Curriculum Vitae
Curriculum Vitae
Dr. Yusuf Mohammad Ali Al-Hiari
Professor of Medicinal Chemistry
Department of Pharmaceutical Sciences
Faculty of Pharmacy
Jordan University
Amman 11942 Jordan
00Tel: 00962-6- 5355000. ext. 23292 (Work), Mobile :
00962777424744
Fax: 00962-6-5300250 Faculty, 00962-6- 5355511-22 University
Email: [email protected], [email protected]
Home Page:
http://eacademic.ju.edu.jo/hiary/Lists/Published%20Research/AllItems.aspx
Personal Information
Marital status: Married, 4 children
Nationality: Jordanian
Age: 46
2001- present Faculty of Pharmacy – Jordan University.
Amman, Jordan.
Professor - Department of Pharmaceutical Sciences.
Specialized in teaching Pharmaceutical Chemistry, including
Organic, Medicinal, Analytical, Instrumental and Biotechnology
Based drug Discovery.
- Dean Assistant for Students Affairs / 2003-2005.
- Head Dept. Pharmaceutical Sciences / 2005-2006; 2008/2009.
- Vice Dean / 2006 - 2007
1998 – 2001 Department of Pharmaceutical Chemistry–Strathclyde
University.
Glasgow, Scotland-UK
Ph.D. in Pharmaceutical Sciences: Medicinal Chemistry.
Title: Steps Toward an Efficient Synthesis of Macrocyclic
Bisbenzylisoquinoline Alkaloid.
1996 – 1997 School of Biological Sciences - Surrey
University.
Surrey, Guilford, UK
M.Sc. in Clinical Biochemistry and Molecular Biology.
1989 – 1993 Faculty of Pharmacy - University of Jordan.
Amman, Jordan
B.Sc. in Pharmaceutical Sciences. Very Good.
1988-1989 Salt Secondary School.
Salt, Jordan
General Secondary Education Certificate Examination.
Distinction.
Work Experience
2001- present Faculty of Pharmacy – Jordan University.
1998 –1999 Pharmacy Department – Strathclyde University
Glasgow, Scotland
Lab. Demonstrator (teaching and research assistant) for MSc and
undergraduate pharmacy students.
1993- 1996Pharmaceutical Chemistry Dept- Faculty of Pharmacy
-University of Jordan.
Amman, Jordan
Teaching Assistant for practical courses: Medicinal, Organic,
Instrumental, Analytical and
Clinical Chemistry.
1994 Community Pharmacy.
Amman, Jordan
1994-1996 Faculty of Education-University of Jordan
9 courses in teaching methodologies and evaluation techniques
for undergraduate and
postgraduate students.
Skills
- Arabic and English (Both excellent)
- Computer Literacy: Word , Excel , Power Point, Chemdraw, Isis
draw, Alchemy 2000, ChemDraw Ultra.
- Chemistry Databases: Beilestine Crossfire System, ISIS, BIDS,
MEDLINE, Scifinder, Web of
Science WOS, SCI, Embase data base, Elsevier, PUP-mide,
Cambridge Database,…etc.
· Operational and theoretical skills in NMR, MS, and IR
Spectroscopy.
· Very good experience in HPLC, GC-MS, LC-MS, CE, and most
gravimetric separation techniques.
· Very good knowledge and satisfactory practical experience in
many Molecular Biology techniques such as DNA Isolation and Gene
Detection, Clonning, Finger-printing, Southern and Northern Plott,
RELF, PCR and all Clinical Biochemistry ones in addition to
Immunology Techniques such as Enzyme Linked Immunoassay (ELISA),
Monoclonal Anti-bodies and Radio Immuno Assay (RIA).
· Specialized skills in synthetic chemistry, organic reactions
and many bioassay procedures.
· Satisfactory experience in Tissue and Cell culture techniques,
mainly animal cell culture.
Teaching Experience at the University of Jordan:
1-Undergraduate Courses, Faculty of Pharmacy:
a- Obligatory courses
- Medicinal Chemistry III, Fifth year students
- Medicinal Chemistry II, Fourth year students
- Medicinal Chemistry I: drug design, Fourth year students
- Medicinal Chemistry III and II / practical, Fourth and Fifth
year students
- Pharmaceutical Analytical Chemistry, second year students
- Pharmaceutical Organic Chemistry I, Second year students
- Pharmaceutical Organic Chemistry I / practical, Second year
students
- Pharmaceutical Organic Chemistry II, Second year students
- Clinical Biochemistry, Forth year students
- Instrumental Analysis, Third year students
b- Elective courses
- Chelation: Principles and Applications in Pharmacy, Fifth year
students
- Pharmaceutical Biotechnology, Fifth year students
- Chromatography, Fifth year students
2-Master students:
- Advanced Medicinal Chemistry, Master students
- Advanced Pharmaceutical Biotechnology, MSc students
3-PhD courses (medicinal chemistry and drug discovery)
- Advanced Research Methodologies in Medicinal Chemistry, Ph.D
course
- Information Technology, Ph.D course
- Selected topics in medicinal chemistry, Ph.D course
- Advanced Spectroscopy, Ph.D course
Administrative Activities:
1- Member of the Postgraduate committee at Deanship of
Postgraduates (2012/2013,2014)
2- Member of the University Council (2012-2013)
3- Head of Department of Pharmaceutical Sciences (2008-2010
).
4- Sabbatical leave (Al-Zaytooneh University, 2007-2008)
5- Vice Dean / 2006 – 2007
6- Head of the Postgraduate committee at Deanship of
Postgraduates (2006/2007)
7- Head of Department of Pharmaceutical Sciences (2005-2006
).
8- Dean Assistant for Students Affairs, Faculty of Pharmacy
(2003-2005).
9- Member of the Postgraduate committee at faculty (2006/2007,
2008-2010)
10- Member of the Postgraduate committee at Deanship of
Postgraduates (2006/2007)
11- Member of the Department Council (2001-2013)
12- Member of the Faculty Council (2003, 2005-2010, 2012,
2013)
13- Head of the Department Council (2005-2006, 2008-2010)
14- Member of the University Council (2002-2003)
15- Sabbatical leave (Al-Zaytooneh University, 2014-2015)
16- Head of the Instrumentation and laboratories committee at
faculty (2015/2016)
17- Head of the scientific committee at faculty (2016/2017)
18- Member of Scientific and Research Council of the Deanship of
Academic Research faculty Al-Zaytooneh University (2016/2017)
19- Member of the Department Council (2015-2017)
Committees / Health sector:
Regular member in consultation and committees of the Jordan Food
and Drug Administration and Ministry of Health.
- Member of the Clinical Studies Committee at Jordan Food and
Drug Administration (JFDA), 2004-2006.
- Member of the Jordanian Pharmaceutical Society, (1993-up
today).
- Member of the Drugs Re-registration Committee at Jordan Food
and Drug Administration (JFDA), 2008-2010; 2012-2014.
Committees / Accreditation sector:
Regular member in consultation, examination, accreditation and
quality assurance committees of the Jordan Accreditation Council
for Higher Education.
- Head of the accreditation committee of Pharmacy colleague at
Al-Hashmeia University, 2013.
- Head of the accreditation committee of Pharmacy colleague at
Amman private University, 2015.
- Member of the accreditation committee of Pharmacy colleague at
Al-Zaytooneh private University, 2015.
- Member of the accreditation committee/Quality assurance -
Pharmacy colleague at Al-Petra Jordan University, 2015-2016.
- Head of the accreditation committee of Pharmacy colleague at
Al-Hashmeia University, 2013.
- Head of the accreditation committee of Pharmacy colleague at
Amman private University, 2015.
- Member of the accreditation committee of Pharmacy colleague at
Al-Zaytooneh private University, 2015.
- Member of the accreditation committee/Quality assurance -
Pharmacy colleague at Al-Petra Jordan University, 2015-2016.
Committees and Societies:Faculty, University and National ;
Academic
- Member of the Postgraduate Studies Committee at the Faculty of
Pharmacy, (2005-2010).
- Member of the Scientific Research Committee at the Faculty of
Pharmacy-University of Jordan, (2001-2007, 2014-00).
- Member of the Research and Instrumentation Committee at the
Faculty of Pharmacy-University of Jordan, (2001- 2003).
- Director (Head) of the General Safety Committee at the Faculty
of Pharmacy-University of Jordan, (2001-2004, 2010-2016).
- Member of the Instrumentation and Laboratory Safety committee
at the Faculty of Pharmacy-University of Jordan, (2003-2005,
2011-12).
- Member of the Courses Evaluation Committee, (2005-2010,
2015).
- Member of the Curriculum Committee at the Faculty,
(2005-2010)
- Member of the Student’s Affair Committee at the Faculty of
Pharmacy, (2003-2005).
- Member of the Royal Society of Chemistry (United Kingdom)-
Student membership, (1999-2001).
- Friend of the Society of Chemistry- Scotland, (1998-1999).
- Member of the Scientific and Research Committee at the
Pharmaceutical Association of Jordan, (2001-2005, 2008-2010).
- Involved in many committees related to Central Tender
Department: Head and member for more than 20 committees.
- Member and examiner at the Boarding Committee of the Jordanian
Pharmaceutical Society, 2003-2004, 2008-2009 (Pharmacy Profession
Qualification Exam).
- Member of the Pharmacy Qualification Exam Committee/ Ministry
of Higher Education, 2005-2006, 2013-2014 (Pharmacy Gradates
Qualification Exam).
- Member of the Higher organizing/ Pharmacy Qualification Exam
Committee/ Ministry of Higher Education, 2006-2007 (Pharmacy
Gradates Qualification Exam/ first semester).
- Head of the Postgraduate committee at the faculty of Pharmacy
2006-2007, 2009-2010.
- Member of the Postgraduate committee at the Deanship of
Postgraduate Studies (2006/2007, 2008-2010)
- Member of the National center of Biotechnology/ Jordan,
2004-2010
- Member at the editorial board of the international
Journal-2006-2007: Pharmacy times-Middle East, established since
1897, published by Medical online Publication SAL, Beirut, Lebanon,
Under licenses from Ascend Media Healthcare.
- Referee for Archiv Der Pharmazie: International Journal of
Medicinal Chemistry, since 2006.
- Referee for Jordan Journal of Pharmaceutical Sciences:
International Journal Pharmaceutical Sciences, since establishment
2007-uptoday.
- Reviewer for King Abdul Aziz University, Deanship of Academic
Research, Saudia Arabia, 2005- …).
- Reviewer for King Saud University, Deanship of Academic
Research, Saudia Arabia, 2009- …).
- Member of the faculty council, 2005-2007, 2008-2010.
- Referee for Medicinal Chemistry research Journal , since
2009.
- Member (Hony. Editor) of the Editorial Board of Journal of
Plant Development Sciences -2011
- Member of the Editorial Board for the Journal of
Pharmaceutical Technology and Drug Research (JPTDR), 12-2011, .
http://www.hoajonline.com/Journal-of-Pharmaceutical-Technology-and-Drug.html#tabs2-2
- Referee for Medicinal Chemistry research Journal , 2013.
- Referee for Medicinal Chemistry Journal , 2013.
Scientific Activities: Conferences, Meeting and Workshops:
- Chairman of the Social Committee of the 2nd International
Conference of the Faculty of Pharmacy, October 16-18/2001,
Amman-Jordan (Member of the Organizing committee, member in the
Scientific Committee, member in the Follow-Up Committee, Conference
book organizer and editor).
- Chairman of the Social Committee of the 5th Scientific
Congress of the Association of the Colleges of Pharmacy in the Arab
World , October 16-18/2001, Amman-Jordan (Member of the Organizing
committee, member in the Scientific Committee, member in the
Follow-Up Committee, Conference book organizer and editor)
- Member of the Scientific Committee which organized the 10th
Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical
Society, March 13-16/2002, Amman-Jordan (Conference book
editor).
- A primary lecturer at the Jordan Ninth Science Week:
Biotechnology and its Role in the Jordanian Economy, entitled:
Pharmaceutical Biotechnology: “Recombinant DNA Technology as a Tool
for the Production of Biopharmaceutical Drugs”, 6-8 October 2003,
University of Science and Technology/ Irbid-Jordan.
- Contributor in the first round of the Continuous Education
Programme supervised by the Jordanian Pharmaceutical Society, 2001,
Amman.
- Organizer and contributor of the second round of the
Continuous Education Programme supervised by the Jordanian
Pharmaceutical Society, 2002, Amman.
- Member of the Organizing Committee/ Scientific Committee which
organized the 11th Pharmaceutical Jordanian Conference of the
Jordanian Pharmaceutical Society, March 28-30 Sep/2005,
Amman-Jordan.
