CURRICULUM VITAE Professor Nicola Jayne Robertson ...

CURRICULUM VITAE

Professor Nicola Jayne Robertson

January 2021

CV_N Robertson Page 20/01/2021 2

Nicola Jayne Robertson WORK ADDRESSES

1. Edinburgh Neuroscience & Centre for Clinical Brain Sciences (CCBS) The University of Edinburgh, Chancellor's Building 49 Little France Crescent, Edinburgh EH16 4SB www.ccbs.ed.ac.uk www.edinburghneuroscience.ed.ac.uk Twitter: @EdinUniNeuro; @EdinUniBrainSci

2. Hon. Consultant Neonatologist

Simpson Centre for Reproductive Health Edinburgh Royal Infirmary

3. The Roslin Institute

University of Edinburgh Easter Bush Campus https://www.ed.ac.uk/roslin/about

4. Academic Neonatology,

Institute for Women’s Health, University College London 74 Huntley Street London, WC1E 6HX http://www.instituteforwomenshealth.ucl.ac.uk/neonatology

Work Telephone: +44 207 679 6052 Mobile: +44 7779248235 E mail: [email protected] [email protected]

HOME ADDRESS The Hermitage, Souldern, Bicester, Oxfordshire, OX27 7JN, UK CURRENT POSTS

• Professor of Perinatal Neuroscience, University of Edinburgh (from October 2020) • Honorary Consultant Neonatologist, Edinburgh Royal Infirmary (from October 2020) • Professor of Perinatal Neuroscience, University College London (from 2012)

GMC number: 3282045 Revalidation: 9.12.19 Next revalidation due: 9.12.24


Education/Qualifications

Dates Degree Institution 1988 1993 1995 1995 1998 2002

MB ChB MRCP (UK) part I MRCP (UK) part II Admitted to the Royal College of Paediatrics and Child Health. Appointed Fellow also. CCST PhD

University of Edinburgh Royal College of Physicians UK Royal College of Physicians UK RCPCH Paediatrics (Neonatology) University of London (Imperial College)

2 children Sophie Robertson-Acolet 19 years, at Bristol University reading Philosophy & Sociology William Robertson-Acolet 17 years, at School in Oxford doing A levels RECENT COURSES September 2018 – CITI training completed Collaborative IRB Training Initiative (CITI) - an educational program for the protection of human subjects in research. CITI is focused on different aspects of bioethics and human subject research. 6-9 February 2019, QRI Auditorium, Hamad Medical Corporation, Doha, Qatar. The 177th GM Trust Course on the Prechtl’s Assessment of General Movement Training Course (Basic) ATHENA SWAN I was lead applicant for the SILVER Athena Swan award for the Institute for Women’s Health, UCL in 2012 The Institute for Women’s Health went on the achieve a GOLD award in 2016. EXPERT PANELS Brain injury Expert Panel Meeting, Department of Health, London, UK. January 2017 Swiss National Foundation Swiss National Research Council Division Biology and Medicine - International Expert 2019-2021 BAPM Working Group 2019-2020 Therapeutic hypothermia -framework for practice INVENTIONS/PATENTS

• Licensing of Orphan Drug Designation for Melatonin use in Birth Asphyxia to Chiesi Pharmaceutici in Nov 2016


• Patent filed with Chiesi Pharmaceutici S.p.A for the dose and formulation of melatonin. Filed March 2017 (Int. pat. Appl. PCT/EP2018/056423)

AWARDS

• 2013 - Royal Society Wolfson Research Merit Award https://royalsociety.org/grants/schemes/wolfson-research-merit/

• March 2015 - UK Neonatal Society David Harvey Senior Fellowship Selected by the Committee on merit with an emphasis on candidates that have improved the wellbeing of underserved populations or addressed understudied problems, through high quality research. I gave the Keynote lecture “The David Harvey Lecture” at the summer Neonatal Society meeting on June 25th 2015 in Winchester.

CITATION INDEX SCORES

• Web of Science h- index: 40 o 5290 citations

• Research Gate score: 44.57

~240 original papers


RESEARCH STATEMENT I have focused on neonatal brain injury and neuroprotection for the past 20 years. As a practising neonatologist at UCLH and the research lead of the Neonatal Neuroprotection Laboratory at UCL, I have had the opportunity to ensure our pre-clinical neuroprotection work is translational and relevant to clinical needs. The last 20 years has been an exciting and fast-moving area of neonatal medicine, with therapeutic hypothermia for neonatal encephalopathy being one of the most significant advances for neonatology. I use MRI, MRS and NIRS to understand brain injury mechanisms both in babies in the NICU and in the piglet model in the laboratory. Since 2003 when I was appointed Senior Lecturer at UCL, I have developed the piglet model into a valuable and unique resource to investigate the safety and efficacy of neuroprotective drugs for newborn infants using clinically relevant MR biomarkers, bedside tools such as EEG and immunohistochemistry. As therapeutic hypothermia is only partially effective, we have studied the safety and efficacy of adjunct therapies. Neuroinflammation is known to exacerbate brain injury in NE; we developed an LPS-sensitized model of hypoxia ischemia. Our studies have focused on optimizing cooling itself and adding melatonin, xenon, argon or erythropoietin (Epo) as adjuncts with cooling. We have a recent MRC DPFS award to investigate the safety and efficacy of human umbilical mesenchymal stem cells in the piglet model of hypoxia ischemia. The laboratory work has been mainly funded by the MRC (Neuroscience and Mental Health Board), following my MRC Young Investigator Award in 2006. In October 2020 I took up the position of Professor of Perinatal Neuroscience within Edinburgh Neuroscience & Centre for Clinical Brain Sciences (CCBS) at the University of Edinburgh. The access to world class laboratories here, including the large animal research and imaging facility (LARIF) next to the Roslin Institute https://www.ed.ac.uk/roslin/facilities-resources/larif will facilitate the clinical translation of the pre-clinical neuroprotection research. I am committed to the delivery of optimal clinical neurocritical care as part of a neuroprotective bundle. In the next 5-10 years I am keen to move towards setting up and inspiring clinical trials of the most promising adjunct therapies with cooling, the development of biomarkers to assess inflammation sensitization and tailoring neuroprotection to specific babies. In 2020/2011 I aim to set up a phase I/IIa clinical trial of melatonin as an adjunctive therapy to cooling, based on promising pre-clinical data (MELBA – Melatonin for birth Asphyxia). I was PI of the TOBY Xenon Trial (MRC Experimental Medicine first in man study) which used imaging biomarkers as surrogate endpoints and I am keen to build on this work. My interest in neuroprotection extends to low resource settings in particular sub-Saharan Africa. In 2019 the Bill and Melinda Gates Foundation awarded funding for pre-clinical work in my laboratory on repurposing Azithromycin as a neuroprotective agent. In Uganda, our studies led to an important message of caution regarding the translation of therapeutic hypothermia (a safe and effective therapy in the UK) to low resource settings. I have collaborations set up in Accra, Ghana where we are studying the seizure burden in NE. As the main burden of neonatal encephalopathy is in low resource settings, my aim is to ensure we develop neuroprotective interventions in the laboratory that are economical, practical, safe and translational to both high and low resource settings.


PROFESSIONAL HISTORY

Dates Detail of position held

Institution

01/08/1988-31/01/1989

House Officer Adult Medicine Royal Infirmary of Edinburgh

01/02/1989- 31/7/1989

House Officer Pediatric Surgery Royal Hospital for Sick Children, Edinburgh

01/08/1989-31/01/1990

Paediatric Neurology Royal Hospital for Sick Children, Edinburgh

01/02/1990-31/07/1990

Neonatal SHO Simpson Memorial Maternity Hospital

01/08/1990-31/01/1991

Paediatric Registrar, Cardiology Royal Children’s Hospital, Melbourne, Australia

01/02/1991- 31/01/1992

Neonatal Registrar/Fellow Royal Women’s Hospital, Melbourne, Australia

01/02/1992- 31/07/1993

Neonatal Registrar/Fellow Monash Medical Centre. Melbourne, Australia

01/08/1993- 31/01/1994

Paediatric SHO Kent and Canterbury Hospital, Canterbury, UK

01/02/1994-31/07/1994

Paediatric SHO Guys Hospital, London

01/08/1994- 30/03/1995

Paediatric SHO in Host Defence & Oncology Great Ormond Street Hospital, London

01/04/1995- 28/02/1997

Senior Registrar in Neonatology & Perinatal Medicine

St George’s Hospital, London, London

01/03/1998-31/03/2003

Lecturer in Neonatology and Consultant Neonatologist

Imperial College London

01/04/2003-30/09/2008

Senior Lecturer in Neonatal Medicine and Honorary Consultant Neonatologist

University College London

01/02/2006- 31/07/2006

Invited Professorship, funded by UNICA (Universities of the Capitals of Europe) and endowed by the City of Lausanne

Division of Neonatology, Faculty of Biology and Medicine at the University of Lausanne

01/08/2006- present

Lead for Academic Neonatology

Institute for Women’s Health, University College London and University College Hospitals

01/10/2008-30/09/2012

Reader in Translational Neonatal Medicine and Honorary Consultant Neonatologist


01/04/2017- 10.9.17

Interim Director (shared post) of the Institute for Women’s Health, UCL


30.7.17 – 15.8.19

Sabbatical: Deputy Division Chief Clinical Research and Senior Attending Neonatology.

Sidra Medical and Research Centre, Doha, Qatar

01/10/2012-30.9.20

Professor of Perinatal Neuroscience and Honorary Consultant Neonatology


01.10.20 to present

Professor of Perinatal Neuroscience and Honorary Consultant Neonatology

University of Edinburgh and Edinburgh Royal Infirmary


OTHER APPOINTMENTS AND AFFILIATIONS Neonatal Society UK

• Committee member 2001 – 2003 • Meetings Secretary 2003 – 2005 • General Secretary 2006 – 2010

European Society for Paediatric Research (ESPR)

• Council member, 2003 – 2005 • Lead for Brain and Development section, 2005 – 2010

Research and Development Lead for the North Central London Perinatal Network: 2005 – 2012 Membership of Professional Bodies Member of the British Association of Perinatal Medicine Member of the Thames Regional Perinatal Group Wellbeing of Women Research Advisory Committee: 2006 – 2009 European Brain Club: elected 2005 Associate editor for Pediatric Research: 2006 – present Academic Paediatric Association – March 2015 Referee for: Journals (Arch Dis Child, J Pediatr, Pediatrics, Stroke, J Cereb Blood Flow Metab, Annals Neurol, PLOS, Acta Pediatrica) Funding bodies (Action Medical Research, MRC, Wellcome, Wellbeing of Women, New Zealand Research Council, Canadian Fellowship Grants)


ACADEMIC SUPERVISION

Period Role Supervisee Title 2003-2005 (completed) MD

Primary supervisor Jeanie Cheong 4.7 Tesla MRI and MRS of NE

2005-2009 (completed) PhD Primary Supervisor

Divyen Shah aEEG Reflects Cerebral Injury in the Newborn

2007-2010 (completed) PhD Second Supervisor

Sudhin Thayyil Minimally Invasive Autopsy


Cornelia Hagmann Qualitative and quantitative MR imaging in preterm infants: relation to neurodevelopmental outcome

2006-2011 (completed) MD Primary Supervisor

Manigandan Chandrasekaran

Cerebral MRS Biomarkers and Outcome in Perinatal Asphyxia


Gemma Williams Mapping Pain and Nociception in the Infant Brain


Sachiko Iwata Safe and effective cooling using phase changing material


Osuke Iwata Cerebral phosphocreatine overshoot after perinatal HI.


