CURRICULUM VITAE PERSONAL DATA Name: Gregory Roland Dressler ...

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CURRICULUM VITAE PERSONAL DATA Name: Gregory Roland Dressler Address: BSRB 2049 1606 Cambridge Rd. 109 Zina Pitcher Dr. Ann Arbor, MI 48104 Ann Arbor, MI 48109-2200 734-764-6490 [email protected] EDUCATION 1977-1981 University of Pennsylvania, Philadelphia, PA, B.S.E. in Bioengineering and Chemical Engineering, cum laude. 1982-1986 University of Pennsylvania, Philadelphia, PA; Ph. D. in Genetics and Molecular Biology. POSTDOCTORAL TRAINING 1987-1989 Postdoctoral Fellow, The Max Planck Institute for Biophysical Chemistry, Goettingen, Germany, Laboratory of Prof. Peter Gruss. ACADEMIC APPOINTMENTS 1990 -1995 Senior Staff Fellow, Unit on Molecular Embryology, Laboratory of Mammalian Genes and Development, NICHD, Bethesda, MD. 1995-1998 Assistant Investigator, Howard Hughes Medical Institute 1995 Assistant Professor, Dept. of Pathology, University of Michigan 2000 Associate Professor, Dept. of Pathology, University of Michigan SCIENTIFIC ACTIVITIES 1993 Ad-Hoc Member for Kidney Center Review Study Section, NIDDK 1994 Ad-Hoc Member for Biological Sciences study section for NRSA Fellowships 1994 Meeting Organizer, ”Antisense Technologies: their uses in development” March 8-9, NICHD, Bethesda, MD 1995 Abstract Reviewer, ASN Annual Meeting 1997 Ad-hoc Member, General Medicine B Study Section, NIH 1997 Abstract Reviewer, ASN Annual Meeting 1998 General Medicine B Study Section, special session Editorial Reviews Board, American Journal of Physiology NIDDK, Renal Program Project Grants, Site visit reviewer Guest Editor, Developmental Genetics, Renal Development Issue Polycystic Kidney Research Foundation, Grant Review Study Section

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1999 NIDDK Study Group, “Prostate Gene Expression Technology” Reviewer, ASN Annual Meeting NIH, Center for Scientific Review, ZRG1 SSS-1, reviewer 2000 NIH General Medicine B Study Section Member NIH Study Section, ZHD1 RRG-K (08) reviewer

2001 Human Frontiers in Sciences Program, reviewer NIH General Medicine B Study Section Member Irish National Research Council, reviewer

2002 NIH General Medicine B Study Section Member Welcome Trust Reviewer

2003 Editorial Board Member, Developmental Dynamics NCI Site Visit, Columbia University School of Medicine NIDDK initiative for the Kidney Gene Expression Atlas The Faculty of 1000, member

2004 NIH Urological Disease and Kidney Development Study Section member NIDDK Special Emphasis Panel ZDK1 GRB-7 2005 NIDDK Special Emphasis Panel P30 PKD NIDDK, MAGUD Advisory Board American Society of Nephrology, Basic Science Committee 2006 PBMK Study Section, Ad-hoc 2007 Editorial Board Member, J. Amer. Society Nephrology Co-organizer, Kidney Development and Repair, NIDDK Conference UKGD Study Section Ad-hoc member

Reviewer for: Mechanisms of Development, Development, Cell, Proceedings of the National Academy of Sciences, Developmental Dynamics, J. of Biological Chemistry, Nature, American J. of Physiology, J. of Clinical Investigation, Molecular and Cellular Biology, Genes & Development, Kidney International, J. of Cell Biology, Cell, Am. J. Pathology, Cancer Research, Nature Genetics, J. of Cell Science, J. American Society of Nephrology GRANT SUPPORT Past 1982-86 National Institute of Health Training Grant CA09171 to the Wistar Institute 1987-89 Alexander von Humboldt Fellowship 1995-98 Support for salary, personnel, and laboratory supplies provided by the Howard Hughes Medical Institute, Chevy Chase, MD. 1996-98 Mentor, Welcome Trust postdoctoral fellowship for J. Martin 1995-00 Principal Investigator, R01 DK51043, Pax-2 in Normal and Cystic Epithelium Development, $84,596 current year; $440,573 total direct costs 1998-02 Co-Investigator, P50 DK39255 (R. Wiggins, P.I.), Project 3, “Functional analysis of RET signaling in renal epithelial cells”, approximately $80,000/year direct costs.