- A guest speaker at the 11th Pharmaceutical Jordanian
Conference of the Jordanian Pharmaceutical Society, title: Original
research paper/primary lecture: Crignard Synthesis of 1-Substituted
Benzyl-1,2,3,4-tetrahydroisoquinoline Models with Potential
Antibacterial and Anticancer Activity, Sept. 28-30/2005,
Amman-Jordan.
- Attendant and contributor in the “The First Conference for
Scientific Research in Jordan”. Organized by the Society of Friends
of the Scientific Research in Jordan Universities, 25-26th/10/2003,
Amman-Jordan.
- ICH/GCP Training Workshop for Clinical Investigators,
2-3/12/2004, Dubi, UAE.
- Contributor and attendant of the Synthesis of Chemicals and
Pharmaceutical Raw Materials Conference, Title: Synthesis of
Pharmaceutical Raw Materials in Jordan. Organized by the Arab
School for Science and Technology, 23-25/5/2005,
Damascus-Syria.
- Workshop by Varian Company-US, entitled: ‘Separation
techniques: HPLC, GC-MS, LC-MS’ Organized by their agent in Amman;
Amin Shukeer drug stores, 4-7-2004, Amman.
- Workshop by Bruker Company, entitled: ‘X-Ray and FT-NIR
techniques’: Principles and Applications, Organized by their agent
in Amman; Sena Establishment for Laboratory Equipment Trading, 31-8
to 1-9 / 2005, Amman.
- Abstract accepted at the 9th International Pharmaceutical
Sciences Conference and Exposition and the 9th General Assembly
Meeting of the Scientific Society of Colleges of Pharmacy of the
Association of Arab Universities in the Arab World, Original
research paper/primary lecture: Synthesis of Substituted
benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline Derivatives and
Investigation the Lithiation-Alkylation Chemistry, 17-21/1/-2005,
Riyadh- Saudi Arabia.
- Primary lecturer and full paper presenter at “The Importance
of Intellectual Property in Scientific Research and Economic and
Industrial Growth in the Arab World” Conference; 23-25/1/2006,
Damascus-Syria. Title: Patent Challenges in Pharmaceutical Sector;
Impact, Overcoming Challenges and Future Prospective, by Dr. Yusuf
Al-Hiari and Dr. Talal Aburjai.
- Workshop entitled: A Non Threatening Approach to the Use of
Statistics in Clinical Trials, 5/4/2006, Prof. James De Muth, Royal
Medical Services, Amman.
- The Third Medical Conference for Royal Medical Services, April
2006, Amman.
- The First Scientific Week for the Faculty of Pharmacy at Amman
University, 3-4/5/2006.
- Primary lecturer and round mediator at the Jordan
International Pharmaceutical Conference 2006: Toward new Trends in
Pharmaceutical Sciences, Al-Zaytoonah University, 5-17-11-06,
Amman-Jordan.
- Primary lecturer and round mediator at the First Scientific
Conference 2006 for OTC drugs: Jordan Pharmaceutical Association,
1-4-12-2006, Amman-Jordan.
- Workshop on new instruments provided by Thermo Company: GC,
GC/MS, LC, LC/MS, Molecular Spectroscopy (UV, FT-IR, NMR) 22-23 May
2007, Amman-Jordan.
- Training course: Literature survey on data bases: SCI-finder
and EBSCO, 12-13/6/2007, University of Jordan-Amman-Jordan.
- Primary lecturer for a full paper “ Synthesis and
Antibacterial Properties of New 8-Nitro fluoroquinolone
Derivatives'', at the 5th International Symposium on Pharmaceutical
Chemistry, abstract and oral presentation, Sep. 5-7, 2007,
Istanbul, Turkey.
- Mid East Medical International Comprehensive Exhibition 2008,
Amman, Oct. 21-23/ 2008, Amman- Jordan.
- Member of the Scientific Committee which organized the 13th
Pharmaceutical Jordanian Conference of the Jordanian Pharmaceutical
Society, April 2010, Amman-Jordan (Conference book editor).
- Member of the Scientific Committee which organized the Faculty
Scientific day-Faculty of Pharmacy, 6th May 2010, Amman-Jordan.
- Guest speaker, National Medical Research Center, Al-Zawia-
Libya, 13May, 2010.
- National Conference for the Development of Study plans,
Teaching and Learning, and Scientific Research in Jordan, June
Amman 15-17, 2010, organized by Ministry of Higher Education and
Scientific Research.
- Lecture and oral presentation: "Synthesis and Antibacterial
Activity of New [1,2,3] triazolo[4,5-h]quinoline Derivatives as
Potential Antimicrobial Agents" at First United Arab Emirates
Conference on Pure and Applied Chemistry (ECPAC11), American
University of Sharjah, Sharjah, UAE, 1-3/3/2011.
- Oral presentation: "Synthesis and Antibacterial Activity of
New [1,2,3] triazolo[4,5-h]quinoline Derivatives as Potential
Antimicrobial /Anti-tuberculosis Agents" The International
Conference on Materials in Jordan, Humboldt Kolleg, German
–Jordanian University (GJU), Amman, Jordan, 9-11 April /4/2011.
- Work shop: Commercialization of R & D results : Patents
and trade secrets, Intellectual Property Commercialization Office
IPCO , Royal Scientific Society- Amman , 18-19 April 2011.
- Oral presentation: " Pyrido-Quinoxalinones, As potentiel
antibacterial and anticancer compounds" The 4th International
Conference on Health Care (ICHC), Al-Ahliyya Amman University,,
Amman, Jordan, 4-5 May /5/2011.
- The Faculty Scientific day-Faculty of Pharmacy, 28th April
2011, Amman-Jordan.
- Contribution in the Scientific day for Hamdi Mango Center for
Scientific Research (HMCSR), 24th May 2011, Amman-Jordan.
Workshop: Use of FT-IR spectroscopy in and out the laboratory,
Organized by GSC company for Agilent Company, 2-11-2011,
Amman-Jordan.
-Reviewer database for " Current Computer-Aided Drug Design
journal " http://bsp-cms. eurekaselect.com/index.php/ CCADD.
Bentham Science Publisher, May 2012-2013.
- Primary lecturer and round mediator : New antibacterial
fluoroquinolones with potential anti-obesity effects
at the Jordan International Pharmaceutical Conference 2015:
Al-Zaytoonah private University, 21-23 October 2015,
Amman-Jordan.
· Workshop: Winter workshop 2015 on heavy metal and water
treatment within collaboration project between German Jordainian
University and Leibniz institute for Analytical Sciences-ISAS,
German University, Madaba, 18-22/10/2015.
- Workshop: Building successful partnerships between Academia
and Industry-The Pharmaceutical Sector, the Jordanian Club of
Humboldt Fellows and Friedrich Naumann Foundation for Liberty,
Amman 13/4/2016
- Lecture and oral presentation: " Novel 5-substituted
indole-2-carboxamide derivatives as potential antihyperlipidaemic
Agents" at Second United Arab Emirates Conference on Pure and
Applied Chemistry (ECPAC16), American University of Sharjah, , UAE,
1-3/3/2016.
- Attendance: The 1st International conference on Natural
Producs and Drug Discovery, Chemistry Dept, Ammn Sep 8-10,
2015.
Social Activities:
- Winner of the Bronze Medal of Prince Hasan Award for Culture
and Youth Development, (1987 and 1988).
- Winner of the Students Jordanian Chess Championship, 1986
(second), 1987 (Third).
- Member at Salt Pioneer Center for Highly Intelligent Students,
(1986-1989 student, 2002- full member).
- Member at Salt Heritage center .
- Certificate of Gratitude from The Jordan Pharmaceutical
Association: for the major contribution in its activities;
in particular; the Continuous Education Program (2001,
2002).
- The Jordan Pharmaceutical Association Award, (2005, 2008,
2010).
Current Areas of Research Projects:
I- Medicinal Chemistry and Organic Synthesis:
(A) Synthesis of Novel Bisbenzylisoquinolines Models:
· This work aims at synthesis of new bisbenzylisoquinoline
models with two ether linkages as potential antimalarial compounds.
The model molecules were designed to exhibit the pharmacophoric
groups occurred in natural bisbenzylisoquinoline, with broad
spectrum of activity. The research has produced initially; three
target molecules which could be potential antimalarial and
possibly, anticancer agents. This research produced many
intermediates with reasonable antibacterial activity, derived from
benzyloxyphenyl-ethanol nucleus and
3,4,8,9-tetrahydro-13-oxa-6-thia-2,10-diazapentacene nucleus.
Moreover, other intermediates showed weak to moderate antifungal
properties.
- New research line was emerged to prepare novel models of
bisbenzylisoquinoline with one ether linkage. For the first time, a
novel metalation approach was developed to prepare such new models
with yields exceeded 80%. Such new approach might revive the
synthetic research toward preparation of naturally occurring
derivatives of the same group. (Two papers are in preparation)
(B) Preparation of Model Benzyl isoquinoloines and Investigation
the Chemistry of Coupling Reactions:
· Introducing benzyl substituents at position 1 of di and
tetrahydroisoquinoline systems was thoroughly investigated using
different methods reported in the literature. Grignard reactions
and metalation chemistry were attempted. Although Grignard
conditions were satisfactory, the new metalation conditions
developed were successful in producing new model derivatives at
position 1 in more than 90% yields. These prepared models exhibit
possible potential as anticancer compounds. The new conditions and
procedures are implemented now in preparing benzyl isoquinoloines
and bisbenzylisoquinoline derivative of natural origin.
(C) Development of Novel Phenoxathiin-Based Antifungal
Agents:
· This research aims at preparing phenoxathiin-based derivatives
of superior antifungal potencies; through the introduction of
well-established antifungal moieties to position 2 and 8 or 3 and 7
of the phenoxathiin nucleus allowing mutual potentiation of the
overall antifungal properties. The proposed potentiating groups
include: pyridine, pyrrole, 1,2,3-triazole, imidazole,
2-aminothiazole, thiazole and others, which have well established
anitfungal properties. Furthermore, allylamine moieties is proposed
to be also conjugated to phenoxathiin nucleus at later stages
allowing the access to quite potent antifungal agents. Moreover,
the proposed phenoxythiin-based derivatives could be chemically
conjugated to various polymers that might generate interesting
materials of possible commercial applications, including the
development of fungus-resistant textiles or plastics. Because of
the tedious procedures and low yields, this research started by
developing and improving approaches needed to prepare the methyl
substituted phenoxathiin system.
(D) Synthesis of New Potentially Anticancer
Azepino-indoloquinoline Systems.
- This work involves addition of
1-Chloro-4-trifluoromethyl-2-nitrobenzene,
2-chloro-4-trifluoromethyl-1,3-dinitrobenzene,
4-chloro-3,5-dinitrobenzoic acid, 2-chloro-3-nitrothiophene and
5-chloro-1,3-dimethyl pyrazole appendages to indole system at
position 3. This was followed by reductive cyclization procedure to
produce either the azepino or the quinoline systems (or both).
Although Bischler-Napieralski was not promising, the
Pictet-Spengler cyclization showed good results. All the indolo
phenyl derivatives substituted with amino, nitro and other groups
were evaluated for their antimicrobial properties, revealing
promising results.
(E) Preparation of Novel Heterocycles [h]Fused Onto
4-Oxoquinolines for Biological Evaluation:
This research involves preparation of 8-nitrofluoroquinolone
system, followed by introducing new appendages at C-7 and finally
formation of new heterocyclic [h]fused systems. The research has
led to novel systems with diverse biological evaluation such as
benzofuroxane, Pyrido[2,3-g]Quinoxalines, triazoles, diazepines and
benzodiazepines fused at h position. More than 10 publications have
been disclosed up today on this line.
(F) Preparation of Potentially Antibacterial 8-nitro/ or 8-amino
Fluoroquinolones with Novel Substitutions at Position 7.
II- Novel Polymeric Modifications with Potential Pharmaceutical
Applications:
· The first area involves chemical modifications of existing
natural and synthetic biodegradable polymers, aiming at utilizing
the newly-developed polymers in pharmaceutical applications, such
as, in new drug delivery systems and sustained release matrices.
The principle of this modification is based on synthesis of
metal-chelating polymeric linkers followed by their cross-synthetic
linking with metallic cations. The generated matrices have proved
to be very useful matrices for prolonging drug release.
III- Novel Polycarbonates Polymer Synthesis with Potential
Industrial Applications:
- The other research area involves preparation of novel
polycarbonate polymers with new or modified procedures for
industrial and possibly pharmaceutical applications.
IV- Analytical Methods Development Related to Drugs or
Separation Techniques:
- Liquid chromatographic determination of Sartans (Irbesartan)
in human plasma with fluorescence detection
- Blood Spot Analysis for Anti epileptic drugs using HPLC system
with fluorescence detection
- Developing and optimization of HPLC, LC/MS methods for new
synthetic systems, drugs and some natural pharmaceutical
products.