Tharindi Hapuarachchi UCL CoMPLEX


Alan Horn (University of Cape Town)

Relation between aEEG and NE score


Cally Tann (Wellcome

Perinatal risk factors for NE in Uganda


Mojgan Ezzati Ischaemic post conditioning as a neurpprotective therapy after perinatal HI

2013-2017 PhD Primary Supervisor

Cristina Uria Brain Intracellular pH in NE: relation to brain perfusion, seizures and neurodevelopmental outcome


Subha Mitra Near Infrared Spectroscopy biomarkers in NE

2015-2020 (awarded)

PhD Primary supervisor

Ingran Lingam

Magnesium as a neuroprotective agent with cooling

2018-2020 PhD Secondary Supervisor

Kathryn Martinello Inflammation-sensitized Brain Injury

2019-2022 PhD Primary Supervisor

Raymand Pang Repurposing Azithromycin as a Neuroprotective Therapy for NE


GRANTS 2004-2019 Total Grant Funding ~£20 million Grant Funding as Principal Investigator ~£16 million

GRANTS Special Trustees of Middlesex Hospital Principal applicant April 2004 – Nov 2007 High field MRI and MRS in Neonatal Encephalopathy £62,825 Department of Health, UK Nov 2006 – Oct 2009 Co-applicant Co-investigators: Andrew Taylor (PI), Neil Sebire, Jocelyn Brooks, Lynn Chitty Less invasive autopsy – the role of MRI in post-mortem examination of fetuses, infants and children £417,000 SPARKS (SPort Aiding Research in KidS) July 2005 – February 2008 Principal applicant Is amiloride neuroprotective following perinatal hypoxia-ischaemia in the developing brain? £129,486 Medical Research Council (UK) New Investigator Award May 2006 – April 2009 Principal applicant Defining the optimal temperature for newborn hypothermic neuroprotection and effect of sodium/proton exchanger blockade £323,381 SPARKS (SPort Aiding Research in KidS) July 2006 – June 2008 Co-applicant Cord blood monocyte MHC Class II expression and fetal bacterial exposure £123,477 Air Products plc March 2007 – February 2008 Principal applicant Neuroprotective effect of Xenon and Hypothermia in a neonatal model of transient hypoxia-ischaemia: an MRI and histology study £323,203 Wellbeing of Women, Charity of the Royal College of Obstetrics and Gynaecology April 2007 – January 2009 Principal Applicant Does melatonin enhance hypothermic neuroprotection following perinatal asphyxia? £125,000


The Great Britain Sasakawa Foundation September 2007 – August 2010 Principal Applicant Improving the care of the extremely preterm infant: a collaborative study between UK and Japan £12,000 External donations through the UCL Development & Corporate Communications Office October 2007 Principal Investigator A pilot feasibility and safety study of a simple, low cost method of whole body cooling in neonatal encephalopathy in Mulago Hospital, Kampala. £25,000 MRC Experimental Medicine Bid 2009 - 2012 (PI: UCL, CI Denis Azzopardi) Neuroprotective effects of hypothermia and xenon following perinatal asphyxia £1.1 million (Imperial College Sponsor) Comprehensive Biomedical Research Centre 2009 - 2011 Principal Investigator High field post-mortem MR microscopy of fetal and neonatal brain and heart. £195,602, Comprehensive Biomedical Research Centre Capital Bid 2011 Principal Investigator Lammers Medical MR compatible incubator £350,000 Comprehensive Biomedical Research Centre 50% funding. NHS 50% funding. 2011 Co-applicant A multimodal, multidisciplinary clinical imaging resource for translational medical research (A 3Tesla whole-body MRI system £993,000 UCH/UCL External Donation through the UCL Development & Corporate Communications Office 2010 Principal Investigator Development of a clinical xenon recirculating ventilator for neuroprotection of the newborn £100,000 Donation Wellbeing of Women (SANDS) 2010 Co-applicant Cardiac Channelopathies and Sudden infant Death Syndrome £95,000 SPARKS (SPort Aiding Research in KidS) 2010 - 2012 Co-applicant


Preterm brain serial imaging and correlation with neurodevelopmental outcome. £180,000 The Wellcome Trust and London School of Hygiene and Tropical Medicine 2010-2013 Supervisor PhD fellowship for Dr Cally Tann (supervisor) £400,000 Action Medical Research 2010 - 2012 Principal Investigator Does the alpha 2 adrenoceptor agonist dexmedetomidine (a sedative drug already in clinical use) enhance neuroprotection when combined with therapeutic hypothermia in a model of perinatal asphyxia? £193,827 Comprehensive Biomedical Research Centre June 2011 Principal Investigator Fast Track Grant. Ischaemic postconditioning: a Novel Neuroprotective Therapy for Perinatal Asphyxia? £40,000 NIHR Clinician Scientist Award March 2011 Supervisor Fellowship awarded to Sudhin Thayyil £1 million MRC (Neuroscience Board) 2012-2014 Principal Investigator Is Ischaemic Post Conditioning Neuroprotective following Perinatal Asphyxia? £808,085 Wellbeing of Women 2012-2014 Principal Investigator Does Argon Augment Hypothermic neuroprotection in a Perinatal Asphyxia model? £200,000 Cerebral Palsy Alliance Innovative Research Grant (ABN 45 000 062 288). Joint PI. Cally Tann, NJ Robertson. Early neurodevelopmental outcomes and cerebral palsy after neonatal encephalopathy in Uganda: an assessment of the role of perinatal infection/inflammation. $35,350 School of Life and Medical Sciences UCL Principal Applicant Jan 2013 Capital Equipment - 31P MRS Neonatal Head Coils £28,000 Matched funding from donor £28,000 Chiesi Farmaceutici S.p.A Principal Applicant


2014-2016 Melatonin for Birth Asphyxia (MELBA): optimizing dose and therapeutic window £1.62 million Wellbeing of Women 2013-2015 Principal Applicant Melatonin neuroprotection in perinatal asphyxia: is melatonin effective as a single therapy and does the therapeutic window extend to 4 h? £179,000 Action Medical Research 2015-2017 Principal Applicant Refining the potential use of magnesium in neonatal encephalopathy: safety, pharmacokinetics and neuroprotection of magnesium-augmented hypothermia compared to hypothermia alone. £200,000 Medical Research Council 2015-2017 Principal Applicant Reducing the Burden of Neonatal Brain Injury: Assessment of Hypothermic & Melatonin Neuroprotection in an Inflammation-Sensitised Piglet Asphyxia Model £1.26 million Beacon Bursary Application: Public Engagement UCL 2015 Principal Applicant Baby Brain Protection: Involving parents in research to prevent brain damage in newborn babies £1950 Medical Research Council 2017-2019 Principal Applicant EMPATHY Study. Epo and Melatonin for Perinatal Asphyxia with Therapeutic Hypothermia £1.25 million FEC Saving Lives at Birth 2017-2020 RS-17-08196: Smart sclera screening of jaundiced newborns in Ghana Co-applicant $244,846 Medical Research Council 2018-2021 Development of a cot-side optical biomarker of brain tissue health following neonatal hypoxic-ischaemic brain injury. Co-applicant £1.02 million FEC Internal Research Fund (Sidra Medicine) 2017-2019

• 2018 – Internal Research Fund Reducing the Disability in Qatar: Precision Medicine for Neonatal Encephalopathy QAR 100,000


NJ Robertson (PI)

• 2019 - Clinical Research Grand Challenge Grant awarded June 2019 QAR 985,000 2020-2022

Early Prediction of Outcome in Neonatal Cyanotic Complex Congenital Heart Disease (EPOCH) NJ Robertson (PI), Olivier Ghez, Zi Hijazi, S Gupta, D Chaussabel, K Fakhro, A Dhullipala, A Ederies

Wellbeing of Women 2019-2021 Camellia Study – Cooling and Melatonin in LPS-Sensitized Birth Asphyxia £250,000 PI: NJ Robertson Co applicants, Kathryn Martinello, Xavier Golay Bill and Melinda Gates Foundation 2019-2021 PAINT Study: Piglet Asphyxia Inflammation model for Neuroprotective Therapies $2,294,887 PI: NJ Robertson Co-applicant/partner: Prof John Barks, University of Michigan Brain Research UK, 2020-2023 Brain Injuries acquired during the neonatal period: investigating mechanisms which can correct depressed cortical activity. £298,000 Co-applicant Wellcome Trust Fellowship (supervisor role) Dr Subha Mitra £1m Wellcome Trust: Clinical Research Career Development Fellowship Investigating the Impact of Seizures on the Brain Awarded Dec 2019, 4 years MRC (Developmental Pathway Funding Scheme) £3.1m Principal Applicant INSTINCT Study: Intranasal Stem Cells for Improving Neurodevelopmental Outcomes in Neonatal Encephalopathy 2020-2023


