CURRICULUM VITAE Srinivasan ThyagaRajan PERSONAL INFORMATION Date of Birth: May 25, 1964 Marital Status: Married, Two children Address: 127/8 F4, First Main Road, Alwarthirunagar Annexe, Chennai 600087 Telephone: 9940201794 E-mail: [email protected]EDUCATION Madras Veterinary College Madras, India. Veterinary Science B. V. Sc. 1981-1987 Kansas State University, KS, U.S.A. Physiology Ph. D. 1988-1993 (Neuroendocrinology) PREVIOUS POSITIONS AND APPOINTMENTS 6/1988-9/1993 Graduate Research Assistant with Teaching Responsibilities, Dept. of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, KS, U. S. A. 10/1993-1/1997 Postdoctoral fellow, Dept. of Neurobiology and Anatomy, School of Medicine and Dentistry, University of Rochester, NY, U. S. A. 2/1997-6/1998 Research Assistant Professor, Dept. of Neurobiology and Anatomy, University of Rochester, NY, U. S. A. 7/1998-6/2001 Assistant Professor, Dept. of Pathology and Human Anatomy, Center for Neuroimmunology, School of Medicine, Loma Linda University, CA, U. S. A. 7/2001-8/2003 Assistant Adjunct Professor, Dept. of Anatomy and Neurobiology, Susan Samueli Center for Complementary and Alternative Medicine, College of Medicine, University of California, Irvine, CA, U. S. A. 9/2003-7/2006 Associate Research Professor, Division of Human Anatomy, Dept. of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA, U. S. A. 8/2006-6/2008 Adjunct Associate Research Professor, Division of Human Anatomy, Dept. of Pathology and Human Anat., School of Medicine, Loma Linda University, Loma Linda, CA, U. S. A. 1/2007-1/2008 Interim Head of the Department, Department of Biotechnology (~6 months) SRM University, Kattankulathur 603 203, Kanchipuram District, Tamil Nadu, INDIA 07/2010-2013 Honorary Consul General of Michigan State University, MI, USA for India representing College of Veterinary Medicine, MSU 07/2011-2013 Adjunct Associate Professor, Department of Pathobiology and Diagnostic Investigation, Michigan State University, MI, USA 12/2012-05/2019 Head, Department of Biotechnology, School of Bioengineering, SRM IST, India 10/2006-05/2019 Professor, Department of Biotechnology, SRM IST, India
21
Embed
CURRICULUM VITAE Srinivasan ThyagaRajan€¦ · CURRICULUM VITAE Srinivasan ThyagaRajan PERSONAL INFORMATION Date of Birth: May 25, 1964 Marital Status: Married, Two children Address:
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
CURRICULUM VITAE
Srinivasan ThyagaRajan
PERSONAL INFORMATION
Date of Birth: May 25, 1964
Marital Status: Married, Two children
Address: 127/8 F4, First Main Road, Alwarthirunagar Annexe, Chennai 600087
M.S. thesis committee member: Schari Flowers, 2004-2006
Guidance to Graduate students: Jeff Carter, Brooke Millar, Sam Perez, and
Dorian Silva, 2003-2006
SRM IST, Kattankulathur, INDIA
B. Tech. (Biotech.) Students: Harini Krishnan; 2009-2011
Miti Mishra and Ranvijay Singh; 2010-2014
S. Gopinath; 2011-2013
R. Karthik Ramakrishnan and Vishak Raman;
2012-2013
Soha Chhaya, Sushrut Shitoot, T. C. ThyagaRajan,
2013-2014
Shaili Gour, T. Kannan, Mantavya Patel, M. M.
Hariharan, V. Prasanna, 2013-16
M. Tech. (Biotech.) Students: Biswa Behera and Vikram Sabapathy;.2005-07.
Ramyapriya, Sam Masih, and Mohd. Zeeshan;
2007-09
A. Sindhu and Preetam Bala; 2009-10
Utsav Sharma and Varun Sharma; 2010-2011
Uday Pratap and Aparna Mohanty; 2011-2012
Anushree Patil, Prathamesh Kale, and Himanshu
Sharma; 2012-2013
6
Anurupa Bhattacharya (External), 2014
Rahul Nair, 2014-2015
Ph. D. (Biotech.) Full-time: Hannah Priyanka 2009-2014
Uday P. Pratap 2012-2017
Hima, L. 2013-
R. Vasantharekha 2012-2018
PAST GRANT SUPPORT
U. S. A.
Somerset Pharmaceuticals Inc., Desmethylselegiline in an in vivo model of neuronal
degeneration and altered immune responses. 9/15/95-6/30/98. Co-P. I. (David L. Felten,
P. I.), 100% effort. $224,000 (TC).
U. S. Army Medical Research and Materiel Command Breast Cancer Research Program, Grant
DAMD17-96-1-6214, “Deprenyl and Protection against Mammary tumors.” 1996-1999.