V- The discovery of novel heterocyclic 2-carboxamide derivatives
with potential dyslipidemic, hypoglycaemic and antioxidant
activity
This research line was introduced to develop novel class of
indole-2-carboxamides, benzofuran-2-carboxamides and
benzothiophene-2-carboxamides with antihyperlipidemic activity.
This novel class of derivatives have shown excellent activity
against triglycerides mainly in a fibrate like manner; stimulation
of lipoprotein lipase enzyme. More research is undergoing to
investigate new heterocycles and further antioxidant and
antihyperglycemic effect.
VI- Evaluation of new phenolic and benzoic acid derivatives as
novel inhibitor of carbonic anhydrase isozyme III by using a
modified Hummel-Dreyer method. (2012- up-to-date).
VIII. Fluoroquinolone as new inhibitors for pancreatic lipase
enzyme. (2013- up-to-date)
Local / National / International projects:
1- Design and Synthesis of Novel Hepatitis C virus-NS3 Protease
Inhibitors (Primary Author, 2002): This project was approved by the
National Committee for the Higher Education Development Fund (HEDF)
and Dar Al-Dawa Pharmaceutical Company. The fund was more than
$350,000 from both and more than JD 260,000 from the
university.
2- Establishing a New Ph.D. Program in Medicinal Chemistry and
Drug Discovery at the Faculty of Pharmacy/University of Jordan,
(Primary Author, 2003): Submitted to the National Committee for the
Higher Education Development Fund (HEDF), September 2003. The
project was subsidized with $ 350,000 by the National Committee for
the Higher Education Development Fund HEDF and $323,000 by the
University.
3- Development of Novel Phenoxathiin-Based Antifungal Agents,
(Primary Author, 2002): This project was funded by the Dean of
Scientific Research-University of Jordan, 10,000 JD.
4- Synthesis of New Potentially Anticancer
Azepino-indoloquinoline Systems, (Primary Author, 2003): This
project was funded by the Deanship of Scientific
Research-University of Jordan, 7500JD.
5- New 7-(3-indolyl)quinolones, Indolo[2,3-c],
[1,10]phenanthrolines and 3,3’-bisindolyl systems: Syntheses and
Antibacterial Study Protocol, (Primary Author, 2004): The project
was sponsored by Hamdi Mango Center for Scientific Research, Jordan
University.
6- Pyrido[2,3-f]Quinoxalines and Pyrido[2,3-g]Quinoxalines, A
Process for their Preparation and their Use as Antiviral and
Antibacterial Agents and [a]Fused
Heterocyclic-Pyrido[2,3-f]Quinoxalines-2-carboxylic acid
Derivativesz and their Pyrido[3,2-g]analoges, A Process for their
Preparation and their Use as Anticancer and Antibacterial Agents,
(Primary Author, 2005): The project was sponsored by Hamdi Mango
Center for Scientific Research, Jordan University.
7- Synthesis and Antitumor Potency of Some Novel
pyrido[2,3-a]carbazoles, (Second Author, June 2006). The project
was sponsored by The Higher Council for Science and Technology.
8- Investigation and Monitoring of Organophosphates Toxicity in
Jordan Valley, (Second Author, 2005). The project was funded by
OPCW-United Nation and The Deanship of Scientific
Research-University of Jordan.
9- Blood Spot Analysis for Anti-epileptic drugs using HPLC
system with fluorescence detection, July 2006-2008, funded by the
Deanship of Scientific Research-University of Jordan.
10- Part 1: N4- (substituted) Pyrido[2,3-f]quinoxalines, A
process for their preparation and their use as potential antiviral
and antimicrobial agents, (Primary Author, 2007-9): The project was
sponsored by Hamdi Mango Center for Scientific Research, Jordan
University.
11- Preparation of new diazepino[2,3-h]quinoline-9-carboxylic
acid derivatives and their analogus [b]fused benzodiazepine
derivatives. Sabbatical leave project. 2007/2008, Al-Zaytooneh
University.
20- Part II: N4- (substituted) Pyrido[2,3-f]quinoxalines, A
process for their preparation and their use as potential antiviral
and antimicrobial agents, (Primary Author, 2009): The project was
sponsored by Hamdi Mango Center for Scientific Research, Jordan
University.
21- Convenient Synthesis and Bioproperties of Heterocycles
[h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid: Substituted
Hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid, (Primary
Author, 2010): This project was funded by the Deanship of
Scientific Research-University of Jordan, 15200JD.
22- Pharmacodynamic evaluation and marker standardisation of
Paronychia argentea (Rijl El Hmameh) as a diuretic herb. (May
2010-2012): This project was funded by the Deanship of Scientific
Research-University of Jordan-15000JD ( in collaboration with
Savant).
23- Synthesis and biological screening of new
Ethyl-9-cyclopropyl-4-fluoro-3-(4-substitutedphenyl)-6-oxo-6,9-dihydro-3H-[1,2,3]triazolo[4,5-h]quinoline-7-carboxylate
derivatives and their carboxylic acid counterparts, (Primary
Author, May 2012): This project was funded by the Deanship of
Scientific Research-University of Jordan, 18.000JD.
24- Evaluation of new inhibitor of carbonic anhydrase isozyme
III by using a modified Hummel-Dreyer method: approach for drug
discovery, (second Author, Aug. 2013): This project was funded by
the Deanship of Scientific Research-University of Jordan.
25- Antibacterial Fluoroquinolones as Novel Inhibitors of
Pancreatic Triacylglycerol enzyme, a New
Target for The Management of Dyslipidaemia, Atherosclerosis and
Obesity, , (sabbatical 2015), This
project is part of the sabbatical leave research for 2015 and
was conducted and funded at
Al-Zaytooneh Private University. Testing and biological
screening part was funded by the Deanship
of Scientific Research-University of Jordan.
26- Purification of Pathogenesis Determinant proteins for the
identification of novel antimicrobial targets: Polyphosphate Kinase
1 active site charecterization, 2014-2016, this project was funded
by Scientific Research
Support Fund-The Ministry of Higher Education for more than
90,000JD.
27- Biological Evaluation of in vitro inhibitory effects of some
medicinal plants of the families Asteraceae, Lamiaceae and
Papaveraceae native to Jordan and synthetic compounds on lipase,
DPPVI and protein glycation. MPH/1/05/2014, SRF-Ministry of Higher
Education, 34600JD, 2014.
28- Lipase inhibitory potential of synthetic fluoroquinolones
and their modulatory effects of adipocytes differentiation and
adipogenesis, DAR/JU [1630], 10000JD, 2013-2014.
29- Natural benzoic and cinnamic acid derivatives as
anti-obesity agents: In vitro modulation of Pancreatic Lipase, DAR
/JU[1745, 10000JD, 2015.
30- Structure-based discovery and crystallographic studies of
benzoic acid derivatives as novel anti-obesity agents, SRF, 2015,
Scientific Research- Support Fund, 150000JD, 2015.
31- Development and investigation of synthetic compounds for
anticancer effects in vitro, DAR /JU[1745, 20000JD, 2016
32- Fabrication of fast oral drug delivery systems using hot
melt extrusion technology to assist swallowing, taste masking and
throwing light onto improved solubility applications, (co-author
with German University,SRSF- 90000, 2016).
33- A promising hybrid anticancer drug based on a stimulated
physicochemical conjugation of a novel anticancer with gold
nanoparticle. (co-author with JUST and yarmook Universities, SRSF-
57000, 2017).
Projects in Collaboration with Local Industry:
1- Developing New Muscle Relaxant, Derived from the Known
Commercial Muscle Relaxant Atra-curium, in collaboration with Hikma
Pharmaceuticals, 2002.
2- Developing New Class of Antifungal Agents Derived from
2-Aminothiazole Nucleus, in collaboration with The international
Company for Pharmaceutical Research, 2003.
3- Developing Bulk Scale Synthetic Approaches to Prepare
Ciprofloxacin, in collaboration with Hikma Chemicals, 2004.
4- Developing Bulk Scale Synthetic Approaches to Prepare
Ceftiufor, in collaboration with Al-Najma Bulk Pharmaceuticals,
2005.
5- Establishing a method of analysis and standardization study
of oral drops formula from (Paronychia argentea extract), for
kidney stones management, Al-Alem for Natural Preparation Co.
Ltd-(Savant) , 2009-2010.
6- Preparation of Novel Compounds With Potential Dyslipidemic
Activity, Jordan Company for Antibody Production (MONOJO),
2011.
5- Developing and standardization Gel formula for Premature
Ejaculation from Natural plant extract, Al-Alem for Natural
Preparation Co. Ltd-(Savant) , 2012-2015.
Projects in Collaboration with Local Universities:
1- Preparation of New indole-2-carboxamides as Potential
Hypolipidimic Activity in Triton WR 1339 Model, During sabbatical
leave at Al-Zaytooneh Private University, 2007-2008.
2- Preparation of New heterocyclic-2-carboxamides as Potential
Hypolipidimic Activity in Triton WR 1339 Model, During sabbatical
leave at Al-Zaytooneh Private University, 2014-2015.
3- In vitro evaluation of un-substituted indole carboxamid
derivatives as PPAR alpha agonist, in collaboration with
Philadelphia University, 2013.
Recent Publications
Publication for associate Professor: 2002-2006
1) Yusuf Al-Hiari, Stephen J. Bennett, Brian Cox, Robert J.
Davies, Abedawn Khalaf, Roger D. Waigh and Alan J. Worsley, Steps
Toward a Practical Synthesis of Macrocyclic Bisbenzylisoquinolines,
Journal of Heterocyclic Chemistry, 42 (4), 647-659, May 2005.
2) Mutasem O. Taha, Khalid M. Aiedeh, Yusuf M. Al-Hiari and
Hatim Al-Khatib, Synthesis of Zinc-Crosslinked Thiolated Alginic
Acid Beads and their In Vitro Evaluation as Potential Enteric
Delivery System Utilizing Folic Acid as Model Drug, De Pharmazia,
60 (10), 736-742, Oct. 2005.
3) Yusuf M. Al-Hiari, Ali M. Qaisi, Mustafa M. El-Abadelah and
Wolfgang Voelter, Synthesis and Antibacterial Activity of Some
Substituted 3-(Aryl)-and 3-(Heteroaryl)indoles, Monatshefte fuer
Chemie / Chemical monthly, 137 (2), 243-248, Feb. 2006, (published
on line first, 20th Jan 2006).
4) Bassam A. Sweileh and Yusuf M. Al-Hiari*, Successful
Synthesis of Industrially Useful Polycarbonates Based on Bisphenol
A by Single Phase Organic Solvent Polymerization, Journal of
Polymer Research, 13 (3), 181-191, June 2006, (published on line
first, 1-12-2005).
5) Yusuf M. Al-Hiari* and Bassam A. Sweileh, Synthesis of
Substituted Benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline
Derivatives and Investigation the Lithiation-Alkylation Chemistry,
Saudi Pharmaceutical Journal , 13 (4) supplement, 34-35, Nov.
2005.
6) Yusuf M. Al-Hiari* and Bassam A. Sweileh, Novel Synthesis and
Antimicrobial Activity of 3,7-Dimethylphenoxathiin Nucleus and Some
Related Analogues, Asian Journal of Chemistry, 18 (3), 2285-2298,
July 2006.
7) Yusuf M. Al-Hiari, Monther A. Khanfar, Ali M. Qaisi, Mohammad
Y. Abu Shuheil, Mustafa M. El-Abadelah and Roland Boese,
Heterocycles [h]Fused Onto 4-Oxoquinolines. Part I. Synthesis of
6-Oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h]-quinoline-7-carboxylic
acid N-oxide, Heterocycles, 68(6), 1163-1172, June 2006. (
published on line first 18th April 2006).
8) Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa
M. El-Abadelah, Pyrido[2,3-f]Quinoxalines-8-Carboxylic Acid
Derivatives and their Isomeric Pyrido[2,3-g]Quinoxalines, A Process
for their Preparation and their Use as Potential Antibacterial
Compounds, Jordan Patent 2323, Feb 2006, (priority date
12/5/2005).
9) Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mona R.
Hassuneh and Mustafa M. El-Abadelah, [a]Fused
Heterocyclic-Pyrido[2,3-f]Quinoxaline-2-Carboxylic Acid Derivatives
and their Pyrido[3,2-g] Analoges, A Procces for their Preparation
and their Potential Uses as Anticancer and Antibacterial Agents,
Jordan Patent 2345, May 2006, (priority date 12/4/2005).
Publication for full Professor: 2006-2011
10) Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and
Mustafa M. El-Abadelah, Antibacterial Agents, European Patent
Application; EP 1 721 898 A1, Nov. 2006.