INVITED TALKS: September 1998 Institute of Developmental Neurology, Psychiatry and Educational Psychology, University of Pisa and Stella Maris Foundation, Pisa, Italy. Magnetic Resonance Spectroscopy of the Neonatal Brain June 2000 17th European Congress of Perinatal Medicine, Porto, Portugal. Plenary Session: Perinatal Asphyxia: from molecular basis to diagnosis, management and follow-up. Magnetic Resonance Spectroscopy: Secondary Energy Failure March 2002 7th Biennial Meeting of the European Society of Magnetic Resonance in Neurology, London MRS of the Developing Brain September 2002 European Society for Paediatric Research, Utrecht, the Netherlands. Plenary talk Mitochondrial changes after hypoxia-ischaemia in neonates. What’s the evidence? May 2004 Royal Society of Medicine, London. Hypothermia for neuroprotection in newborn infants - current research and implications for clinical practice. Cerebral energetics following hypoxia-ischaemia – why does hypothermia help? November 2004 British Institute of Radiology, London. Meeting title: Fetal and neonatal brain magnetic resonance: new developments and future directions. The use of MRS in the assessment of the newborn with neonatal encephalopathy and the translation of research from experimental to clinical neuroprotection December 2004 Institute of Neurology, UCL. Glaxo Smithkline Lecture series. Neuroprotection of the newborn becomes a reality? January 2005 Baby Lifeline Charity Event. Birmingham,UK. Hypoxic-ischaemic brain injury of the infant at term May 2005 XIX Nordic Congress of Perinatal Medicine Lund, Sweden. MRI of the Fetus and Newborn May 2005 UCLH Study Day, Institute of Child Health. Development of the brain in the NICU October 2005 Swiss Society of Neonatology Lausanne, Switzerland. Optimizing hypothermic neuroprotection after hypoxia-ischaemia


October 2006 Uganda Women’s Health Initiative Inaugural Meeting, Kampala, Uganda Therapeutic hypothermia for neonatal encephalopathy in a low resource setting November 2007 Neonatal Update 2007, Imperial College London The metabolism of the newborn brain: strategies for optimising neuroprotection May 2010 Plenary Session: Neonatal Neuroprotection Trials: Challenges and Opportunities Invited talk: Clinical Trials of Brain Protection in the Developing World Society for Pediatric Research Annual Meeting, Vancouver, Canada May 2010 Special Lecture: New Horizons in Neuroprotection of the newborn: cooling is just the beginning 52nd Annual Meeting of the Japanese Society of Child Neurology, Fukuoka, Japan June 2010 “Hot Topic” invited plenary talk: Hypoxic Perinatal Brain Injury: the Global Perspective. 14th Annual Conference of the British Maternal and Fetal Medicine Society, Newcastle, UK October 2010 Invited Talk: Translational studies: the term asphyxiated infant 3rd Congress of the European Academy of Pediatrics Society, Copenhagen, Denmark February 2011 Invited Talk: Biomarkers and Other Surrogates for Brain Injury 6th International Conference of Brain Monitoring and Neuroprotection in the Newborn, Amsterdam, The Netherlands May 2011 Experimental Medicine Day at UCL. Xenon-augmented Neuroprotection for the Treatment of Neonatal Encephalopathy. June 2011 Invited Talk: Hypothermia – what we should do and where we go from here. Evidence based Neonatology – today and tomorrow. Stockholm, Sweden November 2011 Invited Talk: Optimizing Newborn Neuroprotection in Low, Mid and High Resource Settings. Neonatal Update 2011. Imperial College London November 2011 Invited Plenary Talk: Refining Hypothermic Neuroprotection of the Newborn. Excellence in Pediatrics Conference 2011. Istanbul, Turkey February 2012 (invited but could not attend) Invited Lecture: Neuroprotection of the Newborn. Cyprus Perinatal Society, Cyprus


April 2012 Other treatments for Birth Asphxyia. 5th International EURAIBI Meeting, Sienna, Italy. October 2012 Neuroprotection of the Newborn – a series of three lectures. Peruvian Perinatal Society. Lima Peru. September 2013 USANA – United South African Neonatal Association, Cape Town, South Africa. Three invited lectures Neuroprotection I, II and III May 2014 Pediatric Academic Societies, Vancouver, Canada. Invited Plenary Lecture at The Brain Club Old Drugs - New Uses for Neurprotection Melatonin as an adjunct to therapeutic hypothermia – is it ready for prime time? June 2014 Perinatal Medicine, Harrogate Keynote Lecture: New Avenues in Neonatal Neuroprotection July 2014 20th Anniversary Reason Meeting, University of Warwick, Coventry Invited Lecture: Natural Therapies for Newborn Neuroprotection August 2014 European Workshop on Neonatal Transition, Prato, Italy (Ritchie Centre, Monash University) Invited Talk: New Concepts for Brain Protection for Neonatal Encephalopathy September 2014 European Brain Club, NOORDWIJK, The Netherlands 2014 Talk: Remote ischaemic postconditioning protects the white matter following cerebral hypoxia-ischaemia October 2014 European Society for Pediatric Research, Barcelona, Spain Invited Plenary: New Avenues for Neonatal Neuoprotection June 2015 The David Harvey Senior Fellowship Keynote lecture, Winchester Effective and Safe but Cheap and Practical: New Therapies for Neonatal Encephalopathy June 2015 Summer Conference on Neonatology Neonatal Neurology, Avignon, France Invited Talk: New Neuroprotective Strategies September 2015 jENS-15 - 1st Congress of joint European Neonatal Societies (jENS) - 56th ESPR/ESN, Budapest Invited Lecture: Drugs which can damage the brain


October 2015 Research Skills Neonatal Training Day organized by British Association of Perinatal Medicine Why is research in neonatology important for neonatal care? Royal College of Paediatrics and Child Health, London November 2015 6th Irish Neonatal Research Meeting, Dublin Invited talk: New Avenues for Brain Protection 30th November – 1st December 2015 Air Liquide - Argon Organoprotective Network 3rd Meeting, London Argon Augments Therapeutic Hypothermia brain protection in a piglet model of birth asphyxia. January 2016 British Paediatric Neurology Association 42nd Annual Conference Sheffield 27-29 January 2016 Personal Practice Session: Diagnosis and Management of neonatal non-HIE encephalopathies Keynote Speaker: Protecting the term Newborn Brain: Cocktails and Ice

May 2016 The Royal College of Ophthalmologists Annual Congress 2016, ICC Birmingham Pediatric Sub Specialty Day Protecting the infant brain – the Neonatologist’s perspective

July 5-7, 2016 IPOKRaTES Jerusalem Controversies in Neonatology 4 lectures 1. Neuroprotection for NE – cooling and beyond 2. Risk factors and pathogenesis of Term Brain Injury 3. Risk Factors and Pathogenesis of Preterm Brain Injury 4. Imaging and Biomarkers in NE

November 11-12, 2016 2nd Abu Dhabi International Neonatal Multi Specialty Conference Abu Dhabi NMS Rosewood Hotel Abu Dhabi , UAE 1- The clinical application of NIRS and amplitude integrated EEG in newborns 2- An update on brain protection strategies

November 23 - 25, 2016 The 6th INTERNATIONAL CONGRESS OF UENPS Valencia, Spain Invited Speaker SESSION: NEONATAL NEUROLOGY AND NEUROINTENSIVE CARE The Holy Grail of protecting the term brain - are we there yet? SESSION: ILCOR GUIDELINES 2015: A CRITICAL REVIEW. Therapeutic hypothermia for NE: can the trial data be applied to mid and low resource settings? April 2017 Invitation to speak at 2nd Oman Pediatrics Conference 2017, which will be held from 13th April to 15th April 2017 in Muscat, Oman under the Patronage of Ministry of Health. Unable to attend.

May 2017 Invited Talk: New Horizons in Neuroprotection of the Newborn SPIN 2017 Sharing Progress in Neonatology and 32nd International Workshop on Surfactant Replacement, Dublin, Ireland, May 26th and 27th 2017.

June 2017


25th Annual International Neonatal Meeting at Middlesborough 2017 State of art: State of Confusion Invited talk: Protecting the newborn brain – any progress? June 2017 Invited talk: 14 June: Expanding the indications for hypothermia and the methods? 99NICU meetup Karolinska, Stockholm, Sweden June 2017 Ampersand Conference, Edinburgh. Medical Negligence Conference. Neonatal Encephalopathy: new treatments October 2017 VIIIth Recent Advances in Neonatal Medicine - An International Symposium Honoring Prof. Bo Sun - Würzburg, Germany, October 8 – 10, 2017 Pre-Symposium’s Workshop on Sunday, Oct. 8, 2017 VIII: BRAIN / ROP, 16:30 – 18:00 hrs: ● Current and emerging pharmacological treatments of neonatal brain damage and seizures ● Neonatal encephalopathy: New interventions and hope for a better outcome? November 2017 2nd congress of joint neonatal societies (JENS) Venice, Italy Invited talk New avenues for brain protection November 2017 (invited but declined) Evidence based Neonatology conference in Hyderabad, India 2 talks Cooling in sub Saharan Africa New therapies for Brain protection November 16-18 2017 3rd Abu Dhabi International Neonatal Multi Specialty Conference Abu Dhabi, UAE Invited talks: 1- Neonatal Seizures and their treatment - An Update 2- Vulnerable periods and developmental care November 27-29 2017 IPOKRATES Accra, Ghana 27 November -3rd Dec Perinatal asphyxia: pathophysiology

April 5-6, 2018 Neonatology Meeting Florence: Pharmacological treatment of brain injuries: present and future. April 9-12, 2018 99nicu Meetup - advancing the management of newborns” Vienna, Austria. Precision Medicine in NE – is this possible?

June 7-9 2018


Rostock, Germany The Society of Neonatology and Pediatric Intensive Care (Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin GNPI) Neonatal Encephalopathy with special focus on current therapy concepts but also on future concepts from xenon to ischemic postconditioning.

June 11-13 2018 Neonatal conference Buenos Aires 4 lectures:

1. Prognosis using MRI and MRS in Neonatal Encephalopathy 2. Neonatal Seizures 3. New Treatments for Neonatal Encephalopathy 4. Therapeutic hypothermia: the journey over the last few decades

October 15-18 2018 Bill Gates Foundation Grand Challenges Annual Meeting 2018: Berlin Germany Invited speaker for Birth Asphyxia Consortium Hypoxic Injury and Neonatal infection: do current treatments address this common combination? November 22-24 2018 Cool topics in Neonatology, 2018, Melbourne, Australia Invited Talks

1. Inflammation Sensitized Brain Injury: how do we detect and treat it? 2. Melatonin the Healing Hormone- is it ready for prime time? 3. Neonatal Seizures – an update from high and low resource settings

November 23-25, 2018 The Neonate 2nd International Symposium for Asia - Shanghai, November 23-25, 2018

1. Novel Therapies for Neonatal Encephalopathy 2. Neuroprotective Bundle of Care for Preterm Babies

February 20-21, 2019 Bill Gates Birth Asphyxia Consortium Seattle, USA March 20-22, 2019 (declined the invitation) Perinatal Asphyxia meeting, Modena (Italy), organized by Mariani Foundation MR Spectroscopy Biomarkers March 28-30, 2019 7th International Meeting - from Fetal Life to Childhood maternal-infant nutrition congress Istanbul, Turkey Invited Talks

1. New modalities in Neuroprotection 2. Magnetic resonance biomarkers of neonatal brain injury

April 4th-6th, 2019 2nd World Congress Maternal Fetal Neonatal Medicine, London Term NE – how can we augment protection from therapeutic hypothermia?


