™ Your responsive CRO partner, delivering customized solutions and adaptability to changing needs. Customized, Responsive, and On-Time. ™ MPI Research is the CRO that defines responsiveness, moving your drug development program forward with customized solutions for all your preclinical research and early clinical support needs. From discovery services to safety evaluation, including analytical and bioanalytical support, you can count on MPI Research for quick quotes, frequent updates, rapid turnaround, and scientific rigor. At every stage, and on every level, we adapt to your most exacting needs. Explore the breadth of capabilities that make us your responsive CRO at www.MPIResearch.com.
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™
Your responsive CRO partner,
delivering customized solutions and
adaptability to changing needs.
Customized, Responsive, and On-Time.™
MPI Research is the CRO that defines responsiveness,moving your drug development program
forward with customized solutions for all your preclinical research and early clinical support
needs. From discovery services to safety evaluation, including analytical and bioanalytical
support, you can count onMPI Research for quick quotes, frequent updates, rapid turnaround,
and scientific rigor. At every stage, and on every level, we adapt to your most exacting needs.
Explore the breadth of capabilities that make us your responsive CRO at www.MPIResearch.com.
For additional information and a complete list
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XP™
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Above: Confocal IF analysis of rat cerebellum using β3-Tubulin (D71G9) XP™ Rabbit mAb
#5568 (green) and Neurofilament-L (DA2) Mouse mAb #2835 (red). Blue pseudocolor =
DRAQ5® #4084 (fluorescent DNA dye).
XP™ monoclonal antibodies are a line of high quality
rabbit monoclonal antibodies exclusively available
from Cell Signaling Technology. Any product labeled
with XP has been carefully selected based on superior
performance in all approved applications.
XP monoclonal antibodies are generated using XMT™
Technology, a proprietary monoclonal method developed
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eXceptional specificityAs with all of our antibodies, the antibody is specific to your target of
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Unparalleled product quality, validation, and technical support.
Antibodies and Related Reagents for Signal Transduction Research
A Journal with Impact from AAAS, the publisher of Science
Science TranslationalMedicineIntegrating Medicine and Science
“The 2010 selection for the Nobel Prize in Physiology or Medicine
as well as the three Lasker Awards brought welcome opportunities
to celebrate truly groundbreaking translational research.”*
This quote illuminates the importance
of translational medicine discoveries.
A recent journal article features the
sequencing of fetal DNA from plasma
of a pregnant woman to permit prenatal,
noninvasive genome-wide screening
to diagnose fetal genetic disorders.
* Sci Transl Med 22 December 2010:Vol. 2, Issue 63, p. 63ed9DOI: 10.1126/scitranslmed.3001816
Recommendan institutionalsubscriptionto your librarytoday!ScienceOnline.org/recommend
ScienceTranslationalMedicine.org
Indexed inMEDLINE/PubMed
Early Detection ofParkinson’s Disease:The Challenges and Potentialof New Biomarkers
Wednesday, April 27, 201112 noon ET, 9 am PT,4 pm GMT, 5 pm UK
Ten years ormore before the classic tremors of
Parkinson’s disease (PD) appear, the destruction
of dopaminergic neurons in the brain’s nigrostriatal
pathway is well underway. Identifying biological
markers (biomarkers) of PD in its earliest stageswill
be crucial for early interventionwith therapeutics
to prevent or even reverse loss of dopaminergic
neurons. Biomarkers for early PD could be used
to identify patients at risk for PD or in the earliest
stages of the disease and to assess the efficacy of
new drugs or therapies. Biomarkers could also be
used to select appropriate patients for clinical trials
and tomonitor disease progression or drug-induced
remission in real time. So far, only one biomarker
for PD called DaTscan—SPECT imaging of dopamine
transporters at dopaminergic nerve terminals in the
nigrostriatal pathway—has been approved by the
FDA. Given the number of patients with PD (~1mil-
lion in the United States and~5millionworldwide),
developing new biomarkers for detecting the earliest
stages of this disease is imperative if new drugs and
treatments are to be developed.
