Vanessa Garcia; Ismael Varela; Sonia Rebollo; Antoni Planella;Pere-Joan Cardona; Cristina Vilaplana.

10 Title of the work: Low-dose aspirin, co-adjuvant for standard active TB treatment?Name of the conference: Mycoval congressType of participation: Participatory - invited/keynote talkCity of event: Valencia, Spain

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Date of event: 06/2014Cristina Vilaplana.

11 Title of the work: Nyaditum resae®, a new immunomodulatory compound to prevent and treat activetuberculosis (TB)Name of the conference: 9Th International Conference on the Pathogenesis of Mycobacterial InfectionType of participation: Participatory - oral communicationCity of event: Saltsjobaden, SwedenDate of event: 06/2014Elena Marzo; Paula Cardona; Jorge Diaz; Vanessa Garcia; Sonia Rebollo; Antoni Planella; CristinaVilaplana; Pere-Joan Cardona.

12 Title of the work: Could the common anti-inflammatories be the new coadjucant treatment against TB?Name of the conference: 44th Union World Conference on Lung HealthCity of event: Paris, FranceDate of event: 11/2013C Vilaplana; PJ Cardona.

13 Title of the work: An acute and intensive neutrophilic reaction makes possible the progression from latentinfection to active TB.Name of the conference: Front Range Mycobacteria ConferenceCity of event: Fort Collins, Colorado, United States of AmericaDate of event: 2013Elena Marzo; Cristina Vilaplana; Gustavo Tapia; Jorge Diaz; Vanessa Garcia; Pere-Joan Cardona.

14 Title of the work: Spatial growth of M.tuberculosis in lungs: the bubble model.Name of the conference: BioMicroWorld 2013. V Environmental, Industrial and Applied MicrobiologyType of participation: Participatory - oral communicationCity of event: Madrid, SpainDate of event: 2013Clara Prats; Joaquim Valls; Cristina Vilaplana; Elena Marzo; Pere-Joan Cardona; Daniel López Codina.

15 Title of the work: ¿Ibuprofeno o aspirina en el tratamiento contar la tuberculosis?”.Name of the conference: UITBType of participation: Participatory - invited/keynote talkCity of event: Barcelona, SpainDate of event: 2013City organizing entity: Badalona, SpainCristina Vilaplana.

16 Title of the work: A two-compartment system allows lymphatic tissues to control M. tuberculosis infection inthe peripheral organsName of the conference: Mycospain 2012Type of participation: Participatory - invited/keynote talkCity of event: Tres Cantos, SpainDate of event: 2012Organising entity: GLAXOSMITHKLLINE (GSK)

17 Title of the work: Characterization of a new model of active TB in mice.Usefulness of anti-inflammatorytherapy in the treatment of TB.Name of the conference: Tuberculosis.

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City of event: Paris, FranceDate of event: 2012Organising entity: Intitut PasteurElena Marzo; Cristina Vilaplana; Gustavo Tapia; Jorge Diaz; Vanessa Garcia; Pere-Joan Cardona.

18 Title of the work: Desarrollo clínico de la estrategia RUTI para la inmunoterapia de la infección latentetuberculosisName of the conference: XVI Reunion del Grupo Español de micobacteriologia GEMType of participation: Participatory - invited/keynote talkCity of event: Cordoba, SpainDate of event: 2012Cristina Vilaplana; Pere-Joan Cardona.

19 Title of the work: The Scavenger protein Spα modulates the macrophage response to M. tuberculosisName of the conference: European Congress of Immunology : ECICity of event: Glasgow, United KingdomDate of event: 2012Organising entity: European Immunology SocietyLucia Sanjurjo; Nuria Amezaga; Cristina Vilaplana; Neus Caceres; Elena Marzo; Pere-Joan Cardona; MariaRosa Sarrias.

