CURRICULUM VITAE PERSONAL : DR. MANIKA PAL BHADRA. FNASc DESIGNATION: Wellcome Trust Fellow (International) 2005 Program Coordinator Department of Chemical Biology Indian institute of Chemical Technology Uppal Road , Hyderabad-500007, India Tel : 91-40-27193236 Fax : 91-40-27193030 e-mail : [email protected][email protected]EDUCATION: Qualifications Name of the University Subject Grade / Percentage Ph.D Calcutta University, India Adv. Cytology and Mol, Genetics Awarded M.Sc Calcutta University, India Genetics and Molecular Biology I st Division B.Sc Calcutta University, India Specialization in Cytogenetics I st Division RESEARCH EXPERIENCE: Junior Research Fellowship award, 1989-1991, Sponsored by TIFR, India Senior Research Fellowship award, 1991-1993, Sponsored by CSIR, Indi Post doctoral Research Associate, 1995- 1998, University of Missouri, Columbia Senior Research investigator, 1998-2000, University of Missouri Research Assistant Professor, 2002 - 2003, University Of Missouri Visiting Scientist, CCMB, Hyderabad, India 2003-2004 Senior Scientist, IICT- 2004 to 2008 Principal Scientist, IICT- 2008 to 2012 Head of Department for Chemical Biology Division, IICT- 2012 onwards
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CURRICULUM VITAE
PERSONAL : DR. MANIKA PAL BHADRA. FNASc DESIGNATION: Wellcome Trust Fellow (International) 2005 Program Coordinator
Department of Chemical Biology Indian institute of Chemical Technology Uppal Road , Hyderabad-500007, India
biocompatible gold nanoparticles and their potential applications in cancer therapy
7-4484/23/45/455103
7 Kamal A, Tamboli JR, Ramaiah MJ, Adil SF, Koteswara Rao G, Viswanath A, Mallareddy A, Pushpavalli SN, Pal-Bhadra M.
Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.
ChemMedChem. 2012
2012 7(8) 1453-64
8 Pal-Bhadra M, Ramaiah MJ, Reddy TL, Krishnan A, Pushpavalli SN, Babu KS, Tiwari AK, Rao JM, Yadav JS, Bhadra U.
Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells.
BMC Cancer.
2012 12 180
9 Kamal A, Suresh P, Ramaiah MJ, Mallareddy A, Imthiajali S, Pushpavalli SN, Lavanya A, Pal-Bhadra M.
Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.
Bioorg Med Chem.
2012 20(6) 2054
10 Kamal A, Sultana F, Ramaiah MJ, Srikanth YV, Viswanath A, Kishor C, Sharma P, Pushpavalli SN, Addlagatta A, Pal-Bhadra M.
3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization.
Ramaiah, J. N. S. R. C. Murty, Farheen Sultana,G. Ramakrishna, Jaki R. Tamboli, S. N. C. V. L. Pushpavalli, Dhananjaya pal, Chandan Kishor,Anthony Addlagatta and Manika pal Bhadra
isoxazoline hybrids as a new class of tubulin polymerization inhibitors
Commun., 2012, 3, 1386 ( Cover page aticle )
12 Ahmed Kamal, Farheen Sultana, M. Janaki Ramaiah, Y. V. V. Srikanth, A. Viswanath, E. Vijaya Bharathi, Ranjita Nayak, S. N. C. V. L. Pushpavalli, Chatla Srinivas and Manika Pal-Bhadra
3-Diarylethyne quinazolinones: a new class of senescence inducers 1 Ahmed Kamal, Farheen Sultana, M. Janaki Ramaiah, Y. V. V. Srikanth, A. Viswanath, E. Vijaya Bharathi, Ranjita Nayak, S. N. C. V. L. Pushpavalli, Chatla Srinivas and Manika Pal-Bhadra
Med. Chem. Commun.,
2013 1-8 1
13 Ahmed Kamal, G. Ramakrishna, M. Janaki Ramaiah, A. Viswanath, A. V. Subba Rao, Chandrakant Bagul, Debasmitha Mukhopadyay, S. N. C. V. L. Pushpavalli and Manika Pal-Bhadra
Design, synthesis and biological evaluation of imidazo [1,5-a]pyridine–PBD conjugates as potential DNA-directed alkylating agents 1
Med. Chem. Commun., 2012, xx, 1–8 | 1
2012 1-8 1
14 Kamal A, Srikanth YV, Ramaiah MJ, Khan MN, Kashi Reddy M, Ashraf M, Lavanya A, Pushpavalli SN, Pal-Bhadra M.
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-
15 S.N.C.V.L Pushpa Valli, Arpita Sarkar, Indira Bag, M.Janaki Ramaiah. Utpal bhadra and Manika Pal Bhadra.
Role of Drosophila RNAi silencing protein Ago-1 in cell proliferation.