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1999-03 Principal Investigator, R01 DK54723, Cell Migration, Chemoattraction and the RET/GDNF Pathway, approximately $144,000/year direct costs

2003-05 Mentor, Polycystic Kidney Disease Foundation fellowship to Dr. Yi Cai, 40,000/year direct costs.

2003-05 Polycystic Kidney Research Foundation, $50,000 Grant-in-Aid 2003-05 Mentor, American Foundation for Urological Disease Fellowship to Dr.

Doyeob Kim, 40,000/year direct costs. Active

1999-07 Principal Investigator, R01 DK54740, Pax2 Interacting Proteins in Development and Disease, approximately $175,000/year direct costs 2000-05 Mentor, K08 DK02803 to Dr. Sanjeevkumar Patel, 128,000/year direct costs. 2003-07 Principal Investigator, R01 DK062914, Cell Signaling in Developing Epithelia, $175,000/year direct costs

2005-07 Principal Investigator, R21 069689, Differentiation of ES cells into renal epithelia, $90,000/direct costs

2006-11 Principal Investigator, R01 DK073722, Epigenetic Regulation of Kidney Development, $205,000/ year direct costs.

HONORS AND AWARDS 1981 Graduated cum laude 1987 Received the Alexander von Humbold Fellowship MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES American Society of Nephrology Society for Developmental Biology AAAS TEACHING ACTIVITIES 1995-1997 Lecturer, Anatomy & Cell Biology 580 1995- Lecturer, Biology 421 1996-1997 Lecturer, Biology 405 1997- Organized and Lectured the Center for Organogenesis Short Course “Organogenesis of a Complex Tissue” 1997-2003 Lecturer, Renal Section, 2nd Year Medical Students 1999 Anatomy and Cell Biology 530, 3h 2000-06 Pathology 581, Dev. Pathology Section, 3h 2000 Cell and Developmental Biology 580, 3h 2000-06 Pathology 582, course director 2000-04 Cell & Developmental Biology 530, 3h 2001 Cell & Developmental Biology 680, 12h

2002 Biology 201, 1h 2004-06 M1 Renal Embryology 2h, Sex Determination 1h

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TRAINEES

Postdoctoral Fellows Subsequent Position Uwe W. Rothenpieler, M.D. (1990-1993) Medizinische Poliklinik, University of Munich, Gabriella Ryan, Ph.D. (1993-1994) Senior Staff Fellow, NIGR, Bethesda, MD Larry Patterson, M.D. (1992-1994) Bowman Gray School of Medicine, Winston- Salem, NC Mark S. Lechner, Ph.D. (1995-98) The Wistar Institute, Philadelphia, PA Eun-Ah Cho, Ph.D. (1995-2000) NIH, Bethesda, MD. Julie S. Martin, Ph.D. (1996-98) University College London Yi Cai, M.D., Ph.D. (1998-2006) Pediatric Resident, NY Patrick Brophy, M.D. (1999-2002) Dept. of Pediatrics, Univ. of Michigan Sanj Patel, M.D. (1999-2004) Dept. of Medicine, Univ. of Michigan Doyoeb Kim, Ph.D. (2002- Hong Xiao, M.D., Ph.D. (2006- ) Kristopher Schwab, Ph.D. (2006- ) Graduate Students Dawn E. Phelps (1992-1994) Dept. of Genetics, The George Washington University,

