CV-Alex Gella Concusell skill

!!!!!!! ! !! EDUCATION

BioChemistry • Ph.D. September 18th, 2006

Thesis title: “Development of immunoassays for Human Chorionic Gonadotrophin (hCG)”

Faculty of Medicine. Universitat Autònoma de Barcelona. Barcelona. Spain !BioChemistry • MSc September 25th, 2003 Project title: “Preparation of anti-βhCG-peroxidase conjugates for enzyme immunoassays” Faculty of Medicine. Universitat Autònoma de Barcelona. Barcelona. Spain !Chemistry • BSc October 8th, 2001 Faculty of Chemistry. Universidad de Barcelona. Barcelona. Spain !RESEARCH EXPERIENCE !POST-DOCTORAL RESEARCHER - Nucleotides (UTP) on Schwann Cells

Universitat Internacional de Catalunya (UIC) - Peripheral Blood Biomarkers in Psychiatric Diseases

November 2007 – January 2013 - Ab-peptide Aggregates Morphology & Cell Toxicity

Sant Cugat del Vallès, Barcelona, Spain - SSAO activity in Alzheimer's disease !VISITING RESEARCHER - Metal-dependent Enzyme Activities in Peripheral Blood and Università Campus Bio-Medico di Roma CSF in Patients with Alzheimer's disease

March 2012 Supervisor: Dr. Rosanna Squitti, Dr. Mercedes Unzeta

Rome, Italy !POST-DOCTORAL FELLOW - Evaluation of Risk Genes for Schizophrenia by Genetic Universitätsklinikum Würzburg Association Studies and mRNA Expression Analysis

September 2009 – February 2010 Supervisor: Prof. Peter Riederer, Prof. Gerald Stöber,

Würzburg, Germany Dr. Edna Grünblatt !RESEARCH ASSOCIATE - Reference clinical enzyme measurements (ISO 17025:2005) Clinical Enzymology Reference Laboratory - Requirements on IVD diagnostic medical devices (98/79/CE) Universitat Autònoma de Barcelona Supervisor: Dra. Francesca Canalias

January 2006 – January 2008

Barcelona, Spain ! !1

Alejandro Gella, Ph.D. !465 Main Street Apt. 3C

Roosevelt Island 10044 NY

November 20th 1976 +34 659485968

[email protected] !http://www.linkedin.com/pub/alejandro-gella-concustell/5/9b3/a62 !

https://www.researchgate.net/profile/Alejandro_Gella/

PhD RESEARCHER - Immunoassay Development for Human Choriogonadotropin Universitat Autònoma de Barcelona - Monoclonal Antibody Production using Hybridoma Technology February 2006 – September 2007 - Monoclonal Antibody Conjugation (HRP & Colloidal Gold) Faculty of Medicine. - Synthesis of Gold Nanoparticles

Bellaterra, Spain Supervisor: F-Javier Gella !RESEARCH ASSOCIATE - Validation of Clinical Chemistry Reagents

Biosystems S.A. - Internal & External Quality Control

January 1999 – January 2002 - Traceability, Accuracy and Comparability Barcelona, Spain

Ph.D. SUPERVISOR !Faculty of Medicine and Health Sciences.

Universitat Internacional de Catalunya. Spain !Title: Effect of Nucleotides on Schwann Cells PhD. Student: Tania Martiañez Date: December 16th, 2011 !Thesis Title: Influence of Copper and Glycodendrimers on Amyloid-beta Aggregation

PhD. Student: Oxana Klementieva Date: March 9th, 2012 !Thesis Title: Study of Genetic Biomarkers in Psychiatric Disorders

PhD. Student: Monica Segura Date: September 10th, 2012 !Thesis Title: Extracellular UTP Signalling in Schwann Cell Migration: A novel Role of the P2Y2 Receptor PhD. Student: Aloa Lamarca Date: September 13th, 2013 !SKILLS !Cell Culture, Western Blotting, RT-PCR, ELISA, Immunocytochemistry, PCR, Confocal Microscopy, Electron Microscopy, Enzyme Assays, Gene Expression, Method Development, SDS-PAGE, FPLC, Protein Purification, Immunostaining, Slot Blot, Human Sample Processing, DNA/RNA extraction

SCIENTIFIC MEMBERSHIP !- Spanish Society of Clinical Chemistry and Molecular Pathology (SEQC) International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) President - Working Group: Neurochemistry & Neurodegenerative Diseases

- American Association for Clinical Chemistry (AACC) !- The New York Academy of Sciences (NYAS) !- Catalan Society of Biology (SCB) !- Spanish Society of Biochemistry and Molecular Biology (SEBB) ! JOURNAL REFEREE !- Neurochemistry International - Cell Adhesion & Migration - Journal of Proteome Research - Revista del Laboratorio Clinico - Institut d’Estudis Catalans - International Journal of Nanomedicine

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SELECTED PUBLICATIONS2013

2013 !Bolea I, Gella A, Monjas L, Pérez C, Rodríguez-Franco MI, Marco-Contelles J, Samadi A, Unzeta M. Multipotent, Permeable Drug ASS234 Inhibits Aβ Aggregation, Possesses Antioxidant Properties and Protects from Aβ-induced Apoptosis In Vitro. Curr Alzheimer Res 10(8): 797-808. !Gella A, Sole M, Bolea I, Ventriglia M, Siotto M, Durany N, Squitti R, Unzeta M. A comparison between radiometric and fluorimetric methods for measuring SSAO activity J Neural Transm 120(6): 1015-1018. !Martiáñez T, Lamarca A, Casals N, Gella A. N-cadherin expression is regulated by UTP in schwannoma cells. Purinergic Signal 9(2): 259-270. !Bolea I, Gella A, Unzeta M. Propargylamine-derived multitarget-directed ligands: fighting Alzheimer's disease with monoamine oxidase inhibitors. J Neural Transm 120(6): 893-902. !

