CURRICULUM VITAE Diane Marie Simeone … Department_of...Diane M. Simeone, M.D. Curriculum Vitae Page 4 24. “Adrenomedullin Overexpression in Pancreatic Cancer.” Frederick A. Coller

Diane M. Simeone, M.D. Curriculum Vitae

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CURRICULUM VITAE

Diane Marie Simeone

PERSONAL DATA Address: 4838 Hidden Brook Lane Ann Arbor, MI. 48105 EDUCATION 1980-1984 Brown University, Providence, Rhode Island; Neuroscience, B.S. 1984-1988 Duke University Medical School, Durham, North Carolina; M.D.

POSTDOCTORAL TRAINING 1988-1995 General Surgery Resident, University of Michigan Hospitals 1991 University of Michigan Postdoctoral Research Training Program 1994-1995 Administrative Chief Resident, University of Michigan Hospitals ACADEMIC APPOINTMENTS 1995-2003 Assistant Professor of Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI. 1996-2001 Assistant Director of Resident and Student Education, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI. 2002-present Surgical Director, Multidisciplinary Pancreatic Cancer Clinic 2003-present Associate Professor of Surgery and Molecular and Integrative Physiology,University of Michigan Medical School, Ann Arbor, MI. 2005-present Director, Pancreatic Tumor Program, University of Michigan Medical Center 2005-2009 Co-Director, GI Oncology Program, University of Michigan Comprehensive Cancer Center 2007-present Division Chief, Gastrointestinal Surgery, University of Michigan Medical Center 2007-present Associate Chair for Research, University of Michigan Department of Surgery 2007-present Professor of Surgery and Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI. 2007-present Lazar Greenfield Endowed Professorship in Surgery 2009-present Director, GI Oncology Program, University of Michigan Comprehensive Cancer Center 2010-present Program Director, University of Michigan Hepato-Pancreatico-Biliary Fellowship CONSULTING POSITIONS None FUNDED PEER REVIEW GRANT SUPPORT CURRENT SUPPORT: 1. “ATDC Function in Pancreatic Cancer. NIH R01CA131045-01A1 (25% Salary Support). Role: PI. 8/08-6/12. Total Direct Costs: $1,250,000. 2. “University of Michigan Cancer Center Support Grant” (5% salary Support) NIH 5 P30 CA46592-19. PI: Max Wicha. Role: Director, Gastrointestinal Oncology Program. 6/06-5/11. Annual Direct Costs $5,007,710. 3. “Using Systems Biology to Understand Islet Adaptation and Diabetes”. NIH 1 R01 DK079084-01


Page 2 7/07- 6/11. PI: Charles Burant, M.D.)Role: Co-Investigator. Direct Costs $2,034,005. 4. “National Functional Genomics Center- A Center for Genetic Origins of Cancer (CGOC) at the University of Michigan”. Funding Source: Department of Defense. PI: Max Wicha. 09/01/08 - 08/31/13. Role: Co-Investigator. Total Direct Costs for Subproject: $1,032,500. 5. “Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma Detection”. 1R01CA140211-01 PI: David Misek. Role: Co-Investigator (2.5% Salary Support) 07/01/09-06/30/14. Total Direct Costs: $1,250,000.

6 “Induced Glycan Alterations in Sub-Populations of Pancreatic Tumors”. NIH R03 Award. 4/09-3/11. Total Direct Costs $100,000 (Co-Investigator). 7. “Targeting ATDC with PARP Inhibitors in Pancreatic Cancer”. Role: Co-Investigator (5% salary support). PI: Mats Ljungman. R21-CA-150100. Total Costs $418,134. 4/1/10-3/31/12. 8. “Targeting Notch Signaling in Pancreatic Cancer Stem Cells”. Role: PI. AACR-PANCAN Innovation Grant. Total Costs $200,000. 7/01/10-6/30/12. 9. “Novel Approaches for Structural Determination of Cancer Stem Cell Glycans”. NIH R21 CA138331. PI: Kristina Hakansson. Total Cost $614,760. 4/1/10-3/31/13. Role: Co-Investigator (5% salary support). Total Costs for Subproject: $116,989. 10. “Method for Optical Detection of Pancreatic Cancer”. University of Michigan Coulter Translational Research Partnership Grant. Total Costs $150,000. 4/10-3/11. PI: Mycek, Mary-Ann (Role: Co-Investigator). 11. “Translational Research in GI Cancer”. Role: Co-Director of the Administrative Core (10% salary support). NIH GI SPORE Grant. Total Costs $13,246,029. 4/1/10-3/31/15. 12. “Markers of Pancreatic Cancer Using a Glycoproteomic Approach”. Project 2 of GI SPORE. Role: Co-investigator (5% salary support). NIH GI SPORE Grant. Total Costs $1,604,746. 4/1/10-3/31/15. 13. “ATDC as a Therapeutic Target in Pancreatic Cancer”. Project 4 of GI SPORE. Role: PI (15% Salary Support). NIH GI SPORE Grant. Total Costs $1,638,418. 4/1/10-3/31/15.

14. “Cancer Stem Cells and Inhibition of Hedgehog Pathway Signaling in Advanced Pancreas Cancer: A Pilot Study of GDC-0449 in Combination with Gemcitabine”. UMCC2010.003 CTRAC Grant Correlative Study. Role: Co-PI. Total Costs: $50,000 6/1/10-5/31/12.

15. “Effect of the Hedgehog Targeting Antibody 6D7OP on Human Pancreatic Cancer Stem Cells”. MedImmune Sponsored Research Grant. 8/10-7/11. Total Costs $119,481. (Principal Investigator). 16. “Detection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan Biomarkers”. EDRN Multi-Program Biomarker Grant. Total Costs $5,245,457 07/01/10-6/30/15. Role: Institutional PI. (5% salary support) Univ.of Michigan Budget: $522,563. 17. “Wnt Pathway Antagonists in Pancreatic Cancer”. Oncomed Sponsored Research Grant. 8/10-7/11. Role: Co-PI. Total Budget: $104,978. SUBMITTED GRANTS 1. “Notch signaling pathway and cancer stem cells in glioblastoma”. Submitted as a NIH R01 application.

Role: Co-investigator (5% salary support). PI: Xing Fan. Total Costs $1,909,580. 4/1/10-3/31/15. PAST SUPPORT 1. “Neuropeptide Modulation of Enteric Function,” NIH NRSA Grant No. DK08580-02. 1991-1993. $52,000 (Principal Investigator) 2. “Gene Therapy for Pancreatic Carcinoma: Restoration of Cell Cycle Control.” University of Michigan Department of Surgery Research Support Grant 1996-1997. $25,000 (Principal Investigator) 3. “The Role of TGF Signaling Pathway in Normal and Neoplastic Pancreatic Growth.”