11) Khaled M. Aiedeh, Mutasem O. Taha, Yusuf Al-Hiari, Yasser
Bustanji, Hatim S. AlKhatib, Effect of Ionic Cross-linking on the
Drug Release Properties of Chitosan Diacetate Matrices, Journal of
Pharmaceutical Sciences, 96 (1), 38-43, 2007. (accepted, Aug.
2006).
12) Ashok K. Shakya, Yusuf M. Al-Hiari and Omran M.O. Al-Hamami,
Liquid Chromatographic Determination of Irbesartan in Human Plasma,
Journal of Chromatography B, 245-250, 848, 2007, (accepted Oct.
2006)).
13) Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K. Shakya,
Rula M. Darwish, and Rana Abu-Dahab, Synthesis and Antibacterial
Properties of New 8-Nitro fluoroquinolone Derivatives, Molecules,
12, 1240-1258, 2007. (available on line).
14) Mohammad Y. Abu Shuheil, Mona R. Hassuneh, Yusuf M.
Al-Hiari, Ali M. Qaisi, and Mustafa M. El-Abadelah. Heterocycles
[h] -fused onto 4-oxoqinoline-3-carboxylic acid, III. Facile
synthesis and antitumor activity of model heterocycles [a] fused
onto pyrido [2,3-f]quinoxaline-3- carboxylic acids, Heterocycles
2007, 71 (10), 2155-2172.
15) Yusuf M. Al-Hiari, Ali M. Qaisi , Mohammad Y. Abu Shuheil,
Mustafa M. El-Abadelah , and Wolfgang Voelter. Synthesis and
Antibacterial Potency of
4-Methyl-2,7-dioxo-1,2,3,4,7,10-hexahydropyrido[2,3-f]quinoxaline-8-carboxylic
acid, Selected [a]-Fused Heterocyles and Acyclic Precursors,
Zeitschrift fuer Naturforschung, B: Chemical Sciences , 62b (11),
1453-1458; 2007.
16) Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K.
Shakya†, Rula M. Darwish, and Rana Abu-Dahab, Synthesis and
Antibacterial Properties of New 8-Nitro fluoroquinolone
Derivatives, Turkish Journal of Pharmaceutical Sciences, Special
Issue, 38-39, 2007.
17) Bassam A. Sweileh, Yusuf M. Al-Hiari and Khaled M. Aiedeh, A
New Nonphosgene Route to Poly(bisphenol-A carbonate) by Melt Phase
Interchange Reactions of Alkylene Diphenyl Dicarbonates with
Bisphenol A, Journal of Applied polymer sciences, 110(4),
2278-2292, 2008 (Accepted 11 May 2008, on line 15 Aug 2008).
18) Yusuf M. Al-Hiari, Rana Abu-Dahab and Mustafa M.
El-Abadelah, Heterocycles [h]-Fused Onto
4-Oxoquinoline-3-Carboxylic Acid, Part VIII [1]. Convenient
Synthesis and Antimicrobial Properties of Substituted
Hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid and Its
Tetrahydroquino[7,8-b]benzodiazepine Analog, Molecules, 13,
2871-2884, 2008.
19) Yusuf M. Al-Hiari*, Bassam A. Sweileh , Ashok K. Shakya,
Ghassan Abu Sheikha, Sabah I. Almuhtaseb, Synthesis of
1-Benzyl-1,2,3,4-Tetrahydroisoquinoline, Part I: Grignard Synthesis
of 1-(Substitutedbenzyl)-1,2,3,4-Tetrahydroisoquinoline Models with
Potential Antibacterial Activity, Jordan Journal of Pharmaceutical
Sciences, 2(1), 1-21, 2009.
20) Tariq M. Al-Qirim, Ghassan F. Shattat, Moyad J. Shahwan,
Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha and Syed Zaidi,
Pharmacological Evaluation of Novel Indole-2-carboxamides As Potent
Lipid-Lowering Agents in Triton-WR1339-Induced Hyperlipidemic Rats,
Zeitschrift für Naturforschung 64c (9/10), 619-625, 2009 ( accepted
July 2009).
21) Al-Qawasmeh, Raed A.; Zahra, Jalal A.; Khanfar, Monther A.;
Al-Hiari, Yusuf M.; El-Abadelah, Mustafa M.; Voelter, Wolfgang. A
convenient synthesis of
1-alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones. Letters in Organic
Chemistry (2009), 6(6), 511-514.
22) Ghassan Shattat, Tariq Al-Qirim, Kamal Sweidan, Moyad
Shahwan, Waseem El-Huneidi, Yusuf Al-Hiari, The Hypolipidaemic
Activity of Novel Benzofuran-2-carboxamide Derivatives in Triton
WR-1339-Induced Hyperlipidaemic Rats: A Comparison with
Bezafibrate, Journal Of Enzyme Inhibition And Medicinal Chemistry,
25(6), 751-755, 2010 (accepted 25th Sep. 2009).
23) Moyad Shahwan, Ghassan Shattat, Tariq Al-Qirim, Ghassan Abu
Sheikha, Yusuf Al-Hiari, Waseem El-Huneidi, Anan Jarab and Manal
AL-Najdawi. Synthesis and Pharmacological Evaluation of Novel
Substituted and Unsubstituted
N-(benzoylphenyl)-1H-indole-2-carboxamides As Potent
Anti-Hypertriglyceridemic Agents, Zeitschrift für Naturforschung
65c (5/6) , 309-316, 2010 ( accepted Feb. 2010).
24) S. AbuRuz , M. Al-Ghazawi1, Y. Al-Hiari, Dried blood spot
liquid chromatography assay for therapeutic drug monitoring of
lamotrigine, Chromatographia, 71(11/12), 1093-1099, 2010.
25) Yusuf Mohammad Al-Hiari,, Amjad M. Qandil, Rufaida M.
Al-Zoubi, Muhammed H. Alzweiri, Rula M. Darwish, Ghassan F. Shattat
and Tariq M. Al-Qirim,
7-(3-Chlorophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic
acid, Molbank, M669: 1-3, 2010.
26) Bassam A. Sweileh ,*, Yusuf M. Al-Hiari , Mohammad H.
Kailani and Hani A. Mohammad , Synthesis and Characterization of
Polycarbonates by Melt Phase Interchange Reactions of Alkylene and
Arylene Diacetates with Alkylene and Arylene Diphenyl Dicarbonates,
Molecules, 15, 3661-3682, 2010.
27) Ghassan F. Shattat, Tariq M. Al-Qirim, Moyad J. Shahwan,
Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha,
N-substituted-1H-indole-2-carboxamide derivatives, a process for
their preparation and their use as potential antihyperlipidaemic
agents, JP 2519, 13/7/2010. priority number:Jordan Patent ا ع
-2008-373 - (date 14/8/2008), file number 35204.
28) Ghassan Shattat, Rania Al-Qirim, Yusuf Al-Hiari, Ghassan Abu
Sheikha, Tariq Al-Qirim, Waseem El-Huneidi and Moyad Shahwan.
Synthesis and Anti-hyperlipidemic Evaluation of
N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide Derivatives in
Triton WR-1339 Induced Hyperlipidemic Rats, Molecules, 15,
5840-5849, 2010.
29) Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri,
Tariq M. Al-Qirim, Ghassan F. Shattat and Mustafa M. El-Abadleh,
Synthesis and Antibacterial Properties of New N4- acetylated
Hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline-8-carboxylic acids,
Journal Of Enzyme Inhibition And Medicinal Chemistry, 26(5),
649-656, 2011 (accepted 17th Nov. 2010), Published on line
11-1-2011, DOi number doi:10.3109/14756366.2010.543421.
30) Ghassan Abu Sheikha, Buthina Hussin, Yusuf Al-Hiari, Tariq
Al-Qirim, Ghassan Shattat, Synthesis of Benzothiophene Carboxamide
Derivatives and Their Pharmacological Evaluation as Potent
lipid-Lowering Agents in Rats, Zeitschrift für Naturforschung 66 c
, 93-103, 2011 ( accepted Nov. 2010).
31) Rana Abu-Huwaij, Rana M. Obaidat, Kamal Sweidan, and Yusuf
Al-Hiari, Formulation and In Vitro Evaluation of Xanthan Gum or
Carbopol 934-Based Mucoadhesive Patches, Loaded with Nicotine, AAPS
PharmSciTech, 12(1), 21-27, 2011 ( accepted 22 October 2010).
32) Rana M Obaidat, Kamal Sweidan, Wafa Al-Rajab, Mai Khanfar,
Rana Abu-Hwaij, Yusuf Al-Hiari and Samir Al-Gharabli, Development
of local,mucoadhesive, sustained release patches of tetracycline
hydrochloride for treatment of mouth infections: a preliminary in
vitro study, European Journal of Parenteral & Pharmaceutical
Sciences 15(4): 87-94, 2010 ( accepted 2010).
33) Tariq M. Al-Qirim, Ghassan F. Shattat, Kamal Sweidan,
Ghassan M. Abu Sheikha, Yusuf M. Al-Hiari, BENZOFURAN- AND
BENZOTHIOPHENE-2-CARBOXAMIDE DERIVATIVES, A PROCESS FOR THEIR
PREPARATION AND THEIR USE AS POTENTIAL ANTIHYPERLIPIDAEMIC AGENTS,
Jordan Patent 2588- 02/6/2011. (priority date 9/12/2009), JP 2588
approved 27-2-2011,
34) Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mustafa M.
El-Abadelah and Mona R. Hassuneh, Anticancer and Antibacterial
Agents, GB UK Patent, GB 2442 951, 23Feb, 2011. (Date of
publication: 23. 4. 2008).
35) Al-Qirim, Tariq; Shattat, Ghassan; Abu Sheikhaa,
Ghassan;Al-Hiari, Yusuf, Synthesis of Benzothiophene Carboxamide
Derivatives and Their Pharmacological Evaluation as
Potentantihyperlipidimic Agents in Rats 42nd Central Regional
Meeting of the American Chemical Society, Indianapolis, IN, United
States, June 8-10 (2011), CERM-281.
36) Yusuf Al-Hiari *, Ghassan Shattat , Tariq Al-Qirim, Waseem
El-Huneidi, Ghassan Abu Sheikha and Suhair Hikmat,
Antihyperlipidemic Properties of Novel
N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton
WR-1339-Induced Hyperlipidemic Rats, Molecules, 16, 8292-8304,
2011; (doi:10.3390/molecules16108292).
37) Talal Aburjai, Muhammed Alzweiri, Yusuf M. Al-Hiari,
Temperature and pressure behaviours of methanol, acetonitrile/water
mixtures on chromatographic systems, American Journal of Analytical
Chemistry, 2(8), 934-937, 2, 2011.
Publication after 2012
38) Yusuf M. Al-Hiari1*, Amjad M. Qandil, Rufaida M. Al-Zoubi1,
Muhammed H. Alzweiri, Rula M. Darwish, Ghassan F. Shattat4 4 and
Tariq M. Al-Qirim, Synthesis and Antibacterial Activity of Novel
7-
haloanilino-8-nitrofluoroquinolone Derivatives, Medicinal
Chemistry Research, 21, 1734-1740, 2012 (accepted 1-6-2011), (
Online Springer Publisher: DOI: 10.1007/s00044-011-9692-3).
39) Ghassan Shattat, Tariq Al-Qirim, Ghassan Abu Sheikha, Yusuf
Al-Hiari, Kamal Sweidan, Rania Al-Qirim, Suhair Hikmat, Luma
Hamadneh, and Sameer Al-kouz, The Pharmacological Effects of Novel
5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide
Derivatives on Plasma Lipid Profile of Triton-WR-1339-Induced
Wistar Rats, Journal Of Enzyme Inhibition And Medicinal Chemistry,
28(4), 863-869, 2013 (accepted 26th April. 2012, Early Online: 1–7,
Published on line 00-0-2012, DOI: 10.3109/14756366.2012.692085.
40) Muhammed Alzweiri, Yusuf M. Al-Hiari, Talal Aburjai and
Osama Abdel-Aldaem, On-column approach in HPLC-UV analysis of
non-chromophoric compounds using azelaic acid as a model, Jordan
Journal of Pharmaceutical Sciences, 5(3), 243-251, 2012, accepted
May 2012.
41) Mohammad H. Kailani, Amal G. Al-Bakri, Haitham Saadeh, Yusuf
M. Al-Hiari, Preparation and Antimicrobial Screening of Novel 2,
2-dichloro-cyclopropane –cis-dicarbamates and Comparison to their
Alkane and cis-Alkene Analogs, Jordan Journal of Chemistry 7(3),
239-252, 2012, accepted Sep. 2012.