20 Title of the work: Aggregation dynamics and uctuations in in vitro cultures of Mycobacterium tuberculosisName of the conference: XVII Congreso de Física Estadística.City of event: Barcelona, SpainDate of event: 2011Isaac Llopis; Neus Caceres; Clara Prats; Cristina Vilaplana; Pere-Joan Cardona; Daniel Lopez-Codina.

21 Title of the work: New insights on the virulence determination of M.tuberculosis clinical strains by applyingdifferent “in vitro” and “in vivo” strategies.Name of the conference: Eight International Conference on the Pathogenesis of Mycobacterial Infections.City of event: Salsjöbaden, SwedenDate of event: 2011Neus Caceres; Isaac Llopis; Elena Marzo; Cristina Vilaplana; Jorge Diaz; Maria Alonso; Dario Garcia deViedma; Henar Alonso; Sofia Samper; Clara Prats; Daniel Lopez-Codina; Pere-Joan Cardona.

22 Title of the work: The Cavity Model:: a new SCID mice model mimicking disease to evaluateanti-tuberculosis treatmentsName of the conference: Eight International Conference on the Pathogenesis of Mycobacterial InfectionsCity of event: Salsjöbaden, SwedenDate of event: 2011Cristina Vilaplana; Jorge Diaz; Giovanni Piccaro; Gustavo Tapia; Neus Caceres; Elena Marzo; VanessaGarcia; Lanfranco Fattorini; Pere-Joan Cardona.

23 Title of the work: The Granuloma: friend or foe?Name of the conference: Tuberculosis Update MeetingType of participation: Participatory - invited/keynote talkCity of event: Bogota, ColombiaDate of event: 2010Organising entity: CorpoGenCristina Vilaplana.

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24 Title of the work: Combined therapy with isonazid and RUTI is safe and effective in a new latenttuberculosis infection model in mini-pigs.Name of the conference: Tuberculosis: Biology, Phatology and Therapy. Keystone Symposia GlobalHealth Series 2009.Type of participation: 'Participatory - posterCity of event: Keystone, Colorado, United States of AmericaDate of event: 01/2009PJ Cardona; O Gil; I Díaz; C Vilaplana; E Guirardo; N Caceres; M Domingo; L Corner.

25 Title of the work: RUTI effectiveness as a BCG-boosting vaccine and as a fast-prophylactic vaccine inM.tuberculosis aerosol-infected mice modelsName of the conference: Keystone Symposia. Tuberculosis: Biology, Pathology and Therapy.City of event: Keystone Resort, Keystone, Colorado, United States of AmericaDate of event: 2009City organizing entity: United States of AmericaNeus Caceres; Olga Gil; Jorge Diaz; Vanessa Garcia; Ralf Spalleck; Mahavir Singh; Cristina Vilaplana;Pere-Joan Cardona.

26 Title of the work: Resultados definitivos del ensayo clínico de Fase 1 de la vacuna RUTI. Lacomercialización, más cerca.Name of the conference: III Reunión de Laboratorios de Micobacterias: MycospainType of participation: Participatory - invited/keynote talkCity of event: San Lorenzo del Escorial, SpainDate of event: 2009Organising entity: Universidad Autónoma de Madrid Type of entity: UniversityCristina Vilaplana.

27 Title of the work: Therapy with fragments of Mycobacterium tuberculosis after a short-term chemotherapywith isoniazid in a new latent tuberculosis infection model in mini-pigs is safe and effective.Name of the conference: The 8th Elsinore Meeting on Infection Immunity.City of event: Elsinore, DenmarkDate of event: 2009Olga Gil; Jorge Diaz; Cristina Vilaplana; Evelyn Guirado; Neus Caceres; Mariano Domingo; Gustavo Tapia;Leigh Corner; Pere-Joan Cardona.

28 Title of the work: Foamy macrophages are the key cells that allow persistence and dissemination ofMycobacterium tuberculosis infectionName of the conference: Seventh International Confernece on the Pathogenesis fo MycobacterialInfections.Type of participation: 'Participatory - posterCity of event: Saltsjobaden, SwedenDate of event: 06/2008Neus Caceres; Gustavo Tapia; Isabel Ojanguren; Olga Gil; Sergio Pinto; Xavier Vallès; Cristina Vilaplana;Pere-Joan Cardona.

