CURRICULUM VITAE Gustavo Pradilla, M.D. · CURRICULUM VITAE Gustavo Pradilla, M.D. (Revised 12/9/2014) Current Position: ... Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, Di Meco

CURRICULUM VITAE

Gustavo Pradilla, M.D. (Revised 12/9/2014)

Current Position:

Assistant Professor Department of Neurosurgery Emory University School of Medicine, Atlanta, GA Director Cerebrovascular Research Laboratory Acting Chief of Service – Grady Memorial Hospital Co-Director Skull Base Surgery Center – Grady Memorial Hospital

Accreditations, Licenses, and Certifying Examinations:

Medical Degree. Republic of Colombia, Ministry of Health - Ministry of National Education. No. 5318, June 11th, 2002 ECFMG certificate # 0-658-218-3 – issued March 14th, 2005 USMLE Step 3: July 26th 2005 – passed American Board of Neurological Surgeons – Written Examination – March 13th, 2010 – passed. Maryland Board of Physicians –Medical License # D0070174 Florida Board of Medicine – Training License # TRN 17971 Georgia Composite Medical Board – Medical License # 070411 Issued 7/11/13, Exp. 6/30/15

Education:

1988-1994 San Pedro Claver High School Bucaramanga, Colombia 1993-1994 “Youth for Understanding” Student Exchange Program, Dundee Central High School, Dundee, NY 1995-2002 Pontificia Universidad Javeriana School of Medicine Doctor of Medicine and Surgery, Bogotá, Colombia 3/26/01 to 5/26/01 Visiting Medical Student in the Neurosurgery and Neurology Departments, and the Neurological Critical Care Division

December 2001-May 2002 Research Elective, Neurosurgical Oncology Hunterian Brain Tumor Laboratory, Department of Neurosurgery, Johns Hopkins University, School of Medicine

Gustavo Pradilla, M.D. Curriculum vitae p. 2

Post-Graduate Training:

7/02-8/05 Neuroscience Post-Doctoral Research Fellow P.I. Rafael J. Tamargo, M.D., F.A.C.S Division of Cerebrovascular Neurosurgery Johns Hopkins University, School of Medicine Baltimore, MD 9/05-9/06 Halsted Intern in General Surgery Program Director: Pamela A. Lipsett, M.D., F.A.C.S. Department of Surgery, Johns Hopkins Hospital Johns Hopkins University, School of Medicine Baltimore, MD 7/09-6/11 Neuro-oncology Research Fellow, National Cancer Institute (NCI)/The Sidney Kimmel Comprehensive Cancer Center P.I. Stuart Grossman, M.D. Johns Hopkins University, School of Medicine Baltimore, MD 9/06-6/12 Resident in Neurological Surgery Program Director: George Jallo, M.D. Chairman: Henry Brem, M.D., F.A.C.S. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 7/12-6/13 Fellow in Cerebrovascular and Skull Base Surgery Fellowship Directors: Roberto Heros, M.D. and Jacques J. Morcos, M.D. Department of Neurological Surgery University of Miami – Miller School of Medicine

Honors: 1993 Highest Score National Academic Examinations Colombian Institute for Promotion of Superior Education (ICFES) San Pedro Claver High School Bucaramanga, Colombia 2002-2004 Cerebrovascular Post-Doctoral Research Fellowship Cerebrovascular Laboratory Brain Tumor Laboratory Department of Neurosurgery The Johns Hopkins University School of Medicine 2004 Co-recipient of the Galbraith Award of the Joint AANS/CNS Cerebrovascular Section for the study “Simvastatin attenuates


experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: A dose-response effect dependent on endothelial nitric oxide synthase” 2004 Co-recipient of the Agustus McCravey Award of the Southern Neurosurgical Society for the study “Lysis of intraparenchymal hematoma with stereotactically implanted tPA polymers in a rabbit model” 2004 Recipient of the Harvey Cushing Hunterian Research Award Given to the Johns Hopkins Resident/Fellow with the highest achievement in Neurosurgical Research 2008 Recipient of the Sherman Travel Fellowship Award. Awarded fellowship to travel to anatomy conference to expand knowledge of intracranial anatomy and complex surgical approaches 2009 Recipient of the Orden al Mérito (Order of Merit) of the City of Bucaramanga, Colombia. Awarded by the Mayor of the City of Bucaramanga to its distinguished citizens. 2009 Recipient of the Reconocimiento Academico (Academic Recognition) of the Universidad Industrial de Santander (UIS) in Bucaramanga, Colombia awarded by the President of the UIS for contributing to the advancement of the neurosciences and to medical education as an invited speaker and academic collaborator 2011 Recipient of the Walter E. Dandy Award for Excellence in Neurosurgery, Given to the Johns Hopkins Resident/Fellow with the highest achievement in Clinical Neurosurgical Research 2011 Recipient of a fellowship award for the Clinical Trial Methods Course (CTMC) in Neurology awarded by the National Institute of Neurological Disorders and Stroke (NINDS) (August 15-21, 2011, Vail, CO) 2014 Recipient of the “One in one-hundred” Outstanding Post-Doctoral Fellow Mentor award, awarded by Emory University School of Medicine to faculty members for outstanding mentoring of postdoctoral fellows in quality research, support of their career advancement, advice both scientific and professional, and going beyond the call of duty for your trainees 2014 Recipient of the “Kristen’s Legacy of Love Chair of Research” from the Brain Aneurysm Foundation for the study “Effect of Progesterone on Inflammation, Vasospasm, and Early Brain Injury after


Subarachnoid Hemorrhage: Behavioral and Histopathological outcomes in a rodent model”.

Grant support:

7/2009-6/2011 National Cancer Institute (NCI), T32 Neuro-oncology Training Grant, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD 7/2009-6/2011 National Institute of Neurological Disorders and Stroke (NINDS) 1R21NS063131-01A1 Co-Investigator. Common-Path OCT for Real Time Imaging in Minimally Invasive Neurosurgery. Principal Investigator: Dr. Jin Kang, Department of Electrical and Computer Engineering, The Johns Hopkins University. 9/2013-present Cerebrovascular Research Laboratory Start-up Funds Emory University School of Medicine, Department of Neurosurgery 9/2014 – present Brain Aneurysm Foundation Research Grant - $20,000

Professional Memberships: 2002-2005 Active Member Johns Hopkins Post-Doctoral Association 2002-Present Active Member Johns Hopkins Medical/Surgical Association (# 01118016) 2003-Present Active Member American Association of Neurological Surgeons (AANS) (# 411226)

2005-2006 Resident Member American College of Surgeons (ACS) 2008-Present Active Member Congress of Neurological Surgeons (CNS) (#32204) 2007-Present Active Member CNS/AANS joint cerebrovascular section 2010-Present Active Member North American Skull Base Society (NASBS) 2011-Present NeuroHope Foundation (Board Member), Non-profit Facilitating Surgical Care in Africa


2014-Present Active Member Georgia Neurosurgical Society

BIBLIOGRAPHY1-8 1. Frazier JL, Wang PP, Case D, Tyler BM, Pradilla G, Weingart JD, Brem H.

Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma. J Neurooncol. 2003; 64:203-209.

2. Restrepo L, Pradilla G, Llinas R, Beauchamp NJ. Perfusion- and diffusion-

weighted MR imaging-guided therapy of vertebral artery dissection: Intra-arterial thrombolysis through an occipital vertebral anastomosis. AJNR Am J Neuroradiol. 2003; 24:1823-1826.

3. Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, Di Meco F. Local delivery

of antineoplastic agents using biodegradable polymers for the treatment of malignant brain tumors. Expert Rev Neurotherapeutics. 2003; 3:89-102.

4. Pradilla G, Azzam T, Wang PP, Domb AJ, Brem H. Gene therapy for malignant

brain tumors. Expert Rev Neurotherapeutics. 2003; 3:89-105. 5. Pradilla G, Wang PP, Legnani FG, Ogata L, Dietsch GN, Tamargo RJ. Anti-

CD11/CD18 monoclonal antibody therapy prevents vasospasm after subarachnoid hemorrhage in rabbits. J Neurosurg. 2004 July; 101(1):88-91.

6. Pradilla G, Wang PP, Legnani FG, Frazier JL, Tamargo RJ. Pharmacokinetics of

controlled release polymers in the subarachnoid space after subarachnoid hemorrhage in rabbits. J Neurosurg. 2004 July; 101(1):99-103.

7. Frazier JL, Pradilla G, Wang PP, Tamargo RJ. Inhibition of experimental

cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit subarachnoid hemorrhage model. J Neurosurg. 2004 July; 101 (1): 93-98.

8. Pradilla, G., Thai, Q.A., Legnani, F. G., Hsu, W., Kretzer, R.M., Wang, P. P.,

Tamargo, R. J. Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. Neurosurgery 2004 December; 55 (6):1393-99.

9. Mantha, A., Legnani, F.G., Bagley, C.A., Gallia, G., Garonzik, I., Pradilla, G., Amundson, E., Tyler, B.M., Brem, H., Gokaslan, Z. A new model of spinal metastasis in rats. J Neurosurg Spine 2005 March; 2 (3): 303-307 Cover Article.


10. Raza SM, Pradilla G, Legnani FG, Thai QA, Olivi A, Brem H. Local delivery of antineoplastic agents for the treatment of malignant brain tumors. Expert Opin Mol Ther, 2005, (5) 4: 477-494

11. Brastianos, P., Pradilla, G., McCarthy, E., Gokaslan, Z.L. Solitary

osteochondroma of the T12 vertebra: Case Report and Review of the Literature. Neurosurgery, 2005 June; 56 (6):1379.

12. Pradilla, G., Thai, Q.A., Legnani, F.G., Clatterbuck, R.E., Gailloud, P., Murphy,

K.P.J., Tamargo, R.J. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. Neurosurgery, 2005 July; 57 (1 Suppl):184-90.

13. Thai, Q.A., Raza, S.M., Pradilla, G., Tamargo, R.J. Aneurysmal rupture without

subarachnoid hemorrhage, case series. Neurosurgery, 2005, August; 57 (2):225-9. 14. Amundson, E., Pradilla, G., Brastianos, P., McCarthy, E., Gokaslan, Z.L. A

novel model of spinal metastases in rabbits. Neurosurgery, 2005, August; 57 (2): 341-6.