Page 3 Michigan Gastrointestinal Peptide Research Center Grant No. 5 P30 DK34933. 1997-1999. $35,000 (Principal Investigator) 4. “The Role of Smad Genes in Pancreatic Growth Regulation.” American College of Surgeons Faculty Research Fellowship. 7/98-7/00. $60,000 (Principal Investigator) 5. “The Role of Smad Genes in Pancreatic Cancer.” Basic Science Research Partnership, Biomedical Research Council, University of Michigan. 6/98-5/00.$50,000 (Co-Investigator) 6. “Pancreatic Growth Regulation: The Role of TGF .” University of Michigan Department of Surgery Research Support Grant 11/98-11/99. $20,000 (Principal Investigator) 7. “TGF Signaling Pathway in the Pancreas.” NIH K08 DK02637-01. 12/98-12/03. $547,000. (Principal Investigator) 8. “TGF-Mediated Growth Regulation in the Pancreas: the Role of Smads.” Association for Academic Surgery/ Bayer Resident Research Award. 7/99-6/01. $30,000 (mentor for recipient Kathleen van Leeuwen, M.D.) 9. “Growth Regulatory Mechanisms in the Pancreas.” Frederick A. Coller Surgical Society Surgical Research Fellowship. 7/99-6/01. $25,000 (mentor for recipient Kathleen van Leeuwen, M.D.) 10. “TGF-Mediated Regulation of Transcription Factors in the Pancreas.” Michigan Gastrointestinal Peptide Research Center. 10/00-10/01. $15,000 (mentor for recipient Kathleen van Leeuwen, M.D.) 11. “TGF Signaling Mechanisms in the Pancreas.” NIH 1R03DK60486-01. 12/01-12/03, $122,000. (Principal Investigator) 12. “Mechanism of Islet Hyperplasia After Smad4 Disruption”. University of Michigan Department of Surgery Research Support Grant, 2/02-2/03, $25,000 (Principal Investigator). 13. “Ex vivo growth and manipulation of islet precursor cells”. American Diabetes Association Research Award. 2002-2005, $300,000 (Co-Investigator) 14. “Michigan Center for Pancreatic Cancer Molecular Diagnostics” (20% Salary Support). Project 622. Michigan Life Sciences Corridor Grant 7/03-7/04, $786,000 (Co-PI) 15. “Biomarker Discovery for Pancreatic Cancer”. University of Michigan Comprehensive Cancer Center Grant. 7/03-7/04, $30,000 (Principal Investigator). 16. “TGF-Mediated Signaling Mechanisms in the Pancreas”. University of Michigan Gastrointestinal Peptide Center. 10/02/ 11/03, $10,000 (mentor for recipient Charles Binkley, M.D.) 17. “Investigating the Molecular Basis for Radiation Resistance in Pancreatic Adenocarcinoma: The Role of ATDC”. University of Michigan Comprehensive Cancer Center Grant. 7/02-7/03, $20,000 (Principal Investigator) 18. “Director’s Challenge Supplement: Toward a Molecular Classification of Tumors”. NCI. U19 CA84953. 7/1/02-7/1/04, $200,000 (Co-Investigator). 19. “Proteomics Biomarker Development Laboratory”. National Institutes of Health Grant UMCC 0003. 9/99- 8/04, $2,600,000 (Co-Investigator). 20. “Biomarkers in the Diagnosis of Pancreatic Adenocarcinoma: A Prospective Study of Feasibility and Clinical Application”. ASGE/ACG Board of Governors Endoscopic Research Award. 12/02-12/04, $50,000 (Co-Investigator). 21. “Identification of Novel Biomarkers for the Early Detection of Pancreatic Cancer”. NCI-Sponsored Early Detection Research Network (EDRN) Award. UO1 CA84986 8/03-8/05, $153,000 (Principal Investigator). 22. “Development and Validation of Novel Biomarkers for Early Pancreatic Cancer Detection”. Lustgarten Foundation for Pancreatic Cancer Research. 1/04-12/04, $100,000 (Principal Investigator). 23. “Michigan Center for Pancreatic Cancer Molecular Diagnostics” (20% Salary Support). Project 622. Michigan Life Sciences Corridor Grant 7/04-7/06, $1,574,000 (PI)


Page 4 24. “Adrenomedullin Overexpression in Pancreatic Cancer.” Frederick A. Coller Surgical Society Surgical Research Fellowship. 10/05-9/06. $15,000 (mentor for recipient David Heidt, M.D.) 25. “Identification and Molecular Chararacterization of Pancreatic Cancer Stem Cells”. Lustgarten Foundation Project Number RFP06-027. 1/06-5/07. Direct Costs $100,000 (PI). 26. “Understanding Pancreatic Cancer Resistance to Therapy: Pancreatic Cancer Stem Cells”. Elsa Pardee Foundation. 7/06- 6/07 Direct Costs $75,000 (PI). 27. “Chemical Screen for Inhibitors of the Pancreatic Cancer-Associated Protein ATDC”. Margolies Research Award, 6/07. Direct Costs $20,000 (co-PI) (PI: Mats Ljungman). 28. “Pancreatic Cancer Pre-Validation Reference Set for Serum/Plasma Biomarkers”. NCI EDRN Award 7/07. Total Direct costs $270,850. (Co-PI, University of Michigan site) (10% Salary support) (PI: Randall Brand). 29. “Manipulating TGF Signaling to Isolate and Characterize a Replicating Duct-Derived Islet Precursor”. American Diabetes Association Research Award. 10/03-10/07, $975,000 (Co-Investigator) (PI: Charles Burant). 30. "Heavy metals and genetic mutations in pancreatic cancer" NIH 1R03 CA123715-01. (Co-PI) (PI: Amr Soliman) 9/06-8/08. Annual Direct Costs $50,000. 31. “Early detection of pancreatic cancer” 1NIH R21CA118164-01A1 . (Co-Investigator) (PI: Randy Haun). 9/06-8/08 Direct Costs $100,000. 32. “Defining Secreted Glycan Alterations in Pancreatic Cancer.” National Institutes of Health Grant R21 CA122890. 9/06-8/08. $180,284 (Co-Investigator) (Principal investigator: Brian Haab, Ph.D.) 33. “Targeted Therapy of Human Pancreatic Cancer Stem Cells.” University of Michigan Comprehensive Cancer Center (UMCCC) Stem Cell RFA. 2/07-1/08. $50,000 (Principal Investigator). 34. “Neoplasia Detection in Pancreatic Mass Lesions Using Tissue Optical Spectroscopy”. 6/07-5/08. University of Michigan cancer Center Grant. Total Direct Costs $50,000. (Co-Investigator) (PI: James Scheiman). 35. “ Functional Studies of Pancreatic Cancer Stem Cells”. T32 Training Grant, Center for Organogenesis, University of Michigan Medical School. 7/06-6/08. Direct Costs $83,000 (mentor for Cheong J. Lee, M.D.) 36. “Characterization of Pancreatic Cancer Stem Cells”. American Hepato-Pancreatico-Biliary Association. 1/08-12/08. $50,000. (mentor for PI: Beda Sarkar). 37. “Pancreatic TGF-Mediated Signaling Mechanisms”. 1 RO1 DK061507-01A1 4/03-3/09, $1,600,000 (Principal Investigator). 38. “Interactions of AZD7762 with Radiation and Gemcitabine in Human Pancreatic Cancer Xenografts”. Aztra-Zeneca Research Grant. 7/07-12/08. $198,035. (Co-Investigator) (Principal Investigator: Jonathan Maybaum, Ph.D.) 39. “A Lectin Glycoarray Approach to Markers of Pancreatic Cancer”. NIH R21 CA124441 09 (Co-Investigator) (Principal Investigator: David Lubman, Ph.D.) 7/1/07 - 6/30/09 Total direct costs: $220,000. 40.“Defining Secreted Glycan Alterations in Pancreatic Cancer.” Project ID: 4R33CA122890-02 PI: Brian Haab. Role: Co-PI. 8/11/08-7/31/09. Total Direct UM Costs: $21,356. 41. “Pancreatic Pre-Validation Reference Set for Serum/Plasma Biomarkers”. NCI EDRN Award. 7/07-6/09 PI: Randall Brand, M.D. (Role: Co-Investigator). $270,850. 42. “CXC Chemokines and Liver Regeneration”. NIH 2 R01 DK053224-06A2 . 12/1/97-11/30/09 $1,654, 870 PI: Lisa Colletti. Role: Co-Investigator. 43. “Method for Optical Detection of Pancreatic Cancer”. University of Michigan Coulter Translational Research Partnership Grant. Total Costs $100,000. 3/09-2/10. PI: Mycek, Mary-Ann (Role: Co-Investigator). 44. “Primary Human Pancreatic Cancer Xenograft Core: Testing Targeted Therapeutics”. Oncomed Sponsored Research Grant. 1/08-4/10. $440,000. (Principal Investigator).