29 Title of the work: Phase 1 Clinical Trial of a therapeutical vaccine against Latent Tuberculosis (RUTI):Preliminar Results.Name of the conference: Seventh International Confernece on the Pathogenesis fo MycobacterialInfectionsType of participation: 'Participatory - posterCity of event: Salstjobaden, SwedenDate of event: 06/2008

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Cristina Vilaplana; Sergio Pinto; Juan Ruiz Manzano; Mahavir Singh; Ralph Spallek; Eva Montané; JoanCosta; Pere-Joan Cardona.

30 Title of the work: The dynamic hypothesis offers a new rational to develoup future therapeutic strategiesagainst latent tuberculosis infection, like a short-tem chemotherapy plus vaccination with RUTI.Name of the conference: Seventh International Conference on the Pathogenesis for MycobacterialInfections.Type of participation: 'Participatory - posterCity of event: Saltsjobaden, SwedenDate of event: 06/2008Olga Gil; Neus Caceres; Evelyn Guirado; Gustavo Tapia; Cristina Vilaplana; Pere-Joan Cardona.

31 Title of the work: Desarrollo clínico de la vacuna terapéutica RUTI. Resultados de la Fase 1.Name of the conference: Mycospain IIType of event: WorkshopType of participation: Participatory - invited/keynote talkCity of event: Alquezar, SpainDate of event: 2008Organising entity: Universidad de Zaragoza Type of entity: UniversityCristina Vilaplana.

32 Title of the work: Efecto terapéutico de la vacuna RUTI en la infección tuberculosa latente. Nuevasaproximaciones a través del modelo experimental en minipig.Name of the conference: XIII Congreso de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica.City of event: Madrid, SpainDate of event: 2008Olga Gil; Jorge Diaz; Cristina Vilaplana; Evelyn Guirado; Neus Caceres; Mariano Domingo; Leigh Corner;Pere-Joan Cardona.

33 Title of the work: La vacuna terapéutica RUTI, segura e inmunogénica. Estudio de Fase 1, resultadospreliminaresName of the conference: XIII Congreso de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica.City of event: Madrid, SpainDate of event: 2008Cristina Vilaplana; Sergio Pinto; Juan Ruiz-Manzano; Eva Muntané; Joan Costa; Pere-Joan Cardona.

34 Title of the work: Los macrófagos espumosos son las células clave que permiten la persistencia y ladiseminación de la infección por Mycobacterium tuberculosis.Name of the conference: XIII Congreso de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica.City of event: Madrid, SpainDate of event: 2008Neus Caceres; Gustavo Tapia; Isabel Ojanguren; Olga Gil; Sergio Pinto; Cristina Vilaplana; Pere-JoanCardona.

35 Title of the work: Origin and evolution of foamy macrophages: the key cells that allow the evasion andsurvival of Mycobacterium tuberculosis out of the granulomas.Name of the conference: 108th General Meeting of American Society for Microbiology.City of event: Boston, United States of AmericaDate of event: 2008

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Pere-Joan Cardona; Neus Caceres; Gustavo Tapia; Isabel Ojanguren; Frederic Altare; Olga Gil; SergioPinto; Cristina Vilaplana.

36 Title of the work: Preliminary Results of tolerability and immunogenicity of RUTI antituberculous vaccine: arandomised, double-blinde, placebo-controlled Phase I trial.Name of the conference: XIX Congreso de la Sociedad Española de Farmacología Clínica.City of event: Barcelona, SpainDate of event: 2008Eva Muntane; Cristina Vilaplana; Anabel Barriocanal; S Anzola; E Portabella; Nuria Lopez; F Garcia; SergioPinto; Carlos Ferrandiz; Juan Ruiz-Manzano; Pere-Joan Cardona; Joan Costa.