April 15th-17th 2019 Ipokrates Clinical Seminar, Doha Qatar Neonatal Pharmacology

1. Neonatal Seizure Treatments – the new, the old and the useless 2. Potential New Adjunct Therapies to Avoid Adverse Neurodevelopmental Outcome in Neonatal

Encephalopathy May 23 – 25, 2019 IPOKRATES Clinical Seminar Protecting and Developing the Brain Kagawa International Conference Hall, Takamatsu City, Kagawa, Japan

1. MRI/MRS of the Neonatal Brain 2. Adjunct Therapies to include those for HIC and LMIC

17-21 September 2019 3rd Joint European Neonatal Society, Maastricht Invited speaker Pre-congress Course 3 – Basic Neuroscience Research Methods: Bringing Neuroscience into the Clinic Parallel session: Translating neuroscience into clinical practice in low and mid income countries 24th September 2019 Neonatal and Children’s Brain Consortium Ireland, Dublin Invited talk: Neuroprotection for Neonatal Encephalopathy – the old, the new and the unexpected. 4-5th October 2019 Sidra’s Inaugural Pediatric Neuroscience Conference, Doha, Qatar Invited Talk: Neonatal Seizures – update on new treatments. 28th-31st October 2019 Qatar Critical Care Conference 2019 NEW Developments in the Care of the Newborn with HIE 23-26 November 2019 CUDOS-2019, Doha, Qatar Invited Talk: Neonatal Hypoglycemia and Brain Injury 10-13 November 2019 43rd “Miami Neonatology Conference”, Loews Hotel in Miami Beach Invited Speaker

1. Brain protection therapies applicable to low resource settings 2. The heart rules the brain – The impact of congenital heart disease on brain development and

injury in the neonatal period

February 26-28th, 2020 International Neonatology Symposium: Bangkok 2020 Invited speaker:

1. Tailoring Brain Protection to Low Resource Settings 2. Therapies for Neonatal Encephalopathy. What’s Next?

April 1-5, 2020 28th National Neonatology Congress, Turkish Neonatal Society Antalya, Turkey

1. Therapies for NE: what’s next?


2. Predicting outcome and Imaging Markers in NE June 20-24, 2020 Conference on Neonatology, Avignon, France Invited talk 8-10 September, 2020 Best of IPOKRATES, Munich Germany Invited talk and workshop: Pathway of investigation and management of NE 11-13 September, 2020 European Brain Club, Slovenia September 17-19, 2020 12th International Newborn Brain Conference Carton House, Kildare, Ireland Invited talk: Is it time for MRS to enter clinical practice?


PEER REVIEWED PUBLICATIONS 2021 Roopali Soni, Charlotte Hedvig Tscherning Wei-Wei, Nicola J Robertson. Neuroscience meets nurture: the challenges of prematurity and the critical role of family-centred and developmental care as a key part of the neuroprotection care bundle. Arch Dis Child (in press). Javed Ahmed, Pullattayil S. AK, Nicola J Robertson, Kiran More. Melatonin for Neuroprotection in Neonatal Encephalopathy in Newborns: A Systematic Review and Meta-Analysis of Clinical Trials. Eur J Pediatr Neurol 2021 (in press). Aravanan A Chakkarapani, Hany Aly, Manon Benders, C. Michael Cotten, Mohamed El-Dib, Pierre Gressens, Henrik Hagberg, Hemmen Sabir, Pia Wintermark, Nicola J Robertson. Therapies for Neonatal Encephalopathy: Targeting the Latent, Secondary and Tertiary Phases of Evolving Brain Injury. Semin Fetal Neonatal Med. 2021 (in press) Pang R, Avdic-Belltheus A, Meehan C, Sokolska M, Martinello K, Mutshiya T, Yang Q, Torrealdea F, Hristova M, Bainbridge A, Golay X, Juul S, Robertson NJ. Erythropoietin combined with Melatonin for Perinatal Asphyxia with Therapeutic Hypothermia in a Piglet Model (The EMPATHY Study). Brain Comm (in press) Saugstad OD, Robertson NJ, Vento M. A critical review of the 2020 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant. Acta Paediatr. 2021 Jan 8. doi: 10.1111/apa.15754.

Martinello KA, Meehan C, Avdic-Belltheus A, Lingam I, Mutshiya T, Yang Q, Price D, Sokolska M, Bainbridge

A, Hristova M, Tachtsidis I, Tann CJ, Peebles D, Hagberg H, GAM Wolfs TGAM, Klein N, Kramer BW, Fleiss

B, Gressens P, Golay X, Robertson NJ. Hypothermia is not therapeutic in a piglet model of LPS-sensitised neonatal hypoxic ischaemic encephalopathy. Pediatr Res (in press)

2020 Robertson NJ, Meehan C, Martinello KA, Avdic-Belltheus A, Boggini T, Mutshiya T, Lingam I, Yang Q, Sokolska M, Charalambous X, Bainbridge A, Hristova M, Kramer BW, Golay X, Weil B, Lowdell MW. Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia. Cytotherapy. 2020 Nov 28:S1465-3249(20)30930-0. doi: 10.1016/j.jcyt.2020.10.005. Mckinnon K, Kendall GS, Tann CJ, Dyet L, Sokolska M, Baruteau KP, Marlow N, Robertson NJ, Peebles D, Srinivasan L. Biometric assessments of the posterior fossa by fetal MRI: A systematic review. Prenat Diagn. 2020 Nov 29. doi: 10.1002/pd.5874. Mitra S, Bale G, Meek J, Tachtsidis I, Robertson NJ.Cerebral Near Infrared Spectroscopy Monitoring in Term Infants With Hypoxic Ischemic Encephalopathy-A Systematic Review. Front Neurol. 2020 May 27;11:393. doi: 10.3389/fneur.2020.00393. Pang R, Martinello KA, Meehan C, Avdic-Belltheus A, Lingam I, Sokolska M, Mutshiya T, Bainbridge A, Golay X, Robertson NJ. Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia-Ischemia With and Without Inflammation-Sensitization. Front Neurol. 2020 Sep 4;11:883. doi: 10.3389/fneur.2020.00883.


Pang R, Mintoft A, Crowley R, Sellwood M, Mitra S, Robertson NJ. Optimizing hemodynamic care in neonatal encephalopathy. Semin Fetal Neonatal Med. 2020 Oct;25(5):101139. doi: 10.1016/j.siny.2020.101139. Epub 2020 Jul 12. Lingam I, Avdic-Belltheus A, Meehan C, Martinello K, Ragab S, Peebles D, Barkhuizen M, Tann CJ, Tachtsidis I, Wolfs TGAM, Hagberg H, Klein N, Fleiss B, Gressens P, Golay X, Kramer BW, Robertson NJ. Serial blood cytokine and chemokine mRNA and microRNA over 48 h are insult specific in a piglet model of inflammation-sensitized hypoxia-ischaemia. Pediatr Res. 2020 Jun 10. doi: 10.1038/s41390-020-0986-3. Galinsky R, Dean JM, Lingam I, Robertson NJ, Mallard C, Bennet L, Gunn AJ. A Systematic Review of Magnesium Sulfate for Perinatal Neuroprotection: What Have We Learnt From the Past Decade? Front Neurol. 2020 May 27;11:449. doi: 10.3389/fneur.2020.00449. Robertson NJ, Lingam I, Meehan C, Martinello KA, Avdic-Belltheus A, Stein L, Tachrount M, Price D, Sokolska M, Bainbridge A, Hristova M, Fleiss B, Kramer BW, Gressens P, Golay X. High-Dose Melatonin and Ethanol Excipient Combined with Therapeutic Hypothermia in a Newborn Piglet Asphyxia Model. Sci Rep. 2020 Mar 3;10(1):3898. doi: 10.1038/s41598-020-60858-x. Mitra S, Bale G, de Roever I, Meek J, Robertson NJ, Tachtsidis I. Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality. Adv Exp Med Biol. 2020;1232:25-31. doi: 10.1007/978-3-030-34461-0_4. Mitra S, Bale G, de Roever I, Meek J, Robertson NJ, Tachtsidis I. Changes in Brain Tissue Oxygenation and Metabolism During Rewarming After Neonatal Encephalopathy are Related to Electrical Abnormality. Adv Exp Med Biol. 2020;1232:25-31. 2019 Kaynezhad P, Mitra S, Bale G, Bauer C, Lingam I, Meehan C, Avdic-Belltheus A, Martinello KA, Bainbridge A, Robertson NJ, Tachtsidis I. Quantification of the severity of hypoxic-ischemic brain injury in a neonatal preclinical model using measurements of cytochrome-c-oxidase from a miniature broadband-near-infrared spectroscopy system. Neurophotonics. 2019 Oct;6(4):045009. Azzopardi D, Chew AT, Deierl A, Huertas A, Robertson NJ, Tusor N, Edwards AD. Prospective qualification of early cerebral biomarkers in a randomised trial of treatment with xenon combined with moderate hypothermia after birth asphyxia. EBioMedicine. 2019 Aug 23. pii: S2352-3964(19)30559-6. doi: 10.1016/j.ebiom.2019.08.034. Lingam I, Meehan C, Avdic-Belltheus A, Martinello K, Hristova M, Kaynezhad P, Bauer C, Tachtsidis I, Golay X, Robertson NJ. Short-term effects of early initiation of magnesium infusion combined with cooling after hypoxia-ischemia in term piglets. Pediatr Res. 2019 Jul 29. doi: 10.1038/s41390-019-0511-8. Martinello KA, Meehan C, Avdic-Belltheus A, Lingam I, Ragab S, Hristova M, Tann CJ, Peebles D, Hagberg H, Wolfs TGAM, Klein N, Tachtsidis I, Golay X, Kramer BW, Fleiss B, Gressens P, Robertson NJ. Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy. Sci Rep. 2019 Jul 15;9(1):10184. doi: 10.1038/s41598-019-46488-y. Enweronu-Laryea C, Martinello KA, Rose M, Manu S, Tann CJ, Meek J, Ahor-Essel K, Boylan GB, Robertson NJ. Core temperature after birth in babies with neonatal encephalopathy in a sub-Saharan African hospital setting. J Physiol. 2019 Jun 5. doi: 10.1113/JP277820. [Epub ahead of print] .