15. Mavinkurve, G., Pradilla, G., Legnani, F.G., Bagley, C.A., Brem, H., Jallo, G. A

novel intramedullary spinal cord tumor model in rabbits: functional, radiological, and histopathological characterization. J Neurosurg Spine, 2005 August; 3 (2): 142-8

16. Pradilla, G., Legnani, F. G., Petrangolini, G., Francescato, P., Chillemi, F., Tyler,

B. M., Brem, H., Olivi, A., DiMeco, F. Local delivery of a novel endostatin fragment for the treatment of experimental gliomas. Neurosurgery, 2005 November; 57 (5):1032-40

17. Recinos, P.F., Pradilla, G., Thai, Q.A., Crompton, P., Rigamonti, D.

Management of spinal epidural abscesses. Oper Techn Neurosurg (Editor: Spetzler, R.F.), 2005 September; 7: 188-192

18. Pradilla, G., Wang, P.P., Gabikian, P., Li, K.W., Magee, C., Brem, H., Walter, K.A. Local delivery of paclitaxel with the Paclimer® delivery system: a dose escalation toxicity study in a canine model. J Neurooncol. 2006 Jan;76(2):131-8.

19. McGirt, M.J., Woodworth, G., Pradilla, G., Legnani, F.G., Warner, D., Tamargo, R.J., Clatterbuck, R.E., Lynch, J.R, Laskowitz, D.T. Simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. Clinical Neurosurgery, 2004 October; 52 (49): 212-213

20. Legnani, F.G., Pradilla, G., Thai, Q.A., Fiorindi, A., Recinos, P.F., Tyler, B.M., Gaini, S.M., DiMeco, F., Brem, H., Olivi, A. Lactacystin exhibits potent anti-


tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J Neuro-Oncol., 2006 May; 77 (3): 225-32.

21. McGirt, M.J., Pradilla, G., Legnani, F.G., Thai, Q.A., Recinos, P.F., Tamargo,

R.J., Clatterbuck, R.E. Simvastatin ameliorates cerebral vasospasm following experimental subarachnoid hemorrhage. Neurosurgery, 2006 May; 58 (5):945-51; discussion 945-51.

22. Tierney, T., Pradilla, G., Wang, P.P., Clatterbuck, R., Tamargo, R.J.

Intracisternal Delivery of the Nitric Oxide Donor DETA/NO from a Controlled-Release Polymer: Toxicity in Cynomolgus Monkeys. Neurosurgery 2006 May; 58(5):952-60; discussion 952-60.

23. Caplan, J., Pradilla, G., Hdeib, A., Tyler, B.M., Legnani, F.G., Bagley C.A., Brem, H., Jallo, G. A novel model of intramedullary spinal cord tumors in rats: functional progression and histopathological characterization. Neurosurgery. 2006 Jul; 59(1):193-200; discussion 193-200.

24. Thai, Q.A., Pradilla, G., Legnani, F.G., Kretzer, R.M., Hsu, W., Tamargo, R.J.

Lysis of intracerebral hematoma with stereotactically implanted tissue plasminogen activator polymers in a rabbit model. J Neurosurgery, 2006, Sept; 105 (3): 424-429.

25. Recinos, P.F., Pradilla, G, Thai, Q.A., Perez, M., Legnani, F.G., Hdeib, A., Clatterbuck, R.E., Tamargo, R.J. Lipopolysaccharide-induced cerebral vasospasm is comparable to post-hemorrhagic vasospasm in rabbits. Surgical Neurology, 2006 Nov; 66 (5): 463-9; discussion 469.

26. Brem, S., Tyler, B.M., Li, K., Pradilla, G., Legnani, F.G., Caplan, J., Brem, H.

Local delivery of temozolomide by biodegradable polymers is superior to oral administration in a rodent glioma model. Cancer Chemother Pharm, 2007 Oct;60(5):643-50. Epub 2007 Jan 26.

27. Pradilla, G., Jallo, G. Arachnoid cysts: case series and review of the literature.

Neurosurg focus, 2007 Feb; 22 (2) E7 28. Chaichana, K. Capilla-Gonzalez, V., Gonzalez-Perez, O., Pradilla, G., Han, J.,

Olivi, A., Brem, H., Garcia-Verdugo, J.M., Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. J Neurosc Meth. 164 (2007) 261–270


29. Raza, S., Thai, Q.A., Pradilla, G., Tamargo, R.J. Titanium cranioplasty prevents cosmetic deformities after pterional craniotomies. Neurosurgery, Mar;62(3 Suppl 1):262-4; discussion 264-5.

30. Raza, S.M., Thai, Q.A., Jabbour, S., Pradilla, G., Kleinberg, L.R., Wharam, M., Rigamonti, D. Repeat stereotactic radiosurgery for high grade and large intracranial arteriovenous malformations. Surg Neurol. 2007 Jul;68(1):24-34; discussion 34.

31. Pradilla, G., Pradilla-Ardila, G., Hsu, W., Rigamonti, D. Epidural abscesses of the central nervous system. Lancet Neurol 2009; 8: 292–300.

32. Hsu, W., Pradilla, G., Constantini, S., Jallo, G.I. Surgical considerations of spinal ependymomas in the pediatric population. Childs Nerv Syst. 2009 Oct;25(10):1253-9. Epub 2009 Apr 10.

33. Chaichana, K., Pradilla, G., Huang, J., Tamargo, R.J. Role of Inflammation

(Leukocyte-Endothelial Cell Interactions) in Vasospasm after Subarachnoid Hemorrhage. World Neurosurgery, 2010 Jan;73(1):22-41. Epub 2009 Aug 6.

34. Pradilla, G., Rigamonti, D. Epidural abscesses in Africa - Authors' reply. Lancet

Neurol. 2009 Oct;8(10):879-80.

35. Pendleton, C., Zaidi, H., Pradilla, G., Cohen-Gadol, A., Quinones- Hinojosa, A., Harvey Cushing's attempt at the first human pituitary transplantation. Nature Reviews Endocrinology, 2010 January; 6(1):48-52.

36. Jansen, T., Tyler, B., Mankowski, J.L., Renard, V., Pradilla, G., Legnani, F., Laterra, J., Olivi, A. FasL gene knock-down therapy enhances the anti-glioma immune response. Neuro-Oncology, 2010 May; 12(5): 482-9.

37. Tyler, B.M., Fowers, K.D., Li, K., Recinos, V.R., Caplan, J.M., Hdeib, A., Grossman, R., Basaldella, L., Bekelis, K., Pradilla, G., Legnani, F., Brem, H. A thermal gel depot (OncoGel®) for local delivery of Paclitaxel to treat experimental brain tumors. J Neurosurgery, 2010 Aug; 113(2): 210-7.

38. Chaichana, K., Pradilla, G., Gokaslan, Z., Bydon, A. The Clinical Significance of Pneumorachis: A Case Report and Review of the Literature. J Trauma, 2010, March, 68(3):736-744.

39. Pradilla, G., Chaichana, K.L., Hoang, S., Huang, J., Tamargo, R.J. Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery Clinics of North America, 2010 Apr; 21(2): 365-79.

40. Lazaridis, C., Pradilla, G., Nyquist, P.A., Tamargo, R.J. Intra-aortic balloon

pump counterpulsation in the setting of subarachnoid hemorrhage, cerebral vasospasm, and neurogenic stress cardiomyopathy. Neurocrit care, 2010 Aug; 13(1): 101-8.


41. Hsu, W., Pradilla, G., Garonzik, I.M., Conway, J.E. Pretruncal non-aneurysmal subarachnoid hemorrhage causing basilar artery vasospasm. Neurocritical Care, 2010 Oct; 13(2): 256-60.

42. Germanwala, A.V., Thai, Q.A., Pradilla, G., Tamargo, R.J. Simple technique for intraoperative localization of small vascular lesions. Neurosurgery, 2010, Sep; 67(3): 818-22.

43. Pradilla, G., Nagahama, Y., Spivak, A., Bydon, A., Rigamonti, D. Spinal Epidural Abscess: Current Diagnosis and Management. Curr Inf Dis Rep, 2010 Nov;12(6):484-91.

44. Alvernia, J., Pradilla, G., Mertens, P., Lanzino, G., Tamargo, R.J. Latex injections of cadaver heads: technical note. Neurosurgery, 2010 Dec; 67 Operative Neurosurgery, 2:ons362-ons367.

45. Zaidi, H., Pendleton, C., Pradilla, G., Cohen-Gadol, A. Quinones-Hinojosa, A.

Harvey Cushing’s innovative attempt at xenotransplanting a rabbit spinal cord in a patient after resection of peripheral nerve tumor in 1902. Neurosurgery, 2011 Mar;68(3):773-80.

46. See, A.P., Pradilla, G., Lim, M. Heat-shock protein-peptide complex (HSPPC-

96, Oncophage) in the treatment of glioblastoma. Expert Rev Vaccines. 2011 Jun;10(6):721-31.

47. Pradilla, G., Garzon-Muvdi, T., Ruzevick, J.J., Bender, M., Edwards, L., Momin, E.N., Thompson, R.C., Tamargo, R.J. Systemic L-citrulline administration prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after SAH. Neurosurgery, 2012 Mar;70(3):747-56; discussion 756-7

48. Dasenbrock, H.H., Pradilla, G., Gokaslan, Z.L., Bydon, A. The impact of weekend hospital admission on the timing of intervention and outcomes after surgery for spinal metastases. Neurosurgery, 2012 Mar;70(3):586-93.

49. Bender, M., Pradilla, G., James, C., Raza, S., Lim, M., Carson, B.S. Surgical treatment of pediatric trigeminal neuralgia, case series and review of the literature. Child Nerv Sys, 2011 Dec;27(12):2123-9. Epub 2011 Oct 1.

50. Coon, A., Paul, A.R., Colby, G.P., Lin, L.M., Pradilla, G., Huang, J., Tamargo, R.J. Comparison of tertiary center aneurysm location frequencies in 400 consecutive cases: Decreasing incidence of posterior communicating artery region aneurysms. Surg Neurol Int. 2011;2:152. Epub 2011 Oct 29.

51. Tyler, B.M., Hdeib A., Caplan, J., Legnani, F.G., Fowers, K.D., Brem, H., Jallo, G., Pradilla G. Intra-tumoral administration of the paclitaxel delivery system OncoGel® delays the onset of paresis in rats with intramedullary spinal cord gliosarcoma. J Neurosurg Spine. 2012 Jan;16(1):93-101.


52. Wicks, R.T., Pradilla, G., Raza, S.M., Hadelsberg, U., Huang, J., Tamargo, R.J. Impact of Changes in Intraoperative Somato-Sensory Evoked Potentials (SSEPs) on Stroke Rates after Clipping of Intracranial Aneurysms. Neurosurgery, 2012 May;70(5):1114-24; discussion 1124.

53. Bender, M.T., Pradilla, G., Batra, S., See, A.P., Bhutiani, N., James, C., Carson,

B.S., Lim, M. Effectiveness of Repeat Glycerol Rhizotomy in Treating Recurrent Trigeminal Neuralgia. Neurosurgery, 2012 May;70(5):1125-33; discussion 1133-4.