37 Title of the work: Resultados obtenidos en el modelo tuberculosis murino experimental por aerosol deRUTI como candidato de vacuna profiláctica contra la infección por Mycobacterium tuberculosis.Name of the conference: IX Congreso SECALType of participation: Participatory - oral communicationCity of event: Córdoba, SpainDate of event: 11/2007J Díaz; E Moliner; S Pinto; N Cáceres; E Guirado; O Gil; I Amat; M Singh; C Vilaplana; PJ Cardona.

38 Title of the work: El control de la infección tuberculosa latente inducido por RUTI después deun tratamiento corto de quimioterapia se relaciona con un augmento de células T CD4+ y CD8+antígeno-específicas contra antígenos secretados y estructurales.Name of the conference: 40º Congreso Nacional de la Sociedad Española de Neumología y CirugíaTorácica.Date of event: 2007Organising entity: Sociedad Española deNeumología y Cirugía Torácica


Evelyn Guirado; Olga Gil; Cristina Vilaplana; Neus Caceres; Daniel Rivas; Jorge Diaz; Pere-Joan Cardona.

39 Title of the work: El test cutáneo de la tuberculinea (TST) aumenta los valores de los ensayos de liberaciónde interferón-gamma (IGRA).Name of the conference: XII Reunión de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica (SEIMC).City of event: La Coruña, SpainDate of event: 2007Cristina Vilaplana; Juan Ruiz-Manzano; Olga Gil; Federico Cuchillo; Eva Muntane; Mahavir Singh; RalfSpalleck; Vicente Ausina; Pere-Joan Cardona.

40 Title of the work: Inoculation of RUTI, a therapeutic vaccine against latent tuberculosis infection, has aprophylactic effect against Mycobacterium tuberculosis infection in a murine experimental model.Name of the conference: Keystone Symposia on Molecular and Cellular BiologyCity of event: Vancouver, CanadaDate of event: 2007Cristina Vilaplana; Evelyn Guirado; Isabel Amat; Olga Gil; Mahavir Singh; Pere-Joan Cardona.

41 Title of the work: La inoculación de RUTI-vacuna terapéutica contra la infección tuberculosa latente tieneun efecto profiláctico contra la infección por Mycobacterium tuberculosis en un modelo experimental deratón.Name of the conference: 40º Congreso Nacional de la Sociedad Española de Neumología y CirugíaTorácica.City of event: Barcelona, SpainDate of event: 2007

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Organising entity: Sociedad Española deNeumología y Cirugía Torácica


Cristina Vilaplana; Evelyn Guirado; Isabel Amat; Olga Gil; Mahavir Singh; Pere-Joan Cardona.

42 Title of the work: La vacuna terapéutica RUTI induce un aumento de células T CD4+IFNG+ Y TCD8+IFNG+específicas contra antígenos micobacterianos secretados y estructurales.Name of the conference: XII Reunión de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica (SEIMC).City of event: La Coruña, SpainDate of event: 2007Organising entity: Sociedad Española deEnfermedades Infecciosas y Microbiología Clínica


Evelyn Guirado; Olga Gil; Neus Caceres; Cristina Vilaplana; Isabel Amat; Jorge Diaz; Pere-Joan Cardona.

43 Title of the work: RUTI increases CD4+ IFNy+ and CD8+ IFNy+ specific T cells against structural andsecreted antigens from M. Tuberculosis.Name of the conference: Keystone Symposia on Molecular and Cellular BiologyCity of event: Vancouver, CanadaDate of event: 2007Evelyn Guirado; Olga Gil; Neus Caceres; Mahavir Singh; Cristina Vilaplana; Pere-Joan Cardona.

44 Title of the work: RUTI, a therapeutic vaccine design to shorten latent tuberculosis infection,is based on thedynamic hyphotesis.Name of the conference: Keystone Symposia on Molecular and Cellular BiologyCity of event: Cape Town, South African RepublicDate of event: 2007Pere-Joan Cardona; Isabel Amat; Sergio Pinto; Cristina Vilaplana.