Register Now!Early bird discounts availablebefore 25March, 2011.Additional discounts for membersand students/postdocs.Questions can be submitted live during thewebinar or in advance by e-mail. To register, visit
www.sciencemag.org/webinar
WEBINAR
During thisWebinar our distinguished panelists will:
• Explain the need for biomarkers for detecting early
PD and how these biomarkers can be used in drug
development and clinical trials
• Provide an overview of promising new biological and
neuroimagingmarkers
• Discuss the challenges and bottlenecks in the develop-
ment of new biomarkers for PD and the role of the
Parkinson’s ProgressionMarkers Initiative (PPMI).
Moderator:Todd Sherer, Ph.D.TheMichael J. Fox Foundation forParkinson’s Research, NewYork, NY
Participants:KennethMarek,M.D.Institute for NeurodegenerativeDisorders, NewHaven, CT
Michael G. Schlossmacher,M.D., FRCPCUniversity of Ottawa, Ottawa, Ontario
Norbert Schuff, Ph.D.University of California andVAMedicalCenter, San Francisco, San Francisco, CA
AndrewSiderowf,M.D.,MSCEUniversity of Pennsylvania School ofMedicine, Philadelphia, PA
Brought to you byScience/AAAS and ScienceTranslationalMedicine,in associationwith theMichael J. Fox Foundation.
Submission
deadline
August 1
imagination at work
* For the purpose of this prize, molecular biology isdefined as “that part of biology which attempts tointerpret biological events in terms of the physico-chemical properties of molecules in a cell”.
(McGraw-Hill Dictionary of Scientific andTechnical Terms, 4th Edition).
Imagine standing on the podium at the Grand Hotel in Stockholm, making your
acceptance speech for the GE & Science Prize for Young Life Scientists. Imagine
having your essay read by your peers around the world. Imagine discussing your
work in a seminar with other prize winners and Nobel Laureates. Imagine what you
could do with the $25,000 prize money. Now stop imagining. If you were awarded your
Ph.D. in molecular biology in 2010, then submit your 1000-word essay by August 1,
and you can make it reality.
Want to build a better reality? Go to www.gescienceprize.org
The GE & Science Prize for Young Life Scientists.Because brilliant ideas build better realities.
Yournamehere.
2011 ASPIRE Hemophilia Research AwardsPfizer is proud to announce the Advancing Science through Pfizer – Investigator Research Exchange (ASPIRE)2011 Investigator Awards in Hemophilia Research, a competitive, peer-reviewed grants program sponsored byPfizer for investigators in the United States.
Mission
• To support basic science, translational and clinical research through a competitive grants program that advances medicalknowledge in the pathogenesis and treatment of hemophilia.
• To support academic research as well as the career development of promising young and established scientists.
Area of Research Focus
Pfizer will support competitive grant programs which address one of the following areas in Hemophilia A and/or Hemophilia B.
Application & Selection Process
Application is open to US investigators. Selection of research proposals will be performed by an independent, external expertpanel comprised of nationally known academic clinicians. Project duration should be 1-3 years and should be approximately$100,000/year, inclusive of overhead costs (capped at 28%).
For more information please visit www.aspireresearch.org
• Epidemiology / burden of disease / Outcomes Research
• Patient adherence to prescribed regimen
• Routine prophylaxis and preventative treatment
• Surgical prophylaxis, dosing
• On Demand dosing
• Treatment of inhibitors: Immune Tolerance Therapy,inhibitor bypass therapy
• Switching experience
• Management of adolescent Hemophilia patients & quality of life
• Management of the aging hemophilia population
• Basic science: Point of differentiation study
• Clinical monitoring of hemophilia treatment
• Recovery experience (hemophilia B patients)
GrantsNet.The first comprehensivescience grants database.
GrantsNet is expanding its listings of
some 900 funding programs fromprivate
foundations and not-for-profit organizations
to include 400 to 500 new entries from the
grants.gov site. This provides the first
comprehensive database of funding
opportunities to research scientists and
administrators, career counselors, financial
aid specialists, and undergraduate and
graduate students. For listings, go to
www.grantsnet.org
1,000sOFGRANTS
MILLIONSIN FUNDING
www.sciencemag.org/products 113
New instruments that are easier to use, take up less space,
and do more work are changing research labs for the better.