2012 !Valente T, Gella A, Solé M, DuranyN, Unzeta M. I m m u n o h i s t o c h e m i c a l s t u d y o f semicarbazide- sensitive amine oxidase/ vascular adhesion prote in -1 in the hippocampal vasculature: pathological synergy of Alzheimer's disease and diabetes mellitus. J Neurosci Res. 90(10): 1989-96. !Martiáñez T, Carrascal M, Lamarca A, Segura M, Durany N, Masgrau R, Abian J, Gella A. UTP affects the schwannoma cell line proteome through P2Y receptors leading to cytoskeletal reorganization Proteomics, 12(1), 145-156. !

2011 !Gella A, Segura M, Durany N, Pfuhlmann B, Stober G, Gawlik M.

Is Ankyrin a genetic risk factor for psychiatric phenotypes?. BMC Psychiatry, 11, 103-107. !Valente T, Sole M, Gella A, DuranyN, Unzeta M. SSAO and Aβ in vascular damage in the temporal cortex from Alzheimer and Alzheimer with diabetes patients Alzheimer's Disease Research Journal 1-10. !Gella A & Bolea I. Oxidative Stress in Alzheimer’s Disease: Pathogenesis, Biomarkers and Therapy. Alzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets, Dr. Suzanne de La Monte (Ed.), ISBN: 978-953-307-690-4, InTech, !Klementieva O, Benseny-Cases N, Gella A, Appelhans D, Voit B, Cladera J. Dense Shell Glycodendrimers as Potential Non-toxic Antiamyloidogenic Agents in Alzheimer's Disease. Amyloid-Dendrimer Aggregates Morphology and Cell Toxicity. Biomacromolecules, 12(11), 3903-3909. !

2010 !Valente T, Gella A, Fernàndez-Busquets X, Unzeta M, Durany N. Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiology of Disease 37, 67-76. !Fernàndez-Busquets X, Ponce J, Bravo R, Arimon M, Martianyez T, Gella A, Cladera J, Durany N. Modulation of Amyloid beta Peptide1-42 Cytotoxicity and Aggregation in Vitro by Glucose and Chondroitin Sulfate. Current Alzheimer Research 7, 428-438. !!

2009 !Gella A, Durany N. Oxidative Stress in Alzheimer's disease. Cell Adhesion & Migration Vol 3, 88-99

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CONGRESSESS & CONFERENCES

2011 !Bolea I, Gella A, Samadi A, Unzeta M, Marco JL. New multipotent dual inhibitors of MAO and AChE/BuChE as promising molecules for the treatment of Alzheimer's disease The 10th In ternat iona l Conference on Alzheimer's & Parkinson's Diseases Barcelona, Spain !Gella A, Gawlik M, Stöber G. The role for ankyrin-3 in psychiatric phenotypes 10th World Congress of Biological Psychiatry. WFSBP Prague, Czech Republic !Lamarca A, Martiañez T, Segura M, Durany N, Casals N, Gella A. P2Y receptors play a critical role in Schwann cell wound repair 8th World Congress of IBRO. The International Brain Research Organization Florence, Italy !Bolea I, Gella A, Samadi A, Marco JL, Unzeta M. ASS234, a promising multi-target directed ligand for the treatment of Alzheimer's Disease Present and Future Alzheimer's Research. Nature Conferences Madrid, Spain !

2010 !Solé M, Valente T, Durany N, Gella A, Unzeta M. Immunohistological correlation between SSAO/VAP-1, β-amyloid and stress-related proteins, in post-mortem brain of Alzheimer and Alzheimer with diabetes patients 14th Amine Oxidases and Related Diseases Workshop-AO2010. COST Edmonton, Canada !!!

2009 !Durany N, Klementieva O, Beseny N, Gella A, Cladera J. Copper binding effect on amyloid peptide aggregation in Alzheimer's disease 9th World Congress of Biological Psychiatry. WFSBP Paris, France !

2008 !Valente T, Sole M, Durany N, Gella A, Hernandez I, Boada M, Unzeta M. Neurohistological approach of SSAO expression in post-mortem cerebrovascular tissue of Alzheimer and Alzheimer Diabetes patients. 13th Amine Oxidases and Related Diseases Workshop-AO2008. COST Beijing, China. !Gella A, Valente T, Unzeta M, Fernandez-Busquets X, Durany N. Immunochemical Analysis of Advanced Glycation Endproducts and Amyloid in Alzheimer’s disease and Diabetic post-mortem Brain Tissue. Alzheimer’s and Dementia 2008; 4 (S1): T520 11th ICAD Chicago, EEUU !

2007 !Gella A, Canalias F. Development of an ELISA of hCG in human serum using WHO Reference Reagents 17th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine Clin Chem Lab Med 2007; 45 (S1): 446. International Federation Clinical Chemistry Amsterdam, Hollan. !!

REFERENCES !!Prof. Peter Riederer Head of Neurochemistry Laboratory Klinik und Poliklinic fñur Psychiatrie University of Würzburg. Germany Phone: (09 31) 201 - 77200 [email protected] !PD Dr. Edna Grünblatt Head of Neurobiochemistry Department of Child & Adolescent Psychiatry University of Zurich. Switzerland Phone: +41 435564002 [email protected] ! !

Prof. Fco. Javier Gella Head of I+D Reagents

BioSystems S.A. Barcelona. Spain

Phone: +34 933110000 [email protected] !

Prof. Mercedes Unzeta Head of Neuroscience Laboratory

Dept. of Biochemistry & Mol. Biochemistry Universitat Autònoma de Barcelona. Spain

Phone: +34 935811439 [email protected]

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