45 Title of the work: RUTI, un nuevo candidato de vacuna profiláctica contra la infección por Mycobacteriumtuberculosis.Name of the conference: XII Reunión de la Sociedad Española de Enfermedades Infecciosas yMicrobiología Clínica (SEIMC).City of event: La Coruña, SpainDate of event: 2007Organising entity: Sociedad Española deEnfermedades Infecciosas y Microbiología Clínica


Cristina Vilaplana; Evelyn Guirado; Isabel Amat; Olga Gil; Mahavir Singh; Pere-Joan Cardona.

46 Title of the work: Tuberculin Skin Test (TST) increases the value of interferon-y release asays (IGRA).Name of the conference: Keystone Symposia on Molecular and Cellular BiologyCity of event: Vancouver, CanadaDate of event: 2007Cristina Vilaplana; Juan Ruiz-Manzano; Olga Gil; Federico Cuchillo; Eva Muntane; Mahavir Singh; RalfSpalleck; Vicente Ausina; Pere-Joan Cardona.

47 Title of the work: Immunotherapy with RUTI will allow short-course chemotherapy against latenttuberculosis infectionName of the conference: 37th World Conference on Lung Health of the International Union AgainstTuberculosis and Lung Disease (The Union).Type of participation: Participatory - oral communicationCity of event: Paris, FranceDate of event: 2006

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Organising entity: International Union AgainstTuberculosis and Lung Disease (The Union).


Pere-Joan Cardona; Isabel Amat; Evelyn Guirado; Olga Gil; Neus Caceres; Cristina Vilaplana.

Works submitted to national or international seminars, workshops and/or courses

1 Title of the work: De Txéchov a Kafka, el que hem après de la tuberculosiName of the event: Sessió interna CAP DrassanesCorresponding author: YesCity of event: Barcelona, SpainDate of event: 18/04/2016Organising entity: Centro de Prevención y Controlde la Tuberculosis


Cristina Vilaplana.

2 Title of the work: De Txéchov a Kafka, el que hem après de la tuberculosiName of the event: Fórum científico; sesión especial del Día Mundial de la TuberculosisCorresponding author: YesCity of event: Barcelona, SpainDate of event: 17/03/2016Organising entity: Fundación Unidad deInvestigación en Tuberculosis de Barcelona

Type of entity: Foundation

Cristina Vilaplana.

3 Title of the work: Un nuevo modelo experimental murino para estudiar la tuberculosis latente y el papel delos antiinflamatorios: nuevas ideas para problemas viejosName of the event: VII Jornadas Científicas del CIBERESReasons for participation: SpeakerCity of event: Madrid,Date of event: 2013Organising entity: CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)Cristina Vilaplana.

4 Title of the work: Evaluación de nuevas estrategias terapéuticas contra la tuberculosis en modelosexperimentalesName of the event: VI Jornadas Científicas del CIBERESReasons for participation: SpeakerCity of event: Madrid,Date of event: 2012Organising entity: CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)Cristina Vilaplana.

5 Title of the work: Vacunes: realitats i promeses de la ImmunologiaName of the event: XIX Jornades de la Societat Catalana d'ImmunologiaType of event: WorkshopReasons for participation: Upon invitationCity of event: Barcelona, SpainDate of event: 2005Organising entity: Societat Catalana d'ImmunologiaCristina Vilaplana.