54. Pradilla, G., Coon, A., Huang, J., Tamargo, R.J. Surgical treatment of cranial arteriovenous malformations and dural arteriovenous fistulas. Neurosurg Clin N Am. 2012 Jan;23(1):105-22. 55. Hsu, W., Siu, I., Pradilla, G., Richman, J., Flerage, T., Gokaslan, Z., Jallo, G.,

Gallia, G. Animal model of intramedullary spinal cord glioma using human glioblastoma multiforme neurospheres. J Neurosurg Spine. 2012 Mar;16(3):315-9. Epub 2011 Dec 23.

56. Amin, A.G., Ng, J., Hsu, W., Pradilla, G., Raza, S., Quinones-Hinojosa, A., Lim,

M. Postoperative anticoagulation management in patients with mechanical heart valves and subdural hematomas. Neurocrit care, 2013 Aug;19(1):90-4.

57. Bender, M., Pradilla, G., Batra, S., See, A.P., James, C., Carson, B.S., Pardo-Villamizar, C., Lim, M. Glycerol Rhizotomy and Radiofrequency Thermocoagulation for Trigeminal Neuralgia in Multiple Sclerosis. J Neuros 2013 Feb;118(2):329-36

58. Ruzevick, J., Jackson, C., Pradilla, G., Garzon-Muvdi, T., Tamargo, R.J. Aneurysm formation in pro-inflammatory, transgenic haptoglobin 2-2 mice. Neurosurgery, 2013 Jan;72(1):70-6; discussion 76 59. Pradilla, G., Wicks, R.T., Hadelsberg, U., Gailloud, P., Coon, A.L., Huang, J.,

Tamargo, R.J. Accuracy of computed tomography angiography in the diagnosis of intracranial aneurysms. World Neuros. 2013 Dec;80(6):845-52

60. Zeng, J., See, A.P., Phallen, J., Belcaid, Z., Durham, N., Meyer, C., Harris, T., Yu, H., Albesiano, E., Pradilla, G., Ford, E., Wong, J., Hammers, H., Tyler, B., Brem, H., Tran, P.T., Pardoll, D., Drake, C.G., Lim, M. Anti-PD-1 blockade and stereotactic radiation produces long term survivors in mice with intracranial gliomas. Int J Radiation Oncol Biol Phys, 2013, 2013 Jun 1;86(2):343-9

61. Garzon-Muvdi, T., Pradilla, G., Ruzevick, J.J., Bender, M., Edwards, L., Grossman, R., Zhao M., Rudek, M.A., Riggins, G., Tamargo, R.J. A glutamate receptor antagonist, S-4-carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in Haptoglobin 2-2 mice. Neurosurgery, 2013 Oct;73(4):719-28; discussion 729.


62. Pradilla, G., Heros, R.C. Importance of the venous outflow pattern in predicting hyperemic complications after treatment of cerebral AVMs. World Neurosurg. 2013 Sep 11, Epub ahead of print

63. Wicks, R.T., Huang, Y., Zhang, K., Zhao, M., Tyler, B.A., Suk, I., Hwang, L., Ruzevick, J., Jallo, G., Brem, H., Pradilla, G., Kang, J.U. Extravascular Optical Coherence Tomography: Evaluation of Carotid Atherosclerosis and Pravastatin Therapy. Stroke, 2014 Apr;45(4):1123-30.

64. Miller, B.A., Turan, N., Pradilla, G. Inflammation, vasospasm, and brain injury

after subarachnoid hemorrhage. Biomed Res Int. 2014;2014:384342. Epub 2014 Jul 3.

65. Pradilla G., Legnani, F.G., Garzon-Muvdi, T., Vargas, D.L., Thai, Q.A., Williams, J.R., Pardo-Villamizar, C.A., Tamargo, R.J. Time course of ICAM-1 and VCAM-1 expression after subarachnoid hemorrhage in monkeys treated with controlled-release ibuprofen polymers. Submitted.

66. Jackson, C., Pradilla, G., Amin, A., Batra, S., Kleinberg, L., Redmond, K., Olivi, A., Weingart, J., Brem, H, Quinones-Hinojosa, A., Gallia, G., Rigamonti, D., Lim, M. Adjuvant stereotactic radiosurgery following surgical resection of cerebral metastases improves tumor control rates. Submitted.

67. Bhutiani, N., Pradilla, G., Batra, S., Bender, M., See, A.P., Garzon-Muvdi, T., James, C., Carson, B.S., Lim, M. Safety and efficacy of secondary microvascular decompressions as treatment for recurrent trigeminal neuralgia. Submitted.

68. Raza, S.M., Garzon-Muvdi, T., Pradilla, G., Boahene, K., Quinones-Hinojosa, A. Combined Endonasal - Transorbital Approach to the Skull Base: A Single Stage Minimally Invasive Technique for Anterior Cranial Fossa Pathology. Submitted. 69. Chaichana, K., Molina, C., Pradilla, G., Huang, J., Coon, A.L. MCA

fenestration masking as an aneurysm on several imaging modalities. Submitted. 70. Bow, H., Amin, A.G., Thurston, J., Lim, M., Gallia, G., Jallo, G.I., Pradilla, G.

Use of the NICO myriad for endoscopic resection of colloid cysts. Submitted. 71. Ruzevick, J., Raza, S.M., Recinos, P.F., Chaichana, K., Pradilla, G., Olivi, A.,

Weingart, J.D., Evans, J., Quinones-Hinojosa, A., Lim, M. Technical Note: orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies. Submitted.

72. Roy, A.K., Miller, B.A., Holland, C.M., Fountain, A.J., Pradilla, G., Ahmad, F.U. Magnetic Resonance Imaging of Traumatic Injury to the Cranio-vertebral Junction: A Case-Based Review. Submitted.


73. McCracken, D.J., Pradilla, G., Barrow, D.L. Intracranial blister aneurysms. Submitted. 74. Pradilla, G., Barrow, D.L. Commentary for “Normal perfusion pressure breakthrough theory: A reappraisal after 35 years”. Submitted.

EDITED BOOKS 1. Editors: Jallo, G. Korthbauer, K., Pradilla, G., Controversies in Pediatric

Neurosurgery. First Edition. Thieme Medical Publishers, New York, NY. 2010. ISBN (Americas): 1604060743, ISBN (EUR, Asia, Africa, AUS): 978-1604060744

BOOK SECTION EDITOR 1. Section Editor: Neurosurgical infection. In Handbook of Neurosurgery, First

Edition, Ed. D. Rigamonti, Baltimore, MD, 2010. Imperial College Press, London, UK. In press.

BOOK CHAPTERS 1. Pradilla, G., Lesniak, M. S., and Tamargo, R. J. Pediatric intracranial aneurysms.

In Current Management in Child Neurology, Third Edition. Ed. B. L. Maria. Hamilton, Ontario: B. C. Decker Inc., chapter 90: 2004. ISBN 1-5509-292-8

2. Bagley, C., Mavinkurve, G., Pradilla, G., Jallo, G. Advances of

Hydrocephalus Management in Spina Bifida Patients. In Trends in Spina Bifida Research. First Edition. Ed. Mario R. Zesta. 2005, Nova Science Publishers, Inc., Hauppauge, NY. ISBN: 9-781-5945-44-132

3. Thai, Q.A., Pradilla, G., Rigamonti, D. Capillary Telangiectasias, Cavernous Malformations, and Developmental Venous Anomalies: Different Expressions of the Same Disease Process? In Cavernous Malformations of the Brain and Spinal Cord. First edition. Ed. G. Lanzino, R. Spetzler, 2008, Thieme Medical Publishers, New York, NY. ISBN 1-588-903-435

4. Pradilla, G., Thai Q.A., Tamargo R.J. Animal models of subarachnoid

hemorrhage. In Acute Stroke: Bench to Bedside. First edition. Ed. A. Bhardwaj, N. Alkayed, J. Kirsch, and R. Traystman. Marcel Decker, Taylor, & Francis Books, Inc., New York, NY, 2006. ISBN: 0-849-3987-0

5. Thai, Q.A., Pradilla, G., Rigamonti, D. Surgical management of aneurysmal

subarachnoid hemorrhage. In Acute Stroke: Bench to Bedside. First edition. Ed. A. Bhardwaj, N. Alkayed, J. Kirsch, and R. Traystman. Marcel Decker, Taylor, & Francis Books, Inc., New York, NY, 2006. ISBN: 0-849-3987-0


6. Pradilla, G., Thai, Q.A., Gailloud, P., Tamargo, R.J. Central Nervous System vascular malformations. In Current Management in Child Neurology, Fourth Edition. Ed. B. L. Maria. Hamilton, Ontario: B. C. Decker Inc., chapter 90: 2007. ISBN: 1-607-9500-06

7. Pradilla, G., Sciubba, D.M., Jallo, G. Antibiotic coated-catheters for treatment of

pediatric hydrocephalus. In Controversies in pediatric neurosurgery. Ed. G. Jallo, K. Korthbauer, G. Pradilla. Thieme Medical Publishers, New York, NY. 2010. ISBN: 1-604-0607-43

8. Chaichana, K. L., G. Pradilla, and R. J. Tamargo. Pediatric intracranial

aneurysms. In Current Management in Child Neurology - Fourth Edition. Ed. B. L. Maria. Shelton, Connecticut: B.C. Decker, Inc. / People’s Medical Publishing House, chapter 104: 726-732, 2009. ISBN: 1-607-9500-06

9. Pradilla, G., Q.A. Thai, P. Gailloud, and R. J. Tamargo. Central nervous system

vascular malformations. In Current Management in Child Neurology - Fourth Edition. Ed. B. L. Maria. Shelton, Connecticut: B.C. Decker, Inc. / People’s Medical Publishing House, chapter 103: 715-725, 2009. ISBN: 1-607-9500-06

10. Hoang, S., Pradilla, G. Pathogenesis and management of Cerebral Abscesses. In

Handbook of Neurosurgery – First Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press.

11. Hoang, S., Pradilla, G. Post-operative meningitis. In Handbook of Neurosurgery

– First Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press. 12. Bi, W.L., Pradilla, G. Osteomyelitis of the skull and spine. In Handbook of

Neurosurgery – First Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press.

13. Mehta, V.A., Pradilla, G. Shunt infections. In Handbook of Neurosurgery – First

Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press. 14. Momin, E., Pradilla, G. Subdural empyemas. In Handbook of Neurosurgery –

First Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press. 15. Mehta, V.A., Pradilla, G. Cranial and spinal wound infections. In Handbook of


16. Jackson, C., Pradilla, G. Cavernous malformations. In Handbook of


17. Jackson, C., Pradilla, G., Ahn, E. Pediatric Cerebrovascular Disorders. In


Handbook of Neurosurgery – First Edition. Ed. D. Rigamonti. Imperial College Press, London, UK. In press.