Publication after 2013
42) Muhammed Alzweiri, Yusuf M. Al-Hiari, Evaluation of vanillic
acid as inhibitor of carbonic anhydrase isozyme III by using a
modified Hummel-Dreyer method: approach for drug discovery,
Biomedical Chromatography, 27(9), 1157-1161, 2013, accepted March
2013
.
43) Shattat, Ghassan; Al-Qirim, Tariq; Sheikha, Ghassan Abu;
Al-Hiari, Yusuf; Sweidan, Kamal; Al-Qirim, Rania; Hikmat, Suhair;
Hamadneh, Lama; Al-kouz, Sameer The Pharmacological effects of
novel
5-fluoro-N-(9,10-dihydro-9,10-dioxoanthracen-8-yl)-1H-indole-2-carboxamide
derivatives on plasma lipid profile of Triton-WR-1339-induced
Wistar rats , Journal of Enzyme Inhibition and Medicinal
Chemistry , 28(4), 863-869, 2013.
44) Muhammed Alzweiri, Yusuf M. Al-Hiari, Analysis and
Evaluation of Hydroxytyrosol in Olive Leaf Extract, Jordan Journal
of Pharmaceutical Sciences, 6(3), 314-322, 2013.
Publication after 2014
45) Yusuf M. Al-Hiari • Violet N. Kasabri • Ashok K. Shakya ,
Muhammad H. Alzweiri • Fatma U. Afifi •
Yasser K. Bustanji • Ihab M. Al-Masri, Fluoroquinolones: novel
class of gastrointestinal dietary lipid digestion and absorption
inhibitors, Medicinal Chemistry Research, 23(7), 3336-3346, 2014
(accepted 9-1-2014), ( published online: 24/1/2014; Springer
Publisher: DOI: 10.1007/s00044-014-0913-4).
46) Manal AL-Najdawi, Yusuf Al-Hiari, Tariq Al-Qirim,
GhassanShattat, Mohammad Al-Zweri, and Ghassan Abu Sheikha,
Synthesis and Pharmacological Evaluation of Novel Unsubstituted
Indole-Anthraquinone Carboxamide Derivatives as Potent
Antihyperlipidemic Agents, Zeitschrift für Naturforschung 69C,
69(1/2), 21-28, 2014. (accepted Jan 21, 2014).
47) Al-Hiari, Yusuf M.; Shakya, Ashok K.; Alzweiri, Muhammed H.;
Aburjai, Talal; Abu-Dahab, Rana, Synthesis and biological
evaluation of substituted
tetrahydro-1H-quino[7,8-b][1,4]benzodiazepine-3-carboxylic acid
derivatives , Farmacia (2014), 62(3), 570-588.
48) Alzweiri Muhammed; Al-Balas Qosay; Al-Hiari Yusuf,
Chromatographic evaluation and QSAR optimization for benzoic acid
analogues against carbonic anhydrase III, Journal of enzyme
inhibition and medicinal chemistry (2014), 420-429. DOI:
10.3109/14756366.2014.940939
49) Al-Qirim T; Shattat G; Sheikha G A; Jarab A; Sweidan K;
Al-Hiari Y, Synthesis of Novel N-(4-benzoylphenyl)-2-furamide
Derivatives and their Pharmacological Evaluation as Potent
Antihyperlipidemic Agents in Rats, Drug research, 65(3), 158-163,
2015. DOI: 10.1055/s-0034-1375646
50) Sanaa K. Bardaweel, Rula M. Darwish, Muhammed H. Alzweiri
and Yusuf M. Al-Hiari, Synergism and efficacy of some naturally
occurring D-amino acids against clinically relevant bacterial and
fungal species, Jordan Journal of Pharmaceutical Sciences, 7(3),
199-2012, 2014.
51) Suhir Jasim, Tariq Al-Qirim, Ghassan Shattat, Ghassan
AbuSheika, Nadeem Alhusini, Yusuf Al-Hiari, The Pharmacological
effect of Novel
N-(5-Chloro-9,10-Dioxo-9,10-Dihydroanthracen-1-yl)Furan-2-carboxamide
Derivatives on Lipid Metabolism in Triton Induced Rats, SYLWA, 158,
9, 122-128, 2014.
Publication after 2015
52) Alzweiri M*, Shudeifat M, Al-Khaldi K, Al-Hiari Y, Afifi F.
U, Acetylated ferulenol-oxy-ferulenol as a proposed marker for
fresh ferula toxicity: A metabolomic approach, : Journal of Liquid
Chromatography & Related Technologies, accepted march (2015),
38(2), 283-288.
53) Kamal Sweidana,*, Jörn Engelmannb, Walid Abu Rayyanc,
Dima Sabbahc, Musa Abu Zargaa, Tariq Al-Qirimc, Yusuf Al-Hiarid,
Ghassan Abu Sheikhac, Ghassan Shattatc, Synthesis and Preliminary
Biological Evaluation of New Heterocyclic Carboxamide Models, LLDD,
12, 417-429, 2015.
54) Muhammed Alzweiri · Mohammad Khanfar , Yusuf Al-Hiari,
Variations in GC–MS Response Between Analytes and Deuterated
Analogs, Chromatographia 78:251–258, 2015.
55) Ghassan F. Shatat, Ghassan M. Abusheika, Tariq M. Al-Qirm,
Rawan Huiwaitat, Waseem El-Huneidi, Reema Abu Khalaf, Yusuf M.
Al-Hiari , Suhair H. Jasim & Lama Hamadaneh, Novel Pyrrole
Derivatives as Potent lipid-Lowering Agents in
Triton-WR-1339-Induced Hyperlipidemic Rats, Lat. Am. J. Pharm. 34
(6): 1258-64 (2015).
56) Emad M. Abdullat, Nathir M Obeidat Madi T Al-Jaghbir .Yusuf
M Al-Hiari. Kamal Al- Hadidi. Establishing the Cholinesterase
Levels in Jordan: an investigation and monitoring model for
pesticides outbreak. Jordan Medical Journal 2015;
49(3):129-138.
57) Mohammad Mohammad, Violet Kasabri, Hiba Zalloum, Rabab
Tayyem3, Eman AbuRish, Yusuf Al-Hiari, Yasser Bustanji,
Antilipolytic property of curcumin: Molecular docking and kinetic
assessment, REVUE ROUMAINE DE CHIMIE, 1-10, 60(10), 2015.
58) Yusuf M. Al-Hiari, Ashok K. Shakya, Wafa J. Al-Rajab, Emad
A. AbdelRahim, Muhammed H. Alzweiri, Lubna Rustam and Rula Darwish,
Antimicrobial screening of novel N-4-fluorophenyl
quino-[7,8-b][1,4]-benzodiazepin-3-carboxylic acid derivatives,
REVUE ROUMAINE DE CHIMIE, 899-905, 60(9), 2015.
Publication after 2016:
Three papers are accepted and 3 in process
59) Nada Jarrar, Muhammed Alzweiri, Yusuf Al-Hiari, Shrouq
Farah, Mohammad A. Khanfar, Modified Hummel–Dreyer methodand
Molecular Modeling Studies Identified Nicotinic Acid Analogues as
Carbonic Anhydrase III Ligands, LLDD, 13 (5), 401-410, 2016. DOI:
10.2174/1570180812666150821002900
60) Shereen ARABIYAT, Yusuf AL-HIARI, Yasser K. Bustanji, Hiba
ZALLOUM, Violet Kasabri; In Vitro Modulation of Pancreatic Lipase
and Proliferation of Obesity Related Colorectal Cancer Cell line
Panel by Novel Synthetic Triazoloquinolones, REVUE ROUMAINE DE
CHIMIE, accepted June 2016, 61(11-12), 871-879, 2016.
61) Abu Farha, Rana; Bustanji, Yasser Kh; Al-Hiari, Yusuf M;
Al-Qirim, Tariq M; abu-sheikha, Ghassan; albashiti, rabab, Lipid
Lowering Activity of Novel N-(benzoylphenyl)pyridine-3-carboxamide
derivatives in Triton WR-1339 Induced Hyperlipidemic Rats, Journal
Of Enzyme Inhibition And Medicinal Chemistry. 31(4), 138-144, 2016
accepted. 2016. DOI:10.1080/14756366.2016.1222581
62) Amal AbuHanoud, Violet Kasabri, Naiyla Bulayova, Amal akour,
Haidar Bustanji, Nahla Khawaja, Dana Hyasat, , Yasser Bustanji,
Yusuf AlHiari, Rula Silawi; " Evaluation of Oxytocin (OXT),
Endothelin-1 and Nesfatin Plasma Concentrations in Newly-diagnosed
Diabetic and Non-diabetic Patients with Metabolic Syndrome. "'
Jordan Journal of Pharmaceutical Sciences, 00, 00-00, 2016
accepted. 2016.
63) Shereen Arabiyat, Ashraf Al-Rabi'ee, Hiba Zalloum, Violet
Kasabri, Mohammad Hudaib, Mohammad Mohammad, Yusuf Al-Hiari and
Yasser Bustanji ''Antilipolytic and hypotriglyceridemic effects of
dietary Salvia triloba Lf (Lamiaceae) in experimental rats''.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH 2016; 15(4):723-728
Publication 2017:
64) Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas , Yusuf
Al-Hiari , Rula Darwish and Talal Aburjai, Synthesis of New
Nitrofluoroquinolone Derivatives with Novel Anti-Microbial
Properties against Metronidazole Resistant H. pylori, Molecules.
22(1), 71, 2017 accepted. Dec. 2016.
doi:10.3390/molecules22010071.
65) Suhair Hikmat , Tariq Al-qirim , Dania Alkabbani , Ghassan
Shattat , Ghassan Abu Sheikha , Dima Sabbah , Reema Abu khalaf and
Yusuf Al-hiari ; Synthesis and In vivo Anti-hyperlipidemic Activity
of Novel N-Benzoylphenyl-2-Furamide Derivatives in
Triton-WR-1339-Induced Wistar Rats; Trop J Pharm Res, 16(1),
193-201, 2017 (accepted Oct 2016).
66) Haneen K. Mohammad, Muhammed H. Alzweiri, Mohammad A.
Khanfar, Yusuf M. Al-Hiari; 6-Substituted nicotinic acid analogues
as potent inhibitors of CAIII as therapeutic candidates in
hyperlipidemia and cancer, Medicinal Chemistry Research,
26, (7), pp 1397–1404 (accepted 28 2 2017-Springer
Publisher: DOI: 10.1007/s00044-017-1825-x
67) Lama Hamadneh, Luay Al-Essa, Suhair Hikmat, Tariq Al-Qirim,
Ghassan Abu Sheikha, Yusuf Al-Hiari, Nisrin Azmy, Ghassan Shattat,
N-(3-Benzoylphenyl)-1H-Indole-2-Carboxamide Decreases Triglycerides
Levels by Down Regulation of Apoc3 Gene Expression in Acute
Hyperlipidemic Rat Model , Molecular and Cellular Biochemistry (Mol
Cel Biochem), 431(1-2), 133-138, July. 2017. DOI
10.1007/s11010-017-2983-3.
68) Muhammed Alzweiri, Sara Al-Marabeh, Sanaa K. Bardaweel,
Rawhi Alfar and Yusuf M. Al-Hiari, Stability determination for
cyclized 2,4-dinitrophenyl hydrazone derivative of glucose, Journal
of Analytical Science and Technology, 8:9 (0, 1-8, accepted 5th
April. 2017. DOI 10.1186/s40543-017-0117-x.
69) Mohammad Abu-Sini, Amal Mayyas, Nehaya Al-Karablieh, Rula
Darwish , Talal Aburjai, Yusuf Al-Hiari, Shereen Arabiyat, Luay
Abu-Qatouseh, Synthesis of 1,2,3-Triazolo[4,5-h]quinolone
Derivatives with Novel Anti-Microbial Properties against
Metronidazole Resistant Helicobacter pylori, Molecules. 22(5), 841,
2017 accepted. Dec. 2016. doi:10.3390/molecules22050841. Accepted
15 5 2017.
70) Arabiyat S., Kasabri V., Al-Hiari Y., Bustanji Y., Albashiti
R., Almasri I. and Sabbah D., (2017), antilipase and
antiproliferative activities of novel fluoroquinolones and
triazolofluoroquinolones. Chemical Biology and Drug Design 90(6),
1282-1294, 2017 Dec. 2017 (DOI: 10.1111/cbdd.13049).
71) Lubna Swellmeen, Rand Shahin, Yusuf Al-Hiari, Amani Alamiri,
Alaa Hasan, Omar Shaheen, Structure based drug design of Pim-1
kinase followed by pharmacophore guided synthesis of
Quinolone-based inhibitors. Bioorganic & Medicinal Chemistry
(BMC), 25(17), 4855-4875, 21 July 2017.
https://doi.org/10.1016/j.bmc.2017.07.036, Available online 21 July
2017. DOI: 10.1016/j.bmc.2017.07.036
72) Rana Abu Farha, Yasser Bustanji, Yusuf Al-Hiari, Sanaa K.