Washington, DC Jing-Mei Lin (2000-04) Dept. of Pathology, University of Michigan Marc Prindle (2001- ) Cell and Molecular Biology, University of Michigan Dissertation Committees Laura Post, Dept. of Human Genetics, Univ. of Michigan (1996-1999) Pei-Jiun Chen, Dept. of Biology (1997-2000) Kristen Coulter, Dept. of Human Genetics, Univ. of Michigan (1997-2002) Hoonkyu Suh, Dept. of Human Genetics (1998-2002) Tom Hliang, Dept. of Pathology (2000-2002) Yue Ge, Cell and Molecular Biology (2000-2002) Brian Gummow, Physiology (2001-05) Ira Weiner, MSTP (2002-05) Brian MacDonald, Human genetics (2001- 04) Robert Ward, Cell and Molecular Biology (2002- 05) Collen Doyle, Human Genetics (2003-05) Jennifer Linn, Cell and Developmental Biology (2006-) Sara Monroe, Pathology (2006-) EXTRAMURAL INVITED PRESENTATIONS 1992 The Archibald MacCallum Lecture, Dept. of Biochem., McGill University, Montreal. Airlie House meeting, sponsored by NICHD, Airlie, VA.

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1993 Wistar Institute, Philadelphia, PA. Dept. of Genetics, The George Washington University, Washington, DC Dept. of Pathology, University of Michigan, Ann Arbor, MI 1994 Basic Science Symposium, National Kidney Foundation annual meeting, Orlando, FL. Biogen Corporation, Cambridge, MA. Molecular Genetics of Tumor Progression and Metastisis, meeting sponsored by the American Association for Cancer Research, Big Sky, MT. Airlie House Meeting, sponsored by NICHD, Airlie, VA. Brookdale Center for Molecular Biology, Mt. Sinai University Medical School, NY. 36th annual Southeast Regional Developmental Biology Conference, Duke University, Durham, NC. 1995 HHMI Annual Meeting, Chevy Chase, MD. Midwest Society for Pediatric Research, Annual Meeting, Chicago, IL . Seventh International Symposium on Basement Membranes, Bethesda, MD. The Sixth International Workshop on Developmental Nephrology, Airlie, VA. 2nd International Conference on Molecular and Clinical Genetics of Childhood Renal Tumors, Philadelphia, PA. Dept. of Nephrology, Columbia University, New York, NY. 1996 Neckers Seminars in Nephrology, The Neckers Hospital, Paris, France. Hybridon Inc., Worchester, MA. Renal Developmental Biology, ASN Basic Science Symposium, New Orleans, LA. Mini Lecture, ASN Annual meeting, New Orleans, LA. The Max Planck Institute for Developmental Biology, Tuebingen, Germany. HHMI Annual Meeting, Chevy Chase, MD. 1997 Dept. of Cancer Biology, The Cleveland Clinic, Cleveland, OH. Penn Center for Molecular Studies of kidney Diseases, University of Pennsylvania, Philadelphia, PA. Dept. of Cell Biology, Duke University, Durham, NC. International Society of Developmental Biology, annual meeting, Snowbird, UT, (speaker & session chair). NIDDK Workshop on Polycystic Kidney Disease, Crystal City, VA. HHMI Annual Meeting, Chevy Chase, MD 1998 Experimental Biology 98, San Fransisco, CA. Division of Biological Sciences, University of Edinburgh, Edinburgh, UK. Dept. of Biochemistry, University of Virginia Medical center, Charlottesville, VA. Experimental Genetics of the Laboratory Mouse, Jackson Labs, Bar Harbor, ME. HHMI Annual Meeting, Chevy Chase, MD. 23rd Annual Argenteuil Symposium, Princess Lillian Foundation ,”Kidney Development has Clinical Impact”, Brussels, Belgium. 1999 Dept. of Biochemistry, LSU Medical Center, New Orleans, LA Dept. of Anatomy, University of Kansas Medical School, Kansas City, KS Dept. of Biochemistry, Medical College of South Carolina, Charleston, SC 2000 Division of Developmental Biology, Childrens Hospital, Univ. of Cincinnati, OH 2001 Dept. of Molecular Genetics, Baylor College of Medicine, Houston, TX