BMC
biology
2011
16 Ahmed kamal, Dastagiri, M.Janaki Ramaiah, Laxminarayan Reddy, Anjana Devi, SNCVL Pushpavalli, Surendranath Reddy, Manika Pal Bhadra.
Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents.
Eur J Med Chem.
2011 46 (12) 5817-24
17 Ahmed Kamal, M. Kashi Reddy, M. Janaki Ramaiah, Rajender, J. Surendranadha Reddy, Y.V.V. Srikanth, D. Dastagiri, E. Vijaya Bharathi, S.N.C.V.L. Pushpavalli,Pranjal Sarma, Manika Pal-Bhadra
Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents.
Bioorg Med Chem.
2011 19 (8) 2565-81
18 Ravindra M. Kumbhare*, K. Vijay Kumar, M. Janaki Ramaiah, Tulshiram , Dadmal, S.N.C.V.L. Pushpa valli, debasmita Mukhopadyay, Umesh kosurkar and Manika Pal Bhadra*
Synthesis and biological evaluation of novel Mannich bases of 2-arylimidazo[2,1-b]benzothiazoles as potential anti-cancer agents.
Eur J Med Chem.
2011 46(9) 258-66
19 Kamal A, Prabhakar S, Janaki Ramaiah M, Venkat Reddy P, Ratna Reddy Ch, Mallareddy A, Shankaraiah N, Lakshmi Narayan Reddy T, Pushpavalli SN, Pal-Bhadra M.
Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers.
Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1.
Cancer Cell Int.
2011 11 36
23. Bhadra MP, Horikoshi N, Pushpavallipvalli SN, Sarkar A, Bag I, Krishnan A, Lucchesi JC, Kumar R, Yang Q, Pandita RK, Singh M, Bhadra U, Eissenberg JC, Pandita TK.
The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.
Chromosoma. [Epub ahead of print]
2011
24. Yadav JS, Das PP, Reddy TL, Bag I, Lavanya PM, Jagannadh B, Mohapatra DK, Bhadra MP, Bhadra U
Sub-cellular internalization and organ specific oral delivery of PABA nanoparticles by side chain variation
30. Ahmed Kamal, Kokkonda Sreekanth,P.,Praveen kumar,Nagula sankaraiah, Balakishan, M.Janaki Ramaiah, SNCVL Pushpavalli and Manika Pal-Bhadra.
Synthesis and potential cytotoxic activity of Phenanthrylphenol-pyrrolo benzodiazepine conjugates that act through cyclin D1 /cdk4 path way.
European Journalof Medicinal Chemistry
2010 45(6) 2173–2181
31. Ahmed kamal,E.Vijaya bharati,M.Janaki Ramaiah, SNCVL pushpavalli and Manika Pal-Bhadra
Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates.
Bioorg Med Chem Lett.
2010 20(11) 3310-13.
32. Kamal A, Surendranadha Reddy J, Janaki Ramaiah M, Dastagiri D, Vijaya Bharathi E, Ameruddin Azhar M, Sultana F, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S.
Design, synthesis as potential anticancer agents.
Eur J Med Chem.
2010 45(9) 3924-37
33. Ahmed Kamal , K. Srinivasa Reddy , M. Naseer A. Khan , Rajesh V. C. R. N. C. Shetti ,M. Janaki Ramaiah , S. N. C. V. L. Pushpavalli , Chatla Srinivas, Manika Pal-Bhadra , Mukesh Chourasia ,G. Narahari Sastry , Aarti Juvekar , Surekha Zingde , Madan Barkume
Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates
Bioorg. Med. Chem.