Co-P. I. (David L. Felten, P. I.), 85% effort. $601,310 (TC)
Intramural Grant, Loma Linda University, “Sympathetic Noradrenergic Neuronal Modulation
of Th1Vs Th2 Cytokines in Aging: Effects of Deprenyl Treatment.” 2000-2001. P. I.
$6,000.
The Japan Foundation for Aging and Health: Japan-U. S. Cooperative Research Program for
Longevity Sciences. “Desmethyldeprenyl and Neural-Immune Interactions.” 1/1/01-
12/31/01. P. I. $5,000.
Intramural Grant, Loma Linda University, “Estrogen and Reproductive Aging.” 2003-2005.
P. I. $50,000.
India
SRM University. “Estrogen: A Neuroprotective or Proinflammatory Hormone?” August 2009-
July 2010. P. I. Harini Krishnan, II B. Tech. (Biotech.), Co-I. Rs. 0.65 Lakhs.
Department of Science and Technology, Government of India. “Modulation of Neural-Immune
Signaling by Estrogen in Reproductive Aging.” March 2008-February 2011. P. I. F.
NO. SR/SO/HS-46/2007. Rs. 37.44 Lakhs.
World Noni Research Foundation, Chennai. “Physiological significance of Noni
phytochemicals on the Neuro-Endocrine-Immune system.” 2010-2012. P. I. Order
No.: FFEP-CRP-O8-O02. Rs. 10.00 Lakhs.
Department of Biotechnology, Government of India. “Neuroendocrine-Immune Interactions in
Mammary Tumorigenesis.” 2009-2012. P. I. Order No.: BT/PR9199/Med/30/12/2007.
Rs. 40.25 Lakhs.
Ministry of Agriculture, GoI, Coconut Development Board, Kerala. “Health benefits of dietary
intake of Virgin coconut oil on neural-immune network.” 2014-2016. P. I.
F.No.1345/2013 Tech. Rs. 26.29 Lakhs
INVITED SPEAKER 1. Aging: Hypothalamic catecholamines and neuroendocrine functions. Department of
Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New
York, June 18. 1993.
7
2. First International Conference on Immunology and Aging: In a symposium titled Neuro-
Endocrine-Immune System Interaction. National Institutes of Health Campus, Bethesda, MD.
June 16-19, 1996.
3. In Vivo Neuroimmunology and L-deprenyl effect on brain catecholamines/serotonin. Somerset
Pharmaceuticals, Tampa, FL. October 21, 1996.
4. Anti-tumor effect of deprenyl in rats with carcinogen-induced mammary tumors. 1st Annual
University of Rochester Cancer Center Scientific Symposium, Genesee County Museum,
Mumford, NY. November 4, 1996.
5. Sympathetic modulation of immunity in aging. Twenty-first International Symposium on Brain
and the Bio-defense System. Division of Brain Sciences, The Taniguchi Foundation, Kyoto,
Japan. January 19-22, 1998.
6. L-deprenyl-induced inhibition of mammary tumor growth is associated with altered neural
activity and immune function in rats. Era of Hope Meeting, Department of Defense Breast
Cancer Research Program, Atlanta. June 8-11, 2000.
7. Modulation of neuroendocrine-immune signaling by deprenyl and desmethyldeprenyl in aging
and breast cancer. Fifth International National Institute for Longevity Sciences Workshop,
Interventions: Part III, Obu-shi, Aichi, Japan, November 30-December 1, 2000. Co-Chairman
of the scientific session: Antioxidants I.
8. Sprouting of noradrenergic nerve fibers, immune modulation and protection from mammary
tumors. Symposium: Sympathetic nervous system modulation of immune function: role in
immune function abnormalities in the elderly, in cancer, and in autoimmune disease. Annual
meeting of the Psychoneuroimmunology Research Society, Utrecht, The Netherlands, May 19,
2001.
9. Neuroendocrine regulation of immune reactivity: Effects of propargylamines in aging and
breast cancer. Department of Anatomy and Neurobiology, University of California, Irvine.
May 25, 2001 10. Neural Influences on Immune Reactivity in Reproductive Aging. Biomedical Research
Seminar, Loma Linda University, CA. April 22, 2004 11. Communications between the Neuroendocrine System and Immune System in Aging and
Mammary Cancer. School of Biotechnology, SRM University, Kattankulathur, India. November 4, 2006.
12. Neuroimmunomodulation of splenic sympathetic noradrenergic (NA) nerve fibers by estrogen in rats. Silver Jubilee Conference of Indian Academy of Neurosciences, Varanasi, India. November 23, 2007.
13. Fundamental Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious Diseases and AIDS. NIPER, Chandigarh, India. December 11-13, 2008.
14. Female Reproductive Aging and Mammary Cancer: Involvement of Neural-immune Interactions. Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, MI, USA. March 18, 2010.