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Depts. of Pediatrics and Cell and Molecular Biology, Tulane Univ., New Orleans, LA. 8th International Workshop on Developmental Nephrology, Victoria, BC American Society of Nephrology, Annual Meeting, San Fransisco, CA German Society for Nephrology, Annual Meeting, Muenster, Germany Banbury Conference on Epithelial & Endothelial Tube Morphogenesis, Cold Spring Harbor, NY 2002 Dept. of Cell Biology, Univ. of Alabama, Birmingham, AL European Nephrogenesis Workshop IX, Royal College of Physicians, Dublin, Ireland Dept. of Anatomy, Indiana University School of Medicine, Indianapolis, IN. Max Planck Institute for Biophysical Chemistry, Goettingen, Germany Dept. of Medicine, Vanderbilt University, Nashville, TN. 2003 Dept. of Pathology, Boston University School of Medicine Dept. of Genetics, St. Jude’s Children’s Research Hospital, Memphis, TN American Society of Nephrology Annual Meeting, San Diego 2004 Keystone Meeting on Cell Signaling in Development, Santa Fe, NM. Dept. of Genetics, Cell Biology, and Anatomy, Univ. of Nebraska, Omaha Third Course on Genetics and Renal Disease, Genoa, Italy 2005 Dept. of Biochemistry & Biophysics, Oregon State Univ., Corvallis Dept. of Biology, Purdue University Indianapolis, IN. Division of Nephrology, Brigham and Women’s Hospital, Boston, MA. Plenary lecture, American Society of Nephrology Annual Meeting, Philadelphia, PA 2006 ICOS Corporation, Bothel, WA.

Maine Medical Center Research Institute, Portland, ME Dep. of Pediatrics, Hospital for Sick Children, Toronto, Canada Ottawa Health Research Institute, Ottawa, Canada Plenary lecture, American Society of Nephrology Annual Meeting, San Diego, CA International Nephrology Conference, Ann Arbor, MI Columbus Children’s Research Institute, Columbus, OH Dept. of Pathology, Northwestern University, Chicago, Il

2007 Dept. of Biology, Univ. of Kentucky, Lexington Kidney Development and Repair, NIDDK Conference, Alexandria, VA co-organizer Forefront Symposium on Nephrogenetics, Danvers , MA Dept. of Medicine, Vanderbilt University, Nashville, TN California National Primate Center, UC Davis, CA International Symposia on Kidney Development and Tissue Engineering, Oulu, Finland International Developmental Nephrology Workshop, Pecs, Hungary Dept. of Medicine, University of Cincinnati, OH Plenary lecture, American Society of Nephrology Annual Meeting, San Fransisco, CA COMMITTEE AND ADMINISTRATIVE SERVICE 1996-2005 Organogenesis Symposium Organizing Committee

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Reviewer for Organogenesis Training Grant Applications 1997-2007 Interim Co-director, Center for Organogenesis 1998-2007 Graduate Program in Cell and Molecular Biology 1998-2004 Pathology Graduate Program Preliminary Exam Committee 1998-2004 Graduate Program in Biomedical Sciences Admissions Committee 2006- American Society of Nephrology, Basic Science Committee BIBLIOGRAPHY 1. Dressler, G.R. and Fraser, N.W. (1987). DNA Sequences Downstream of the Adenovirus Type

2 Fiber Polyadenylation Site Contain Transcription Termination Signals. J. Virol. 61, 2770-2776.

2. Dressler, G.R., Rock, D.L., Fraser, N.W.(1987). Latent Herpes Simplex Virus Type 1 DNA is

not Extensively Methylated in vivo. J. Gen. Virol. 68, 1761-1765. 3. Chowdhury, K., Dressler, G.R., Breier, G., Deutsch, U., Gruss, P. (1988) The primary structure

of the murine mKr2 gene and its specific expression in adult and developing neurons. EMBO J. 7, 1345-1353.

4. Breier, G., Dressler, G.R., Gruss, P. (1988) Primary structure and developmental expression

pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster. EMBO J. 7, 1329-1336.

5. Deutsch, U., Dressler, G.R., Gruss, P. (1988) Pax 1, a member of a paired box homologous

murine gene family, is expressed in segmented structures during development. Cell 53, 617-625.