2010 May
34. Ahmed Kamal, J. Surendranadha Reddy, M. Janaki Ramaiah, E. Vijaya Bharathi,
Synthesis and biological evaluation of anilino substituted
Dastagiri, M. Kashi Reddy, S. N. C. V. L . Pushpavalli, and Manika Pal-Bhadra
pyrimidine linked pyrrolobenzodiazepines as potential anticancer agent
35. Ahmed Kamal, G. Ramakrishna, P. Raju, A. Viswanath, M.Janaki Ramaiah, , G. Balakishan Manika Pal-Bhadra.
Synthesis and anticancer activity of chalcone linked imidazolones
Bioorg.Med Chem Lett.
2010 20(16) 4865-4869
36. Ahmed Kamal,D. Dastagiri, M. Janaki Ramaiah, E. Vijaya Bharathi, J. Surendranadha Reddy, G. Balakishan, Pranjal Sarma, S. N. C. V. L. Pushpavalli, Manika Pal-Bhadra, Aarti Juvekar, Subrata Sen, Surekha Zingde
Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates
Bioorg. Med. Chem
2010 18(18) 6666-6667
37. Ahmed Kamal, D. Dastagiri, M. Janaki Ramaiah, J. Surendranadha Reddy,E. Vijaya Bharathi, Srinivas Chatla, S. N. C. V. L. Pushpavalli, Dhananjaya Pal, Manika Pal-Bhadra
Synthesis of Imidazothiazole-Chalcone Derivatives as Anticancer and apoptosis Inducing Agents. Accepted
Chem-med- chem.
2010 Sep10
38. Kamal, A., E. Vijaya Bharathi., J. Surendranadha Reddy., M. Janaki Ramaiah., D. Dastagiri., A. Haribabu., A.Viswanath., T. Lakshminarayan Reddy., T. Basha Shaik., S. N. C. V. L. Pushpavalli Manika Pal Bhadra.
Synthesis and Biological Evaluation of 3,5-Diaryl isoxazoline/isoxazole Linked 2,3-Dihydroquinazolinone Hybrids as Anticancer agents
European Journal of Medicinal chemistry (Submitted).
2010
39 Kamal, A., Rajesh, V.C.R.N.C. Shetti., M.Janaki Ramaiah., P.Swapna., K.Srinivasa Reddy., A.MallaReddy., P. Narasimha Rao., Mukesh Chourasia., G.Narahari sastry., Aarti Juvekar., Suresh Zingde., Pranjal Sharma., S.N.C.V.L. Pushpavalli and Manika Pal Bhadra.
Carbazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Design, synthesis, cytotoxicity and effect on cellular targets. Med Chem Comm (Submitted).
2010
40. Santosh P S, Arora N, Sarma P, Pal-Bhadra M, Bhadra U.
Interaction map and selection of microRNA targets in Parkinson's disease-related genes.
J Biomed Biotechnol.
2009 36 31-45.
41. Chandrasekhar S, Rao CL, Seenaiah M, Naresh P, Jagadeesh B, Manjeera D, Sarkar A, Bhadra MP
Total synthesis of azumamide E and sugar amino acid-containing analogue.
J Org Chem.
2009 74(1)
401-4.
42. Utpal Bhadra, Sunit Kumar Singh, Praveensingh B Hajeri and Manika Pal-Bhadra
microRNA Tales in Fly Development: In Book” “Regulation of Gene Expression by Small RNA
Eds J.J. Rossi and R.K. Gaur. CRC Press, California, USA,
2009 123-148
43. Ahmed Kamal, Vankatesh Tekumalla, Anita Krishnan, Manika Pal-Bhadra and Utpal Bhadra
Development of Novel Pyrrolo[2,1-c][1,4]Benzodiazepi
ne -Galactoside Prodrugs for Selective Therapy of Cancer by ADEPT and PMT.
44. Sunit K. Singh, Manika Pal Bhadra, Hermann J Girschick and Utpal Bhadra
MicroRNAs – micro in size but macro in function..
FEBS J.
45 Manika Pal-Bhadra, Linga Mamatha, Pil-Hoon Park, Shivendra D. Shukla and Utpal Bhadra.
Histone H3 methylation is an epigenetic imprint for alcohol induced liver injury
Life Sciences
2007 81 979-987
46. J. S. Yadav, Manoj Kumar Gupta, I. Prathap, Manika Pal Bhadra, Parsi K. Mohan and Bulusu Jagannadh
Synthesis and cellular uptake of cell delivering 2,6-pyridinediylbisalkanamide submicron-sized sheets in HeLa cells.
Chem. Commun.
2007 3832-3834.