Bardaweel, Tariq Al-Qirim, Ghassan Abu Sheikha, Rabab Albashiti ,
Pharmacological Evaluation of Novel Isonicotinic Carboxamide
Derivatives as Potential Anti-hyperlipidemic and Antioxidant
Agents, Archiv der Pharmazie/ Arch. Pharm. Chem. Life Sci, 350,
e1700024, 2017. Accepted 21 july 2017, DOI
10.1002/ardp.201700024.
73) Rama Kahwaji, Violet Kasabri,* 1 Nailya Bulatova, Amal
Akour, Haidar Bustanji, Nahla Khawaja, Dana Hyasat, Ayman Zayed,
Munther Momani, Yasser Bustanji, Yusuf AlHiari, Sundus Mashallah,
Mais Al-Nouaaimi , Evaluation of correlations of Plasma Levels of
Oxytocin, Omentin-1 and Irisin in Diabetic and Non-Diabetic
Metabolic Syndrome Patients: A Cross Sectional Study in Jordan,
Jordan Medical Journal, J Med J 2017; Vol. 51 (3):97-108).
Publication after 2018:
74) Yousef Alabsi, Yusuf Al-Hiari, Violet Kasabri, Shereen
Arabiyat, Rabab Bashiti, Sundos Alalawi And Rula Al-Shahrabi; '' In
Vitro Modulation Of Pancreatic Lipase And Proliferation Of Obesity
Related-Colorectal Cancer Cell Line Panel By Novel Synthetic
Fluoroquinolones ''. REVUE ROUMAINE DE CHIMIE 2018, 63(12),
1123-1134.
75) Ghassan Abu Sheikha, Majdi M. Bkhaitan, Hanin Kalloush, Lama
Hamadneh, Reema Abu Khalaf, Tariq Al-Qirim, and Yusuf Al-Hiari.
Synthesis of Novel Benzimidazole-2-Carboxamide Derivatives and In
Vivo Antihyperlipidemic Activity Evaluation. Chem. Pharm.
Bull..;66(4):423-426, Accepted, JAN. 2018. doi:
10.1248/cpb.c17-00908.
Publication after 2019:
76) Tanzeela Abdul Fattah, Aamer Saeed, Yusuf M. Al-Hiari,
Violet Kasabri, Ihab M. Almasri, Sundos AlAlawi, Fayaz Ali Larika
and Pervaiz Ali Channara ‘’Functionalized Furo[3,2-c]coumarins as
Anti-proliferative, Anti-lipolytic, and Anti-inflammatory
Compounds: Synthesis and Molecular Docking Studies’’. JOURNAL OF
MOLECULAR STRUCTURE 2019; 1179:390-400.
77) Mamdooh N, Kasabri V, Al-Hiari Y, Almasri I, Al-Alawi S,
Bustanji Y’’ Evaluation of selected commercial pharmacotherapeutic
drugs as potential pancreatic lipase inhibitors and
antiproliferative compounds. DRUG DEVELOPMENT RESEARCH. 2019
;80(3):310-324. DOI: 10.1002/ddr.21499.
78) Imad I. Hamdan, Violet Kasabri, Yusuf M. Al-Hiari, Dina
ElSabawi, Hiba Zalloum;’’ Lipase inhibitory activity of selected
pharmaceutical agents’’; ACTA PHARMACEUTICA . 2019; 69:1–16.
Original research paper.
https://doi.org/10.2478/acph-2019-0010.
79) Manal Al-Najdawi, Bilal Al-Jaidi, Qosay Al-Balas, Haifa'a
Odetalla, Tariq Al-Qirim, Ghassan Shattat and Yusuf Al-Hiari,
Synthesis, molecular docking and evaluation of hypolipidemic
activities of novel benzophenonecarboxamide derivatives, Indian
Journal of Chemistry/ IJC-B Vol.58B (05) [May 2019], 587-593,
2019.
80) Shereen Arabiyat ; Violet Kasabri; Yusuf Al-Hiari; Ihab
AL-MASRI; Sundus Alalawi; YASSER BUSTANJI,
DUAL GLYCATION-INFLAMMATION MODULATION, DPP-IV AND PANCRAETIC
LIPASE INHIBITORY POTENTIALS AND ANTIPROLIFERATIVE ACTIVITY OF
NOVEL FLUOROQUINOLONES, Asian Pacific Journal of Cancer Prevention
(APJCP), V 20, Issue 8, August 2019, 2503-2514. Accepted 18/8/2019.
DOI: 10.31557/APJCP.2019.20.8.2503.
81) Lubna Swellmeen*, Amal Uzrail, Rand Shahin and Yusuf
AL-Hiari; Synthesis of Fluoroquinolones Derivatives as
Antimicrobial Agents, Oriental Journal of Chemistry (Orient J
Chem), 35(4), 1248-1253; 2019. DOI :
http://dx.doi.org/10.13005/ojc/350401.
82) Aya Qasem , Violet Kasabri, Eman AbuRish, Yasser Bustanji,
Yusuf Al-Hiari,Reem AlAbbasi, Bashaer AbuRmilha , Sundus Alalawi ‘’
EVALUATION OF POTENTIAL CYTOTOXIC EFFECT OF DIFFERENT PROTON PUMP
INHIBITORS ON DIFFERENT HUMAN CANCER CELL LINES’’. ANTICANCER
AGENTS IN MEDICINAL CHEMISTRY ACCEPTED/2019.
83) Alaa Hamdan, Violet KASABRI, Yusuf Al-Hiari, Shereen
ARABIYAT, Sundus ALALAWI’’ Dual Anti-Inflammatory And
Anti-Glycation propensities of A Potentially Novel Class of
Functionalized Flouroquinolones’’ Journal of Heterocyclic
Chemistry, JHC , 00(0), 0000-000; 2019. ; accepted 7/10/2019.
84) Amani Al-Ma’ani, Yusuf Al-Hiari, Violet
Kasabri, Noor Mamdooh, Sundus
Alalawi & Ahmad Telfah, FUNCTIONALISED
TRIAZOLOQUINOLONES AS A POTENTIALLY NOVEL CLASS OF ANTIDIABESITY
AND ANTIPROLIFERATIVE COMPOUNDS: SYNTHESIS AND PHARMACOLOGICAL
APPRAISAL, Analytical Chemistry Letters, Volume 9 (6) -000,
2019. Published Online: 28 Jan 2020.
Publication after 2020:
85) Mthanna AlKhalil, Yusuf Al-Hiari, Shereen Arabiyat, Violet
Kasabri, Shereen Arabiyat, Muhammad Al-Zweiri, Noor Mamdooh, Ahmad
Telfah;’’ Selected Pharmacotherapy Agents as Antiproliferative and
anti-inflammatory compounds’’, DRUG DEVELOPMENT RESEARCH , 000,000,
2020. Puplished on line fiesrt 14/1/2020.
86) Shereen ARABIYAT, Violet Kasabri, Yusuf AL-HIARI,
‘’Antilipolytic-Antiproliferative Activity Of Novel Antidiabesity
Triazolo/Fluoroquinolones’’. Jordan Journal of Pharmaceutical
Sciences, Volume 13, (1), 85-100, 2020, accepted 19/3/2019.
· MAHA R. AL RIMAWI1,*, , YUSUF M. AL-HIARI2, , AMAL G.
AL-BAKRI3, and SANAA K. BARDAWEEL, . Antibacterial and Anticancer
Properties of New Fluoroquinolones, Asian Journal of Chemistry;
Vol. 32, No. 2, 427-434, 2020.
Submitted 2020
87) Rula AL-SHAHRABI, Violet KASABRI, Yusuf Al-Hiari, Shereen
ARABIYAT, Sundus ALALAWI’’ Functionalized Flouroquinolones As A
Potentially Novel Class Of Anti-Inflammatory And Anti-Glycation
Compounds: Synthesis And Pharmacological Appraisal’’ ANALYTICAL
CHEMSITRY LETTERS submitted 2/2019.
88) Abdelrahman
89) Shereen p chloro telfah and maliti
Violet Kasabri, Shereen ARABIYAT, Hiba ZALLOUM, Yusuf AL-HIARI,
Yasser K. BUSTANJI, Sundos MASHALLA, Ahmad TELFAH, Jehad ALMALITI;
‘’Synthesis, docking studies and evaluation of novel
fluoroquinolones as potential antidiabesity and antiproliferative
compounds’’ ANTICANCER AGENTS IN MEDICINAL CHEMISTRY. Submitted
2/2018
90) Abdurahman paper submitted EJMC 9 2019
91) Shireen ahmd jihad-apioptosis ---pCl,p-F
92) Ofloxacin tolfah
93) Lubna MCRE
94) Manal 2
95) Imad FQ pl m-Methyl maha
96) Sarah 1
97) Sarah 2 apioptosis
98) Someya
99) Rola
100) Ala a tabaza 1 and 2
101) Ala a tabaza 1 and 2
102) yarmook
Published Papers/Posters/Abstracts in Scientific
Conferences:
1. Yusuf Al-Hiari* and Roger D. Waigh, Novel Synthesis of
Bisbenzylisoquinoline Alkaloids, The 24th RSC Perkin Division For
Scotland, Poster and abstract, 18th of Feb 1998-Saint Andrew
University / Dundee, Scotland.
2. Yusuf Al-Hiari* and Roger D. Waigh, Steps Toward an Efficient
Synthesis of New Biologically Active Bisbenzylisoquinoline
Alkaloids, The 2nd International Conference of the Faculty of
Pharmacy, October, 2001, Amman-Jordan, and the 5th Scientific
Congress of the Association of the Colleges of Pharmacy in the Arab
World , Poster and abstract, October, 2001, Amman-Jordan.
3. Yusuf Al-Hiari* and Roger D. Waigh, Steps Toward an Efficient
Synthesis of Macrocyclic Bisbenzylisoquinoline Alkaloids, The 10th
Pharmaceutical Jordainian Conference of the Jordainian
Pharmaceutical Society, Poster, abstract and lecture, March
13-16/2002, Amman-Jordan.
4. Yusuf Al-Hiari*, Pharmaceutical Biotechnology: “Recombinant
DNA Technology as a Tool for the Production of Biopharmaceutical
Drugs, The Jordan Ninth Science Week: Biotechnology and its Role in
the Jordanian Economy, A primary lecturer and abstract, 6-8 October
2003, University of Science and Technology, Irbid-Jordan.
5. Yusuf M. Al-Hiari* and Bassam A. Sweileh, Crignard Synthesis
of 1-Substituted Benzyl-1,2,3,4-tetrahydroisoquinoline Models with
Potential Antibacterial and Anticancer Activity, The Eleventh
Jordainian Pharmacy Conference, Original research paper, abstract
and lecture, September 28-30, 2005, Amman-Jordan.
6. Yusuf M. Al-Hiari* and Bassam A. Sweileh, Synthesis of
Substituted benzyl-N-acyl-1,2,3,4-Tetrahydroisoquinoline
Derivatives and Investigation the Lithiation-Alkylation Chemistry,
The 9th International Pharmaceutical Sciences Conference and
Exposition and the 9th General Assembly Meeting of the Scientific
Society of Colleges of Pharmacy of the Association of Arab
Universities in the Arab World, Original research paper, abstract
and lecture, 17-21/12/2005, Riyadh- Saudi Arabia.
7. Yusuf M. Al-Hiari* and Dr. Talal Aburjai, Patent Challenges
in Pharmaceutical Sector; Impact, Overcoming Challenges and Future
Prospective, “The Importance of Intellectual Property in Scientific
Research and Economic and Industrial Growth in the Arab World”
Original research paper, abstract and lecture, 23-25/1/2006,
Damascus-Syria.
8. Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa
M. El-Abadelah, Novel Biologically Active 2-Quinoxalinone and
Benzofuroxan Systems Obtained by Substitution at Position 7 of
8-Nitrofluoroquinolones, Nagazaki Pharmaceutical Conference, July
2006, Nagazaki University, Japan.
9. Yusuf M. Al-Hiari* , Inas Saleh Al-Mazari , Ashok K. Shakya†,
Rula M. Darwish, and Rana Abu-Dahab, Synthesis and Antibacterial
Properties of New 8-Nitro fluoroquinolone Derivatives, abstract and
oral presentation (invited speaker), 5th International Symposium on
Pharmaceutical Chemistry, Sep. 5-7, 2007, Istanbul, Turkey.