Page 5 PATENTS 1. Title: Compositions and Methods for Treating and Diagnosing Pancreatic Cancer Inventors: Michael F. Clarke, Max S. Wicha, Diane M. Simeone Country: Europe Filing date: 01/24/2008 2. Title: Compositions and Methods for Treating and Diagnosing Pancreatic Cancer Inventors: Michael F. Clarke, Max S. Wicha, Diane M. Simeone Country: United States Filing date: 01/24/2008 3. Title: Methods and Compositions for the Identification of Cancer Markers Inventors: Jia Zhao, Diane M. Simeone, David M. Lubman Country: United States Filing date: 10/22/2008 4. Title: Composition and Methods for Treating Cancer Inventors: Diane M. Simeone, Mats Ljungman, Liang Xu, Lidong Wang Country: Patent Cooperation Treaty Filing date: 12/12/2008 5. Title: Composition and Methods for Treating Cancer Inventors: Diane M. Simeone, Mats Ljungman, Liang Xu, Lidong Wang Country: United States Filing date: 12/12/2008 6. Title: Compositions and Methods for Diagnosing and Treating Pancreatic Cancer Inventors: Diane M. Simeone, Chenwei Li Country: Patent Cooperation Treaty Filing date: 03/05/2009 7. Title: Pancreatic Cancer Autoantibody Markers Inventors: David M. Lubman, Diane M. Simeone, Evelyn H. Kim, Tasneem H. Patwa, Laila Poisson, Huy Vuong Country: United States - Provisional Filing date: 05/01/2009 8. Title: Multimodal Spectroscopic System and Methods for Classifying Biological Tissue

Inventors: Malavika Chandra, Mary-Ann Mycek, James M. Scheiman, Diane M. Simeone, Barbara McKenna, Robert H. Wilson, Julianne K. Purdy

Country: United States Filing date: 06/05/2009 9. Title: Pancreatic Cancer Markers Inventors: Diane M. Simeone, David M. Lubman, Chen Li Country: Patent Cooperation Treaty Filing date: 09/09/2009 10. Title: Methods for Diagnosing the Malignant Potential of Pancreatic Cystic Lesions Inventors: Brian B. Haab and Diane M. Simeone Country: United States Patent Application Number: 61/291,654 CERTIFICATION AND LICENSURE:


Page 6 Board of Medicine Physician License (Michigan)

HONORS AND AWARDS: 1981-1984 Mary E. Baldwin Academic Scholarship (Brown University) 1982-1984 Judge E. Rathbun Academic Scholarship (Brown University) 1984-1988 Sigma Xi Scientific Honor Society 1985-1987 American Heart Association Research Scholarship 1985-1988 Duke University Medical Alumni Association Scholarship 1986-1988 President of Duke University Engel Society 1987-1988 Alpha Omega Alpha Honor Society, Duke University Medical School 1990 Bronze Beeper Award for Excellence in Teaching, University of Michigan Medical School 1992 Frederick A. Coller Resident Research Award 1994 Young Investigator Award, University of Michigan, Department of Surgery 1994-1995 Administrative Chief Resident, University of Michigan, Dept. of Surgery 2003 Member, Surgery Biology Club I 2005-2010 Best Doctors of America 2006 William W. Coon Faculty Teaching Award, Univ. of Michigan Dept of Surgery 2007-2010 Best Surgeons in America 2008 President, Society of University Surgeons 2009 AACR Award: Most Cited Article, Cancer Research, 2007 2010 America’s Top Doctors for Cancer 2010 The Randy Pausch Family AACR-PANCAN Innovation Award MEMBERSHIPS IN PROFESSIONAL SOCIETIES 1993-1994 Administrative Board, House Officer’s Association 1992-1997 Candidate Group, American College of Surgeons 1996 Regional Faculty for Ethicon Endo-Surgery, Inc. 1996 Association for Academic Surgery 1996 American Board of Surgery 1997 Associate Fellow, American College of Surgeons 1997 Society of American Gastrointestinal Endoscopic Surgeons 1997 Society for Surgery of the Alimentary Tract 1998 University of Michigan Comprehensive Cancer Center 1998 Frederick A. Coller Surgical Society 1998 University of Michigan Gastrointestinal Peptide Research Center, Gastrointestinal and Prevention Programs 1999 American Pancreatic Association 1999 Fellow, American College of Surgeons 1999 Society of University Surgeons 2003 Surgery Biology Club I 2003 Early Detection Research Network (NCI) Associate Member 2003 American Hepato-Pancreato-Biliary Association 2003 Michigan Diabetes Research and Training Center 2003 Pancreas Club 2006 University of Michigan Center for Organogenesis


Page 7 2006 American Surgical Association 2007 Society of Clinical Surgery 2007 American Society for Clinical Oncology 2009 American Association of Cancer Research TEACHING ACTIVITIES National 1996 Faculty mentor, Laparoscopic Training Course for General Surgery Residents, Ethicon Endo-Surgery, Cincinnati, Ohio 1999 Instructor, “Fundamentals of Surgical Research Course”, Association for Academic Surgery, Milwaukee, WI. 2005 Faculty Instructor, Fundamentals of Surgical Research Course and AAS Career Development Course, San Francisco, CA, October 2005. University of Michigan Lectures/Small Group Instructional Activities/Journal Clubs

1996-present Director, Selected Readings Resident Teaching Conference 1996 Director, Laparoscopic Journal Club (resident teaching) 1996 Faculty mentor, Medical Student Surgical Skills Workshop 1996-present Faculty Lecturer, M3 General Surgery Sequence (Acute/Chronic Pancreatitis, and Pancreatic Cancer- 4/yr) 1996-present House Officer Teaching Conference (varying lectures, including: “Abdominal Trauma”, “Penetrating Chest and Neck Trauma”, “Stomach and Duodenum”, “Diverticular Disease”, “Portal Hypertension”, “Crohn’s Disease”, “Small Bowel Neoplasms”, “Acute Pancreatitis”). 1997-present Faculty Lecturer, M2 Gastrointestinal Sequence (Pancreatic Cancer) 1998-1999 Faculty Lecturer, M3 General Surgery Sequence (GI Review-4/yr) 1998-present Participate in monthly GI Journal Club and GI Tumor Board (resident and student teaching) 1998-1999 Faculty Instructor, M1 ITTP Clinical Skills Laboratory 1999 Faculty Instructor, M1 Physical Diagnosis Examination 1998-1999 Faculty Instructor, Comprehensive Clinical Assesssment Exam: Breaking Bad news 2000 Faculty Lecturer, M4 Surgical Anatomy Course- Hernias of the Abdominal Wall 1999 Faculty Lecturer, M1 Medical Physiology Course- Clinical Case Seminars 1999 Faculty Instructor, Surgical Resident Laparoscopic Training Course 2002 – present Faculty Lecturer, M4 Surgical Anatomy Course- Pancreas and Spleen 2002 – present Faculty Lecturer, M1 Medical Physiology Course- Clinical Case Seminar 2002- present Faculty Instructor, K30 Medical School Course in Translational Research Genomics/Proteomics Section 2002- present House Officer Teaching Conference: Pancreatic Cancer 2004 Faculty Lecturer, Cancer Biology Course 553 (Ph.D.-training course): Surgical Oncology 2005-2006 Faculty Instructor, M4 Surgery Forum, “The Research/Academic Tract 2005 M1/M2 Surgery Interest Group, “Life as An Academic Gastrointestinal Surgeon”, Oct 26th, 7:00-9:00 p.m. 2005 Lecture to Radiation Oncology residents, “Pancreatic Cancer”. 2005 M3/M4 Surgery Interest group, “Pursuing a Career in Academic Surgery”, November 10, 6:30-8:30 p.m.