6. Dressler, G.R. and Gruss, P. (1988) Do multi-gene families regulate vertebrate development?

Trends in Genetics 4, 214-219 7. Dressler, G.R., Deutsch, U., Balling, R., Simon, D., Guenet, J-L., Gruss, P. (1988) Murine genes

with homology to Drosophila segmentation genes. Development 104 supplement, 181-186. 8. Duprey, P., Chowdhury, K., Dressler, G.R., Balling, R., Simon, D., Guenet, J.-L., Gruss, P.

(1988) A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes & Develop. 2, 1647-1654.

9. Dressler, G. R. and Fraser, N. W. (1989) The Adenovirus-2 major late transcription termination

region contains multiple functional elements. J. Gen. Virol. 70, 1337-1345. 10. Dressler, G. R. (1989) An update on the vertebrate homeobox. Trends in Genetics 5, 129-131. 11. Dressler, G. R. and Gruss, P. (1989) Anterior boundries of Hox gene expression in mesoderm

derived structures correlate with the linear gene order along the chromosome. Differentiation 41, 193-201.

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12. Püschel, A. W., Balling, R., Dressler, G. R., Gruss, P. (1989) The Hox 1.1 promoter directs

expression to a specific region of the embryo in transgenic mice. in Current Communications in Molecular Biology: Molecular Genetics of Early Drosophila and Mouse Development. (M. R. Capecchi, ed.)pp91-95.

13. Dressler, G.R., Deutsch, U., Chowdhury, K., Nornes, H., Gruss, P. (1990) Pax2 a new murine

paired box containing gene and its expression in the developing excretory system. Development 109, 787-795.

14. Nornes, H., Dressler, G. R., Knapik, E. W., Deutsch, U., Gruss, P. (1990) Spatially and

temporally restricted expression of Pax2 during murine neurogenesis. Development 109, 797-809.

15. Schoeller, H., Dressler, G. R., Balling, R., Rohdewold, H., Gruss, P. (1990) Oct4, a germ line

specific transcription factor mapping to the mouse t-complex. EMBO J. 9, 2185-2195. 16. Dressler, G. R. and Douglass, E. C. (1992) Pax-2 is a DNA binding protein expressed in

embryonic kidney and Wilms' tumor. Proc. Natl. Acad. Sci. USA 89, 1179-1183. 17. Pueschel, A. W., Westerfield, M., Dressler, G. R. (1992) Comparative analysis of Pax-2 protein

distributions during neurulation in mice and zebrafish. Mech. Develop. 38, 197-208. 18. Rothenpieler, U. W. and Dressler, G. R. (1993) Pax-2 is required for mesenchyme to epithelium

conversion during kidney development. Development 119, 711-720. 19. Phelps, D. E., Dressler, G. R. (1993) Aberrant expression of Pax-2 in Danforth's short tail (Sd)

mice. Develop. Biol. 157, 251-258. 20. Rothenpieler, U.W. and Dressler, G. R. (1993) Differential Distribution of

Oligodeoxynucleotides in Developing Organs with Epithelial and Mesenchymal Interactions. Nucleic Acids Res. 21, 4961-4966.

21. Dressler, G. R., Wilkinson, J. E., Rothenpieler, U. W., Patterson, L. T., Williams, L., Westphal,

H. (1993) Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalitites. Nature 362, 65-67.

22. Dressler, G.R. (1994) The pros and cons of c-ret. Current Biol. 4, 354-356. 23. Patterson, L.T. and Dressler, G. R. (1994) Regulation of Kidney Development: new insights

from an old model. Curr. Opin. Genet. Develop. 4, 696-702. 24. Dressler, G. R. (1995) Developmental Control Genes, in Molecular Nephrology (D.

Schloendorff and J. Bonventre eds.) Marcel Dekker, New York, pp1-13.

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25. Ryan, G., Steele-Perkins, V., Morris, J., Rauscher, F. J. III, Dressler, G.R. (1995) Repression ofPax-2 byWT1 during normal kidney development. Development 121, 867-875.