47. Manika Pal-Bhadra, Utpal Bhadra and J.A. Birchler
Misregulation of Sex-lethal and disruption of MSL complex localization in Drosophila species hybrids
Genetics 2006 174 927-935
48. Charlotte Grimaud, Frédéric Bantignies, Manika Pal-Bhadra, Pallavi Ghana, Utpal Bhadra, and Giacomo Cavalli.
RNAi components are required for nuclear clustering of Polycomb group response elements
Cell 2006 124 957-971
49. Bhadra, U., Pal-Bhadra, M., J. Kundu, and Birchler J.A. (First two authors contributed equally).
MSL complex insulates the response of Histone modifiers to x linked genes in males.
Genetics
2005
169
2061-2074
50. Pal-Bhadra M., U. Bhadra and J.A. Birchler ()2004;
Interrelationship between transcriptional and post transcriptional silencing.
In Book Cold Spring Harbor Symposium
2004 69 433-8.
51. Pal- Bhadra, M., Leibovitch B. A. Gandhi,
Heterochromatin Silencing and HP1
Science 2004 303 669-672.
S, G, Rao, M., Bhadra U., Birchler J.A.and Elgin S.C.R.
localization in Drosophila are dependent on the RNAi machinery.
52. Birchler, J. A., Bhadra U. and Pal–Bhadra, M.
Transgene cosuppression in Drosophila. In Book ‘RNAi:a guide to Gene Silencing
Eds. Gregory Hannon, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,NewYork
2004 pp23-43
53. Birchler, J. A., Bhadra, U. and Pal-Bhadra M.
Role of trans-acting dosage modifiers in X chromosomal dosage compensation (review)
Genetica 2003 117 179-190.
54. Bhadra, U and Pal-Bhadra M.
Transgene insertion, genomic stress and Cell surveillance: a lesson from Drosophila. In Book ‘Bioresources and Environmental Stresses’ Eds by Prof. Hideaki Matsumoto, University of Okayama press, Okayama , Japan
2003 9-14.
56. Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (First two authors contributed equally).
RNAi related mechanisms affect both transcriptional and post-transcriptional transgene silencing in Drosophila
Molecular Cell
2002 9 315-323
57. Birchler J. A., Bhadra Dosage dependent Developm 2001 234 275-
U., Pal -Bhadra M. and Auger D.L. .
gene regulation in multicellular eukaryotes: dosage compensation, aneuploid syndromes and polygenic quantitative traits
ental Biology
288
58. Birchler J. A., Pal Bhadra M. and Bhadra ,U
Making noise about silence : Repression of Repeated genes in animals..
Curr. Opin. of Genes and Development
2000
10
211-216
59. U. Bhadra, Pal-Bhadra M. and Birchler J. A.
Histone acetylation and gene expression of Sex-lethal mutants in Drosophila.
Genetics 2000 155 753-763.
60. Pal-Bhadra M., Bhadra U. and Birchler J. A. (First two authors contributed equally).
Cosuppression in nonhomologous transgenes involves mutually related endogenous sequences
Cell 1999 99 35-46
61. Birchler J. A., Pal Bhadra M. and Bhadra U.
Less from More: cosuppression of transposable elements
Nature Genetics
1999 21 148-151.
62. Bhadra U., Pal Bhadra M. and Birchler J. A.
Role of male specific lethal genes in modifying the effects of sex chromosomal dosage in Drosophila.
Genetics 1999 152
249-168
63. Bhadra. U., Pal-Bhadra M. and Birchler J. A.
Interaction among dosage dependent trans-acting modifiers of gene expression and position effect
Genetics 1998 150 251-263
variegation in Drosophil.
64. Pal-Bhadra M., Bhadra. U. and Birchler J. A.
Role of multiple trans-acting regulators in modifying the effect of the retrotransposon, copia, on host gene expression in Drosophila.
Mol. Gen. Genet.
1998 259 198-206.
65. Pal Bhadra M., Bhadra U. and Birchler J. A. (First two authors contributed equally).
Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase gene by white-Adh transgenes is Polycomb dependent.
Cell 1997 90 (3) 479-490.
66. Bhadra U., Pal-Bhadra M. and Birchler, J. A.
A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats.
Genetics 1997a 146 903-917
67. Bhadra U., Pal-Bhadra, M. and Birchler, J. A.(Berl.)
A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster
Mol. Gen. Genet
1997b 254 621-634.