Tann CJ, Webb EL, Lassman R, Ssekyewa J, Sewegaba M, Musoke M, Burgoine K, Hagmann C, Deane-Bowers E, Norman K, Milln J, Kurinczuk JJ, Elliott AM, Martinez-Biarge M, Nakakeeto M, Robertson NJ, Cowan FM. Early Childhood Outcomes After Neonatal Encephalopathy in Uganda: A Cohort Study. EClinicalMedicine. 2018 Dec;6:26-35. Barkhuizen M, van Mechelen R, Vermeer M, Chedraui P, Paes D, van den Hove DLA, Vaes B, Mays RW, Steinbusch HWM, Robertson NJ, Kramer BW, Gavilanes AWD. Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy. Behav Brain Res. 2019 Jan 10;362:77-81. doi: 10.1016/j.bbr.2019.01.016. Moral Y, Robertson NJ, Goni-de-Cerio F, Alonso-Alconada D. Neonatal hypoxia ischaemia: cellular and molecular brain damage and therapeutic modulation by neurogenesis. Rev Neurol. 2019 Jan 1;68(1):23-36. Review. Spanish. 2018 de Roever I, Bale G, Mitra S, Meek J, Robertson NJ, Tachtsidis I. Investigation of the Pattern of the Hemodynamic Response as Measured by functional Near-INfraed Spectroscopy (fNIRS) studies in Newborns, less than a month old: A Systematic Review. Front Hum Neurosci. 2018 Oct 2;12:371. Mitra S, Kendall GS, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Price D, Mckinnon K, Gunny R, Huertas-Ceballos A, Golay X, Robertson NJ. Proton magnetic resonance spectroscopy Lactate/NAA within 2 weeks of birth accurately predicts 2 year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed. 2018 Oct 15. Robertson NJ, Martinello K, Lingam I, Avdic-Belltheus A, Meehan C, Alonso-Alconada D, Ragab S, Bainbridge A, Sokolska M, Tachrount M, Middleton B, Price D, Hristova M, Golay X, Soliani Raschini A, Aquino G, Pelizzi N, Facchinetti F. Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: a translational study. Neurobiol Dis. 2019 Jan;121:240-251. Akin MA, Sahin O, Cansever M, Sirakaya E, Robertson NJ. Early Retinal Findings Following Cooling in Neonatal Encephalopathy. Neuropediatrics. 2018 Sep 20. Niermeyer S, Robertson NJ, Ersdal HL. Beyond Basic Resusucitation: What are the next steps to improve the outcomes of resuscitation at birth when resources are limited? Semin Fetal Neonatal Med. 2018 Oct;23(5):361-368. Bale G, Mitra S, de Roever I, Sokolska M, Price D, Bainbridge A, Gunny R, Uria-Avellanal C, Kendall GS, Meek J, Robertson NJ, Tachtsidis I. Oxygen Dependency of Mitochondrial Metabolism Indicates Outcomes of Newborn Brain Injury. J Cereb Blood Flow Metab. 2018 May 18:271678X18777928. Dhillon SK, Lear CA, Galinsky R, Wassink G, Davidson JO, Juul S, Robertson NJ, Gunn AJ, Bennet L. The Fetus at the Tipping Point: modifying the outcome of fetal asphyxia. J Physiol. 2018 Dec;596(23):5571-5592.

Hassell J, Tann C, Idro R, Robertson NJ. Contribution of Perinatal Conditions to Cerebral Palsy in Uganda. Lancet Glob Health. 2018 Mar;6(3):e248-e249. Lingam I, Robertson NJ. Magnesium as a Neuroprotective Agent: A Review of its Use in the Fetus, Term Infants with Neonatal Encephalopathy and in the Adult Stroke Patient. Dev Neurosci. 2018;40(1):1-12.


2017

Mitra S, Bale G, Highton D, Gunny R, Uria-Avellanal C, Bainbridge A, Sokolska M, Price D, Huertas-Ceballos A, Kendall GS, Meek J, Tachtsidis I, Robertson NJ. Pressure passivity of cerebral mitochondrial metabolism is associated with poor outcome following perinatal hypoxic ischemic brain injury. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17733639. Cally J Tann, Margaret Nakakeeto, Barbara A Willey, Margaret Sewegaba., Emily L Webb, Ibby Oke, Emmanuel D Muutaza, Donald Peebles, Margaret Musoke, Kathryn A Harris, Neil J Sebire Nigel Klein Jennifer J Kurinczuk Alison M Elliott, Nicola J Robertson. Perinatal Risk Factors For Neonatal Encephalopathy: An Unmatched Case-Control Study. Arch Dis Child Fetal Neonatal Ed. 2017 Aug 5. pii: fetalneonatal-2017-312744. Christabel Enweronu-Laryea and Nicola Robertson. Helping Babies Breathe can reduce Deaths with the Right Combination of Training and Expertise. Acta Paediatr. 2017 Oct;106(10):1552-1553. Ezzati, M, Kawano G, Rocha-Ferreira E, Alonso-Alconada D, Hassell JK, Broad KD, Fierens I, Fleiss B, Bainbridge B, Price DL, Kaynezhad P, Anderson B, Hristova m, Tachtsidis I, Golay X, Gressens P, Sanders

RD, and Robertson NJ. Dexmedetomidine Combined with Therapeutic Hypothermia is associated with Cardiovascular Instability and Neurotoxicity in a Piglet Model of Perinatal Asphyxia. Dev Neurosci 2017 Apr 8. doi: 10.1159/000458438. Broad KD, Kawano G, Fierens I, Rocha-Ferreira E, Hristova M, Ezzati M, Rostami J, Alonso-Alconada D, Chaban B, Hassell J, Fleiss B, Gressens P, Sanders RD, Robertson NJ. Surgery increases cell death and induces changes in gene expression compared with anesthesia alone in the developing piglet brain. PLoS One. 2017 Mar 29;12(3):e0173413. Martinello K, Hart AR, Yap S, Mitra S, Robertson NJ. Management and Investigation of Neonatal Encephalopathy: 2017 update. Archives Dis Child Fetal and Neonatal Ed. Apr 6. pii: fetalneonatal-2015-309639. doi: 10.1136/archdischild-2015-309639. Rocha-Ferreira E, Kelen D, Faulkner S, Broad KD, Chandrasekaran M, Kerenyi A, Kato T, Bainbridge A, Golay X, Sullivan M, Kramer BW, Robertson NJ. Systemic pro inflammatory cytokine status with therapeutic hypothermia in a piglet hypoxia-ischemia model. J Neuroinflammation 2017 Mar 3;14(1):44.

2016

Broad KD, Hassell J, Fleiss B, Kawano G, Ezzati M, Rocha-Ferreira E, Hristova M, Bennett K, Fierens I, Burnett R, Chaban B, Alonso-Alconada D, Oliver-Taylor A, Tachsidis I, Rostami J, Gressens P, Sanders RD, Robertson NJ. Isoflurane exposure induces Cell Death, Microglial Activation and Modifies the Expression of Genes Supporting Neurodevelopment and Cognitive function in the Male Newborn Piglet Brain. PLOS One 2016;11(11):e0166784. Gunn AJ, Laptook AR, Robertson NJ, Barks JD, Thoresen M, Wassink G, Bennet L. Therapeutic hypothermia translates from ancient history in to practice. Pediatr Res. 2016 Nov 2. doi: 10.1038/pr.2016.198. Rocha-Ferreira E, Kelen D; Faulkner S; Broad KD; Chandrasekaran M; Kerenyi A; Kato T; Bainbridge A; Golay X; Sullivan M; Kramer BW; Robertson NJ. Effect of therapeutic hypothermia on the evolution of serum and CSF cytokines in a piglet asphyxia model: relation to brain Lac/Naa and cell death. Journal of Neuroinflammation in press


Lingam I, Avdic-Belltheus A, Robertson NJ. Using animal models to improve care of neonatal encephalopathy. Arch Dis Child Educ Pract Ed. 2016 May 4. pii: edpract-2015-309927. doi: 10.1136/archdischild-2015-309927. Mitra S, Bale G, Mathieson S, Uria-Avellanal C, Meek J, Tachtsidis I, Robertson NJ. Changes in Cerebral Oxidative Metabolism during Neonatal Seizures Following Hypoxic-Ischemic Brain Injury. Front Pediatr. 2016 Aug 10;4:83. Rocha-Ferreira E, Rudge B, Hughes MP, Rahim AA, Hristova M, Robertson NJ. Immediate Remote Ischemic Postconditioning Reduces Brain Nitrotyrosine Formation in a Piglet Asphyxia Model. Oxid Med Cell Longev. 2016;2016:5763743. Orasanu E, Melbourne A, Cardoso MJ, Lomabert H, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching. Brain Behav. 2016 May 17:e00488. [Epub ahead of print] PMID: 27257515 Lingam I, Avdic-Belltheus A, Robertson NJ. Using animal models to improve care of neonatal encephalopathy. Arch Dis Child Educ Pract Ed. 2016 May 4. pii: edpract-2015-309927. doi: 10.1136/archdischild-2015-309927. [Epub ahead of print] No abstract available. PMID: 27147551 Proisy M, Mitra S, Uria-Avellana C, Sokolska M, Robertson NJ, Le Jeune F, Ferré JC. Brain Perfusion Imaging in Neonates: An Overview. AJNR Am J Neuroradiol. 2016 Apr 14. [Epub ahead of print] Review. PMID: 27079367 Tann CJ, Nakakeeto M, Hagmann C, Webb EL, Nyombi N, Namiiro F, Harvey-Jones K, Muhumuza A, Burgoine K, Elliott AM, Kurinczuk JJ, Robertson NJ, Cowan FM. Early cranial ultrasound findings amongst infants with neonatal encephalopathy in Uganda: an observational study. Pediatr Res. 2016 Apr 11. doi: 10.1038/pr.2016.77. [Epub ahead of print] PMID: 27064242 Saugstad OD, Robertson NJ, Vento M. A critical review of the 2015 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant. Acta Paediatr. 2016 May;105(5):442-4. doi: 10.1111/apa.13358. No abstract available. PMID: 27062471 Melbourne A, Eaton-Rosen Z, Orasanu E, Price D, Bainbridge A, Cardoso MJ, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal development in the preterm thalamus and posterior white matter: MRI correlations between diffusion weighted imaging and T2 relaxometry. Hum Brain Mapp. 2016 Mar 21. doi: 10.1002/hbm.23188. [Epub ahead of print] PMID: 26996400 Cheong JL, Bainbridge A, Anderson PJ, Lee KJ, Burnett AC, Thompson DK, Roberts G, Wood SJ, Doyle LW, Robertson NJ. Altered posterior cingulate brain metabolites and cognitive dysfunction in preterm adolescents. Pediatr Res. 2016 Jan 28. doi: 10.1038/pr.2015.272. [Epub ahead of print] PMID: 26821169 Mitra S, Bale G, Meek J, Mathieson S, Uria C, Kendall G, Robertson NJ, Tachtsidis I. In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. Adv Exp Med Biol. 2016;876:493-9. doi: 10.1007/978-1-4939-3023-4_62.