18. Pradilla, G., Solero, C., DiMeco, F. Parasagittal meningiomas. In Meningiomas.

Ed. Al-Mefty, O., McDermott, M.W., DeMonte, F. Second Edition. Thieme Medical Publishers, New York, NY, USA. 2011. ISBN: 1604060530

19. Pradilla, G., Garzon-Muvdi, T., Tamargo, R.J. Far-Lateral Transcondylar

Approaches. In Contemporary Skull Base Surgery – First Edition. Ed. Alfredo Quinones-Hinojosa. Plural publishing. 2010. ISBN: 1597563595.

20. Pradilla, G., Garzon-Muvdi, T., Tamargo, R.J. Surgical Management of

Infratentorial Arteriovenous Malformations. Chapter 82. In Schmidek & Sweet, Operative Neurosurgical Techniques: Indications, Methods, and Results – Sixth Edition. Elsevier Publishers, Philadelphia, PA, 2012. ISBN: 1416068392.

21. Pradilla, G., Pradilla, I.F., Pardo-Villamizar, C.A. Intracranial Abscess and other

purulent intracranial infections. Chapter 38, Unit 3, Pages 487-496. In Textbook Fundamentals in Medicine - Infectious Diseases – 7th Edition, Corporation for Biological Investigation, Medellin, Colombia. 2014.

22. Pradilla, G., Morcos, J.J. Need for gross total resection of cranial base

meningiomas. Section VII, Chapter 32, In Controversies in Neuro-Oncology: Best Evidence Medicine for Brain Tumor Surgery – First Edition. Ed. Quiñones- Hinojosa, A., Raza, S.M. Thieme Medical Publishers, New York, NY. 2014.

ISBN: 9781604067552 23. Chaichana, K., Pradilla, G., Tamargo R.J. Neuroimaging assessment of cerebral

vasospasm. In Animal Models of Acute Neurological Injuries II. Second edition. Ed. Chen, J.; Xu, X.; Xu, Z. Humana Press/Springer. ISBN: 978-1-60327-184-4. New York, NY, 2012.

24. Tyler, B.M., Pradilla, G., Hadelsberg, U., Bow, H., Suk, I., Brem, H. Treatment

of Brain Tumors. In Focal Controlled Drug Delivery. First Edition. Part II, pages 169-194. Ed. Domb, A.J., Khan, W. Springer, New York, NY, 2014.

ISBN: 978-1-4614-9433-1 25. Johnson, J.N., Pradilla, G., Morcos, J.J. The role of the neurosurgeon in the

treatment of cerebral ischemia. In Current Progress in Neurosurgery, Vol 1. First Edition. 2014. Ed. Misra, B.K. In press.

26. Mangravitti, A., Pradilla, G., Schildhaus, N., Tyler, B.M. Rodent models of

central nervous system tumors. In Rodents: Evolution, Classification and Role in Human Health and Well-Being. 2014, in press.


27. Pradilla, G., Turan, N., Barrow, D.L. Internal Carotid Artery Supraclinoid Aneurysms. In Atlas of Neurosurgical Techniques, Brain. 2nd Edition, Thieme Medical Publishers Inc., New York, NY. Ed. Sekhar, L.N., Fessler, R.G. 2014 in press. SCIENTIFIC ABSTRACTS 1. Ziai WC, Pradilla G, Razumovsky AY. Diagnosis of cerebral vasculitis: Role of

transcranial Doppler sonography. 25th Meeting of the American Society of Neuroimaging, Tampa, FL, March 7-10, 2002.

2. Frazier JL, Pradilla G, Wang PP, Berry D, Tyler B, Langer R, Brem H.

Intracranial delivery of DNA to brain tumor cells using biodegradable polymers. 52nd Meeting of the Congress of Neurological Surgeons, Philadelphia, PA, September 21-26, 2002.

3. Frazier JL, Wang PP, Pradilla G, Tyler B, Brem H, Weingart JD. Local

intracranial delivery of minocycline for the treatment of 9l gliosarcoma. 52nd Meeting of the Congress of Neurological Surgeons, Philadelphia, PA, September 21-26, 2002.

4. Pradilla G, Petrangolini G, Legnani FG, Tyler B, Francescato P, Chillemi F,

Brem H, Olivi A, Di Meco F. Inhibition of angiogenesis in vitro and in vivo by local delivery of a novel endostatin fragment. Proceedings of the 94th Meeting of the American Association for Cancer Research, Volume 44, 2nd Edition, Abstract # 1652, pg 324, Washington, D.C., July 11-14, 2003.

5. Pradilla G, Wang PP, Frazier JL, Carinci A, Tamargo RJ. Measuring the kinetics

of controlled release polymers within a rabbit model of subarachnoid hemorrhage. Annual Meeting of the Joint AANS/CNS Section on Cerebrovascular Surgery, Phoenix, AZ, February 3-6, 2003.

6. Pradilla G, Wang PP, Frazier JL, Carinci A, Legnani FG, Tamargo RJ.

Pharmacokinetics of controlled release polymers in the subarachnoid space for the treatment of chronic vasospasm after subarachnoid hemorrhage. 8th International conference on cerebral vasospasm, Chicago, IL, July 9-12, 2003.

7. Pradilla G, Kretzer RM, Carinci A, Wang PP, Frazier JL, Ogata L, Gebremariam

A, Dietsch GN, Tamargo RJ. Anti-cd11/cd18 monoclonal antibody therapy prevents vasospasm after subarachnoid hemorrhage in rabbits. 8th International Conference on Cerebral Vasospasm, Chicago, IL, July 9-12, 2003.

8. Pradilla G, Clatterbuck RE, Tierney T, Wang PP, Gailloud P, Murphy KP,

Tamargo RJ. Local delivery of nitric oxide donors via controlled release polymers prevents vasospasm after subarachnoid hemorrhage: Efficacy and toxicity studies


in primates. 8th International Conference on Cerebral Vasospasm, Chicago, IL, July 9-12, 2003.

9. Frazier JL, Pradilla G, Wang PP, Tamargo RJ. Inhibition of experimental

cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit subarachnoid hemorrhage model. 8th International Conference on Cerebral Vasospasm, Chicago, IL, July 9-12, 2003.


A, Dietsch GN, Tamargo RJ. Treatment with an anti-CD11/CD18 monoclonal antibody prevents chronic vasospasm in a rabbit subarachnoid hemorrhage model.

Neurosurgery 2003 Aug; 53 (2): 702. 53rd Meeting of the Congress of Neurological Surgeons, Denver, CO, October 18-23, 2003.

11. Frazier J, Pradilla G, Wang PP, Tamargo RJ. Intracranial delivery of ibuprofen

from a controlled-release polymer prevents chronic vasospasm in a rabbit subarachnoid hemorrhage model. 53rd Meeting of the Congress of Neurological Surgeons, Denver, Colorado, October 18-23, 2003. Neurosurgery 2003 Aug; 53 (2): 816.

12. Wang PP, Pradilla G, Ziewacz JE, Winter J, Li KW, Gabikian P, Magee C, Brem

H, Walter KA. Local Intracranial Delivery of Paclitaxel with the PACLIMER Delivery System: A Dose-Escalation Toxicity Study in a Canine Model. 53rd Meeting of the Congress of Neurological Surgeons, Denver, Colorado, October 18-23, 2003.


A, Dietsch GN, Legnani FG, Tamargo RJ. Treatment with an anti-CD11/CD18 monoclonal antibody prevents post-hemorrhagic vasospasm in a rabbit model of subarachnoid hemorrhage. XII European Congress of Neurosurgery, Lisbon, Portugal, September 7-12, 2003.

14. Pradilla G, Clatterbuck RE, Tierney T, Wang PP, Gailloud P, Murphy KP,

Tamargo RJ. Prevention of subarachnoid hemorrhage induced vasospasm with local delivery of a nitric oxide donor via controlled release polymers: Efficacy and toxicity studies in primates. XII European Congress of Neurosurgery, Lisbon, Portugal, September 7-12, 2003.

15. Pradilla G, Petrangolini G, Legnani FG, Tyler B, Francescato P, Chillemi F,

Brem H, Olivi A, Di Meco F. Intracranial delivery of a novel endostatin fragment for treatment of 9L gliosarcoma in rats. XII European Congress of Neurosurgery, Lisbon, Portugal, September 7-12, 2003

16. Tamargo R J, Pradilla G, Wang PP, Legnani FG, Ogata L, Dietsch GN. Anti-

CD11/CD18 monoclonal antibody prevents vasospasm after subarachnoid


hemorrhage in rabbits. American Academy of Neurological Surgery, Williamsburg, VA, October 29-November 1, 2003.

17. Tamargo RJ, Clatterbuck RE, Tierney T, Pradilla G, Wang PP, Gailloud P,

Murphy KP. Polymeric controlled release of a nitric oxide donor in the subarachnoid space prevents vasospasm after subarachnoid hemorrhage in monkeys: Efficacy and toxicity studies. 56th Meeting of the Neurosurgical Society of America, Sunriver Resort, CO, June 8-11, 2003.

18. Ziai WC, Stevens RD, Pradilla G, Bhardwaj A, Mirski M. C-reactive protein in

subarachnoid hemorrhage. 33rd Critical Care Congress, Orlando, FL, February 20-25, 2004. Crit Care Med, 2003 Dec; 31 (12) Suppl. Part 2: 46.

19. Pradilla G, Legnani FG, Hsu W, Goodwin C, Recinos P, Tyler B, Olivi A, Brem

H. Lactacystin prolongs survival of animals in the 9L gliosarcoma model when locally delivered via controlled-release polymers. Annual Meeting of the Southern Neurosurgical Society, Amelia Island, FL, March 24-28, 2004.

20. Thai QA, Pradilla G, Legnani FG, Kretzer RM, Hsu W, Tamargo RJ. Lysis of

intraparenchymal hematoma with stereotactically implanted tPA polymers in a rabbit model. Agustus McCravey Award of the Southern Neurosurgical Society. Annual Meeting of the Southern Neurosurgical Society, Amelia Island, FL, March 24-28, 2004.

21. Thai QA, Pradilla G, Legnani FG, Hsu W, Recinos P, Kretzer RM, Wang PP,

Tamargo RJ. Prevention of experimental post-hemorrhagic vasospasm with delayed intracranial delivery of nitric oxide-loaded polymers in a rabbit model. Annual Meeting of the Southern Neurosurgical Society, Amelia Island, FL, March 24-28, 2004.

22. Legnani FG, Pradilla G, Raza SM, Zamora G, Tyler B, Brem H, Di Meco F,

Olivi A. Verapamil administration decreases resistance to mitoxantrone therapy in malignant gliomas and pro-metastatic tumor cell lines in vitro. Annual Meeting of the American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004.