Page 8 2006 M1 Lecture, GI Sequence, “Gastrointestinal Cancer- Surgical Considerations", January 11, 2006, 9-10 am. 2007 “Biomarkers for Pancreatic Adenocarcinoma”. Training Program in Translational Research, Univ. of Michigan Health System. Fall, 2007. 2007 “Biomarkers for Early Detection of Pancreatic Cancer.” School of Public Health Epidemiology Seminar Series, December 7, 2007. 2007 “Update on Pancreatic Cancer: Stem Cells and Biomarkers”. GI Grand Rounds, December 11, 2007. 2008 “Life as an Academic GI Surgeon”. M1 Lecture. January 24th, 2008. 1-2 pm. 2008 M2 GI Curriculum Lecture “Pancreatic Cancer”, February 21, 2008. 10-11 am. 2008 House Officer Lecture “Keys to Success During Academic Development Time”, April 24, 2008. 9-10 am. 2008 General Surgery Senior Resident Conference “Pancreatic Adenocarcinoma”, May 8, 2008, 8-9 a.m. 2009 M4 Surgery Boot Camp lecture, “How to begin your academic career”. Feb. 11, 2009. 2009 Surgery Senior Resident Teaching Conference, “Management of Cystic Tumors of the

Pancreas”. February 12, 2009. 2009 M2 GI Curriculum Lecture “Pancreatic Cancer”, February 18, 2009. 10-11 am.

2009 Gastroenterology Basic Science Lecture Series, “ATDC: a Novel Oncogene in Pancreatic Cancer.” March 16, 2009.

2009 HOI-II Surgery Resident Teaching Conference, Pancreatic Adenocarcinoma”. April 23, 2009.

2009 Special Lecture Series on Organogenesis of the Pancreas, “Pancreatic Cancer Stem Cells”, October, 29, 2009.

2009 Organogenesis series, Pancreas Module, “Panel Discussion”. November 12, 2009. 2009 Cancer Center Innovation Series, “Cancer Stem Cells: Implications for Treating

Pancreatic Cancer”. December 3, 2009. 2010 Cancer Center Research Internship Program, “Development of a Translational Research

Program in Pancreatic Cancer”. June 14, 2010.

Examinations 1996-present Participate in administration of mock oral examinations to General Surgery House Officers (yearly) 1996-present Participate in the administration of oral examinations to 3rd year medical students at the end of their surgical clerkship (2-4/yr) Leadership Positions/Administration 1996‐2001 Assistant Director, Resident and Medical Student Education, Department of

Surgery, which includes the following responsibilities: HO I/II career and personal counseling, coordinating/creating the HO I/II rotation and vacation schedules, organizing yearly airway training program for interns,assisting in medical student match scramble, addressing HO I/II disciplinary issues, create monthly conference schedule for general surgery residents Medical student counseling: senior year, career, personal


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2003-present Surgical Director, Multidisciplinary Pancreatic Tumor Clinic, University of Michigan Cancer Center, which includes the following responsibilities: supervise clinic, developed and supervise database, run two monthly meetings: Pancreatic Cancer Basic Science Working Group, and Pancreatic Tumor Clinical Group Meeting, supervise maintenance and updating of University of Michigan Pancreatic Cancer web site. 2005-present Co-Director, GI Oncology program, University of Michigan Comprehensive Cancer

Center. Responsibilities include: faculty recruitment, assist in preparation of core grant renewal, organize monthly GI Oncology Research Conference, participate in Directors meetings. 2008- present Director, Pancreatic Tumor Destination Program, University of Michigan Medical Center Mentoring Activities 1997-present Speaker at Career Seminar Series for year 1 and 2 medical students 1998 Faculty mentor, University of Michigan SROP Program (student Monica Willis) 2000 Faculty mentor, University of Michigan UROP Program (student C.J. Lee) 2003-2005 Faculty mentor, University of Michigan UROP Program (student David Hu)

2004-2007 Ph.D. Thesis Committee, Maren Fuentes (graduate student, Dept. of Cellular and Molecular Biology

2005-present Ph.D. Thesis Committee, Nancy Dai (graduate student, Depts. of Surgery and Pathology) I have served as mentor for the following individuals: Lisa Kunze (resident- faculty advisor), Adam Hassan (medical student- faculty advisor), Monica Willis (undergraduate- research advisor, SROP Program), Kathy Graziano (resident- faculty and research advisor; AAS Resident Research Award), Stephanie Devaney (medical student- faculty advisor, AMWA mentorship program), Lizhi Zhang (post-doctoral fellow- research advisor), Michael Shillingford (medical student- faculty advisor), Charles Binkley (resident- faculty and research advisor, recipient of NRSA award), Aaron Eckhauser (medical student- research advisor), Vanessa Erickson (medical student-faculty advisor), Chao Jun Duan (post-doctoral fellow- research advisor), Tina Barkley (medical student- faculty advisor), Jackie Lee (medical student- faculty advisor), Amy White (medical student- faculty advisor), Redah Mahmood (undergraduate- research advisor), David Hu (first year medical student- research and faculty advisor), Gangyong Li (post-doctoral fellow), Vijaya Rumachandran (post-doctoral fellow), Lidong Wang (post-doctoral fellow), David Heidt (research advisor, recipient of NRSA award), Chenwei Li (post-doctoral fellow)., Maren Fuentes (Ph.D. Thesis Review Committee), Cara Cimmino (medical student-faculty advisor, 2005), Nathan Mollenberg (medical student- research advisor, 2005), Claire Hampton (Univ of Michigan undergraduate research program(UROP, summer 2005), Naveen Ahuja (faculty advisor, 2005-2006), Josh Kaplan, (faculty research advisor-2005, Summer Biomedical Research Program), Dawn Barnes (research advisor 2007-2008, T32 Surgery Oncology Training Grant), Michelle Anderson (2007- present, mentor for K23 grant), Anudeep Mukkamala (undergraduate, Univ. of Michigan- research, 2007-2008), Beda Sarkar (research advisor 2007-2008, AHPBA Research Fellowship), C.J. Lee (Faculty advisor 2002-2008, Organogenesis Center research Fellowship, T32 Training grant) Joseph Dosch (research mentor, Ph.D student, 2007-present), Kyle Szuminski (undergraduate, University of Michigan, research mentor, 2008-2009), Erica Proctor (faculty research advisor, 2009-present, T32 Training Grant, American College of Surgeons Resident Research Award), Gazala Khan (Med Onc faculty, research mentor, 2009-2010), Eric Kim (Med Onc fellow, research mentor, 2010), Taylor Detzler (2010, Univ of Michigan Cancer Research Summer Research Program (CaRSIP) recipient), Fil Bednar (Faculty research


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mentor, 2008-present, Organogenesis Center Research Award, American College of Surgeons Resident Research Award).

COMMITTEES (NATIONAL) Coller Society Councilor, 1999-2002 Audit Committee, 2002-2004 Grants Review Committee, 2006 Association for Academic Surgery Program Committee, 1999-2001 Society of University Surgeons

Executive Council, 2002-present Chairman of the Publications Committee, 2002-2004 AAS-SUS Joint Meeting Task Force, 2002-2005 SUS Genomics Conference Committee, 2003-2004 Councilor at Large, 2004-2007 Chair, Membership Committee 2004-2007 Scholarship Committee 2004-2007 President-Elect 2007-2008 President 2008-2009 Vice President, Academic Surgical Congress, 2009. Scholarship Committee, 2007-2010

SSAT (Society of Surgeons of the Alimentary tract) Abstract Review Committee, 2004-2006. Research Committee 2005-2010 Chair, Research Committee, 2008-2011 American College of Surgeons Clinical Congress Paper Sessions Review Committee, 2005-2006. American Hepato-Pancreato-Biliary Association Program Committee 2005-2008. American Pancreatic Association

Abstract Review Committee, 2005-2007 Councilor, 2006-2009 Chair, Liason Committee, 2007 Chair, Basic Science Committee, 2008-present President- Elect 2009-2010

Invited Participant: PanCan Summit on Pancreatic Cancer, 2007. American College of Surgeons Clinical Congress Abstract Review Committee, 2007. MAYO Clinic Pancreatic SPORE Grant, External Review Committee Member, 2007-present. Lustgarten Foundation Scientific Advisory Board, 2007-2010. ASCO Scientific Program Committee- Gastrointestinal Cancer (Non-colorectal), 2007-2009. American College of Surgeons, Commission on Cancer, Pancreatic Cancer Expert Panel, 2007. MD Anderson Pancreatic SPORE Grant, External Review Committee, 2007-present. PanCAN Grants Review Committee, 2007. National Pancreas Foundation Grant Review Council, 2008-2011. Pancreasfest (NIDDK/NAPS2/NAPSG) Program Committee, 2008-2009. PanCAN CAPTURE Project Steering Committee, 2008-2010.