2015

Azzopardi D, Robertson NJ, Bainbridge A, Cady E, Charles-Edwards G, Deierl A, Fagiolo G, Franks NP, Griffiths J, Hajnal J, Juszczak E, Kapetanakis B, Linsell L, Maze M, Omar O, Strohm B, Tusor N, Edwards


AD. Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial. Lancet Neurol. 2015 Dec 18. pii: S1474-4422(15)00347-6. doi: 10.1016/S1474-4422(15)00347-6 Broad KD, Fierens I, Fleiss B, Rocha-Ferreira E, Ezzati M, Hassell J, Alonso-Alconada D, Bainbridge A, Kawano G, Ma D, Tachtsidis I, Gressens P, Golay X, Sanders RD, Robertson NJ. Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia. Neurobiol Dis. 2015 Dec 10;87:29-38. Ezzati M, Bainbridge A, Broad KD, Kawano G, Oliver-Taylor A, Rocha Ferreira E, Alonso-Alconada D, Fierens I, Rostami J, Hassell J, Tachtsidis I, Gressens P, Hristova M, Bennett K, Lebon S, Fleiss B, Yellon D, Hausenloy DJ, Golay X, Robertson NJ. Limb Remote Ischemic Postconditioning Protects Cerebral White Matter in a Piglet Model of Perinatal Asphyxia. J Cereb Blood Flow Metab. 2015 Oct 8. pii: 0271678X15608862.

Arthurs OJ, Guy A, Thayyil S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Jacques TS, Chong WK, Gunny R, Saunders D, Olsen OE, Owens CM, Offiah AC, Chitty LS, Taylor AM, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group. Comparison of diagnostic performance for perinatal and paediatric post-mortem imaging: CT versus MRI. Eur Radiol. 2015 Oct 21 Caldwell M, Moroz T, Hapuarachchi T, Bainbridge A, Robertson NJ, Cooper CE, Tachtsidis I. Modelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia. PLoS One. 2015 Oct 7;10(10):e0140171. Hagmann CF, Chan D, Robertson NJ, Acolet D, Nyombi N, Nakakeeto M, Cowan FM.Neonatal neurological examination in well newborn term Ugandan infants. Early Hum Dev. 2015 Dec;91(12):739-49. Fleiss B, Tann CJ, Degos V, Sigaut S, Van Steenwinckel J, Schang A-L, Kichev A, Robertson NJ, Mallard C, Hagberg H, Gressens P. Inflammation-induced sensitization of the brain in term infants. Dev Med Child Neurol. 2015 Apr;57 Suppl 3:17-28. K Jane Hassell, Ezzati M, Alonso-Alconada D, Hausenloy D, Robertson NJ. New Horizons for Newborn Brain Protection: enhancing endogenous neuroprotection. Arch Dis Child Fetal and Neonatal Ed 2015 Jun 10. pii: fetalneonatal-2014-306284. doi: 10.1136/archdischild-2014-306284. Eaton-Rosen Z, Melbourne A, Orasanu E, Cardoso MJ, Modat M, Bainbridge A, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI. Neuroimage. 2015 Feb 12. pii: S1053-8119(15)00102-0. Arthurs OJ, Thayyil S, Pauliah SS, Jacques TS, Chong WK, Gunny R, Saunders D, Addison S, Lally P, Cady E, Jones R, Norman W, Scott R, Robertson NJ, Wade A, Chitty L, Taylor AM, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group. Diagnostic accuracy and limitations of post-mortem MRI for neurological abnormalities in fetuses and children. Clin Radiol. 2015 Aug;70(8):872-80. Alonso-Alconada D, Broad KD, Bainbridge A, Chandrasekaran M, Faulkner SD, Kerenyi Á, Hassell J, Rocha-Ferreira E, Hristova M, Fleiss B, Bennett K, Kelen D, Cady E, Gressens P, Golay X, Robertson NJ. Brain cell death is reduced with cooling by 3.5°C to 5°C but increased with cooling by 8.5°C in a piglet asphyxia model. Stroke. 2015 Jan;46(1):275-8. Pickard JM, Bøtker HE, Crimi G, Davidson B, Davidson SM, Dutka D, Ferdinandy P, Ganske R, Garcia-Dorado D, Giricz Z, Gourine AV, Heusch G, Kharbanda R, Kleinbongard P, MacAllister R, McIntyre C, Meybohm P, Prunier F, Redington A, Robertson NJ, Suleiman MS, Vanezis A, Walsh S, Yellon DM, Hausenloy DJ. Remote ischemic conditioning: from experimental observation to clinical application:


report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Res Cardiol. 2015 Jan;110(1):453. 2014

Robertson NJ, Marlow N. Depth and duration of cooling for perinatal asphyxial encephalopathy. JAMA. 2014 Dec 24-31;312(24):2623-4. Arthurs OJ, Thayyil S, Owens CM, Olsen OE, Wade A, Addison S, Jones R, Norman W, Scott RJ, Robertson NJ, Taylor AM, Chitty LS, Sebire NJ; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group.Diagnostic accuracy of post mortem MRI for abdominal abnormalities in foetuses and children. Eur J Radiol. 2015 Mar;84(3):474-81. Eaton-Rosen Z, Melbourne A, Orasanu E, Modat M, Cardoso MJ, Bainbridge A, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Longitudinal measurement of the developing thalamus in the preterm brain using multi-modal MRI. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):276-83. Melbourne A, Eaton-Rosen Z, De Vita E, Bainbridge A, Cardoso MJ, Price D, Cady E, Kendall GS, Robertson NJ, Marlow N, Ourselin S. Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):268-75. Arthurs OJ, Thayyil S, Olsen OE, Addison S, Wade A, Jones R, Norman W, Scott RJ, Robertson NJ, Taylor AM, Chitty LS, Sebire NJ, Owens CM; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group. Diagnostic accuracy of post-mortem MRI for thoracic abnormalities in fetuses and children. Eur Radiol. 2014 Nov;24(11):2876-84. Robertson NJ, Thayyil S, Cady EB, Raivich G. Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications. Curr Pediatr Rev. 2014;10(1):37-47. Arthurs OJ, Thayyil S, Addison S, Wade A, Jones R, Norman W, Scott R, Robertson NJ, Chitty LS, Taylor AM, Sebire NJ, Offiah AC; Magnetic Resonance Imaging Autopsy Study (MaRIAS) Collaborative Group. Diagnostic accuracy of postmortem MRI for musculoskeletal abnormalities in fetuses and children. Prenat Diagn. 2014 Dec;34(13):1254-61. Iwata S, Tachtsidis I, Takashima S, Matsuishi T, Robertson NJ, Iwata O. Dual role of cerebral blood flow in regional brain temperature control in the healthy newborn infant. Int J Dev Neurosci. 2014 Oct;37:1-7. Galinsky R, Bennet L, Groenendaal F, Lear CA, Tan S, van Bel F, Juul SE, Robertson NJ, Mallard C, Gunn AJ. Magnesium is not consistently neuroprotective for perinatal hypoxia-ischemia in term-equivalent models in preclinical studies: a systematic review. Dev Neurosci. 2014;36(2):73-82. Tann CJ, Nkurunziza P, Nakakeeto M, Oweka J, Kurinczuk JJ, Were J, Nyombi N, Hughes P, Willey BA, Elliott AM, Robertson NJ, Klein N, Harris KA. Prevalence of bloodstream pathogens is higher in neonatal encephalopathy cases vs. controls using a novel panel of real-time PCR assays. PLoS One. 2014 May 16;9(5):e97259. Ezzati M, Broad K, Kawano G, Faulkner S, Hassell J, Fleiss B, Gressens P, Fierens I, Rostami J, Maze M, Sleigh JW, Anderson B, Sanders RD, Robertson NJ. Pharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model. Acta Anaesthesiol Scand. 2014 Jul;58(6):733-42.


Melbourne A, Eaton-Rosen Z, Bainbridge A, Kendall GS, Cardoso MJ, Robertson NJ, Marlow N, Ourselin S. Measurement of myelin in the preterm brain: multi-compartment diffusion imaging and multi-component T2 relaxometry. Med Image Comput Comput Assist Interv. 2013;16(Pt 2):336-44. Kendall GS, Melbourne A, Johnson S, Price D, Bainbridge A, Gunny R, Huertas-Ceballos A, Cady EB, Ourselin S, Marlow N, Robertson NJ. White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants. Radiology. 2014 Apr;271(1):230-8. Uria-Avellanal C, Robertson NJ. Na⁺/H⁺ exchangers and intracellular pH in perinatal brain injury. Transl Stroke Res. 2014 Feb;5(1):79-98. Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Lee AC, Kozuki N, Blencowe H, Vos T, Bahalim A, Darmstadt GL, Niermeyer S, Ellis M, Robertson NJ, Cousens S, Lawn JE. Pediatr Res. 2013 Dec;74 Suppl 1:50-72. doi: 10.1038/pr.2013.206. Review. Mallard C, Davidson JO, Tan S, Green CR, Bennet L, Robertson NJ, Gunn AJ. Astrocytes and microglia in acute cerebral injury underlying cerebral palsy associated with preterm birth. Pediatr Res. 2014 Jan;75(1-2):234-40. Melbourne A, Kendall GS, Cardoso MJ, Gunny R, Robertson NJ, Marlow N, Ourselin S. Preterm birth affects the developmental synergy between cortical folding and cortical connectivity observed on multimodal MRI. Neuroimage. 2014 Apr 1;89:23-34. Bainbridge A, Tachtsidis I, Faulkner SD, Price D, Zhu T, Baer E, Broad KD, Thomas DL, Cady EB, Robertson NJ, Golay X.Brain mitochondrial oxidative metabolism during and after cerebral hypoxia-ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy. Neuroimage. 2014 Nov 15;102 Pt 1:173-83. 2013 Comparison of three hypothermic target temperatures for the treatment of hypoxic ischemia: mRNA level responses of eight genes in the piglet brain. Olson L, Faulkner S, Lundströmer K, Kerenyi A, Kelen D, Chandrasekaran M, Ådén U, Olson L, Golay X, Lagercrantz H, Robertson NJ, Galter D. Transl Stroke Res. 2013 Apr;4(2):248-57. Degraeuwe PLj, Jaspers GJ, Robertson NJ, Kessels AG. Magnetic resonance spectroscopy as a prognostic marker in neonatal hypoxic-ischemic encephalopathy: a study protocol for an individual patient data meta-analysis. Syst Rev. 2013 Oct 25;2:96. Moroz T, Hapuarachchi T, Bainbridge A, Price D, Cady E, Baer E, Tachtsidis I, Broad K, Ezzati M, Robertson NJ, Thomas D, Golay X, Cooper CE. Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating brain energetics. Adv Exp Med Biol. 2013;789:339-44. Hapuarachchi T, Moroz T, Bainbridge A, Price D, Cady E, Baer E, Broad K, Ezzati M, Thomas D, Golay X, Robertson NJ, Tachtsidis I. Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes. Adv Exp Med Biol. 2013;789:331-7. Horn AR, Swingler GH, Myer L, Linley LL, Chandrasekaran M, Robertson NJ. Early clinical predictors of a severely abnormal amplitude-integrated electroencephalogram at 48 hours in cooled neonates.Acta