23. Hsu W, Pradilla G, Goodwin C, Legnani FG, Tyler B, Raza SM, Vick J, Olivi A,

Brem H. Local delivery of lactacystin via controlled release polymers prolongs survival in a 9L gliosarcoma model. Annual Meeting of the American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004.

24. Goodwin C, Pradilla G, Vargas D, Raza SM, Legnani FG, Tyler B, Brem H,

Olivi A. Fas-ligand mediates cytotoxicity of peri-tumoral t-lymphocytes in the 9L gliosarcoma model. Annual Meeting of the American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004.


25. Amundson E, Pradilla G, Bastianos P, Brem H, Gokaslan Z. A novel rabbit model of spinal metastasis in rabbits using the VX-2 carcinoma. Annual Meeting of the American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004.

26. Pradilla G, Hsu W, Kretzer RM, Recinos P, Thai QA, Legnani FG, Tamargo RJ.

Local delivery of thrombolytics by controlled-release polymers for the treatment of intracerebral hemorrhage. Meeting of the American Association of Neurological Surgeons, Orlando, FL, May 1-6, 2004. J Neurosurg, 2004 April;100 (4): 791-791.

27. Tamargo RJ, Pradilla G, Wang PP, Legnani FG, Ogata L, Dietsch GN. Anti- CD11/CD18 monoclonal antibody therapy prevents vasospasm after subarachnoid hemorrhage in rabbits. Fifty-seventh (2004) Annual Meeting of the Neurosurgical Society of America, El Dorado, Santa Fe, New Mexico, June 6-9, 2004. 28. Olivi A, Legnani FG, Pradilla G, Tyler BM, Chillemi F, DiMeco F. Local

delivery of a fragment of human endostatin combined with systemic administration of BCNU prolongs survival in a rodent experimental glioma model. Joint Meeting of the American Academy of Neurological Surgery, the German Academy of Neurosurgery and the German Society of Neurosurgery, Dresden, Germany October 5–8, 2004.

29. Pradilla G, Wang PP, Legnani FG, Frazier JL, Thai QA, Tamargo RJ. Local

delivery of drugs to the subarachnoid space for treatment of vasospasm is not affected by presence of blood in the rabbit model of subarachnoid hemorrhage. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

30. Pradilla G, Legnani FG, Tyler BM, Gaini S, Chillemi F, Francescato P, Brem H,

Olivi A, DiMeco F. Combined treatment of systemic BCNU and a locally delivered anti-angiogenic fragment of human endostatin prolong survival in rats challenged intracranially with 9L gliosarcoma. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

31. Legnani FG, Zamora G, Pradilla G, Hertig S, Tyler BM, Gaini S, DiMeco F,

Brem H, Olivi A. The angiogenesis inhibitor minocycline significantly enhances the cytotoxicity of carboplatin on cell lines of malignant gliomas and CNS metastatic tumors. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

32. Legnani FG, Hertig S, Pradilla G, Zamora G, Tyler BM, Gaini S, DiMeco F,

Brem H, Olivi A. Epirubicin inhibits growth in malignant glioma and CNS pro-metastatic tumor cell lines in vitro. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.


33. Legnani FG, Pradilla G, Goodwin C, Vargas DL, Tyler BM, Gaini S, DiMeco F, Brem H, Olivi A. T-cell apoptosis surrounding malignant gliomas could be related to decreased anti-tumor immunity and might be caused by tumor-derived Fas ligand in the 9L gliosarcoma model. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

34. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Brem H, Jallo GI. A novel

intramedullary spinal cord tumor model in rabbits. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

35. Pradilla G, Legnani FG, Hsu W, Tyler BM, Gaini S, DiMeco F, Olivi A, Brem H.

The proteasome inhibitor lactacystin prolongs survival in animals intracranially challenged with 9L gliosarcoma when delivered locally via controlled-release polymers. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

36. Brem S, Tyler BM, Pradilla G, Legnani FG, Brem H. Local delivery of

temozolomide for treatment of 9L gliosarcoma in rats. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

37. Mantha A, Legnani FG, Pradilla G, Tyler BM, Brem H, Gokaslan Z. A novel

model of intra-osseous spinal metastatic tumors in rats. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

38. Pradilla G, Thai QA, Legnani FG, Tamargo RJ. Frontozygomatic titanium

cranioplasty prevents aesthetic defects of the frontozygomatic fossa after pterional craniotomy. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

39. Pradilla G, Thai QA, Legnani FG, Hsu W, Kretzer RM, Wang PP, Tamargo RJ.

Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

40. Pradilla G, Thai QA, Legnani FG, Clatterbuck RE, Gailloud P, Murphy KPJ,

Tamargo RJ. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

41. McGirt MJ, Pradilla G, Lynch JR, Legnani FG, Perez M, Tamargo RJ,

Clatterbuck RE, Laskowitz DT. Simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: A dose response effect dependent on endothelial nitric oxide synthase (eNOS). Galbraith Award of the joint AANS/CNS Cerebrovascular Section. 54th Meeting of the Congress of


Neurological Surgeons, San Francisco, CA, October 16-21, 2004. Neurosurg, 2004 August; 55 (2): 473-474 A764.

42. Thai QA, Pradilla G, Wang PP, Tamargo RJ. Intraoperative angiographically-

assisted localization for small vascular malformations: Technical Note. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

43. Thai QA, Pradilla G, Tamargo RJ. Contralateral approaches to bilateral

aneurysms: Case Series. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

44. Thai QA, Raza S, Pradilla G, Tamargo RJ. Aneurysmal rupture without

subarachnoid hemorrhage: Case Series and Literature Review. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

45. Thai QA, Pradilla G, Legnani FG, Kretzer RM, Hsu W, Tamargo RJ. Lysis of

intraparenchymal hematoma with stereotactically implanted tPA polymers in a rabbit model. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

46. Thai QA, Pradilla G, Legnani FG, Brem H, Tamargo RJ. Stereotactic

implantation of controlled-release “string” polymers in a human head: Technical Report. 54th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2004.

47. Thai QA, Pradilla G, Wang PP, Tamargo RJ. Intraoperative angiographically-

assisted localization for small vascular malformations: technical note. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.

48. Thai QA, Pradilla G, Tamargo RJ. Contralateral approaches to bilateral

aneurysms: Case Series. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.

49. Thai QA, Raza S, Pradilla G, Tamargo RJ. Aneurysmal rupture without

subarachnoid hemorrhage: Case Series and Literature Review. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.

50. Thai QA, Pradilla G, Legnani FG, Hsu W, Kretzer RM, Tamargo RJ.

Stereotactically implanted tPA polymers effectively lysed intraparenchymal hematomas in a rabbit model. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual symposium, Baltimore, MD, November 30th, 2004.


51. Thai QA, Pradilla G, Legnani FG, Brem H, Tamargo RJ. Stereotactic

implantation of controlled-release “string” polymers in a human head: Technical Report. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.

52. Pradilla G, Thai QA, Legnani FG, Clatterbuck RE, Gailloud P, Murphy KPJ,

Tamargo RJ. Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.


Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium, Baltimore, MD, November 30th, 2004.

54. Hertig S, Legnani FG, Pradilla G, Zamora G, Thai QA, Tyler BM, Gaini SM,

DiMeco F, Brem H, Olivi A. Epirubicin has potent anti-glioma activity and shows sustained-release when incorporated into a biodegradable controlled-release polymer in vitro. Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium. Baltimore, MD, November 30, 2004.

55. Legnani FG, Pradilla G, Thai QA, Vargas DL, Tyler BM, Zamora G, Gaini SM,

DiMeco F, Brem H, Olivi A. Local delivery of verapamil decreases Multi-Drug Resistance in a novel mitoxantrone resistant tumor model in rats Abstracts of the Johns Hopkins Hospital Anesthesia and Critical Care Medicine 6th Annual Symposium. Baltimore, MD, November 30, 2004.

56. Mavinkurve G., Pradilla G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib

A, Bagley CA, Brem H, Jallo G. A novel rat model for intramedullary spinal cord glioma. AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, CA, December 8 – 11, 2004.

57. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib

A, Bagley CA, Brem H, Jallo G. A novel model of primary spinal cord tumors in rabbits: Functional, Radiological and Histopathological characterization. AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, CA, December 8 – 11, 2004.

58. Pradilla G, Mavinkurve G, Legnani FG, Tyler BM, Gosalia N, Pindrik J, Hdeib

A, Bagley CA, Brem H, Jallo G. Toxicity and efficacy study of locally-delivered chemotherapy in a novel rat model of intramedullary spinal cord tumors.


AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, CA, December 8 – 11, 2004.

59. Zamora-Berridi G, Legnani FG, Pradilla G, Hertig S, Tyler BM, Brem H, Olivi

A. Cytotoxicity and in vivo safety of carboplatin and minocycline for the treatment of malignant gliomas. AANS/CNS Section on Pediatric Neurological Surgery Annual Meeting, San Francisco, CA, December 8 – 11, 2004.

60. Thai QA, Pradilla G, Wang PP, Tamargo RJ. Localization of small vascular

malformations with a radio-opaque wire localizer: Technical Note. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

61. Thai QA, Pradilla G, Tamargo RJ. Treatment of bilateral aneurysms using a

unilateral craniotomy: Case Series. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

62. Thai QA, Raza SM, Pradilla G, Tamargo RJ. Aneurysmal rupture presenting

only with intraparenchymal or intraventricular hemorrhages: Case Series and Literature Review. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.


Stereotactically implanted tPA polymers effectively lysed intraparenchymal hematomas in a rabbit model. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

64. Thai QA, Pradilla G, Legnani FG, Hsu W, Brem H, Tamargo RJ. “String”

polymer implantation in a human cadaver head using stereotactic techniques: Technical Report. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

65. Pradilla G, Thai QA, Legnani FG, Tamargo RJ. Aesthetic defects of the fronto-

zygomatic fossa after pterional craniotomy can be prevented using a frontozygomatic titanium cranioplasty. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

66. Pradilla G, Thai QA, Legnani FG, Hsu W, Clatterbuck RE, Gailloud P, Murphy

KP, Tamargo RJ. Ibuprofen polymers placed in the subarachnoid space prevent angiographic vasospasm after subarachnoid hemorrhage in monkeys. Joint


Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.


The nitric-oxide donor DETA-NO prevents vasospasm in a rabbit model of SAH when administered in a delayed fashion via controlled-release polymers. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005.

68. Pradilla G, Thai QA, Legnani FG, Raman SP, Hdeib A, McGirt MJ, Tamargo RJ,

Clatterbuck RE. Delayed administration of simvastatin prevents cerebral vasospasm in a rabbit model of subarachnoid hemorrhage. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA, February 1-4, 2005. J Neurosurg, 2005 February; 102 (2): 423-424.