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Other dissemination activities

Title of the work: "Què és fer ciència?"Name of the event: II dia de la CiènciaType of event: Conferences givenCity of event: Badalona, SpainDate of event: 2011Organising entity: Ajuntament de Badalona

R&D management and participation in scientific committees

Organization of R&D activities

1 Title of the activity: MycoBCN MycoNET MeetingType of activity: MeetingConvening entity: Unitat de Tuberculosi Experimental; Universitat Autònoma de Barcelona.City convening entity: Badalona,Start-End date: 29/09/2016 - 30/09/2016 Duration: 2 days

2 Title of the activity: Correlating Clinical and Experimental PathologyType of activity: International Scientific Conference Geographical area: Non EU InternationalConvening entity: Unitat de Tuberculosi ExperimentalCity convening entity: Empúries, Catalonia, SpainStart-End date: 08/06/2016 - 10/06/2016 Duration: 3 days

3 Title of the activity: Mathematical approaches to better understand and tackle tuberculosis, 45th UnionWorld Conference on Lung HealthType of activity: symposium 24Convening entity: International union Against the tuberculosis and Lung diseaseCity convening entity: Barcelona, Catalonia, SpainStart date: 31/10/2014

4 Title of the activity: “1st Symposium TBWatch: Can we eradicate TB?”Type of activity: Symposium Geographical area: European UnionConvening entity: FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYACity convening entity: Barcelona, Catalonia, SpainStart date: 27/09/2012 Duration: 1 day

5 Title of the activity: “1st Mediterranean Workshop on Tuberculosis”Type of activity: Workshop Geographical area: European UnionConvening entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANSTRIAS I PUJOLCity convening entity: L'Escala, Catalonia, SpainStart date: 08/09/2010 Duration: 3 days

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R&D management

1 Name of the activity: “1st Symposium TBWatch: Can we eradicate TB?”Type of management: Management of organised eventsPerformed tasks: Management of the scientific programme. Management of the participation of thespeakers (travels, fees, social events). Search and preparation of documents to apply for funding.Entity: FUNDACIO PER A LA UNIVERSITAT OBERTA DE CATALUNYAStart date: 12/2010 Duration: 10 months

2 Name of the activity: “1st Mediterranean Workshop on Tuberculosis”Type of management: Management of organised eventsPerformed tasks: Obtention of funding (the event was funded by Genoma España). Management of thescientific programme and the participation of the speakers. Obtention of a certified accreditation by the"Consell Català de Formació Continuada de les Professions Sanitàries (CCFCPS)" with 2,4 credits.Entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOLStart date: 05/2010 Duration: 7 months

3 Name of the activity: NEWTBVAC: Discovery and preclinical development of new generation tuberculosisvaccines.Type of management: Management of R&D&I actions and projectsPerformed tasks: Scientific and finantial management (including reporting)Entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOLStart date: 2009 Duration: 5 years

4 Name of the activity: NOPERSIST: Novel strategies for the prevention and control of persistent infections.Type of management: Management of R&D&I actions and projectsPerformed tasks: Scientific and finantial management (including reporting)Entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOLStart date: 2009 Duration: 5 years

5 Name of the activity: LATENT TUBERCULOSIS: New tools for the detection and clearance of dormantMycobacterium tuberculosis. (StopLATENT-TB)Type of management: Management of R&D&I actions and projectsPerformed tasks: Scientific and finantial management (including reporting)Entity: FUNDACIÓ INSTITUT D'INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOLStart date: 2006 Duration: 5 years

Evaluation and revision of R&D projects and articles

1 Name of the activity: ReviewerPerformed tasks: Reviewer for Nature Genetics JournalEntity where activity was carried out: Nature Publishing GroupStart date: 2016

2 Performed tasks: Projects ReviewerEntity where activity was carried out: Agencia Nacional de Evaluación de la Calidad y Acreditación(ANECA)Start date: 2015

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3 Performed tasks: Projects ReviewerEntity where activity was carried out: MedicalResearch Council South Africa

Type of entity: State agency

Start date: 2015

4 Performed tasks: ReviewerEntity where activity was carried out: BMC journals

5 Performed tasks: ReviewerEntity where activity was carried out: Frontiers Journals

6 Performed tasks: ReviewerEntity where activity was carried out: Inmunology

7 Performed tasks: ReviewerEntity where activity was carried out: Lancet

8 Name of the activity: ReviewerPerformed tasks: ReviewerEntity where activity was carried out: FEMS Microbiology journal