15. Current Status in Cancer Biology. Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai. February 27, 2012
16. Pharmacological Properties and Clinical Applications of Morinda citrifolia. Noni Search 2014; Ninth national symposium “Noni for Everyone,” Goa. September 27, 2014
17. A conundrum: Does immune system operate in isolation or regulated by neuroendocrine system? Immunocon-2014, Madurai Kamaraj University, Madurai. December 13, 2014
18. Neuroendocrine-Immune system and Homeostasis and Neuroendocrine-Immune interactions in Aging and Age- related diseases. Academies’ Lecture Workshop, Vels University, Chennai. March 12, 2015
19. Medicinal plants in the treatment of cancer and neurodegenerative diseases. Second World Noni Congress: Noni and Medicinal plants for Inclusive Growth and Wellness. SRM University. March 20, 2016
8
20. Reproductive Aging: Key neural-immune interactions during early middle age in brain and lymphoid organs. Symposium on Neural Functions of Aging Brain organized by ICUBR & SSH and RGCB, Thiruvananthapuram, September 28, 2016.
PUBLICATIONS
1. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1 stimulates the
release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo. Life Sci.
48:925-930, 1991.
2. ThyagaRajan, S., Meites, J. and Quadri, S. K. Underfeeding-induced suppression of
mammary tumors: counteraction by estrogen and haloperidol. Proc. Soc. Exp. Biol. Med.,
203:236-242, 1993.
3. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1ß increases
5-hydroxyindoleacetic acid release in the hypothalamus in vivo. Brain Res. Bull., 31:745-748,
1993.
4. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Correlations of catecholamine
release in the medial preoptic area with proestrous surges of luteinizing hormone and prolactin:
effects of aging. Endocrinology 135:119-126, 1994.
5. ThyagaRajan, S., Meites, J. and Quadri, S. K. Deprenyl treatment reinitiates estrous cycles,
reduces serum prolactin and decreases the incidence of mammary and pituitary tumors in old
acyclic rats. Endocrinology 136:1103-1110, 1995.
6. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Cyclic changes in the release of
norepinephrine and dopamine in the medial basal hypothalamus: effects of aging. Brain Res.,
689:122-128, 1995.
7. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Cyclic and age-related changes in
norepinephrine concentrations in the medial preoptic area and arcuate nucleus. Brain Res.
Bull., 38:561-564, 1995.
8. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Tyrosine hydroxylase and DOPA
decarboxylase activities in the medial preoptic area and arcuate nucleus during the estrous
cycle: effects of aging. Brain Res. Bull., 42:265-271, 1997.
9. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Anti-tumor effect of L-deprenyl in rats with
carcinogen-induced mammary tumors. Cancer Letters 123:177-183, 1998.
10. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Restoration of sympathetic noradrenergic
nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized
and old Fischer 344 rats. J. Neuroimmunol., 81:144-157, 1998.
11. ThyagaRajan, S., Madden, K.S., Kalvass, J. C., Dimitrova, S., Felten, S. Y. and Felten, D. L.
L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of
noradrenergic nerve fibers in the spleens of old F344 rats. J. Neuroimmunol., 92:9-21, 1998.
9
12. ThyagaRajan, S., Stevens, S. Y. and Felten, D. L. Region-specific alterations in the
concentrations of catecholamines and indoleamines in the brains of young and old F344 rats
after L-deprenyl treatment. Brain Res. Bull., 48:513-520, 1999.
13. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Effects of L-deprenyl
treatment on noradrenergic innervation and immune reactivity in lymphoid organs of young
F344 rats. J. Neuroimmunol., 96:57-65, 1999.
14. ThyagaRajan, S. and Quadri, S. K. L-deprenyl inhibits tumor growth, reduces serum
prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced
mammary tumors. Endocrine, 10:225-232, 1999.
15. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Inhibition of tumor growth
by L-deprenyl involves neural-immune interactions in rats with spontaneously developing
ThyagaRajan, S. Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric
oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats. Int
Immunopharmacol. 29(2):591-598, 2015
35. Pratap, U.P., Patil, A., Sharma, H.R., Hima, L., Chockalingam, R., Hariharan, M. M., Shitoot,
S., Priyanka, H.P., ThyagaRajan, S. Estrogen-induced neuroprotective and anti-inflammatory
effects are dependent on the brain areas of middle-aged female rats. Brain Res. Bull. 124:238-
253 2016.
36. Pratap, U.P., Hima, L., Priyanka, H.P., ThyagaRajan, S. Noni (Morinda citrifolia L.) fruit
juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats.
J. Ethnopharmacol. 198:363-371, 2017
37. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., Srinivasan, A.V., ThyagaRajan, S.
Interrelationship between Mini-Mental State Examination scores and biochemical parameters
in patients with mild cognitive impairment and Alzheimer's disease. Geriatr Gerontol Int.
17(10):1737-1745, 2017
38. Ravichandran, K. A., Karrunanithi, S., Hima, L., Pratap, U.P., Priyanka, H.P., ThyagaRajan,
S. Estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth
factor through free radical generation in the thymus and mesenteric lymph nodes of middle‐aged ovariectomized female Sprague–Dawley rats. Clin. Exp. Neuroimmunol. 8: 341-350,