Experimental intraparenchymal hematoma thrombolysis using controlled-release tissue plasminogen activator polymers. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

70. Thai QA, Raza SM, Pradilla G, Tamargo RJ. Aneurysmal ruptures presenting

without subarachnoid hemorrhage: Case Series and Literature Review. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

71. Hertig S, Legnani FG, Pradilla G, Zamora G, Thai QA, Tyler BM, Gaini SM,

DiMeco F, Brem H, Olivi A. Epirubicin has potent anti-glioma activity and shows sustained-release when incorporated into a biodegradable controlled-release polymer in vitro. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

72. Legnani FG, Pradilla G, Thai QA, Vargas DL, Tyler BM, Zamora G, Gaini SM,

DiMeco F, Brem H, Olivi A. Local delivery of verapamil decreases Multi-Drug Resistance in a novel mitoxantrone resistant tumor model in rats. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

73. Legnani FG, Pradilla G, Goodwin C, Vargas DL, Xia S, Tyler BM, Gaini SM,

DiMeco F, Brem H, Olivi A. Direct activation of the wild-type Fas Receptor fails to induce apoptosis in experimental gliomas in vitro. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

74. Hdeib A, Pradilla G, Mavinkurve G, Legnani FG, Caplan JM, Williams T,

Bagley CA, Brem H, Jallo G. Safety of locally delivered chemotherapy for


experimental intramedullary spinal cord tumors in rabbits. 73rd Annual Meeting of the AANS, New Orleans, LA, April 16-25, 2005.

75. Caplan JM, Pradilla G, Legnani FG, Hdeib A, Williams T, Mavinkurve G,

Bagley CA, Brem H, Jallo G. Experimental intramedullary gliomas in rats: functional progression and histopathological characterization. 73rd Annual Meeting of the AANS, New Orleans, LA, April 16-25, 2005.

76. Fiorindi A, Legnani FG, Tyler BM, Pradilla G, Perin A, Longatti P, Brem H,

Olivi A. Oral administration of GPI 15427 in association with BCNU polymer in the treatment of intracranial 9L rat gliosarcoma. 73rd Annual meeting of the AANS, New Orleans, LA, April 16-25, 2005.

77. Pradilla G, Hdeib A, Legnani FG, Williams T, Tyler BM, Caplan JM, Bagley C,

Brem H, Jallo G. Locally delivered OncoGel (1.5-mg/ml Paclitaxel) is safe for intramedullary injections and significantly prolongs onset of paraparesis in a rat model of intramedullary spinal cord tumors. 73rd Annual Meeting of the AANS, New Orleans, LA, April 16-25, 2005.

78. Fowers K, Brem H, Brugge W, Hdeib A., Jallo G, Pradilla G, Tyler B, Callahan

K. Preclinical and clinical development of a physically targeted controlled Paclitaxel release product, OncoGel, for local solid tumor management. 12th International Symposium on recent advances in drug delivery systems, Salt Lake City, Utah, February 21-24, 2005.

79. Legnani FG, Pradilla G, Thai QA, Tyler BM, Zamora G, DiMeco F, Brem H,

Olivi A. The Fas/Fas ligand pathway fails to induce apoptosis in experimental glioma cells and could be responsible for the apoptosis of T-cell surrounding malignant gliomas in vivo. 6th Meeting of the European Association for NeuroOncology, Edinburgh, United Kingdom, May 5-8, 2005.

80. Legnani FG, Pradilla G, Thai QA, Tyler BM, Zamora G, DiMeco F, Brem H,

Olivi A. Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. 6th Meeting of the European Association for NeuroOncology, Edinburgh, United Kingdom, May 5-8, 2005.

81. Caplan J, Hdeib A, Pradilla G, Tyler BM, Brem H, Jallo G. Local delivery of

paclitaxel from the Paclimer® delivery system for the treatment of intramedullary spinal cord tumors in an experimental rat model. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

82. Caplan J, Hdeib A, Pradilla G, Tyler BM, Brem H, Jallo G. A Novel Model of

Infiltrative Intramedullary Spinal Cord Tumors in Rats: Functional Progression and Histopathological Characterization. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.


83. Hdeib A, Caplan J, Pradilla G, Tyler BM, Brem H, Jallo G. Local Delivery of

Paclitaxel with the OncoGel® delivery system for the Treatment of Intramedullary Spinal Cord Tumors in an Experimental Rodent Model. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

84. Hdeib A, Caplan J, Pradilla G, Tyler BM, Brem H, Jallo G. Locally Delivered

OncoGel against an Established 9L Intramedullary Spinal Cord Gliosarcoma Delays the Onset of Paresis in an Experimental Rodent Model. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

85. Tyler BM, Brem S, Caplan J, Hdeib A, Legnani FG, Pradilla G, Brem H.

Validation of an Experimental Malignant Glioma Model with Temozolomide and Radiation Therapy. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

86. Pradilla G, Basu S, Thai QA, Hdeib A, Legnani FG, Tamargo RJ, Clatterbuck

RE. Simvastatin administration reverses cerebral vasospasm in rabbits by increasing endothelial nitric oxide synthase (eNOS) expression. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

87. Pradilla G, Vargas DL, Thai QA, Legnani FG, Clatterbuck RE, Mankowski JL,

Pardo CA, Tamargo RJ. Endothelial expression of ICAM-1and VCAM-1 after subarachnoid hemorrhage in monkeys treated with locally-delivered ibuprofen. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

88. Recinos PF, Pradilla G, Thai QA, Hdeib A, Legnani FG, Clatterbuck RE,

Tamargo RJ. Lipopolysaccharide (LPS)-induced cerebral vasospasm is comparable to SAH-induced vasospasm in rabbits. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

89. Raza SM, Thai QA, Jabbour SK, Pradilla G, Kleinberg LR, Wharam MD,

Rigamonti D. Fractionated stereotactic radiosurgery for large intracranial arteriovenous malformations. 55th Meeting of the Congress of Neurological Surgeons, Boston, MA, October 8-13, 2005.

90. Jabbour SK, Raza SM, Thai QA, Pradilla G, Kleinberg LR, Wharam MD,

Rigamonti D. Fractionated stereotactic radiosurgery for large intracranial arteriovenous malformations. 46th meeting of the American Society of Therapeutic Radiation Oncology (ASTRO), Denver, CO, October 16-20, 2005.

91. Raza SM, Thai QA, Jabbour SK, Pradilla G, Kleinberg LR, Wharam MD,

Rigamonti D. Fractionated stereotactic radiosurgery for large intracranial


arteriovenous malformations. 7th International Stereotactic Radiosurgery Society Congress, Brussels, Belgium, September 11-15, 2005.

92. Caplan J, Hdeib A, Pradilla G, Tyler BM, Legnani FG, Pennant W, Volkov A,

Brem H, Jallo G. 20Gy single and fractionated radiotherapy dose schedules prolong paresis-free survival in an experimental rat intramedullary spinal cord tumor model. Annual meeting of the AANS/NCS pediatric neurosurgery joint section, Birmingham, AL

93. Caplan JM, Hdeib A, Pradilla G, Tyler BM, Legnani FG, Pennant W, Volkov A,

Brem H, Jallo G. Microsurgical resection improves hind-limb function until onset of paresis in an experimental intramedullary spinal cord tumor. Annual meeting of the AANS/NCS pediatric neurosurgery joint section, Birmingham, AL

94. Recinos PF, Pradilla G, Thai QA, Hdeib A, Perez M, Legnani FG, Clatterbuck

RE, Tamargo RJ. Controlled-release of lipopolysaccharide in the subarachnoid space of rabbits induces chronic vasospasm. Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, Orlando, FL, February 17-20, 2006.

95. Legnani, FG, Hertig, S, Vick J, Pradilla G, Tyler BM, Li K, DiMeco F, Brem H,

and Olivi A. Epirubicin inhibits growth in malignant glioma and CNS pro-metastatic tumor cell lines both in vitro and in vivo. Oral presentation, 5th Annual International Neuro-Oncology Update, Memphis, TN, August 24-25, 2006.

96. Legnani FG, Pradilla G, Thai QA, Tyler BM, DiMeco F, Brem H, and Olivi A.

Apoptosis in experimental glioma cells and could be responsible for the apoptosis of T-cell surrounding malignant gliomas in vivo. Poster presentation, 5th Annual International Neuro-Oncology Update, Memphis, TN, August 24-25, 2006.

97. Caplan J, Hdeib A, Pradilla G, Tyler BM, Brem H, and Jallo G. A Novel Model

of Intramedullary Spinal Cord Tumors and Novel Approaches to their Treatment. Oral presentation, 5th Annual International Neuro-Oncology Update, Memphis, TN, August 24-25, 2006.

98. Pennant WA, Caplan JM, Reidler JA, Hdeib A, Pradilla G, Tyler BM, Brem H,

and Jallo GI. 20 Gy Radiotherapy Prolongs Paresis-Free Survival alone and in Combination with Locally Delivered Paclitaxel (OncoGel®) in an Experimental Rat Intramedullary Spinal Cord Tumor Model. Oral presentation, 5th Annual International Neuro-Oncology Update, Memphis, TN, August 24-25, 2006.

99. Li, K.W., Siu, I., Tyler, B.M., Han, J., Renard, V.M., Pradilla, G., Pardoll, D.,

Brem, H. Stat-3 Inhibition by Liposomal siRNA for the Treatment of Rodent Gliomas. Presented at the 74th Annual meeting of the AANS, Washington, D.C., April 14-19, 2007.


100. Pendleton, C., Zaidi, H., Pradilla, G., Cohen-Gadol, A., Quinones- Hinojosa, A., Dr. Harvey Cushing's Radical Attempt at Human Pituitary Transplantation. Presented at the 11th International Pituitary Congress, Washington, D.C., June 13-15, 2009.

101. Germanwala, A. V., Thai, Q.A., Pradilla, G., Tamargo, R.J. Simple technique for

intraoperative angiographic localization of small vascular lesions. 62nd Annual Meeting of the Neurosurgical Society of America, The Homestead, Hot Springs, Virginia, June 7-10, 2009

102. Jackson, C., Pradilla, G., Rigamonti, D., Lim, M. Adjuvant stereotactic

radiosurgery increases tumor control rates in patients with cerebral metastases after surgical resection. 15th Annual Scientific Meeting of the Society for Neuro-Oncology, Montreal, Canada, November 18-21, 2010.

103. Zhang, K., Huang, Y., Pradilla, G., Tyler, B., Kang, J.U. Real-time intra-

operative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. Optical Techniques in Neurosurgery, Brain Imaging, and Neurobiology Conference, SPIE BiOS: Biomedical Optics Symposium, San Francisco, CA, January 22-27, 2011.