9 Name of the activity: ReviewerPerformed tasks: ReviewerEntity where activity was carried out: Plos Journals

10 Name of the activity: ReviewerPerformed tasks: ReviewerEntity where activity was carried out: Respiratory Research Journal

Other achievements

Stays in public or private R&D centres

Entity: Tuberculosis Immunology Group of the National Heart and Lung Institute, Imperial College of LondonCity of entity: London, United KingdomStart date: 08/2008 Duration: 8 monthsGoals of the stay: Visitant researcher, collaborationProvable tasks: Evaluation of the percentage of multifunctional T cells in the volunteers included in thePhase 1 Clinical Trial of the antituberculous vaccine RUTI

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Obtained grants and scholarships

Name of the grant: SOLICITUD DE AYUDAS PARA LA ORGANIZACIÓN Y REALIZACIÓN DEWORKSHOPS Y REUNIONES CIENTÍFICAS EN TEMÁTICAS RELATIVAS A GENÓMICA, PROTEÓMICAY BIOINFORMÁTICAAims: Organizacion de workshop internacionalAwarding entity: Fundación Genoma España Type of entity: FoundationConferral date: 2010

Other types of collaboration with researchers or technologists

1 Type of relationship: Participation in long term collaboration agreements between bodiesName principal investigator (PI, Co-PI....): Joaquim Valls; Daniel López-Codina; Clara Prats; CristinaVilaplana; Pere-Joan CardonaDescription of the collaboration: Research collaborationParticipating entity/entities:Universitat Politècnica de Catalunya Type of entity: UniversityCity participating entity: Barcelona, Catalonia, Spain

Start date: 2010

2 Type of relationship: Networks without joint projectName principal investigator (PI, Co-PI....): Cristina VilaplanaDescription of the collaboration: Membership of the accredited research group by the Agaur: “Grup deMicrobiologia Clínica i Patologia Infecciosa Experimental de la Fundació Institut d’Investigació en Ciènciesde la Salut Germans Trias i Pujol” (2009 SGR 1485)Participating entity/entities:Hospital Universitari Germans Trias i Pujol Type of entity: Healthcare InstitutionsCity participating entity: Badalona, Catalonia, Spain

Scientific societies and professional associations

1 Name of the society: European Respiratory ERSocietyStart date: 2015

2 Name of the society: European Society of Clinical Microbiology and Infectious DiseasesStart date: 2015

3 Name of the society: Sociedad Española de Pneumología y Cirugía Torácica (SEPAR)City affiliation entity: SpainStart date: 2014

4 Name of the society: International Union Against Tuberculosis and Lung DiseaseCity affiliation entity: Paris, FranceStart date: 2013

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5 Name of the society: Sociedad de Enfermedades Infecciosas y Microbiología Clinica (SEIMC)Start date: 2001

6 Name of the society: Col·legi de Metges de BarcelonaStart date: 1999

Co-operation networks

1 Name of the network: Africa-Europe Host-Directed Therapies TB Clinical Trials NetworkIdentification of the network: Africa-Europe HDT-NETStart date: 2015

2 Name of the network: Group 17 - Corporate Research Program on TuberculosisIdentification of the network: CIBERESParticipating entity/entities: CIBER ENFERMEDADES RESPIRATORIAS (CIBERES)Start date: 2007

Obtained accreditations/recognitions

1 Description: AQU research accreditationAccrediting entity: AGENCIA PER A LA QUALITAT DEL SISTEMA UNIVERSITARI DE CATALUNYADate of recognition: 17/09/2013

2 Description: Registered independent expert for European research and innovation (EX2013D132306)Accrediting entity: European Community -FP7 Type of entity: European Community- Research &

InnovationDate of recognition: 2013

CVN - Cristina Vilaplana Massaguer · PDF file2b24b79a2c491916ba3c7b7d9602b69e 6 Education University education 1st and 2nd cycle studies and pre-Bologna degrees 1 University degree:

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