Paediatr. 2013 Aug;102(8):e378-84. Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM; MARIAS collaborative group. Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet. 2013 Jul 20;382(9888):223-33. Horn AR, Swingler GH, Myer L, Linley LL, Raban MS, Joolay Y, Harrison MC, Chandrasekaran M, Rhoda NR, Robertson NJ. Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours. BMC Pediatr. 2013 Apr 10;13:52. doi: 10.1186/1471-2431-13-52. Hassell J, Reiter R, Robertson NJ. Melatonin: role in neurodevelopment during the perinatal period. Fetal and Maternal Medicine 24, pp 76-107 doi:10.1017/S0965539513000089 Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM; for the MARIAS collaborative group. Lancet. 2013 S0140-6736(13)60134-8. Azzopardi D, Robertson NJ, Kapetanakis A, Griffiths J, Rennie JM, Mathieson SR, Edwards AD. Anticonvulsant effect of xenon on neonatal asphyxial seizures. Arch Dis Child Fetal Neonatal Ed. 2013 Apr 9. [Epub ahead of print] Thayyil S, Shankaran S, Wade A, Cowan FM, Ayer M, Satheesan K, Sreejith C, Eyles H, Taylor AM, Bainbridge A, Cady EB, Robertson NJ, Price D, Balraj G. Whole-body cooling in neonatal encephalopathy using phase changing material. Arch Dis Child Fetal Neonatal Ed. 2013 May;98(3):F280-1. Melbourne A, Kendall GS, Cardoso MJ, Gunney R, Robertson NJ, Marlow N, Ourselin S. Radial structure in the preterm cortex; persistence of the preterm phenotype at term equivalent age? Med Image Comput Comput Assist Interv. 2012;15(Pt 3):256-63. Robertson NJ, Faulkner S, Fleiss B, Bainbridge A, Andorka C, Price D, Powell E, Lecky-Thompson L, Thei L, Chandrasekaran M, Hristova M, Cady E, Gressens P, Golay X, Raivich G. Melatonin Augments Hypothermic Neuroprotection in a Perinatal Asphyxia Piglet Model. Brain. 2013 Jan;136(Pt 1):90-105. Sanders RD, Hassell J, Davidson AJ, Robertson NJ, Ma D. The Impact of Anaesthetics and Surgery on Neurodevelopment: an update. Br J Anaesth. 2013 Jun;110 Suppl 1:i53-i72. Robertson NJ, Kato T, Bainbridge A, Chandrasekaran M, Iwata O, Kapetanakis A, Faulkner S, Cheong J, Iwata S, Hristova M, Cady E, Raivich G. Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. J Neurochem. 2013 Mar;124(5):645-57. 2012

Roberson NJ, Kato T, Bainbridge A, Chandrasekaran M, Iwata O, Kapetanakis A, Faulkner S, Cheong J, Iwata S, Hristova M, Cady EB, Raivich G. Methyl-isobutyl Amiloride Reduces Brain Lac/NAA, Cell Death and Microglial Activation in a Perinatal Asphyxia Model. J Neurochem 2012 Nov 22. doi: 10.1111/jnc.12097. [Epub ahead of print] Bainbridge A, Kendall GS, Vita ED, Hagmann C, Kapetanakis A, Cady EB, Robertson NJ. Regional neonatal brain absolute thermometry by (1) H MRS. NMR Biomed. 2012 Oct 16. doi: 10.1002/nbm.2879. Faulkner SD, Downie NA, Mercer CJ, Kerr SA, Sanders RD, Robertson NJ. A xenon recirculating ventilator


for the newborn piglet: developing clinical applications of xenon for neonates. Eur J Anaesthesiol. 2012 Dec;29(12):577-85. Cardoso MJ, Melbourne A, Kendall GS, Modat M, Robertson NJ, Marlow N, Ourselin S. AdaPT: An adaptive preterm segmentation algorithm for neonatal brain MRI. Neuroimage. 2012 Aug 14;65C:97-108. Yang T, Zhuang L, Rei Fidalgo AM, Petrides E, Terrando N, Wu X, Sanders RD, Robertson NJ, Johnson MR, Maze M, Ma D. Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia. PLoS One. 2012;7(5):e37020. Bennet L, Tan S, Van den Heuij L, Derrick M, Groenendaal F, van Bel F, Juul S, Back SA, Northington F, Robertson NJ, Mallard C, Gunn AJ. Cell therapy for neonatal hypoxia-ischemia and cerebral palsy. Ann Neurol. 2012 May;71(5):589-600. Kendall GS, Hristova M, Zbarsky V, Clements A, Peebles DM, Robertson NJ, Raivich G.Distribution of pH changes in mouse neonatal hypoxic-ischaemic insult. Dev Neurosci. 2011;33(6):505-18. Robertson NJ, Tan S, Groenendaal F, van Bel F, Juul SE, Bennet L, Derrick M, Back SA, Valdez RC, Northington F, Gunn AJ, Mallard C. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? J Pediatr. 2012 Apr;160(4):544-552.e4. Kerenyi A, Kelen D, Faulkner SD, Bainbridge A, Chandrasekaran M, Cady EB, Golay X, Robertson NJ. Systemic effects of whole-body cooling to 35 °C, 33.5 °C, and 30 °C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia. Pediatr Res. 2012 May;71(5):573-82. Moroz T, Banaji M, Robertson NJ, Cooper CE, Tachtsidis I. Computational modelling of the piglet brain to simulate near-infrared spectroscopy and magnetic resonance spectroscopy data collected during oxygen deprivation. J R Soc Interface. 2012 Jul 7;9(72):1499-509. Horn AR, Swingler GH, Myer L, Harrison MC, Linley LL, Nelson C, Tooke L, Rhoda NR, Robertson NJ. Defining hypoxic ischemic encephalopathy in newborn infants: benchmarking in a South African population. J Perinat Med. 2012 Aug 28

2011 Thayyil S, Sebire NJ, Chitty LS, Wade A, Olsen O, Gunny RS, Offiah A, Saunders DE, Owens CM, Chong WK, Robertson NJ, Taylor AM. Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol). BMC Pediatr. 2011 Dec 22;11:120. Robertson NJ, Hagmann CF, Acolet D, Allen E, Nyombi N, Elbourne D, Costello A, Jacobs I, Nakakeeto M, Cowan F. Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in Uganda: study protocol. Trials. 2011 Jun 4;12:138. doi: 10.1186/1745-6215-12-138. Hagmann CF, Brotschi B, Bernet V, Latal B, Berger TM, Robertson NJ. Hypothermia for perinatal asphyxial encephalopathy. Swiss Med Wkly. 2011 Feb 16;141:w13145. doi: 10.4414/smw.2011.13145.

Cardoso MJ, Melbourne A, Kendall GS, Modat M, Hagmann CF, Robertson NJ, Marlow N, Ourselin S. Adaptive neonate brain segmentation. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):378-86. Hagmann CF, Robertson NJ, Acolet D, Nyombi N, Ondo S, Nakakeeto M, Cowan FM. Cerebral measurements made using cranial ultrasound in term Ugandan newborns. Early Hum Dev. 2011


May;87(5):341-7. doi: 10.1016/j.earlhumdev.2011.01.044. Epub 2011 Feb 24. Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF; Eunice Kennedy Shriver National Institute of Child Health and Human Development Hypothermia Workshop Speakers and Moderators. Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop. J Pediatr. 2011 Nov;159(5):851-858 Cady EB, Penrice J, Robertson NJ. Improved reproducibility of MRS regional brain thermometry by 'amplitude-weighted combination'. NMR Biomed. 2011 Aug;24(7):865-72. Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Hristova M, Liu M, Kapetanakis A, Evans s, De Vita E, Kelen D, Sanders R, Thayyil S, Edwards AD, Maze M, Cady EB, Raivich G, Robertson NJ. Xenon augmented hypothermia reduces early lactate/NAA and cell death in Perinatal Asphyxia. Ann Neurol 2011;70(1):133-150 Wilkinson DJ, Thayyil S, Robertson NJ. Ethical and practical issues relating to the global use of therapeutic hypothermia for perinatal asphyxial encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2011 Jan;96(1):F75-8. doi: 10.1136/adc.2010.184689. 2010 Kendall GS, Kapetanakis A, Ratnavel N, Azzopardi D, Robertson NJ; Cooling on Retrieval Study Group. Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2010 Nov;95(6):F408-12. Thayyil S, Chitty LS, Robertson NJ, Taylor AM, Sebire NJ. Minimally invasive fetal postmortem examination using magnetic resonance imaging and computerised tomography: current evidence and practical issues. Prenat Diagn. 2010 Aug;30(8):713-8. Hagmann C, Robertson NJ, Acolet D, Chan D, Onda S, Nyombi N, Nakakeeto M, Cowan F. Cranial ultrasound findings in well newborn Ugandan infants. Arch Dis Child Fetal Neonatal Ed. 2010 Sep;95(5):F338-44. Asaduzzaman M, Chaussalet TJ, Adeyemi S, Chahed S, Hawdon J, Wood D, Robertson NJ. Towards effective capacity planning in a perinatal network centre. Arch Dis Child Fetal Neonatal Ed. 2010 Jul;95(4):F283-7. Thayyil S, Chandrasekaran M, Taylor A, Bainbridge A, Cady EB, Chong WK, Murad S, Omar RZ, Robertson NJ. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics. 2010 Feb;125(2):e382-95. Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM. Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet. 2009 Aug 8;374(9688):467-75. Thayyil S, Chandrasekaran M, Chitty LS, Wade A, Skordis-Worrall J, Bennett-Britton I, Cohen M, Withby E, Sebire NJ, Robertson NJ, Taylor AM Diagnostic accuracy of post-mortem magnetic resonance imaging