Society of Clinical Surgery, Admissions Committee, 2008-2011.


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Chair, American Gastroenterological Association (AGA) Pancreatic Physiology and Basic Pancreatic Biology Abstract Review Committee, 2008-2009.

AACR-PanCAN Scientific Review Committee, 2009. AACR Program Committee, “Stem Cell Biology/Cancer Stem Cells/ Developmental Oncobiology”, 2010. Scientific Advisory Board, Hirshberg Foundation for Pancreatic Cancer Research, 2010-2011.

COMMITTEES (HOSPITAL) General Surgery Committee on Medical Student Education Committee on Ambulatory Care Planning Committee on Women in Surgery Department of Surgery Representative, University of Michigan House Officers Organization Contract Negotiating Team The Department of Surgery Research Advisory Committee, ad hoc Reviewer, 2002-2004. The New Patient Access Group Committee, 2004. Field of Dreams Cancer Symposium Committee, 2004 Search Committee for Surgical Director of Liver Transplantation, 2004. Tissue Procurement Advisory Committee, 2005-present. Grant Reviewer, University of Michigan Medical School Clinical Research Initiatives Program, 2006. Search Committee, Chair of Molecular and Integrative Physiology, 2006. Department of Surgery Advisory Board, 2007. Search Committee, Director, GI Medical Oncology, 2008. Search Committee, UM Comprehensive Cancer Center Associate Director of Clinical Research, 2009. Search Committee, University of Michigan Trauma Center Director, 2009. Senior Leadership Committee, Michigan Institute for Clinical and Health Research (MICHR), 2009. MICHR Postdoctoral Translational Scholars Program Grant Review Committee, June, 2009. STUDY SECTIONS Ad hoc: The Department of Veterans Affairs Office of External Reviews, Outside reviewer, August, 2001. NIH Special Emphasis Panel (ZDK1-GRB8-M1): “Endoscopic Clinical Research in Pancreatic and Biliary Diseases”, 2004. Grant Review Committee,The Lustgarden Foundation for Pancreatic Cancer Research, 2004. NIH Clinical and Integrative Gastrointestinal (CIGP) Study Section, 2004-2005. NIH Special Emphasis K08 Panel: “Cancer Stem Cells”, June, 2008. NIH Special Emphasis R01 Panel: “Tumor Stem Cells in Cancer Biology, Prevention, and Therapy”. July 2008. Member: NIH Clinical and Integrative Gastrointestinal (CIGP) Study Section, 2006-2010. JOURNAL REFEREE Editorial Board Surgery 2002- present Pancreatology 2006-present Annals of Surgery 2007-present Translational Oncology 2007-present


Page 12 Journal of Gastrointestinal Surgery 2007-present Ad Hoc Reviewer AJP: GI and Liver Physiology Cancer Research AJP: Cellular Physiology Clinical Gastroenterology and Hepatology Gastroenterology American Journal of Pathology Neoplasia Oncology Journal of Cellular Physiology Clinical Cancer Research Journal of Surgical Oncology Cytokine Cancer Molecular Cancer Research Oncogene Cancer Letters Molecular and Cellular Biology Digestive Diseases and Sciences Pancreas Cell and Tissue Research Cell Stem Cell PloS ONE BIBLIOGRAPHY Peer-Reviewed Publications 1. Mulholland MW, Romanchuk G, Lally K, and Simeone DM: Nerve growth factor promotes neurite

outgrowth in guinea pig myenteric plexus ganglia. Am J Physiol, 267:G716-G722,1994. 2. Simeone DM, Romanchuk G, and Mulholland MW: Dual pathways regulate neurite outgrowth in enteric

ganglia. Am J Physiol 267:G723-G729, 1994. 3. Simeone DM, Kimball B, Mulholland MW: Bombesin mediates Ca2+ fluxes in myenteric neurons via a

phospholipase C-dependent mechanism. Surg Forum, 45:197-199, 1994. 4. Simeone DM, Yule DI, Logsdon CL, and Williams JA: CA2+ signaling through secretagogue and growth

factor receptors on pancreatic AR42J cells. Regul Peptides 55:197-206, 1995. 5. Simeone DM, Kimball B, and Mulholland MW: Bombesin-mediated calcium fluxes in myenteric plexus

neurons. Peptides 16:1307-1311, 1995. 6. Simeone DM, Sandelin K, and Thompson NW: The undescended superior parathyroid gland: a potential

cause of failed cervical exploration for hyperparathyroidism. Surgery 118:949-956, 1995. 7. Simeone DM, Kimball BC, and Mulholland MW: Acetylcholine-induced calcium signaling

associated with muscarinic receptor activation in cultured myenteric neurons. J Am Coll Surg 182:473-481, 1996.

8. Michaels A, Gerndt SJ, Taheri PA, Wang SC, Wahl WL, Simeone DM, Williams D,Greenfield LJ, and Rodriguez JL: Blunt force injury of the aorta. J Trauma 41:105-109,1996.

9. Few J, Thompson NW, Angelos P, Simeone DM, Giordano T, Reeve T: Riedel’s thyroiditis: treatment with tamoxifen. Surgery 120 (6):993-998, 1996.

10. Simeone DM, Cascarelli A, and Logsdon CD: Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumor cell growth. Surgery 122:428-433, 1997.

11. Simeone DM, Cascarelli A, and Logsdon CD: Disruption of the transforming growth factor beta (TGF) signaling pathway in human pancreatic cancer cells. Surg Forum1997; XLVIII: 176-178.

12. Simeone DM and Pranikoff T: Mesenteric cyst. New Eng J Med 1999; 341: 659. 13. Simeone DM, Hassan A, and Scheiman J: Giant peptic ulcer: a surgical or medical disease? Surgery 1999;

126(3): 474-478. 14. Simeone DM, Pham T, Logsdon CD. Disruption of TGF signaling pathways in human pancreatic cancer

cells. Ann Surg 2000; 232: 73-80. 15. Simeone DM, Scheiman J, and Thompson NW: The “serendipitous” surgical cure of the Zollinger-Ellison

syndrome in a patient with multiple endocrine neoplasia type 1 despite an unsuspected diagnosis of either disease. J Clin Gastroenterology 32(3): 268-271, 2001.


Page 13 16. Zhang L, Graziano K, Pham T, Logsdon CD, Simeone DM. Adenovirus-mediated gene transfer of

dominant-negative Smad4 blocks TGF signaling in pancreatic acinar cells. Am J Physiol: Gastrointestinal and Liver Physiol 280: G1247-1253, 2001.

17. Cowles RA, Moyer CA, Sonnad SS, Simeone DM, Knol JA, Eckhauser FE, Mulholland MW, Colletti LM. Doctor-patient communication in surgery: attitudes and expectations of general surgery patients about the involvement and education of surgical residents. J Am Coll Surg 193: 73-80, 2001.

18. Simeone DM, Zhang L, Graziano K, Nicke B, Pham T, Schaefer C, Logsdon CD. Smad4 mediates activation of mitogen-activated protein kinases by TGF in pancreatic acinar cells. Am J Physiol Cell Physiol 281: C311-C319, 2001.

19. Ji B, Bi Y, Simeone DM, Mortenson R, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology 121: 1380-1390, 2001.

20. Peterson DA, Graziano K, Ford JW, Deogracias MP, Knipp BS, Eagleton MJ, Simeone DM, Stanley JC, Upchurch GR. Nitric oxide synthase inhibition in vitro is associated with increased nuclear factor-kB activity in rat aortic smooth muscle cells. Surg Forum 52: 370-372, 2001.