TEACHING AN OLD ROBOT NEW TRICKSRedd & Whyte’s Preddator S1 Microplate Dispenser offers yet
another entry into the compact dispensing market. “Its really
key features are that it can dispense all types of reagents,” ex-
plains the virtual start up’s CEO, Roger Poole. “It can do that ac-
curately and repeatedly, and that’s the key. That’s what scientists
have been missing out on.”
The Preddator can dispense cells, gels and matrigels, oils and
greases, and other complex materials, and has been specifi cally
designed to avoid the tip blockage that plagues other dispensing
devices.
Designed as a “value-added” version of a robot long used in
the automotive and printed circuit board market, the Predda-
tor is now available in four-channel and single-channel versions.
“One of the reasons why we chose that specifi c robot is it has
a very small footprint and a very open architecture, so the re-
search scientists can get at it,” Poole says.
Compactness has been key for Olympus in developing
two new products: the FluoView FV10i, a completely self-
contained laser-scanning microscope that sits comfortably on
the benchtop, and the FSX100 Bio Imaging Navigator, another
compact microscope. The fi rst generation FV10i uses an oil-
based objective, and Olympus has developed a new version
with components “inside the box” that will allow the user to
do long-term, live-cell imaging, while using carbon dioxide, heat,
a water objective, and hardware to ensure that the sample will
stay hydrated.
“This allows researchers to accomplish almost everything that
“People don’t need to
read the manual to know
how to use it.”
www.sciencemag.org/products116
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or
materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.
Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
LIFE SCIENCE TECHNOLOGIES
NEW PRODUCTS: SMALL DEVICES
AAAS/Science Business Office Feature
BENCHTOP EVAPORATOR
The EZ-2 Elite is designed to remove high boiling point solvents
and deliver enhanced solvent recovery thereby improving fi nal
drying of stubborn samples and enabling fast lyophilization of
HPLC fractions. The high-performance scroll pump used with
the EZ-2 Elite delivers deeper vacuum than the diaphragm pumps
used on other EZ-2 systems. This advance plus internal enhance-
ments to the heat vapor duct and system components enable the
EZ-2 Elite to routinely evaporate challenging high boiling solvents
including DMSO and NMP. In addition, these enhancements en-
sure that such challenging solvents only condense in the Speed-
Trap. The EZ-2 Elite is designed to concentrate or completely
dry samples. The system will accommodate a wide selection of
sample holders enabling evaporation from most common sample
container formats including round-bottom fl asks up to 500 ml,
tubes up to 160 mm long, custom reaction blocks, and shallow or
deep-well microplates.
Genevac
For info: 845-255-5000 www.genevac.com
BACTERIAL TRANSFORMATIONThe new Eppendorf Eporator offers a fast, simple, and safe op-
tion to transform bacteria, yeasts, and other microorganisms with
DNA/RNA. When bacteria or yeast strains are exposed to short
high-voltage pulses, macromolecules such as plasmid DNA can
diffuse into the cell through temporary pores in the cell mem-
brane. The results are highly reproducible, and in comparison with
chemical methods, electroporation yields up to 10 times higher
transformation effi ciency. Two new program buttons, designed
for storage and recall of most commonly used parameters, along
with the simple one-button operation, guarantee intuitive use for
faster sample handling. State-of-the-art electronics and an inte-
grated electroporation chamber offer higher safety for the user
and minimize the risk of sample loss. Eppendorf offers electropor-
ation cuvettes with three different gap widths. Due to its compact
design, the Eporator can be transported easily within the lab and
stored during times when it is not in use. Eppendorf
For info: 800-645-3050 www.eppendorf.com
YEAST COLONY COUNTER The new ProtoCOL 2 automated colony counting and zone measurement system can be used
for quick and easy analysis of standard and large plates. The system offers a combination of
a unique lighting method and a new total viable count (TVC) software that makes counting
colonies as small as a pinprick, fast and accurate. Because the ProtoCOL 2 has an integrated
processor there is no need to purchase a separate computer. The fi ve separate ProtoCOL 2
software modules can all be integrated into a CFR 21 Part 11 environment, allowing scientists to
purchase only those needed for their laboratory. The available software modules include colony
counting, spiral plate counts, AMES test counts, and inhibition zone measurements. The new
ProtoCOL 2 is perfect for microbiology laboratory scientists looking for a sensitive, easy-to-use,
yet inexpensive colony counter or zone sizing system.