10. Yusuf M. Al-Hiari*, Ashok K. Shakya, Ghassan Abu Sheikha,
Bassam A. Sweileh, Preparation of new
diazepino[2,3-h]quinoline-9-carboxylic acid derivatives and their
analogus [b]fused benzodiazepine derivatives, The 12th
Pharmaceutical Jordainian Conference of the Jordainian
Pharmaceutical Society, Full Lecture and abstract, April
10-12/4/2008, Amman, Jordan.
11. Yusuf M. Al-Hiari, Synthesis of Substituted
benzyl-1,2,3,4-Tetrahydroisoquinoline Derivatives Originating from
Natural Sources: Grignard and Lithiation Approaches, Scientific day
of Medicinal, Aromatic and Poisonous Plants, abstract as full
lecture, Zarka University College, Al-Balqa’ Applied University,
23, April 2008.
12. Yusuf M. Al-Hiari and Bassam A. Sweileh, Novel Synthesis of
Macrocyclic Bisbenzylisoquinoline Models With One Ether Linkage
Utilizing Lithiation-Alkylation Approach, Jordan International
Pharmaceutical Conference, abstract as full lecture, Al-Zaytoonah
Private University of Jordan, 15-17-Oct. 2008.
13. Yusuf M. Al-Hiari Heterocycles [h]-Fused Onto
4-Oxoquinoline-3-Carboxylic Acid, Novel Biologically Active
2-Quinoxalinone Systems Obtained by Substitution at Position 7 of
8-Nitrofluoroquinolones, The Fourth International Conference;
Research and Development in Drugs: Current challenges,
Pharmaceutical and Drug Industries Division-National Research
Centre, abstract as full lecture, Cairo/Egypt, 3-5 March 2009.
14. Bassam A. Sweileh, Yusuf M. Al-Hiari, Mohammad H. Kailani,
Synthesis and Characterization of Polycarbonates by Melt-Phase
Interchange Reactions of Alkylene and Arylene Diacetates with
Alkylene and Arylene Diphenyl Dicarbonates: A New Synthetic
Approach, The 9th Jordanian Chemical Conference, The Jordanian
Chemical Society, Hashemite University, 28 th April 2009.
15. Yusuf M. Al-Hiari, Pharmaceutical biotechnology: the art of
the future, The 13th Pharmaceutical The 13th Jordanian conference
of pharmacist of the Jordainian Pharmaceutical Association, Full
Lecture and abstract, April 22-24/4/2010, Amman, Jordan.
16. Yusuf M. Al-Hiari, Novel Biologically Active 2-Quinoxalinone
Systems Obtained by Substitution at Position 7 of
8-Nitrofluoroquinolones, The 13th Pharmaceutical The 13th Jordanian
conference of pharmacist of the Jordainian Pharmaceutical
Association, abstract, April 22-24/4/2010, Amman, Jordan.
17. Yusuf M. Al-Hiari, Ashok K. Shakya, Muhammed H. Alzweiri and
Mustafa M. El-Abadelah, Formal Synthesis and Antibacterial
Properties of New N4- acetylated
Hexahydro-2,7-dioxopyrido[2,3-f]quinoxaline- 8-carboxylic acids,
The 13th Pharmaceutical The 13th Jordanian conference of pharmacist
of the Jordainian Pharmaceutical Association, abstract, April
22-24/4/2010, Amman, Jordan.
18. Yusuf M. Al-Hiari , Manal M Al-Najdawi, and Tariq M.
Al-Qirim. Synthesis and Pharmacological Evaluation of Novel
N-(benzoylphenyl)-1H-indole-2-carboxamides As Potent
Anti-Hypertriglyceridemic Agents. 11th Eurasi Conference on
Chemical Sciences, abstract, 6-10 October 2010, the Dead
Sea-Jordan. (poster).
19. Yusuf Al-Hiari and Ashok K. Shakya, Synthesis and
antibacterial activity of new [1,2,3] triazolo[4,5-h]quinoline
derivatives as potential antimicrobial agents. The 3ed Jordanian
International Pharmaceutical Conference, abstract and oral
presentation, 20-22 October 2010, Al-Zaytoonah Private University
of Jordan, Amman-Jordan.
20. Yusuf Al-Hiari and Ashok K. Shakya, "Synthesis and
Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline
Derivatives as Potential Antimicrobial/AntiTuberculosis Agents".
First United Arab Emirates Conference on Pure and Applied Chemistry
(ECPAC11), abstract and oral presentation, 1-3/3/2011, American
University of Sharjah, Sharjah, UAE.
21. Yusuf Al-Hiari and Ashok K. Shakya: "Synthesis and
Antibacterial Activity of New [1,2,3] triazolo[4,5-h]quinoline
Derivatives as Potential Antimicrobial /Anti-convulsant Agents".
The International Conference on Materials in Jordan, Humboldt
Kolleg, abstract and oral presentation, 9-11 April /4/2011, German
–Jordanian University (GJU), Amman, Jordan.
22. Yusuf Al-Hiari, " Pyrido-Quinoxalinones, As potentiel
antibacterial and anticancer compounds" , The 4th International
Conference on Health Care (ICHC), abstract and oral presentation ,
4-5 May /5/2011, Al-Ahliyya Amman University,, Amman, Jordan.
23. Al-Qirim, Tariq; Shattat, Ghassan; Abu Sheikhaa, Ghassan;
Al-Hiari, Yusuf, Synthesis of Benzothiophene Carboxamide
Derivatives and Their Pharmacological Evaluation as
Potentantihyperlipidimic Agents in Rats 42nd Central Regional
Meeting of the American Chemical Society, Indianapolis, IN, United
States, June 8-10 (2011), CERM-281.
24. Yusuf M. Al-Hiari, Rania Al-Qirem and Ghassan F. Shattat,
Novel 5-Fluoroindole-2-Carboxamide Derivatives As Potential
Antihyperlipidemic Compounds, The 14th Annual Scientific Congress
of the Association of the Pharmacy Colleges in the Arab World and
the 2nd International Conference of the College of Pharmacy
and Health Sciences, Ajman University of Science and Technology
(AUST), oral presentation, AUST- Ajman, UAE, in Feb. 7-9, 2012.
25. Yusuf M. Al-Hiari, Novel Biologically Active 2-Quinoxalinone
Systems Obtained by Substitution at Position 7 of
8-Nitrofluoroquinolones, The 13th Pharmaceutical The 13th Jordanian
conference of pharmacist of the Jordainian Pharmaceutical
Association, abstract, April 22-24/4/2010, Amman, Jordan.
26. G. Shattat, T. Al-Qirim, R. Al-Qirim, Y. M. Al-Hiari, G. Abu
Sheikha and E. El-Huneidi, Indole- 2- Carboxamide Derivatives As
Novel Anti-hyperlipidemic Agents In Triton Wr-1339- Induced
Hyperlipidemic Raqts, The 14th Annual Scientific Congress of the
Association of the Pharmacy Colleges in the Arab World and the
2nd International Conference of the College of Pharmacy and
Health Sciences, Ajman University of Science and Technology (AUST),
Poster, AUST- Ajman, UAE, in Feb. 7-9, 2012.
27. Yusuf M. Al-Hiari and Ashok K. Shakya, Muhammed H. Alzweiri,
Talal A. Aburjai and Nizar M. Mhaidat: "Synthesis and Biological
Activities of New 9-cyclopropyl-4-fluoro-3-(4-susbstituted
phenyl)-6-oxo-6,9-dihydro-3-H-[1,2,3] triazolo[4,5-h]quinoline
-7-carboxylic acid derivatives ”. The Third International
Conference of the Faculty of Pharmacy-The University of Jordan, and
the 15th Scientific Congress of the Association of the Pharmacy
Colleges in the Arab World ,October 9-11, 2012, Amman-Jordan, Oral
presentation , Amman-Jordan.
28. Jamila J. Dibas, Fatma U. Afifi and Yusuf M. Al-Hiari "
Evaluation of unexplored poppy from the flora of Jordan: Papaver
polytrichum Bioss.et Kotschy- Papaveraceae”. The Third
International Conference of the Faculty of Pharmacy-The University
of Jordan, and the 15th Scientific Congress of the Association of
the Pharmacy Colleges in the Arab World ,October 9-11, 2012,
Amman-Jordan, poster , Amman-Jordan.
29. Shdeifat M. Al-khaldiK., Al-Zweri M., Afifi Fatma U., and
Al-Hiari M. Yusuf " Identification of Ferulenol and
4-hydroxycumarin in Feruka communis samples collected in Jordan
using different methods”. The Third International Conference of the
Faculty of Pharmacy-The University of Jordan, and the 15th
Scientific Congress of the Association of the Pharmacy Colleges in
the Arab World ,October 9-11, 2012, Amman-Jordan, poster ,
Amman-Jordan.
30. Yusuf M. Al-Hiari, Ghassan F. Shattat and Rania Al-Qirem,
“Novel 5- Fluoroindole-2 Carboxamide Derivatives as Potential
Antilyperlipidaemic Compounds”, 11th International Conference on
Chemistry and Its Role in Development, Mansoura - Sharm El Sheikh,
Egypt, 11-15 March 2013
31. Yusuf. M. Al-Hiari • Violet N. Kasabri • Ashok K. Shakya ,
Muhammad H. Alzweiri • Fatma U. Afifi •
Yasser K. Bustanji • Ihab M. Al-Masri, Fluoroquinolones: novel
class of gastrointestinal dietary lipid digestion and absorption
inhibitors, 15th National Congress of Pharmacy from Romania, XVth
edition, 24-27 September, lecture and abstract, Palas Complex,
Iași, Romania, 2014.
32. Primary lecturer and round mediator : Yusuf. M. Al-Hiari,
Ashok K. Shakya , Muhammad H. Alzweiri, • talal Aburjai, Nizar
Mhidat., Triazolo[4,5-h]quinolones as Potential Antimicrobal
Agents; The 15th Scientific Congress of the Jordanian Pharmacists
Association “Pharmacy Perspectives": An Evolving Role in Community
Health, 3-5 April 2014, Amman-Jordan.
33. Primary lecturer : Yusuf M. Al-Hiari, Rania Al-Qirem,
Ghassan F. Shattat, Tariq Al-Qirim, and Manal Al-Najdawi, “Novel 5-
Substituted indole -2 Carboxamide Derivatives as Potential
Antilyperlipidaemic Agents”, The International Conference on
Materials in Jordan' Building International network for enhancement
of Research in Jordan', Humboldt College, German –Jordanian
University (GJU), Amman 3-5 April 2014.
34. Primary lecturer : Yusuf M. Al-Hiari, Nada Jarar, and
Muhammad H. Alzweiri , “Nicotonic acid analogues as CAIII
inhibitors”, The International Conference on Materials in Jordan'
Building International network for enhancement of Research in
Jordan', Humboldt College, German –Jordanian University (GJU),
Amman 3-5 April 2014.
35. Primary lecturer: Yusuf. M. Al-Hiari,
Triazolo[4,5-h]quinolones as Potential Antimicrobal Agents, The
Scientefic Day, Al-Zaytoonah private University , Al-Zaytoonah
private University, 21 October 2014.
.
36. Primary lecturer and round mediator : Yusuf. M. Al-Hiari
& Violet N. Kasabri , New antibacterial fluoroquinolones with
potential anti-obesity effects at the Jordan International
Pharmaceutical Conference 2015: Al-Zaytoonah private University,
21-23 October 2015, Amman-Jordan.
37. - Lecture and oral presentation: Yusuf. M. Al-Hiari, " Novel
5-substituted indole-2-carboxamide derivatives as potential
antihyperlipidaemic Agents" at Second United Arab Emirates
Conference on Pure and Applied Chemistry (ECPAC16), American
University of Sharjah, , UAE, 1-3/3/2016.
38- Invited and guest speaker, plenary lecturer, Yusuf. M.
Al-Hiari, ‘Novel heterocyclic carboxamide derivatives as potential
antihyperlipidaemic Agents’ at 27th National and 15th International
Chemistry Conference, organized by Department of Chemistry,
University of Malakand, Pakistan , August 22-25 2016.
39- Invited and guest speaker, plenary lecturer, Yusuf. M.
Al-Hiari, ‘Novel heterocyclic carboxamide derivatives as potential
antihyperlipidaemic Agents’ at The Third international conference
on (Research to Applications & Markets,, organized by
Maghreb-Alexander Von Humboldt Alumni, Tunis , RAM
16-18/9/2016.
Registered Patents
1- Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mona R.
Hassuneh and Mustafa M. El-Abadelah, [a]Fused
Heterocyclic-Pyrido[2,3-f]Quinoxaline-2-Carboxylic Acid Derivatives
and their Pyrido[3,2-g] Analoges, A Procces for their Preparation
and their Potential Uses as Anticancer and Antibacterial Agents,
Jordan Patent 2345, May 2006, (priority date 12/4/2005).
2- Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa
M. El-Abadelah, Pyrido[2,3-f]Quinoxalines-8-Carboxylic Acid
Derivatives and their Isomeric Pyrido[2,3-g]Quinoxalines, A Process
for their Preparation and their Use as Potential Antibacterial
Compounds, Jordan Patent 2323, Feb 2006, (priority date
12/5/2005).
3- Ghassan F. Shattat, Tariq M. Al-Qirim, Moyad J. Shahwan,
Yusuf M. Al-Hiari, Ghassan M. Abu Sheikha,
N-substituted-1H-indole-2-carboxamide derivatives, a process for
their preparation and their use as potential antihyperlipidaemic
agents, JP 2519, 13/7/2010. priority number:Jordan Patent ا ع
-2008-373 - (date 14/8/2008), file number 35204.
4- Yusuf M. Al-Hiari*, Ali M. Qaisi, Jalal A. Zahra, Mustafa M.
El-Abadelah and Mona R. Hassuneh, Anticancer and Antibacterial
Agents, GB UK Patent, GB 2442 951, 23Feb, 2011, University of
Jordan. (Date of publication: 23. 4. 2008)
5- Tariq M. Al-Qirim, Ghassan F. Shattat, Kamal Sweidan, Ghassan
M. Abu Sheikha, Yusuf M. Al-Hiari, BENZOFURAN- AND
BENZOTHIOPHENE-2-CARBOXAMIDE DERIVATIVES, A PROCESS FOR THEIR
PREPARATION AND THEIR USE AS POTENTIAL ANTIHYPERLIPIDAEMIC AGENTS,
Jordan Patent 2588- 02/6/2011. (priority date 9/12/2009), JP 2588
approved 27-2-2011.
International Patents applications through Jordan University
1-Ali M. Qaisi, Yusuf M. Al-Hiari*, Jalal A. Zahra, and Mustafa
M. El-Abadelah, Antibacterial Agents, European Patent Application;
No. 06 252 509.2, University of Jordan, 12 May 2006, (priority date
12/5/2005). Published on Scifinder (EP 1 721 898 A1) and European
patent office Nov. 2006. (registered 2012-2013).
Thesis Supervision and Examination:
- MSc Students Supervision / main supervisor:
- MSc thesis; Inas Al-Mazari, 2004 “Synthesis of Potentially
Antibacterial Novel Fluoroquinolone Derivatives Prepared from
Introducing New Appendages at C-7 Position of
7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic
acid”, The university of Jordan, defence date: 26/12/2005.
- MSc thesis; Rofeida Al-Zubi, 2007, “Preparation of potentially
antibacterial novel 8-nitrofluoroquinolone derivatives”, The
university of Jordan, defense date: 3/8/2008.
- MSc thesis; Maha Al-Remawi, 2009, “Preparation and
antimicrobial evaluation of 7-anilino- 8-nitrofluoroquinolones”,
The university of Jordan, defence date: 3/8/2010.
- MSc thesis; Imad Ahmed, 2009 “Convenient Synthesis and
Bioproperties of Heterocycles [h]-Fused Onto
4-Oxoquinoline-3-Carboxylic Acid: Halogenated
Tetrahydro-1H-quino[7,8-b] [1,4-]benzodiazepin-3-carboxylic
Derivatives”, The university of Jordan, defence date:
6/12/2010.
- MSc thesis; Rania Al-Qarm, 2009, “Novel
5-Fluoroindole-2-carboxamide Derivatives As Potential
Antihyperlipidaemic Compounds”, The university of Jordan, defence
date: 30/11/2010.
- MSc thesis; Botheina Huseen, 2009, “Preparation and
antihyperlipidemic properties of new benzothiophen-2-carboxamide
derivatives ”, The university of Jordan, defence date:
18/7/2010.
- MSc thesis; Nada Jarrar, 2014, “Screening of Nicotinic acid
analogues as potential carbonic anhydrase III inhibitors ”, The
university of Jordan, defence date: 23/5/2014.
- MSc thesis; Haneen Khaled , 2015, “SCREENING AND SIZE EFFECT
INVESTIGATION OF NICOTINIC ACID ANALOGUES AS POTENTIAL CARBONIC
ANHYDRASE III INHIBITORS TO TREAT HYPERLIPIDEMIA ”, The university
of Jordan, defence date: 5/8/2015.
- MSc thesis; Yousef Shukri Al Absi, Dec. 2017, “Anti-Pancreatic
Lipase and Anti-Proliferative Activities of New Fluoroquinolones”,
The university of Jordan, defence date: Dec. 2017.
- MSc Students Supervision / co- supervisor:
- MSc thesis; Rughia Atia, 2011-2012, “ The Effect of
Triazoloquinolones on Male Fertility of Albino Rats” AL-albayt Beat
University, defence date: 29/7/2012.
- MSc thesis; Omaymah Ghaleb Al-Jamal, 2011-2012, “Effect of
newly prepared compound in induced diabetic and hyperlipidemic
albino rats” AL-albayt University, defence date: 29/7/2012.
- PhD Supervision / main supervisor:
- PhD thesis; Lubna Al-Sweelmeen, 2010, “Synthesis and
biological evaluation of novel H-Fused heterocycles derived from
floruoquinlones: Diazepines and benzodiazepines ”, 2010-2011.
defence date: 1/12/2011
- PhD thesis; Manal Al-Najdawee, 2010, “The discovery of novel
heterocyclic-2-carboxamide derivatives and their potential
dyslipidemic and antioxidant activity”, defence date: 4/8/2011.
- PhD thesis; Shereen Arabiyat, 2016, “Synthesis, Docking
studies and evaluation of Novel Fluoroquinolnes and
triazolofluoroquinolones as potential pancreatic lipase inhibitors
and antiproliferative compounds”, defence date: 9/8/2016.
- PhD Supervision / co-supervisor:
- PhD thesis/co-supervisor; Jameela Dabas, 2010, “Phytochemical
and pharmacological screening of wild Jordanian Papaver polytricum
Boiss. et Kotschy and partial chemical modification of selected or
isolated major compounds.”, 2010. Defence date: 5/1/2012
- PhD thesis; Rana Abo Farha/co-supervisor;, 2015,
“Pharmacological Screening of Newly Synthesized Derivatives of
Nicotinic Acid and Isonicotinic Acid as Potential
Anti-hyperlipidemic, Antioxidant and Cytotoxic agents
”, defence date: 15/7/2015.
- PhD thesis/co-supervisor; Soha tolfah, 2016, “drug discovery
and chromatographic optimization of new carbonic anhydrase III
ligands”, defence date: 22/12/2016.
- Thesis Examiner/ The University of Jordan:
1- MSc thesis entitled: “ Synthesis of Acyclic Nucleoside
Phosphonates Pro-Drugs with Potential Antiviral Activity ” By Rami
Horani, 2002.
2- MSc thesis entitled: “ The Effect of Crude Extract of
Licorice on The Pharmacokinetics of Ciprofloxacin in an Animal
Models”By Naser Shreem, 2003.
3- MSc thesis entitled: “ Analytical Method Development and
Validation for the Evaluation of the Degradation of the
Experimental Compound (EXP152) Developed as a Potential
Neuromuscular Blocker, in Plasma”By Hind Nabeel Taha, March
2004.
4- MSc thesis entitled: “ Screening of Some Common Medicinal
Plants of Jordan for Alpha Amylase Inhibition Activity,”By Tark
Maayeh, July 2005.
5- MSc thesis entitled: “ Investigation of Diclofinac-Bismuth
complex as an Oral Suspension Preparation” By Mohamad abu Znaid,
Aug. 2005.
6- MSc thesis entitled: “Synthesis of Potentially Antibacterial
Novel Fluoroquinolone Derivatives Prepared from Introducing New
Appendages at C-7 Position of
7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic
acid”, By Inas Saleh, Dec. 2005.7- MSc thesis entitled: “
Development of a Flow Injection Method for the Determination of
5-Aminosalicy;ic Acid in Pharmaceutical Raw Material and Tablet
Dosage Form” By Moutasim Eid AbuAl Ruz, Jan. 2006.8- MSc thesis
entitled: “ Preparation and Characterization of Organic Salts of
Valproic Acid, A Preformulation Study” By Mohammad Khanfer, 13th
May 2007.9- MSc thesis , By Saja Awad , 16th May 2007.
10- MSc thesis; Rofeida Al-Zubi, “Preparation of potentially
antibacterial novel 8-nitrofluoroquinolone derivatives”, 3/8/2008.
11- PhD Thesis, by Sana Ayash, Faculty of agriculture, Jordan Univ.
2008.
11- MSc thesis; Reem Jamal Awwad, “Evaluation of the wound
healing activity of hexane extract of Alkanna Strigosa in albino
rat model”, May 2009.
13- MSc thesis, By Eman Yousuf Ali Abu-Rish, “Comparative study
of the bilogical potency of Two recombinant human Erythropoiten
pharmaceutical producs in jordan”, Faculty of pharmacy, July
2009.14- PhD Thesis, by Reema A. Abu Khalaf, '' Discovery of new
cholesteryl ester transfer protein (CTEP) inhibitors via
ligand-based pharmacophore modeling and QSAR analysis and
subsequent hit optimization'' Faculty of pharmacy, Aug 200915- PhD
Thesis, by Afaf H. Al-Nadaf, '' Discovery and optimization of new
beta secatase inhibitors as possible treatment for Alzhimer 's
disease '' Faculty of pharmacy, Jan, 2010.16- MSc thesis, By Needa
Zalloum, “Screening and evaluation of available hypoglycemic agents
for their potential protective and treating effects of Diabetic
Retinopathy”, Faculty of pharmacy, May 5, 2010.
17- MSc thesis by Maha Al-Remawi, “Preparation and antimicrobial
evaluation of 7-anilino- 8-nitrofluoroquinolones”, August 3
2010.
18- MSc thesis by Botheina Huseen, “Preparation and
antihyperlipidemic properties of new benzothiophen-2-
carboxamide derivatives ”, July 18 2010.
19- MSc thesis; Rania Al-Qarm, “Novel
5-Fluoroindole-2-carboxamide Derivatives As Potential
Antihyperlipidaemic Compounds”, November 30 2010.
20- MSc thesis; Imad Ahmed, “Convenient Synthesis and
Bioproperties of Heterocycles [h]-Fused Onto
4-Oxoquinoline-3-Carboxylic Acid: Halogenated
Tetrahydro-1H-quino[7,8-b] [1,4-]benzodiazepin-3-carboxylic
Derivatives”, December 6 2010.
21-MSc thesis; Yahya Tabaza, “physical and chemical stability
studies of different excepients on ciprofloxacin solid formula ”, 8
2013.
- MSc thesis; Nada Jarrar, “Screening of Nicotinic acid
analogues as potentioal carbonic anhydrase III inhibitors ”, The
university of Jordan, defence date: May 2014.
- External examiner; 1- The final and third year pharmacy
students at Al-Fatih University- Tripoli-Libya, 2004 .
2- Msc Thesis: Pharmacological Evaluation of Aminoacetylenic
Phthalamide Compounds as Anti-inflammatory Agents, By Jinan Ali
Salih Al-qaisi, Feb 2009, Petra University, Jordan. 3- The final
and third year pharmacy students at Al-Fatih University- Medicinal
Chemistry I and II, Tripoli-Libya, may 2010 .4-MSc thesis; Ibrahim
Hamdan, “ Synthesis and Biological Evaluation of DiSubstituted
1,3,4-oxadiazole Derivatives”, Jordan Universityof science and
technology (JUST), 12 May 2011. 5-MSc thesis; Leena Ali Al-Hawash,
“ Stability indicating HPLC method of Trandolapril in
pharmaceutical formulation and bulk materials”, Al-Ahliyya Amman
University, 2 July 2012. 6-MSc thesis; Eyad Dawud, “ Simultaneous
HPLC Determination of ACF inhibitors in Pharmaceutica Formulation,
, Al-Ahliyya Amman University, 4 April 2013.
7-MSc thesis; Amani Omarin“ Assay and Stability indicating HPLC
method of Tadalafil in pharmaceutical formulation and bulk
materials by HPLC”, Al-Ahliyya Amman University, 26th Sep. 2013.8-
MSc thesis; Munia Sowaileh“ Design and Synthesis of N-substituted
Aminobenzamide Derivatives Targeting Dipeptidyl Peptidase-IV
enzyme”, Jordan University of Science and Technology, July. 2013.8-
MSc thesis : Bayan Hishmah; “ Design, Synthesis and Biological
Evaluation of Novel PI3K alpha Inhibitors ”, Al-Zaytoonah
University of Jordan, Dec., 2014.9- MSc thesis : Hamada Abd
El-Aziz; “Synthesis and biological Evaluation of Flurinated
alkyloxy Benzylamino B