in fetuses, children and adults: a systematic review. Eur J Radiol. 2010 Jul;75(1):e142-8. 2009 Thayyil S, Costello A, Shankaran S, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy implications for neonatal units in India. Indian Pediatr. 2009 Apr;46(4):283-9. Kapetanakis A, Azzopardi D, Wyatt J, Robertson NJ. Therapeutic hypothermia for neonatal encephalopathy: a UK survey of opinion, practice and neuro-investigation at the end of 2007. Acta Paediatr. 2009 Apr;98(4):631-5. Hagmann C, de Vita E, Bainbridge A, Cady EB, Gadian D, Robertson NJ. MRI T2 is an objective measure of cerebral WM signal abnormality in preterm infants at term equivalent age. Radiology 2009;252:209-17. Thayyil S, Robertson NJ, Scales A, Weber MA, Jacques TS, Sebire NJ, Taylor AM; MaRIAS (Magnetic Resonance Imaging Autopsy Study) Collaborative Group. Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model. Arch Dis Child. 2009 May;94(5):354-8. 2008 Thayyil S, Robertson NJ, Scales A, Sebire NJ, Taylor A. Parental consent for research and sudden infant death. Lancet 2008;372(9640):715 Iwata S, Iwata O, Olson L, Kapetanakis A, Kato T, Evans S, Araki Y, Kakuma T, Matsuishi T, Setterwall F, Lagercrantz H, Robertson NJ. Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a "phase changing material" mattress in a newborn piglet model. Arch Dis Child. 2009 May;94(5):387-91. Robertson NJ, Nakakeeto M, Hagmann C, Cowan FM, Acolet D, Iwata O, Allen E, Elbourne D, Costello A, Jacobs I. Therapeutic hypothermia for birth asphyxia in low-resource settings: A pilot randomised controlled trial. The Lancet. 2008;372(9641):801-3. Cady EB, Iwata O, Bainbridge A, Wyatt JS, Robertson NJ. Phosphorus MRS 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. J Neurochem 2008;107(4):1027-35 Iwata O, Iwata S, Bainbridge A, De Vita E, Matsuishi T, Cady EB, Robertson NJ. Supra- and sub-baseline phosphocreatine recovery in developing brain after transient HI. Brain. 2008;131(8):2220-6. 2007 Iwata O, Iwata S, Thornton JS, De Vita E, Bainbridge A, Herbert L, Scaravilli F, Peebles D, Wyatt JS, Cady EB, Robertson NJ. "Therapeutic time window" duration decreases with increasing severity of cerebral hypoxia-ischaemia under normothermia and delayed hypothermia in newborn piglets. Brain Res 2007;1154:173-80. Hagmann CF, NJ Robertson, WC Leung, WK Chong, LS Chitty. Fetal brain imaging: Ultrasound or MRI. A comparison between magnetic resonance imaging and a dedicated multidisciplinary neurosonographic opinion. Acta Pediatrica 2008 Apr;97(4):414-9


Iwata S, Iwata O, Thornton JS, Bainbridge A, Peebles D, Wyatt JS, Cady EB, Robertson NJ. Superficial brain is cooler in small piglets: Neonatal hypothermia implications. Ann Neurol 2006;60(5):578-85. Hagmann CF, Robertson NJ, Sams VR, Brookes JA. Postmortem magnetic resonance imaging as an adjunct to perinatal autopsy for renal-tract abnormalities. Arch Dis Child Fetal Neonatal Ed. 2007;92(3):F215-8 2006 Iwata S, Iwata O, Thornton JS, Shanmugalingam S, Bainbridge A, Peebles D, Wyatt JS, Cady EB, Robertson NJ. Superficial brain is cooler in small piglets: neonatal hypothermia implications. Ann Neurol 2006;60(5):578-585 Hagmann CF, Robertson NJ, Azzopardi D. Artefacts on EEG may influence the amplitude integrated EEG classification: a qualitative analysis in neonatal encephalopathy. Pediatrics 2006;118(6):2552-4 Kendall GS, Robertson NJ, Iwata O, Peebles D, Raivich G. N-methyl-isobutyl-amiloride Ameliorates Brain Injury when Commenced Prior to Hypoxia Ischemia in Neonatal Mice. Pediatr Res 2006;59:227-231 O’Brien F, Iwata O, Thornton JS, DeVita E, Sellwood M, Iwata S, Sakata Y, Charman S, Ordidge R, Cady E, Wyatt JS, Robertson NJ. Delayed whole body cooling to 33oC or 35oC and the development of impaired energy generation consequential to transient cerebral hypoxia-ischaemia in the newborn piglet. Pediatrics 2006;117(5):1549-59 Cheong JLY, Cady EB, Penrice J, Wyatt JS, Cox IJ, Robertson NJ. Proton magnetic resonance spectroscopy in newborn infants with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations. Am J Neuroradiol 2006;27(7);1546-54 Shanmugalingam S, Thornton JS, Iwata O, Bainbridge A, O’Brien FE, Priest AN, Cady EB, Ordidge RJ, Wyatt JS, Robertson NJ. Prognostic utility of early Cerebral Magnetic Resonance Tissue Water Spin-Spin Relaxometry and objective comparison with Proton MR Spectroscopy in Neonatal Encephalopathy. Pediatrics 2006;118(4):1467-1477 De Vita E, Bainbridge A, Cheong JLY, Hagmann C, Lombard R, Chong WK, Wyatt JS, Cady EB, Ordidge RJ, Robertson NJ. Magnetic resonance imaging of neonatal encephalopathy at 4.7 Tesla: initial experiences. Pediatrics 2006;118(6):e1812-21 2005 Robertson NJ, Bhakoo KK, Puri B, Edwards AD, Cox IJ. Amiloride and hypothermia preserve energetics in a neonatal brain slice model. Pediatr Res 2005;58:288-296 Iwata O, Thornton J, Sellwood M, Iwata S, Sakata Y, Noone M, O’Brien F, Bainbridge A, De Vita E, Raivich G, Peebles D, Scaravilli F, Cady E, Ordidge R, Wyatt JS, Robertson NJ. Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia. Ann Neurol 2005;58:75-87 2004 Robertson NJ, Stafler P, Battini R, Cheong J, Tosetti M, Bianchi MC, Cox IJ, Cowan FM, Cioni G. Brain lactic alkalosis in Aicardi-Goutières syndrome. Neuropediatrics. 2004 Feb;35(1):20-6.


2003 Robertson NJ, Kuna J, Cox PM, Lakhoo K. Spontaneous intestinal perforation and Candida peritonitis presenting as extensive necrotizing enterocolitis. Acta Paediatr. 2003;92(2):258-61. 2002 Robertson NJ, Cowan FM, Cox IJ, Edwards AD. Brain alkaline intracellular pH after neonatal encephalopathy. Ann Neurol. 2002 Dec;52(6):732-42.

2001

Robertson NJ, Lewis RH, Cowan FM, Allsop JM, Counsell SJ, Edwards AD, Cox IJ.Early increases in brain myo-inositol measured by proton magnetic resonance spectroscopy in term infants with neonatal encephalopathy. Pediatr Res. 2001 Dec;50(6):692-700 Boardman JP, Syrris P, Holder SE, Robertson NJ, Carter N, Lakhoo K. A novel mutation in the endothelin B receptor gene in a patient with Shah-Waardenburg syndrome and Down syndrome. J Med Genet. 2001 Sep;38(9):646-7.

2000

Robertson NJ, Kuint J, Counsell TJ, Rutherford TA, Coutts A, Cox IJ, Edwards AD. Characterization of cerebral white matter damage in preterm infants using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab. 2000 Oct;20(10):1446-56. 1999 Robertson NJ, Cox IJ, Cowan FM, Counsell SJ, Azzopardi D, Edwards AD.Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res. 1999 Sep;46(3):287-96. 1998 Robertson NJ, Hamilton PA. Randomised trial of elective continuous positive airway pressure (CPAP) compared with rescue CPAP after extubation. Arch Dis Child Fetal Neonatal Ed. 1998 Jul;79(1):F58-60. Robertson NJ, McCarthy LS, Hamilton PA, Moss AL. Nasal deformities resulting from flow driver continuous positive airway pressure. Arch Dis Child Fetal Neonatal Ed. 1996 Nov;75(3):F209-12.


Book Chapters

Janet Rennie, Nicola J Robertson. Pathways involving hypoxia and perfusion failure. In: Pathogenetic pathways to Cerebral Palsy. MacKeith Press. 2013

Robertson NJ and Groenendaal F. Roberton Textbook of Neonatology. Hypoxic-ischaemic Brain Injury. ISBN. Published 2012. Cambridge University Press.

Roberson NJ and Thayyil S. Hypothermic Neural Rescue in Mid and Low Resource Environments. Neonatal Neural Rescue: A Clinical Guide, edited by Dr Azzopardi, Professor Edwards and Professor Gunn. Cambridge University Press. 2012

Robertson NJ. Neonatal Neurology in the Developing World. In: Acquired Brain Injury in the Fetus and Newborn. Edited by Michael Shevell and Steven Miller. 2012

Invited reviews Robertson NJ. Air or 100% oxygen for asphyxiated babies? Time to decide. Crit Care. 2005 Apr;9(2):128-30. Wyatt JS, Robertson NJ. Time for a cool head - neuroprotection becomes a reality. Early Human Dev 2005;81:5-11 Kelen D, Robertson NJ. Experimental treatments for hypoxic ischaemic encephalopathy. Early Hum Dev. 2010 Jun;86(6):369-77. Epub 2010 Jun 8. Sanders RD, Manning HJ, Robertson NJ, Ma D, Edwards AD, Hagberg H, Maze M.Preconditioning and postinsult therapies for perinatal hypoxic-ischemic injury at term. Anesthesiology. 2010 Jul;113(1):233-49. Review. Thayyil S, Robertson NJ. University College London (UCL) Symposia on neonatal neurology and neuro protection. Indian Pediatr. 2010 May 7;47(5):395. Robertson NJ, Kendall GS, Thayyil S. Techniques for therapeutic hypothermia during transport and in hospital for perinatal asphyxial encephalopathy. Semin Fetal Neonatal Med. 2010 Oct;15(5):276-86. Robertson NJ, Edwards AD. Recent advances in developing neuroprotective strategies for perinatal asphyxia. Curr Opin Pediatr. 1998 Dec;10(6):575-80. Books

Co-editor and Author of Neonatal Cerebral Investigation Eds: Rennie JM, Hagmann CF, Robertson NJ Cambridge University Press ISBN:978-0-521-83848-1 Published 2008 Runner up prize for the BMJ book of the year 2009

CURRICULUM VITAE Professor Nicola Jayne Robertson ...

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