1 CURRICULUM VITAE PERSONAL RECORDS Name : Shyamal K. Roy Nationality : USA Address: (Home) : 2645 N. 160th Avenue Omaha, NE 68116 : (Office) : Departments of OB/GYN and Cellular and Integrative Physiology, DRC 8042 984515 Nebraska medical Center Omaha, NE 68198-4515 Tel: (402)-559-6163 Fax: (402)-559-6164 ACADEMIC RECORDS Year Degree Obtained Educational Institution 1973 B. Sc. (Physiology) City College, University of Calcutta, India 1975 M. Sc. (Physiology) University of Calcutta, India 1980 Ph. D. (Reproductive All India Institute of Medical Sciences, Endocrinology) New Delhi, India Continued Education 1987 Certificate in Molecular American Type Culture Collection, Biology (NIH Subsidiary), Rockville, MD 1993 Certificate in Cell Life Technologies, Germantown, MD Signaling 1998 Education Workshop UNMC (based on Dean’s nomination) ACADEMIC EXPERIENCES Year Status Educational Institutions 1976-77 Lecturer Department of Physiology, City College, University of Calcutta, India 1980-81 Post-doctoral Fellow Department of Physiology, All India Institute of Medical Sciences, New Delhi, India 1981-82 Instructor Department of Physiology, All India Institute of Medical Sciences, New Delhi, India 1982-85 Post-doctoral Fellow Department of Physiology, University of Kansas Medical Center, Kansas City, KS 1985-89 Research Assistant Department of Physiology, University of Professor Kansas Medical Center, Kansas City, KS 1990-94 Assistant Professor Departments of Obstetrics & Gynecology and Cellular and Integrative Physiology
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CURRICULUM VITAE
PERSONAL RECORDS
Name : Shyamal K. Roy
Nationality : USA
Address: (Home) : 2645 N. 160th Avenue
Omaha, NE 68116
: (Office) : Departments of OB/GYN and Cellular
and Integrative Physiology, DRC 8042
984515 Nebraska medical Center
Omaha, NE 68198-4515
Tel: (402)-559-6163
Fax: (402)-559-6164
ACADEMIC RECORDS
Year Degree Obtained Educational Institution
1973 B. Sc. (Physiology) City College, University of Calcutta, India
1975 M. Sc. (Physiology) University of Calcutta, India
1980 Ph. D. (Reproductive All India Institute of Medical Sciences,
Endocrinology) New Delhi, India
Continued Education
1987 Certificate in Molecular American Type Culture Collection,
Biology (NIH Subsidiary), Rockville, MD
1993 Certificate in Cell Life Technologies, Germantown, MD
Signaling
1998 Education Workshop UNMC (based on Dean’s nomination)
ACADEMIC EXPERIENCES
Year Status Educational Institutions
1976-77 Lecturer Department of Physiology, City College,
University of Calcutta, India
1980-81 Post-doctoral Fellow Department of Physiology, All India
Institute of Medical Sciences, New Delhi,
India
1981-82 Instructor Department of Physiology, All India
Institute of Medical Sciences, New Delhi,
India
1982-85 Post-doctoral Fellow Department of Physiology, University of
Kansas Medical Center, Kansas City, KS
1985-89 Research Assistant Department of Physiology, University of
Professor Kansas Medical Center, Kansas City, KS
1990-94 Assistant Professor Departments of Obstetrics & Gynecology
and Cellular and Integrative Physiology
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University of Nebraska Medical Center
Omaha, NE
1994-99 Associate Professor Same as above
1998 Tenure Same as above
1999-present Professor with tenure Same as above
HONORS
1. Junior Research Fellow of Indian Council of Medical Research, Govt. of India.
2. Post-doctoral Fellow of Family Planning Foundation of India.
3. Rockefeller Foundation International Post-doctoral Research Scientist.
4. Invited speaker to California Primate Research Center, Davis, CA.
5. Invited speaker to 2nd Asian and Oceanian Congress on Physiological Sciences, New
Delhi, India (1992).
6. Invited speaker to the USDA Institute at Clay Center, Nebraska.
7. Invited speaker to the Department of Animal Sciences, University of Nebraska, Lincoln.
8. Invited speaker to the Missouri-Kansas Reproductive Biology Symposium.
9. Invited speaker to International Symposium on “Prospects of zona pellucida glycoproteins
for immunocontraception,” New Delhi, India (1995).