104. Pradilla, G., Garzon-Muvdi, T., Momin, E.N., Thompson, R.C., Tamargo, R.J.

Systemic L-Citrulline administration is safe and decreases symptomatic cerebral vasospasm in Haptoglobin transgenic mice after SAH. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010.

105. Garzon-Muvdi, T., Pradilla, G., Grossman, R., Riggins, G.J., Tamargo, R.J. The glutamate receptor inhibitor, S-4-Carboxyphenylglicine (S-4-CPG), crosses the blood brain barrier (BBB) in a murine model of subarachnoid hemorrhage (SAH). 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 106. Pradilla, G., Garzon-Muvdi, T., Khan, H., Momin, E.N., Pardo-Villamizar, C., Tamargo, R.J. ICAM-1 and VCAM-1 upregulation in transgenic haptoglobin mice after experimental SAH. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 107. Pradilla, G., Garzon-Muvdi, T., Khan, H., Momin, E.N., Pardo-Villamizar, C., Tamargo, R.J. Expression of the Pro-inflammatory Cytokine IL-1a in a Murine Transgenic Haptoglobin model of SAH. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 108. Garzon-Muvdi, T., Pradilla, G., Khan, H., Momin, E.N., Pardo-Villamizar, C., Tamargo, R.J. Differential expression of the regulatory cytokine IL-10 in a mouse model of subarachnoid hemorrhage with different haptoglobin genotypes 1-1 and 2-2. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA,


October 16-21, 2010. 109. Garzon-Muvdi, T., Pradilla, G., Khan, H., Momin, E.N., Pardo-Villamizar, C., Tamargo, R.J. Expression of the chemokine RANTES and in a mouse model of subarachnoid hemorrhage with different haptoglobin genotypes 1-1 and 2-2. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 110. Garzon-Muvdi, T., Pradilla, G., Legnani, F.G., Vargas, D.L., Thai, Q.A., Pardo- Villamizar, C., Tamargo, R.J. Local delivery of ibuprofen via controlled-release polymers decreases expression of cell adhesion molecule VCAM-1 in endothelial cells of intracranial vessels. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 111. Han, J., Jackson, C., Pradilla, G., See, A.P., Ng, J., Phallen, J., Albesiano, E., Pardoll, D., Lim, M. A locally-delivered STAT-3 inhibitor (NSC 74859) is safe for intracranial delivery and prolongs survival of animals challenged with intracranial GL-261. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 112. Han, J., Albesiano, E., Pradilla, G., See, A.P., Woodworth, G.F., Kim, Y., Pardoll, D., Lim, M. STAT-3 inhibition results in up-regulation of selected pro- inflammatory cytokines in murine gliomas (GL-26 and GL-261). 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 113. DiMeco, F., Casali, C., Legnani, F.G., Vetrano, I., Pradilla, G., Broggi, G., Solero, C. Surgical management of meningiomas invading the superior sagittal sinus: immediate and long term outcome in a series of 184 cases. 60th Meeting of the Congress of Neurological Surgeons, San Francisco, CA, October 16-21, 2010. 114. Bender, M., Pradilla, G., James, C., Raza, S., Lim, M., Carson, B.S. Surgical Treatment of Pediatric Trigeminal Neuralgia with Microvascular Decompression. 39th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery, Cleveland, OH, November 30 – December 3, 2010. 115. Salmasi, V., Pradilla, G., Reh, D., Gallia, G. Expanded endonasal endoscopic approach for resection of a cavernous sinus teratoma. 21st North American Skull Base Society Meeting, Scottsdale, AZ, February 16-17, 2011. 116. Han, J., Albesiano, E., Pradilla, G., Lim, M. Stat-3 inhibition alters the immune profile in murine gliomas. 15th Annual Meeting of the Society for Neuro- Oncology (SNO), November 18–21, 2010, Montreal, Quebec, Canada. Neuro Oncol (2010) 12 (suppl 4): iv7-iv25. 117. Pradilla, G., Garzon-Muvdi, T., Bender, M., Ruzevick, J., Edwards, L., Thompson, R.C., Tamargo, R.J. L-citrulline treatment prevents morphometric


basilar artery vasospasm and increases iNOS, eNOS, COX-1, and COX-2 expression in a transgenic murine model of SAH. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 118. Pradilla, G., Garzon-Muvdi, T., Vargas, D.L., Legnani, F.G., Thai, Q.A., Pardo, C.A., Tamargo, R.J. Intrathecally administered ibuprofen effectively decreases ICAM-1 expression and angiographic vasospasm in a primate model of SAH. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 119. Garzon-Muvdi, T., Pradilla, G., Ruzevick, J., Bender, M., Edwards, L., Tamargo, R.J. Inhibition of vasospasm in haptoglobin 2-2 mice using S-4-CPG (S-4- carboxyphenylgicine), a metabotropic glutamate receptor antagonist. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 120. Garzon-Muvdi, T., Pradilla, G., Momin, E., Ruzevick, J., Bender, M., Edwards, L., Tamargo, R.J. Time course of the upregulation of ICAM-1 and VCAM-1 after subarachnoid hemorrhage in Hp2-2 mice. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 121. Tyler, B., Pradilla, G., Aprhys, C., Khan, U., Basaldella, L., Nance, E., Kumar, A., Hanes, J., Brem, H., Olivi, A. FasL gene knock-down therapy enhances the anti-glioma immune response. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 122. Dasenbrock, H.H., Pradilla, G., Gokaslan, Z.L., Bydon, A. The impact of weekend hospital admission on the timing of and outcomes after surgery for spinal metastases in the United States, 2005-2008. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 123. Amin, A.G., Ng, J., Hsu, W., Pradilla, G., Raza, S., Quinones-Hinojosa, A., Lim, M. Postoperative anticoagulation in patients with mechanical heart valves following surgical treatment of subdural hemorrhage. 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO, April 9-13th, 2011. 124. Pradilla, G., Garzon-Muvdi, T., Ruzevick, J.J., Bender, M., Edwards, L.E., Momin, E., Thompson, R.C., Tamargo, R.J. L-Citrulline therapy prevents basilar artery vasospasm in haptoglobin 2-2 transgenic mice after induced subarachnoid hemorrhage. Vasospasm 2011. 11th International Conference on Neurovascular Events after SAH, Cincinnati, Ohio, July 21-23, 2011. 125. Garzon-Muvdi, T., Pradilla, G., Ruzevick, J.J., Bender, M., Edwards, L., Tamargo, R.J. Administration of S-4-CPG (S-4-carboxyphenylgicine) decreases vasospasm in haptoglobin 2-2 mice by inhibition of metabotropic glutamate


receptors. Vasospasm 2011. 11th International Conference on Neurovascular Events after SAH, Cincinnati, Ohio, July 21-23, 2011. 126. Zhang, K., Wicks, R., Pradilla, G., Kang, J.U., Brem H. Intra-operative Optical Coherence Tomography (OCT) Guided Tumor Resection. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 127. Bender, M., Pradilla, G., Batra, S., See, A., James, C., Carson, B.S., Lim. Effectiveness of Repeat Glycerol Rhizotomy in Treating Trigeminal Neuralgia. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 128. Bender, M., Pradilla, G., Batra, S., See, A., Bhutiani, N., James, C., Lim, M., Carson, B.S. Effectiveness of Repeat Radiofrequency Thermocoagulation in the Treatment of Recurrent Trigeminal Neuralgia. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 129. Bender, M., Pradilla, G., Batra, S., See, A., Bhutiani, N., James, C., Lim, M., Carson, B.S. Surgical treatment of Trigeminal Neuralgia in Patients with Multiple Sclerosis. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 130. Papadimitriou, K., Pradilla, G., Sciubba, D., Gallia, G., Gokaslan, Z. The Transmandibular Circumglossal Retropharyngeal Approach to Lesions of the Craniocervical Junction: Indications and Clinical Outcomes. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 131. Pradilla, G., Bhutiani, N., Batra, S., Bender, M., See, A., Garzon-Muvdi, T., James, C., Carson, B.S., Lim, M. Safety and Efficacy of Secondary Microvascular Decompression as Treatment for Recurrent Trigeminal Neuralgia. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 132. Garzon-Muvdi, T., Pradilla, G., Wicks, R.T., Ruzevick, J., Edwards, L., Bender, M., Mejia, J.A., Tamargo, R.J. Calcitonin gene-related peptide (CGRP) expression in Hp2-2 mice after subarachnoid hemorrhage (SAH) in intracranial structures. 61st Annual Meeting of the Congress of Neurological Surgeons, Washington, DC, October 1-6, 2011. 133. Tamargo, R. J., Wicks, R.T., Pradilla, G., Raza, S.M., Hadelsberg, U., Coon, A.L., Huang, J. Correlation of changes in intraoperative somatosensory evoked potentials (SSEPs) during aneurysm surgery with postoperative stroke rates. 73rd Annual Meeting of The American Academy of Neurological Surgery, Scottsdale, Arizona, October 19-22, 2011. 134. Bender, M., Pradilla, G., Wicks, R., Garzon-Muvdi, T., Jarso, S., Brayton, C.


Weingart, J., Brem, H., Tyler, B. Toxicity study of Temozolomide polymers in cynomolgus monkeys. Brain Science Institute Drug Discovery in Academia Conference, Baltimore, MD, December 18, 2011. 135. Wicks, R.T., Zhang, K., Huang, Y., Hutt, M., Bow, H., Ruzevick, J., Kang, J., Tyler, B., Jallo, G., Brem, H., Pradilla, G. "Optical coherence tomography (OCT) imaging of carotid artery calcifications in a murine model of atherosclerosis." American Association of Neurological Surgeons (AANS) 80th Annual Meeting; Miami, FL. April 14-18, 2012. 136. Ruzevick, J.J., Jackson, C., Pradilla, G., Garzon-Muvdi, T., Tamargo, R.J. “Role

of the haptoglobin protein in carotid artery aneurysm formation”. Congress of Neurological Surgeons XX Annual Meeting; Chicago, IL. October 6-10, 2012.