21. Chen X, Ji B, Han B, Ernst SA, Simeone DM, Logsdon CD. Pancreatic and systemic inflammatory response induced by NF-kB activation in the pancreas. Gastroenterology 122: 448-457, 2002.

22. Burant CF, Simeone DM. Connections between islet development and developing useful islets. Trends Endocrinol Metab 13: 48-49, 2002.

23. Binkley CE, Cinti S, Simeone DM, Colletti LM. Bacillus Anthracis as an agent of bioterrorism: a review emphasizing surgical treatment. Ann Surg 236: 9-16, 2002.

24. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson J, Giordano, TJ, Misek D, Hanash S. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res. 63: 2649-2657, 2003.

25. Ji B, Simeone DM, Mortensen RM, Logsdon CD. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacology Toxicol 28: 11, 2002.

26. Shedden KA, Taylor JM, Giordano T, Kuick R, Misek DE, Rennert G, Schwartz, Gruber S, Logsdon C, Simeone DM, Greenson JK, Cho KR, Beer DG, Fearon ER, Hanash S. Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathologic tree-based framework. Am J Pathol 163(5): 1985-1995, 2003.

27. Tretalaur M, Zhang L, Simeone DM, O’Shea S, Burant C. Nestin lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes 52:2503-2512, 2003.

28. Arumugam T, Simeone DM, Schmidt AM, Logsdon CD. S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem 279: 5059-5065, 2004.

29. Zhang L, Duan C, Binkley C, Uhler M, Logsdon CD, Simeone DM. A TGF-induced Smad3/Smad4 complex directly activates Protein Kinase A. Mol Cell Biol 24: 2169-2180, 2004.

30. Knipp BS, Peterson DA, Ford JW, Ailawadi G, Eagleton MJ, Roelofs KJ, Hannawa KK, Ji B, Logsdon CD, Graziano K, Simeone DM, Thompson RW, Henke PK, Stanley JC, Upchurch GR. Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is regulated by NFkB and AP-1. J Surg Res 116: 70-80, 2004.

31. Hong SH, Misek DE, Wang H, Puravs E, Giordano TJ, Greenson JK, Brenner DE, Simeone DM,

Logsdon CD, and Hanash SM. An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res 2004; 64: 5504-5510.

32. Zhang L, Binkley C, Giordano T, Burant C, Logsdon CD, Simeone DM. Raf-1 kinase inhibitory protein inhibits -Cell proliferation. Surgery 2004; 136: 708-715. 33. Binkley CE, Zhang L, Greenson JK, Giordano TJ, Kuick R, Misek D, Hanash S, Logsdon CD, Simeone DM. The molecular basis of pancreatic fibrosis: common

stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas 2004; 29: 254-263.

34. Okami J, Simeone DM, Logsdon CD. Silencing of the hypoxia inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res 2004; 64: 5338-5346.

35. Allen AM, Zalupski MM, Robertson JM, Eckhauser, FE, Simeone, DM, Brown, D, Hejna G, Normolle D, Lawrence TS, McGinn CJ. Adjuvant therapy in pancreatic cancer: Phase I trial of radiation dose escalation with concurrent full-dose gemcitabine. Int J Rad Oncol Biol Phys 2004; 59: 1461-1467.

36. Arumugam T, Simeone DM, Van Golen K, Logsdon CD. S100P promotes pancreatic cancer growth, survival, and invasion. Clin Cancer Res 2005; 11: 5356-5364.

37. Zhang L, Mahmood R, D’Silva N, Greenson J, Logsdon CD, Simeone DM. Rap1GAP is a novel pancreatic cancer tumor suppressor gene on chromosome 1p35. Cancer Res 2006; 66: 898-906.


Page 14 38. Newman E, Simeone DM, Mulholland, MW. Adjuvant treatment strategies for pancreatic cancer. J

Gastrointest Surg 2006; 10: 916-926. 39. Simeone DM, Zhang L, Treutelaar M, Zhang L, Graziano K, Logsdon, CD, Burant CB. Islet hypertrophy

following pancreatic disruption of Smad4 signaling Am J Physiol: Endo Metab 2006; 291: E1305-1316. 40. Heidt, DG, Burant C, Simeone DM. Total pancreatectomy: indications, operative technique, and post-

operative sequelae J Gastrointest Surg 2007; 11: 209-216. 41. Zhao J, Simeone DM, Heidt DG, Anderson MA, Lubman DM. Comparative serum glycoproteomics using

lectin selected sialic acid glycoproteins with mass spectrometric analysis: application to pancreatic cancer serum. J Proteome Res. 5: 1792-1802, 2006.

42. Yoo C, Zhao J, Pal M, Hersberger K, Huber C, Simeone DM, Beer D, Lubman. Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples. Electrophoresis 2006; 27: 3643-3651.

43. Hong S-H, Misek DE, Wang H, Puravs E, Hinderer R, Giordano TJ, Greenson JK, Brenner DE, Simeone DM, Logsdon CD and Hanash SM. Identification of a specific vimentin isoform that induces an antibody response in pancreatic cancer. Biomarker Insights 2006; 2:175-183.

44. Patwa TH, Zhao J, Anderson M, Simeone DM, Lubman, DM. Screening of glycosylation patterns in serum using natural glycoprotein microarrays and multi-lectin fluorescence detection. Anal Chem 2006; 78: 6411-21.

45. Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay NV, Wicha MS, Clarke MF, Simeone DM. Identification of pancreatic cancer stem cells Cancer Res 2007; 67: 1030-1037.

46. Huang E, Li C, Heidt D, Simeone DM. Cancer stem cells: a new paradigm for understanding tumor progression and therapeutic resistance Surgery 2007; 141: 415-419.

47. Simeone DM, Ji B, Banerjee M, Arumugam T, Li D, Anderson M, Bamberger AM, Greenson J, Brand RE, Ramachandran V, Logsdon CD. CEACAM1, a novel biomarker for pancreatic cancer. Pancreas 2007; 34(4): 436-443.

48. Zhao J, Qiu W, Simeone DM, Lubman DM. N-linked glycosylation profiling of pancreatic cancer serum using capillary liquid phase separation coupled with mass spectrometric analysis. J Proteome Res 2007; 6(3): 1126-1138.

49. Ramachandran V, Arumugam T, Hwang RF, Greenson J, Simeone DM, Logsdon CD. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the ADMR receptor. Cancer Res 2007; 67: 2666-2675.

50. Chen S, LaRoche T, Hamelinck D, Bergsma D, Brenner D, Simeone DM, Brand, R, Haab, BB. Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays. Nature Methods 2007; 4: 437-444.

51. Dalerba P, Dylla SJ, Park I-K, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007; 104: 10158-10163.

52. Misek D, Patwa TH, Lubman DM, Simeone DM. Early detection and biomarkers in pancreatic cancer. J Natl Compr Cancer Netw 2007; 5: 1034-1041.

53. Zhao J, Patwa TH, Qiu W, Shedden K, Hinderer R, Misek DE, Anderson MA, Simeone DM, Lubman DM. Glycoprotein microarrays with multi-lectin detection: unique lectin binding patterns as a tool for classifying normal, chronic pancreatitis, and pancreatic cancer sera. J Proteome Res 2007; 6 (5) 1864-1874.

54. Chen J, Anderson MA, Misek DE, Simeone DM, Lubman DM. Characterization of apolipoprotein and apolipoprotein precursors in pancreatic cancer serum samples via two-dimensional liquid chromatography and mass spectrometry J Chromatography 2007; 1162: 117-125.


Page 15 55. Desai SP, Ben-Josef E, Normolle DP, francis IR, Greenson JK, Simeone DM, Chang AE, Colletti LM,

Lawrence TS, Zalupski MM. A Phase I study of oxiplatin, full-dose gemcitabine and concurrent radiation therapy in patients with pancreatic cancer. J Clin Oncol.2007; 25 (29): 4587-92.