10. Invited speaker to a NICHD forum on current status on ovarian regulation
11. Invited speaker to the Department of Pharmacology, UNMC
12. Invited speaker to the Department of Biochemistry and Molecular Biology, UNMC
13. Invited speaker to the Department of Cell Biology and Anatomy, UNMC
14. Invited speaker to the Department of OB/GYN, University of Ghent, Belgium
15. Invited speaker to the International Workshop on Early Folliculogenesis and Oocyte
Development: Basic and Clinical Aspects held at Royal College of London by Ares-
Serono Foundation
16. Invited speaker to the Department of Integrated and Molecular Physiology, University of
Kansas Medical Center, Kansas City, KS, 2002
17. Invited speaker to the Center for Reproductive Biology and Department of Pediatrics,
University of Michigan, Ann Arbor, Michigan 2003
18. Recipient of the Golden Forceps Award of the Department of OB/GYN, UNMC, 2005.
19. Keynote speaker (Osborn memorial Lecture), The Gilbert S. Greenwald Symposium on
Reproduction, Kansas City, MO, 2005
20. Recipient of the UNMC Distinguished Scientist Award for 2007
21. Invited speaker to Donald C. Johnson Lecture, Department of Integrated and Molecular
Physiology, University of Kansas Medical Center, Kansas City, KS, 2009
22. Invited speaker to department of genetics, Cell Biology and Anatomy, UNMC-2010
23. Invited speaker to department of Biology, Wichita State University, 2012.
MEMBERSHIP IN SCIENTIFIC SOCIETIES
1. Society for the Study of Reproduction, USA.
2. Endocrine Society, USA.
3. Society for the Study of Fertility, U. K.
4. American Association for the advancement of Science, USA.
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ADMINISTRATIVE RESPONSIBILITIES
1. Ad hoc Reviewer ---- Biology of Reproduction
Endocrinology
Molecular and Cellular Endocrinology
Journal of Histology
Human Reproduction
Molecular Human Reproduction
Reproduction
American Journal of Physiology
2. Ad hoc member -- The Welcome Trust Research Grant review panel, U. K.
3. Ad hoc reviewer -- USDA review panel for Programs on Reproductive Biology
4. Ad hoc member -- NIH panel to discuss the present status and formulate the future direction
of research in ovarian biology, 1986.
5. Ad hoc member -- NIH panel to discuss the emerging roles of cytoskeleton in Reproductive
Endocrinology.
6. Ad hoc member -- MBRS Study Section on Neurobiology and Physiology, NIH, 2002.
7. Ad hoc member -- Reproductive Endocrinology Study Section, NIH (2002, 2003)
8. Ad hoc Member -- Seed Research Grant Review Committee, UNMC
9. Member -- Integrated Clinical Endocrinology and Reproduction Study Section,
23. Summer student-2006-Jean Huff, M1 Student, UNMC, currently a physician
24. Summer student-2007-Kristina Derrick, M1 student, currently a physician
25. Summer student-2008-Chelsea Newman, M1 Student, UNMC, currently a physician
26. Graduate student (Rotation)-Che Qi- Department of Cellular and Integrative Physiology,
UNMC. Presently doing residency program
27. Graduate student (Rotation)-Jennifer Green- Department of Cellular and Integrative
Physiology, UNMC. Currently a physician
28. Ph. D. Student—Anindit Mukherjee --- Department of Cellular and Integrative
Physiology, 2007-2012. Now a post-doctoral trainee in University of Pittsburgh.
29. Ph. D. Student-- Prabuddha Chakraborty-- Department of Cellular and Integrative
Physiology, 2009-2016. Now a post-doctoral trainee in the Institute of
Genetics, University of North Carolina, NC
RESEARCH INTERESTS AND EXPERIENCES
My research interests began with the study of the mechanism(s) of embryo implantation
and pregnancy recognition in laboratory mammals and in sub-human primates. Those studies
included in vitro culture of rat and mouse preimplantation embryos, histochemical and bio-
chemical studies of lysosomal hydrolases in embryo and uterus during pregnancy and
pseudopregnancy, biochemical studies on carbohydrate metabolic enzymes in rodents' embryos
and monkey uterus, and embryo transfer to foster mothers.