137. Huang, Y., Wicks, R., Zhang, K., Zhao, M., Tyler, B.M., Hwang, L., Pradilla, G.,

Kang, J.U. In-vivo and in-situ detection of atherosclerotic plaques using full-range complex-conjugate-free spectral domain optical coherence tomography in the murine carotid. Proc. SPIE 8565, March 8, 2013. Photonic Therapeutics and Diagnostics IX, 85654P

138. Ruzevick, J.J., Recinos, P.F., Raza, S.M., Chaichana, K.L., Pradilla, G., Olivi, A.,

Gallia, G.L., Weingart, J.D., Quinones-Hinojosa, A., Lim, A. Use of an Ultrasonic Osteotome for Orbitozygomatic Craniotomies. North American Skull Base Society Meeting 24th Annual Meeting; San Diego, CA. February 14-16, 2014. Published in J Neurol Surg – Skull Base, 2014; 75 - A189 DOI: 10.1055/s-0034-1370595

139. Ruzevick J, Caplan JM, Yang W, Pradilla G, Colby GP, Coon AL, Huang J,

Tamargo RJ. The contralateral approach reduces costs and length of stay associated with treating bilateral unruptured aneurysms of the anterior circulation. (Accepted to the Congress of Neurological Surgeons Annual Meeting, Boston, MA, October 18-22, 2014) (Digital Poster)

140. Ruzevick J, Caplan JM, Yang W, Pradilla G, Colby GP, Coon AL, Huang J,

Tamargo RJ. The contralateral approach is a safe alternative to a staged approach for treating bilateral anterior circulation aneurysms. (Accepted to the Congress of Neurological Surgeons Annual Meeting, Boston, MA, October 18-22, 2014) (Digital Poster)

141. McCracken, J., Lovasik, B., Caplan, J., Turan, N., McCracken, C., Barrow, D.,

Cawley, M.C., Dion, J., Tamargo, R., Nogueira, R., Pradilla, G. Resolution of Oculomotor Nerve Palsy Secondary to Ruptured Posterior Communicating Artery Aneurysms: Comparison Between Clipping and Coiling. (Accepted to the Congress of Neurological Surgeons Annual Meeting, Boston, MA, October 18-22, 2014) (Oral Presentation)


EDITORIAL BOARD MEMBER: PLOS One AD HOC REVIEWER:

Neurosurgery World Neurosurgery BioMed Research International

PLATTFORM PRESENTATIONS:

July 8, 2003: 8th International Conference on Cerebral Vasospasm, Chicago, Illinois. Presentation: “Anti-CD11/CD18 Monoclonal Antibody Therapy Prevents Vasospasm after Subarachnoid Hemorrhage in Rabbits”. July 8, 2003: 8th International Conference on Cerebral Vasospasm, Chicago, Illinois. Presentation: “Pharmacokinetics of Controlled Release Polymers in the Subarachnoid Space for the Treatment of Chronic Vasospasm after Subarachnoid Hemorrhage”. July 8, 2003: 8th International Conference on Cerebral Vasospasm, Chicago, Illinois. Presentation: “Inhibition of Experimental Cerebral Vasospasm by Intracranial Delivery of Ibuprofen from a Controlled-Release Polymer in a Rabbit Subarachnoid Hemorrhage Model”. July 8, 2003: 8th International Conference on Cerebral Vasospasm, Chicago, Illinois. Presentation: “Local delivery of Nitric Oxide Donors via controlled release polymers prevents vasospasm after subarachnoid hemorrhage: Efficacy and toxicity studies in primates”. October 20, 2003: 53rd Annual Meeting, Congress of Neurological Surgeons, Denver, Colorado. Presentation: “Treatment with an Anti-CD11/CD18 Monoclonal Antibody Prevents Chronic Vasospasm in a Rabbit Subarachnoid Hemorrhage Model”. October 22, 2003: 53rd Annual Meeting, Congress of Neurological Surgeons, Denver, Colorado. Presentation: “Intracranial Delivery of Ibuprofen from a Controlled-release Polymer Prevents Chronic Vasospasm in a Rabbit Subarachnoid Hemorrhage Model”. September 11, 2003: XII European Congress of Neurosurgery, Lisbon, Portugal. Presentation: “Prevention of subarachnoid hemorrhage induced


vasospasm with local delivery of a nitric oxide donor via controlled release polymers: efficacy and toxicity studies in primates”. September 11, 2003: XII European Congress of Neurosurgery, Lisbon, Portugal. Presentation: “Treatment with an anti-CD11/CD18 monoclonal antibody prevents post-hemorrhagic vasospasm in a rabbit model of subarachnoid hemorrhage”. May 4, 2004: Annual Meeting of the American Association of Neurological Surgeons, Orlando, Florida. Presentation: “Local delivery of thrombolytics by controlled-release polymers for the treatment of intracerebral hemorrhage”. October 19, 2004: 54th Meeting of the Congress of Neurological Surgeons, San Francisco, California. Oral presentation: “Combined treatment of systemic BCNU and a locally delivered anti-angiogenic fragment of human endostatin prolongs survival in rats challenged intracranially with 9L gliosarcoma”. February 3, 2005: 2005 Joint Annual Meeting AANS/CNS Cerebrovascular Section & American Society of Interventional & Therapeutic Neuroradiology, New Orleans, LA. Oral presentation: “Delayed administration of simvastatin prevents vasospasm in a rabbit model of subarachnoid hemorrhage”. October 11, 2005: 55th Meeting of the Congress of Neurological Surgeons, Boston, MA. Open paper presentation: “Endothelial expression of ICAM-1and VCAM-1 after subarachnoid hemorrhage in monkeys treated with locally-delivered ibuprofen”. October 11, 2005: 55th Meeting of the Congress of Neurological Surgeons, Boston, MA. Open paper presentation: “Simvastatin administration reverses cerebral vasospasm in rabbits by increasing endothelial nitric oxide synthase (eNOS) expression”.

April 13th, 2011: 79th Annual Meeting of the American Association of Neurological Surgeons, Denver, CO. Oral presentation: Intrathecally administered ibuprofen effectively decreases ICAM-1 expression and angiographic vasospasm in a primate model of SAH.

LECTURES:

“Minimal access surgery for ICH, experience with the six-pillars approach”. Brain path user experience dinner symposium. Boston, MA, October 20th, 2014.


“Minimally-invasive surgery for intracerebral hemorrhage”. Department of Neurology Grand Rounds, Emory University School of Medicine, Atlanta, GA, October 17th, 2014. “An Introduction to Neurosurgery”, Neurosurgery Interest Group, Emory University School of Medicine, Atlanta, GA September 15th, 2014 “Preliminary experience in ICH using the six-pillars approach”, First Annual Subcortical Surgery Group Meeting, Park City, UT August 15th, 2014 “Pathophysiology and Therapeutics in Cerebral Vasospasm”, Grady Anesthesiology Department Grand Rounds Lecture, Atlanta, GA May 15th, 2104 “Surgical approaches to the pineal region”, Emory Neurosurgery Residents Teaching Session, Atlanta, GA April 16ht, 2014 “Aneurysmal subarachnoid hemorrhage: evaluation and treatment”. Grady EMS training course, Atlanta, GA April 14th, 2014 “Revascularization in tumors of the skull base” II Neuro-Oncology and Skull Base Surgery Symposium”, Cartagena, Colombia March 20th, 2014 “Need for gross-total resection of skull meningiomas”, Cartagena, Colombia March 20th, 2014 “Surgery Vs. radiosurgery in glomus jugulare tumors”, Cartagena, Colombia March 20th, 2014 “Subarachnoid hemorrhage: evaluation, transport and early interventions”. Air Methods Critical Care Recertification Course, Gainesville, GA March 5th, 2014 “Cerebral Vasospasm, Pathophysiology of an inflammation-mediated event”, Emory University School of Medicine, Department of Neurosurgery Grand Rounds, Atlanta, GA September 12th, 2013 “Intraoperative Monitoring in Aneurysm Surgery” University of Miami, School of Medicine, Department of Neurosurgery Grand Rounds Miami, FL, April 18th, 2013. “Prognostic Markers for Malignant Gliomas”. 1ST Joint Neurosurgical Symposium, Seoul National University, Seoul, North Korea, March 26th, 2011


“The Inflammatory Hypothesis of Cerebral Vasospasm”. University of Miami, School of Medicine, Department of Neurosurgery Grand Rounds. Miami, FL, October 7th, 2010. “Redefining Cerebral Vasospasm: The Role of Inflammation”. I Joint Congress: “Updates in Neuroscience”. Fundación Santa Fé de Bogotá, Bogotá, Colombia, August 13th, 2010. “Intracranial-to-Intracranial Bypass Surgery for Giant Cerebral Aneurysms”, Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, July 8th, 2010. “Controversies in Surgical Treatment of Parasagittal Meningiomas”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, January 7th, 2010.

“Controlled-release polymers in Brain Tumor Therapy: From Bench-work to Bedside”. Amrita Medical Institute, Advances in Brain Tumor Therapy Symposium, Cochin, Kerala, India, October 10th, 2009. “Drug-delivery Strategies in Malignant Brain Tumor Therapy”. Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India, October 8th, 2009. “Aneurysmal Subarachnoid Hemorrhage: Diagnosis and Treatment”. I National Medical Congress, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia, August 7th, 2009 “Interdisciplinary management of cerebral metastatic disease”. I National Medical Congress, Universidad Industrial de Santander, Bucaramanga, Santander, Colombia, August 7th, 2009 “Management of C1-C2 instability”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, February 12th, 2009 “Distal Anterior Cerebral Artery Aneurysms”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, January 7th, 2009 “Surgical Approaches to Pineal Region Tumors”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, September 11th, 2008 “Cerebral Vasospasm”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, June 12th,


2008 “Surgical Treatment of Intraventricular Central Neurocytomas”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, April 4th, 2008 “Intra-aortic balloon pump therapy in refractory cerebral vasospasm and CHF”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, April 26th, 2007. “Tumors of the Glomus Jugulare”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, February 1st, 2007. “Management of Sacral Nerve Root/Tarlov’s cysts”. Johns Hopkins University, Department of Neurosurgery, Grand Rounds Presentation. Baltimore, MD, August 17th, 2006.

TEACHING INTERESTS: Laboratory Instructor Neuro-Oncology Research Elective for Medical Students Hunterian Research Laboratory P.I. Dr. Henry Brem The Johns Hopkins University, School of Medicine 2003-2005 Laboratory Instructor Cerebrovascular Research Elective for Medical Students Cerebrovascular Research Laboratory P.I. Dr. Rafael J. Tamargo The Johns Hopkins University, School of Medicine 2003-2005, 2009-2011 Laboratory Instructor Neuroanatomy Course for Medical Students The Johns Hopkins University, School of Medicine 2010-2011 Laboratory Instructor Microsurgical Neuroanatomy and Skull Base Techniques Course for Residents The Johns Hopkins University, School of Medicine 2010-2012


PROFESSIONAL COMMITTEES: 2013 – Present Trauma Outcomes Review Committee – Grady Memorial Hospital 2013 – Present Grady Memorial Hospital - Medical Executive Committee 2014 - Present Representative of the Georgia Neurosurgical Society to the Board

of Directors of the Southern Alliance for Physician Specialties – CME

2014 – Present Subcortical Surgery Group – Board of Directors member

CURRICULUM VITAE Gustavo Pradilla, M.D. · CURRICULUM VITAE Gustavo Pradilla, M.D. (Revised 12/9/2014) Current Position: ... Legnani FG, Pradilla G, Wang PP, Brem H, Olivi A, Di Meco

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