26. Dressler, G. R. (1995) Transcription factors in renal development: the WT1 and Pax-2 story.

Sem. Nephrol. 15, 263-271. 27. Dressler, G. R. (1995) The genetic control of renal development. Curr. Opin. Hyper. Nephrol.

4, 253-257. 28. Gnarra, J. R. and Dressler, G. R. (1995) Expression of Pax-2 in renal cell carcinoma and growth

inhibition by antisense oligonucleotides. Cancer Research.55, 4092-4098. 29. Torres, M., Gomez-Pardo, E., Dressler, G. R. and Gruss, P. (1995) Pax-2 controls multiple steps

in urogenital development. Development 121, 4057-4065. 30. Phelps, D.E. and Dressler, G. R. (1996) Identification of NovelPax-2 binding sequences by

chromatin immunoprecipitation. J. Biol. Chem. 271, 7978-7985. 31. Dressler, G. R. (1996) Pax-2, kidney development and oncogenesis. Med. Ped. Oncol. 27, 440-

444. 32. Winyard, P.J.D., Risdon, A.R., Sams, V.R., Dressler, G.R. and Woolf, A.S. (1996) The Pax2

transcription factor is overexpressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J. Clin. Invest. 98, 451-459.

33. Lechner, M. S. and Dressler, G. R. (1996) Mapping of Pax-2 transcription activation domains.

J.Biol. Chem. 271, 21088-21093. 34. Dehbi, M., Gharemani, M., Lechner, M., Dressler, G. and Pelletier, J. (1996) The paired-box

transcription factor, PAX2, positively modulates expression of the Wilms’ tumor suppressor gene (WT1). Oncogene 13, 447-453.

35. Vega, Q.C., Worby, C.D., Lechner, M.S., Dixon, J.E. and Dressler, G.R. (1996) Glial derived

neurotrophic factor is a ligand for RET and promotes kidney morphogenesis. Proc. Natl. Acad. Sci. USA.93, 10657-10661

36. Dressler, G. R. (1997) Genetic control of kidney development. Adv. Nephrol. 26, 1-17. 37. Valentini, R., Brookhiser, W. T., Park, J., Yang, T., Briggs, J., Dressler, G.R., and Holzman,

L.B. (1997) Post-translational processing and renal expression of mouse indian hedgehog cDNA. J. Biol. Chem. 272, 8466-8473.

38. Lechner, M. S. and Dressler, G. R (1997) The molecular basis of embryonic kidney

development. Mech. Develop. 62, 105-120.

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39. Leavey, S.F., Arend, L.J., Dare, H., Dressler, G.R., Briggs, J.P. and Margolis, B.L. (1998) Expression of Grb7 growth factor receptor signaling protein in kidney development and in the adult kidney. Am. J. Physiol. 275, F770-F776.

40. Cho, E. A., Patterson, L.P., Brookhiser, W.T., Mah, S., Kintner, C. and Dressler, G.R. (1998)

Expression and function of cadherin-6 in the developing kidney. Development 125, 803-812. 41. Cho, E.A. and Dressler, G.R. (1998) Mouse Tcf-4 binds b-catenin and is expressed in distinct

regions of the developing brain and limbs. Mech. Develop. 77, 9-18. 42. Tang, M.J., Worley, D., Sanicola, M. and Dressler, G.R. (1998) The RET-Glial Cell-derived

Neurotrophic Factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells. J. Cell Biol. 142, 1337-1345.

43. Weiss, J.B., Von Ohlen, T., Mellerick, D.M., Dressler, G., Doe, C.Q. and Scott, M.P. (1998).

Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes & Dev. 12, 3591-3602.

44. Yang, Y., Jeanpierre, C., Dressler, G.R., Lacoste, M., Niaudet, P. and Gubler, M.-C. (1999)

WT1 and Pax-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial scelrosis. Am J. Pathol 154, 181-192.

45. Dressler, G.R. (1999) Kidney development branches out. Dev. Genetics 24, 189-193. 46. Schwarz, M., Alvarez-Bolado, G., Dressler, G., Urbanek, P., Busslinger, M., and Gruss, P.