68. Pal-Bhadra M., Bhadra U. and Chatterjee R.N.
In situ transcription analysis of chromatin template activity of 3L trisomies of inter specific hybrids of Drosophila melanogaster and Drosophila simulans
Cell and Chromosome Research
1993 16(1) 16-22
69. Bhadra U., Pal-Bhadra, M. and Chatterjee R.N.
Effect of gene dosage on autosomal gene transcription in D. melanogaster
Prospective of Cytology and Genetics
1991 7 959-967.
70. Chatterjee R.N., Bhadra U., Mukherjee, J. and Pal, M.
Regulation of X chromosomal organization for dosage compensation in Drosophila
Advances in Molecular Biology
1990 1 298-307.
Book chapters published:-
1. Utpal Bhadra, Sunit Kumar Singh, Praveensingh B Hajeri and Manika Pal-
Bhadra (2009) microRNA Tales in Fly Development: In Book “Regulation of
Gene Expression by Small RNAs” Eds J.J. Rossi and R.K. Gaur. CRC
Press, California, USA, pp123-148.
2. Pal-Bhadra M., U. Bhadra and J.A. Birchler (2005) Interrelationship between
transcriptional and post transcriptional silencing. In Book Cold Spring
Harbor Symposium 2004;69:433-8.
3. Birchler, J. A., Bhadra U. and Pal–Bhadra, M. (2004) Transgene
cosuppression in Drosophila. In Book ‘RNAi:a guide to Gene Silencing’ Eds.
Gregory Hannon, Cold Spring Harbor Laboratory Press, Cold Spring
Harbor, New York pp23-43
4. Bhadra, U and Pal-Bhadra M. (2003) Transgene insertion, genomic stress
and Cell surveillance: a lesson from Drosophila. In Book ‘Bioresources and
Environmental Stresses’ Eds by Prof. Hideaki Matsumoto, University of
Okayama press, Okayama , Japan pp 9-14.
Reports Bhadra U. and Chatterjee R. N. (1986) A method of polytene chromosome preparation of salivary gland of Drosophila for in situ transcription and in situ hybridization technique. Drosophila Information Service 63: 140-141. Bhadra U., Pal-Bhadra. M. and Chatterjee R. N. (1991) The larval denticle
distribution pattern in the strains of autosomal trisomies in Drosophila melanogaster Drosophila Information Service 71 : 243-44. Pal-Bhadra M., Bhadra U. and Chatterjee R.N. (1991) MgCl2 induced 93D and other puffs in Drosophila melanogaster. Drosophila Information Service 71 : 242-43.
INTERNATIONAL PATENTS:
1. Development of effective gene knock out system using gene silencing, University of Missouri, Columbia, USA
2. PABA nanotubes for oral delivery in Drosophila
3. PARA Amino Benzoic Acids based Nanotubes. Yadav Jhillu Singh, Lavanya
Madugula, Das Pragna P, Krishnan Anita, Jagannad Bulusu, Pal Bhadra
Manika, Bhadra Utpal, Indian Patent Application No:1584/CHE/2009, filling date
3/7/2009
INVITED TALKS:
Michigan State University, Ann Arbor, Michigan (December, 1999) Dosage compensation and transacting regulators in Drosophila.
University of Toledo, Ohio, USA (October 2000) Cosuppression in Drosophila: its
impact on reverse genetics
Institut Jacques Monod, CNRS, Universites Paris Paris Cedex 05, France (November 2000) Noise about Silence: Transcriptional and post-transcriptional gene silencing in Drosophila.
Institut de genetique humaine, CNRS, Montpellier-Cedex 5, France (November,
2000) Gene silencing in Drosophila: where more is always less.
University of Missouri, Missouri, USA (June, 2001) Functional genomics using Post- transcriptional gene silencing is a useful tool for other insects.
Shantha Biotechniques Pvt. Ltd (October 2001) Most comprehensive pathways
for drug development using microarray and RNA interference.
Shantha Biotechniques Pvt. Ltd (March 2001) A new approach for molecular diagonostics for early detection and subclassification of Cancer.
1st Asia-Pacific Affymetrix user meeting, Ring rose Hotel, Singapore November 2-5, 2004.
HUGO Conference September 27-30 (2008) – Identification and molecular
characterization of novel protein partners of piwi in Droaophila melanogaster.