For the last 19 years, I have been working on the biology and endocrinology of ovarian
follicles and non-follicular compartments. More specifically, I am attempting to unravel the
intricate cellular and molecular changes that occur in growing follicles during their sojourn from
primordial to antral to ovulatory stages, and the modulatory roles of endocrine and paracrine
factors in these processes. For this purpose, I have developed a model, which allows, for the first
time to study directly the biology of intact preantral follicles in each stage of development and
the importance of this model has already been internationally recognized. Besides, this model
has already initiated an awareness to address follicular development from an entirely new
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dimension in a variety of species. Using hamster as an animal model, I have already shown the
roles of gonadotropins on follicular DNA replication and steroidogenesis, and documented the
presence of peptide receptors, in a series of publications. My current interests include the
understanding of the stage specific changes in follicular protein synthesis in signaling follicular
differentiation and its hormonal control, specific gene expression during granulosa cell
differentiation, molecular and cellular mechanisms of growth factors mediation of signal
transduction and subsequent intracellular events in follicular cells. We are looking into the cell-
type specific hormonally regulated expression of growth factor receptor messenger RNA
expression during follicular development. I have developed a long-term culture system that
supports the growth of intact antral follicles in vitro for several days. This model adds a new
dimension to studying the factors regulating follicular development, effects of xenobiotics on the
biology of follicular cells -- cellular and molecular aspects, expression of specific genes (e.g.
growth factor genes, etc.), proto-oncogenes and foreign genes introduced in vitro. We were the
first to develop a successful technique to dissociate intact preantral follicles from human ovaries
and a long-term culture system for their in vitro growth and differentiation. These latter
techniques will add significantly to the current understanding of the mechanism of endocrine and
autocrine/ paracrine regulation of human folliculogenesis. We are also studying the endocrine
regulation of epithelial-mesenchymal interaction in forming theca cells during follicular de-
velopment, and cell lineage in the developing ovary.
Currently, my laboratory focuses on understanding the mechanisms whereby estrogen
regulates the differentiation of granulosa cells, and promotes the formation and development of
primordial follicles.
GRANT SUPPORT
Grant application pending: R01 HD-038468 (Roy) 01/01/2015 – 12/31/2019 NIH/NICHD Primordial follicle formation: Role of estrogen The goal of this project is to identify molecular mechanism(s) involved in primordial follicle formation in the ovary Role in Project: PI Grant #: 1528415 NSF
Primordial follicle formation: Role of BMP2 and Estradiol-17 The goal of this project is to identify the role of BMP2 in primordial follicle formation. Role in the Project: PI
Past Research Support P01-HL062222 (Zucker) 07/01/2005-06/30/2014 DHHS/NIH/NHLBI Neurocirculatory function in chronic heart failure Core C - Molecular Biology, Biochemistry and Histology Core The goal of this core unit is to provide complementary molecular, cellular, biochemical and scientific support for the four research projects by carrying out a variety of biochemical, molecular biological and histological techniques.
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Role in Project: Core Director
SUB090218 (Davis) 04/01/2009-03/31/2014 DHHS/NIH/NICHD Aging Pituitary Gonadal Axis Project 2: Role of Glycosylation in FSH Signaling in FSH Target Cells To study the effects of di- and tetra-glycosylated isoforms of FSH on granulosa cells, intact ovarian follicles, and bone cells. Role in Project: Co-I
Roy 07/01/2013– 6/30/2014 UNMC Bridge Funding Follicular morphogenesis during perinatal development The goal of this project is to identify molecular mechanism(s) involved in primordial follicle formation in the ovary Role in Project: PI Roy/Wang 07/01/2013 – 6/30/2014 Olson Foundation Role of estrogen in Primordial follicle formation The goal of this project is to identify the mechanisms whereby membrane estrogen receptor mediates estrogen action during primordial follicle formation in the ovary Role in Project: Co-PI Padmanavan, P 07/01/2007-06/30/2009 NIH P01 Prenatal programming of reproductive Health and Disease Role in the Project: Co-I 31-3205-0852 (Roy) 07-01-2011-6-30-2011 NRI/UNMC Laser Capture Microdissection: Tissue-based translational research Equipment grant for the Imaging Core; Role in the project: PI
PUBLICATIONS
1. Sengupta J, Roy SK, Manchanda SK Hormonal control of implantation: A possible
lysosomal function in the embryo-uterus interaction. J Steroid Biochem 11: 729-744, 1979
2. Roy SK, Sengupta J, Manchanda SK Effect of a long-acting fluorinated androgen on
implantation in 'delayed' mice. Hormn Res 12: 22-31, 1980
3. Roy SK, Sengupta J, Manchanda SK Induction of implantation by androgen in mice with