56. Chandra M, Heidt DG, Simeone DM, McKenna B, Scheiman J, Mycek M-A. Probing pancreatic disease using tissue spectroscopy. J Biomedical Opt 2007 12(6): 060501.

57. Zhao J, Patwa TH, Lubman DM, Simeone DM. Protein biomarkers in cancer: natural glycoprotein microarray approaches. Current Opinion in Molecular Therapeutics 2008; 10 (6): 602-610.

58. Simeone DM. SSAT/AGA/ASGE State of the Art Conference on Cystic Neoplasms of the Pancreas. J Gastrointest Surg. 2008; 12(8) 1475-7.

59. Lee CJ, Anderson MA, Hines OJ, Reber HA, Kochman ML, Foley PJ, Drebin J, Oh D, Ginsberg G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Stokes JB, Bauer T, Adams RB, Scheiman J, Simeone DM. Risk of malignancy in resected cystic tumors of the pancreas < 3 cm in size: it is safe to observe asymptomatic patients? A multi-institutional report J Gastrointest Surg 2008; 12: 234-242.

60. Sonnenday C, and Simeone, DM. “Criminal” tumor profiling: when is aggressive therapy indicated for a non-aggressive entity? Ann. Surg. 2008; 247 (4): 580-2.

61. Lee CJ, Dosch J, Simeone DM. Pancreatic cancer stem cells. J Clin Oncol 2008; 26 (17): 2806-12. 62. Lee CJ, Li C, Simeone DM. Human pancreatic cancer stem cells: implications for how we treat pancreatic

cancer. Translational Oncology 2008; 1: 14-18. 63. Patwa T, Wang T, Simeone DM, Lubman D. Enhanced detection of autoantibodies on protein micorarrays

using a modified protein digestion technique. J Proteome Res 2008; 7 (6) 2553-61. 64. Grote T, Siwak DR, Fritsche HA, Joy C, Mills GB, Simeone DM, Whitcomb D, Logsdon CD. Validation of

reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA 19-9 levels in pancreatic cancer. Proteomics 2008; 8(15): 3051-60.

65. Yang H, Lee CJ, Zhang L, Simeone DM. Regulation of transforming growth factor -induced responses by protein kinase A in primary pancreatic acinar cells. Am J Physiol:GI 2008; 5 (1):G170-8.

66. Simeone DM. Pancreatic cancer stem cells: implications for how we treat pancreatic cancer. Clin Cancer Res 2008; 14: 5646-5648.

67. Li C, Simeone DM, Brenner D, Anderson MA, Shedden KA, , Ruffin M, Lubman DM. Pancreatic Cancer serum detection using a lectin/glyco-antibody array method. J Proteome Res. 2009; 8(2): 483-492.

68. Wang L, Heidt DG, Lee CJ, Logsdon CD, Zhang L, Fearon ER, Ljungman ME, Simeone DM. Oncogenic function of ATDC (TRIM 29) in pancreatic cancer through Wnt pathway activation and -catenin stabilization. Cancer Cell 2009; 15: 207-219.

69. Bednar F and Simeone DM. Pancreatic cancer stem cells and relevance to cancer treatments. J Cell Biochem 2009; 107: 40-45.

70. Sarkar B, Dosch J and Simeone DM. Cancer stem cells: a new theory regarding a timeless disease. Chem Rev 2009; 109:3200-3208.

71. Desai S, Ben-Josef E, Griffith KA, Simeone DM, Greenson J, Francis I, Hampton J, Colletti L, Chang A, Lawrence TS, Zalupski MM. Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreatic cancer. Int J Rad Onc Biol Phys 2009 Apr 29 [Epub ahead of print].

72. Patwa TH, Poisson LM, Pal M, Ghosh D, Misek DE, Simeone DM, Lubman DM. The identification of phosphoglycerate kinase-1 (PGK-1) and histone 4 auto-antibodies in pancreatic cancer patient serum using a natural protein microarray. Electrophoresis 2009; 30: 2215-2226.

73. Dosch JS, Pasca di Magliano M, Simeone DM. Pancreatic cancer and hedgehog pathway signaling: new insights. Pancreatology 2010; 10: 151-157.


Page 16 74. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol NJ, Emens, L, O’Reilly E, Korc M, Ellis

L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese, Simeone DM, Hingorani S, Berlin J, Tepper J. Consensus Report of NCI Clinical Trials Planning Meeting on Pancreas Cancer Treatment. J Clin Oncol 2009 27: 5660-5669.

75. Kryczek I, Liu R, Wang G,Wu K, Shu X, Szeliga W, Vatan L, Finlayson E, Huang E, Simeone DM, Redman B, Welling TH, Chang A, Zou W. FOXP3 defines regulatory T cells in human tumor and autoimmune disease Cancer Res 2009; 69:3995-4000.

76. Patwa TH, Qiu Y, Zhao J, Simeone DM, Lubman DM. All-liquid separations, protein microarrays, and mass spectrometry to interrogate serum proteomes: an application to serum glycoproteomics. Methods Mol Biol 2009; 520: 75-87.

77. Patwa T, Li C, Simeone DM, Lubman DM. Glycoprotein analysis using protein microarrays and mass spectrometry. Mass Spec Rev 2010 Jan 13 [Epub ahead of print]..

78. Kryczek I, Banerjee M, Cheng P, vatan L, Szeliga W, Wei S, Huang E, Finlayson E, Simeone DM, Welling TH, Chang A, Coukos G, Zou W. Phenotype, distribution, generation, functional and clinical relevance of Th17 cells in the human tumor microenvironment. Blood 2009 May 21 [Epub ahead of print].

79. Brand RE, Greer JB, Zolotarevsky E, Brand R, Du H, Simeone DM, Zisman A, Gorchow A, Lee S-Y, Roy HK, Anderson MA. Pancreatic cancer patients who smoke and drink are diagnosed at younger ages. Clin Gastroenterol Hepatol 2009; 9: 1007-1012.

80. Khan GN and Simeone DM. Cancer stem cell resistance and therapeutics in pancreatic cancer. Expert Opinion Biol Ther (in press).

81. Li C, Lee CJ, Simeone DM. Identification of human pancreatic cancer stem cells. Methods Mol Biol 2009; 568: 161-173.

82. Sundaram B, Robbins JB, Zeglis MD, Scheiman JM, Simeone DM, Francis IR. Mesenteric venous collateral vessels mimicking cystic pancreatic neoplasm Br J Radiol 2010; 83: e175-e178..

83. Khan G, Pasca di Magliano M, Simeone DM. Frontiers in pancreatic cancer research. Surg Oncol Clin N Am 2010; 19: 431-451.

84. Chokshi NK, Simeone DM, Chari RS, Dorey F, Guner YS, Upperman JS. A survey of academic surgeons: work, stress, and research. Surgery 2009; 146: 462-468.

85. Wilson RH, Chandra M, Scheiman J, Simeone DM, McKenna B, Purdy J, Mycek M-A. Optical spectroscopy detects histological hallmarks of pancreatic cancer. Optics Express 2009; 17(20):17502-17516.

86. Pausawasdi N, Heidt DG, Kwon R, Simeone DM, Scheiman J. Long term follow-up of patients with incidentally discovered pancreatic cystic neoplasms evaluated by endoscopic ultrasound. Surgery 2010; 147: 13-20.

87. Haab BB, Porter A, Yue T, Li L, Scheiman J, Anderson MA, Barnes D, Schmidt M, Feng Z, Simeone DM. Glycosylation variants of mucins and CECAMS as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms. Ann Surg 2010; 251: 937-945.

88. Chandra M, Scheiman J, Simeone DM, McKenna B, Purdy J, Mycek M-A. Spectral areas and ratios classifier (SpARC) algorithm for pancreatic tissue classification using optical spectroscopy. J Biomedical Optics 2010; 15(1):010514.