(1999) Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech. Dev. 82, 29-39

47. Dressler, G. R. and Woolf, A. S. (1999) Pax2 in development and renal disease. Int. J. Dev.

Biol. 43, 463-468. 48. Ostrom, L., Tang, M.-J., Gruss, P., and Dressler, G.R. (2000) Reduced Pax2 gene dosage

increases apoptosis and slows the progression of renal cystic disease. Dev. Biol. 219, 250–258 49. Mah, S.P., Saueressig, H., Goulding, M., Kintner, C., and Dressler, G.R. (2000) Kidney

development in cadherin-6 mutants: delayed mesenchymal-to-epithelial conversion and loss of nephrons. Dev. Biol. 223, 38-53.

50. Lechner, M.S. Levitan, I. and Dressler, G.R. (2000) PTIP, A novel BRCT-domain protein

interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 28, 2741-2751. 51. Dressler, G.R. (2001) The Development of the Excretory System. In: Mouse Development (J.

Rossant and P. Tam, eds.) Academic Press, NY, pp395-420.

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52. Brophy, P.D, Ostrom, L., Lang, K.M. and Dressler, G.R. (2001) Regulation of Ureteric Bud Outgrowth by Pax2 Dependent Activation of the Glial Derived Neurotrophic Factor Gene. Development 128, 4747-4756.

53. Cai, Y., Lechner, M.S., Nihalani, D., Prindle, M., Holzman, L.B. and Dressler, G.R. (2002)

Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2 dependent transactivation. J. Biol Chem. 277, 1217-1222.

54. Tang, M.J., Cai, Y., Tsai, S.J., Wang, Y.K. and Dressler, G.R. (2002) Ureteric Bud Outgrowth

in Response to RET Activation is Mediated by Phosphatidylinositol-3 Kinase. Dev. Biol. 243, 128-136.

55. Silberstein, G. B, Dressler, G.R. and Van Horn, K. (2002) Expression of the Pax2 oncogene in

human breast cancer and its role in progesterone dependent mammary growth. Oncogene 21, 1009-1016.

56. Hoffmeister, A., Ropolo, A.,Vasseur, S., Mallo, G.V., Bodeker, H., Ritz-Laser, B., Dressler,

G.R., Vaccaro, M.I., Dagorn, J.C., Moreno, S. and Iovanna, J.L. (2002) The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation-domain interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J. Biol. Chem. 277, 22314-22319.

57. Dressler, G.R. (2002) Tubulogenesis in the developing mammalian kidney. Trends Cell Biol.

12, 390-395. 58. Cho, E.A. and Dressler, G.R. (2003) The Formation and Development of Nephrons. In: The

kidney: Normal Development to Congenital Abnormalities (P. D. Vize, A. S. Woolf, J. B. L. Bard, eds) Academic Press, pp195-210.

59. Cho, E.A., Prindle, M.J. and Dressler, G.R. (2003) The BRCT domain protein PTIP is required

for progression through mitosis. Mol. Cell. Biol. 23, 1666-1673

60. Cai, Y., Brophy, P., Levitan, I. and Stefano, S. and Dressler, G.R. (2003) Groucho suppresses

Pax2 transactivation by inhibition of JNK mediated phosphorylation. EMBO J.22, 5522-5529 61. Brophy, P.D., Lang, K.M., and Dressler, G.R. (2003) The secreted frizzled related protein

SFRP2 is a target of the Pax2 transcription factor. J. Biol. Chem. 278, 52401-52405. 62. Patel, S. R. and Dressler, G.R. (2004) Expression of Pax2 in the intermediate mesoderm is

regulated by YY1. Dev. Biol. 267, 505-516. 63. Dressler, G. R. (2004) Cell Lineages and Stem cells in the Embryonic Kidney. In: Handbook of

Stem Cells, Vol.1: Embryonic Stem Cells (R. Lanza, ed.) Elsevier Science, San Diego, CA, p335-344.