Synbiosis
For info: 800-686-4451 www.synbiosis.com
AUTOMATIC FUSION MACHINESample preparation by the fused bead technique is widely ac-
cepted as giving better precision and accuracy than most other
techniques when analyzing minerals, ceramics, and similar sam-
ples by X-ray fl uorescence (XRF). The Vulcan fusion system uses
automatic fusion control to achieve better sample uniformity and
repeatability. The Vulcan MA comes in several different versions.
The basic XRF version has two, four, or six fusion stations, with
automatically controlled fl ame temperatures under microproces-
sor control and the facility to store up to 10 different melting pro-
grams. Stable fl ame temperatures and simplicity of operation
ensure good sample-to-sample repeatability. Controlled tempera-
ture ramping is also possible. Other confi gurations are designed
for sample preparation for ICP or AAS, or even a mixture of XRF
and ICP or AAS, and it is possible to combine the Vulcan with a
dedicated fume extraction system to provide an integrated sam-
ple preparation workstation.
Analysco Limited
For info: +44-(0)-1993-831792 www.analysco.co.uk
BIOCHEMICAL DETECTOR The SpectroSens monitoring and data analysis control unit is a
benchtop control center capable of monitoring up to eight inde-
pendent inline SpectroSens optical sensors. SpectroSens sen-
sors employ an innovative technology that interprets changes
in refractive index to provide real-time process monitoring. The
new data-monitoring unit advances the company’s systems by
providing a built-in, touch-screen interface while reducing the
footprint by over 50 percent. Due to its new ergonomic form
and smaller size, the SpectroSens unit is perfectly suited for
use in a range of environments, from a small process-develop-
ment laboratory up to industrial scale requirements. The multi-
channel capabilities of the device allow it to be connected to a
number of SpectroSens sensors, whether in a single, multistage
process or in situations where multiple processes are running
in parallel.
Stratophase
For info: +44-(0)-1794-511226 www.stratophase.com
Flattening the World: Building the21st Century Global Knowledge Society
We live in a time when collaborations between countries and continents have never been easier, at least from a
technical standpoint. A stunning example is the Large Hadron Collider, which is being used by a multinational group
of physicists to understand the fundamental building blocks and laws of nature, from subatomic to cosmic. Stores
of information and knowledge can be accessed from anywhere by anyone. Remote sensing technology enables the
detailed observation of virtually every aspect of our planet’s surface, subsurface, and climate. Technology and the
Internet are transforming education. Learning is, in principle, available to everyone everywhere.
The 21st century is shaping up to be a challenging one. The issues that face us are many: climate change,
energy, agriculture, health, water, biodiversity and ecosystems, population growth, and economic development.
The 2012 program will focus on the complex challenges of the 21st century that are both global in their
scope and profoundly interconnected as well as ways to tackle them on a global scale through international,
multidisciplinary efforts.
Symposium proposals for the 2012 meeting are now being solicited. To submit a proposal, visit
www.aaas.org/meetings. The deadline for submission is Tuesday, 26 April 2011.
Call for Poster SubmissionsStudent Poster CompetitionOpen to college undergraduate and graduate students only
The competition recognizes the individual efforts of students who are actively working toward a college-level degree.
Winners in each category receive a cash award and framed certificate, and are listed in Science.
General Poster SessionOpen to postdocs and professionals
This session provides an opportunity for postdocs and professionals to present their research to the broad community
of scientists attending the AAAS Annual Meeting.
Information about the call for poster submissions for the 2012 Annual Meeting will be available at
aaas.org/meetings on 12 May 2011.
2012 AAAS ANNUALMEETING
16–20 February • Vancouver, Canada
Call for Symposium Proposals
www.neb.com
UNDERSTANDING CHANGE
Streamline epigenetics research with EpiMark™
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Analysis of the different methylation states in Balb/C mouse tissue samples
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Identify and quantitate methylation states with the