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64. Lin, J., Patel, S.R., Cheng, X., Cho, E. A., Levitan, I., Ullenbruch, M., Phan, S.H., Park, J.M. and Dressler, G.R. (2005) Kielin/Chordin-like protein (KCP), a novel enhancer of BMP signaling attenuates renal fibrotic disease. Nature Medicine, 11, 387-393 (featured in news and views p.373)

65. Kim, D. and Dressler, G.R. (2005) Nephrogenic factors promote differentiation of mouse

embryonic stem cells into renal epithelia. J. Am. Soc. Nephrol. 16, 3527-3534. 66. Patel, S. R. and Dressler, G. R. (2005) BMP signaling in development and disease. Trends in

Mol. Med. 11, 512-518. 67. Dressler, G. R. (2006) Cell lineages and stem cells in the embryonic kidney. In: Essentials of

Stem Cell Biology (R. Lanza, ed.) Elsevier Science, San Diego, CA, p227-236. 68. Lin, J., Patel, S. R., Wang, M. and Dressler, G.R. (2006) The cysteine rich domain protein KCP

suppresses TGF- /Activin signaling in renal epithelia. Mol. Cell. Biol. 26, 4577-4585. 69. Dressler, G. R. (2006) The cellular basis of kidney development. Ann. Rev. Cell Dev. Biol. 22,

509-529. 70. Self, M., Lagutin, O., Bowling, B., Hendrix, J., Cai, Y., Dressler, G. R. and Oliver, G. (2006)

The Six2 gene is required for suppression of inductive signals and progenitor cell renewal in the developing kidney. EMBO J, 25, 5214-5228.

71. Clarke, J. C., Patel, S. R., Raymond, R. M., Andrew, S., Robinson, B. G., Dressler, G. R. and

Brophy, P. D. (2006) Pax2 regulates the expression of c-Ret during branching morphogenesis in the mammalian kidney. Hum. Mol. Genetics, 15, 3420-3428.

72. Dressler, G.R. (2007) Stem cells in kidney development and regeneration. Prog. Tissue Eng., in

press 73. Kim, D, Wang, M., Cai, Q., Brooks, H. and Dressler, G.R. (2007) The Pax2 Interacting Protein

PTIP is Required for Urine Concentration and Osmotolerance in Collecting Duct Epithelia. J. Am. Soc. Nephrol. 18, 1458-1465.

74. Kim, D. and Dressler, G. R. (2007) PTEN modulates GDNF/RET mediated chemotaxis and

branching morphogenesis in the developing kidney. Dev. Biol.,307, 209-299. 75. Cho, Y.W., Hong, T., Hong, S.H., Yu, H., Kim, D., Guszczynski, T., Dressler, G.R., Copeland,

T., Kalkum, M. and Ge, K. (2007) PTIP associates with MLL3 and MLL4 containing histone H3 lysine 4 methyltransferase complex. J. Biol Chem. 282, 20395-20406.

76. Gong, K.Q., Yallowitz, A.R., Sun, H., Dressler, G.R. and Wellik, D.M. (2007) Physical

association of a Hox-Eya-Pax complex at enhancer sequences regulates expression of early patterning genes in the developing kidney. Mol. Cell Biol. in press.

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77. Viana, R., Batourina, E., Hunag, H., Dressler, G.R., Behringer, R.R., Kobayashi, A., Shapiro, E., Hensle, T. and Mendelsohn, C. (2007) The development of the bladder trigone, the center of the anti-reflux mechanism. Development, in press

78. Patel, S.R., Kim, D., Levitan, I. and Dressler, G.R. (2007) The BRCT-domain containing protein

PTIP interacts with a histone H3 lysine 4 methyltransferase complex to regulate development. submitted.

79. Feng, M and Dressler, G.R. (2007) Drosophila PTIP interacts with the Polycomb/Trithorax

pathways and is essential for development. submitted. 80. Kim, D. and Dressler, G.R. (2007) An essential role for PTIP in maintaining embryonic stem

cell pluripotency. submitted. 81. Prindle, M., Patel, S.R., and Dressler, G.R. (2007) Characterization of cell growth and the DNA

damage response in PTIP mutant fibroblasts. submitted.