89. Lee CJ, Spalding A, Ben-Josef E, Wang L, Simeone DM. In vivo bioluminescent imaging of radiated orthotopic pancreatic xenografts in NOD/SCID mice: a novel method for assaying clinical efficacy of ionizing radiation. Translational Oncology 2010; 3: 153-159.

90. Anderson, MA, Brenner DE, Scheiman JM, Simeone DM, Singh N, Sikora MJ, Zhao L, Rae JM. Reliable gene expression measurements from endoscopic fine needle aspirates of pancreatic tumors: effect of amplicon length and quality assessment. J Mol Diagnostics (in press).

91. Dai L, Shedden KA, Lee CJ, Li C, Quoc H, Simeone DM, Lubman DM. Quantitative proteomic profiling of pancreatic cancer stem cells. J Proteome Res (in press).


Page 17 92. Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone

DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, and Lawrence TS. Mechanism of radiosensitization by the Chk1/2 inhibitor, AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombination repair. Cancer Res 2010 May 25 [Epub ahead of print].

93. Zhuge Y, Kaufman J, Simeone DM, Chen H, Velazquez OC. Is there still a glass ceiling for women in academic surgery? Ann Surg (in press).

94. Li C, Kim HY, Vuone H, Patwa T, Pal M, Brand RE, Simeone DM and Lubman DM. The Identification of Auto-Antibodies in Pancreatic Cancer Patient Sera Using a Naturally Fractionated Panc-I Cell Line. Cancer Biomarkers (in press).

Articles Submitted 1. Yang H, Gangyong Li G, Michael D. Uhler MD, Simeone DM. TGF-Induced Smad4-PKA Regulatory Subunit Interaction Regulates Smad Nuclear Trafficking (submitted Mol Cell Biol). 2. Li C, Hynes M, Dosch J, Wu J-J, Pasca di Magliano M, Sarkar B, Simeone DM. c-Met: a new cancer stem cell marker and therapeutic target for pancreatic cancer (submitted to Gastroenterol). 3. Boyd AD, Brown D, Henrickson C, Hampton J, Zhu B, Almani F, Ben-Josef E, Zalupski M, Simeone DM, Taylor J, Armitage R, and Riba M. Screening for depression, sleep related disturbances, and anxiety in patients with adenocarcinoma of the pancreas: A preliminary study (submitted). 4. Chandra M, Lloyd WR, Wilson RH, Scheiman J, Simeone DM, Purdy J, McKenna B, Mycek MA. Principal component analysis of optical response: a framework for automated clinical detection of pancreatic cancer (submitted to Optics Express). 5. Wilson RH, Chandra M, Lloyd W, James Scheiman J, Simeone DM, Purdy J, McKenna B,

and Mycek M-A.

Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues (submitted to Optics Express). 6. Yue T, Li L, Anderson MA, Brenner DE, Simeone DM, Feng Z, Brand RE, Haab BB. Enhanced sensitivity of pancreatic cancer detection by measuring the CA 19-9 antigen on specific protein carriers (submitted to JNCI).

Abstracts Submitted 1. Yue, T; Li Lin; Anderson M; Brenner DE; Simeone DM; Feng Z; Brand RE; Haab BB. Candidate biomarkers for pancreatic cancer evaluated using antibody-lectin sandwich arrays in multiple sample sets. Submitted to the 2010 US HUPO conference.

Invited Non-Peer Review Articles 1. Lee CJ, Simeone DM. Surgical Treatment of Pancreatic Cancer. Cancer News on the Net (in press). 2. Simeone DM. Society of University Surgeons Presidential Address: The Evolution of the SUS. Surgery 2009; 146: 131-7. Books Greenfield’s Surgery. Editors: Mulholland MW, Lillemoe KD, Doherty GM, Simeone DM, Upchurch GR. Lippincott Williams and Wilkins, 5th edition (in press). Books/Chapters 1. Greenfield LJ, Mulholland MW, Oldham KT, et al: Contributors: DeLucia A, Simeone DM,

Magee J, et. al: Review for Surgery: Scientific Principles and Practice. Philadelphia, PA, JB Lippincott Co., 1993.

2. Mulholland MW and Simeone DM: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al (eds): Textbook of Gastroenterology, 3rd Edition. Philadelphia, PA, JB Lippincott Co., 1999: 2107-2120.


Page 18 3. Mulholland MW and Simeone DM: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al

(eds): Atlas of Gastroenterology, 2nd Edition. Philadelphia, PA, JB Lippincott Co., 1999: 421-425. 4. Simeone, DM: “Gallbladder and Biliary Tree: Anatomy and Structural Anomalies.” In Yamada, T., et al

(eds): Textbook of Gastroenterology, 3rd Edition. Philadelphia, PA, JB Lippincott Co.,1999: 2244-2257. 5. Simeone, DM: “Gallbladder and Biliary Tree: Anatomy and Structural Anomalies.” In Yamada, T. et al

(eds): Atlas of Gastroenterology, 2nd Edition. Philadelphia, PA, JB Lippincott Co.,1999: 464-471. 6. Simeone, DM: “Small Intestine Anatomy and Physiology.” In Greenfield, L. et al (eds): Surgery:

Scientific Principles and Practice, 3rd Edition.Philadelphia, PA, Lippincott Co., 2001: 787-798. 7. Graziano K, and Simeone DM: “Gastric Ulcer.” In Bland, KI. et al (eds): The Practice of General Surgery. Philadelphia, PA,

W.B. Saunders, 2002: 379-382. 8. Simeone DM and Mulholland MW: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al (eds): Textbook of

Gastroenterology, 4th Edition. Philadelphia, PA, JB Lippincott Co. 2003: 2013-2026. 9. Simeone DM and Mulholland MW: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al

(eds): Atlas of Gastroenterology, 3rd Edition. Philadelphia, PA, JB Lippincott Co., 2003: 495-499. 10. Simeone, DM: “Gallbladder and Biliary Tree: Anatomy and Structural Anomalies.” In Yamada, T. et al

(eds): Atlas of Gastroenterology, 3rd Edition. Philadelphia, PA, JB Lippincott Co., 2003: 553-560. 11. .Simeone, DM. “Gallbladder and Biliary Tree: Anatomy and Structural Anomalies.” In Yamada, T. et al

(eds): Textbook of Gastroenterology, 4th Edition, Philadelphia, PA, JB Lippincott Co. 2003: 2166-2177. 12. Binkley C, Simeone DM. “Pancreatic Cancer.” In Williams JA et al (eds): Encyclopedia of

Gastroenterology. Elsevier Co., 2004: 41-48. 13. Simeone, DM. Commentary, "Prevention." In Von Hoff D, Evans D, and Hruban R., eds.: Pancreatic

Cancer. Jones & Bartlett, Publishers, Sudbery, MA, 2005: pp 152-153. 14. Simeone DM. “Complications of Pancreatic Surgery.” In Doherty GM, and Mulholland MW, eds.:

Complications in Surgery, Philadelphia, PA, Lippincott, Williams, and Wilkins. 2006: 463-476. 15. Simeone, DM: “Small Intestine Anatomy and Physiology.” In Greenfield, L. et al (eds): Surgery:

Scientific Principles and Practice, 4th Edition. Philadelphia, PA, Lippincott Co. 2006: 756-767. 16. Simeone, DM. “Tumors of the Exocrine Pancreas.” In, Sabel M, Sussman J, and Sondak, V., eds.: Surgical

Foundations: Essentials in Surgical Oncology. Mosby. 2007: 265-278. 17. Mulholland MW, Hussain, H. and Simeone DM. “Hepatic Cyst Disease.” In Shackleford, Surgery of the

Alimentary Tract. 6th Edition, Saunders, 2007: 1630-1639. 18. Mulholland MW and Simeone DM. “Benign Gastric Disorders.” In Maingot’s Abdominal Operations. 11th

Edition, McGraw Hill Medical. 2007: 333-352. 19. Lee, Cheong J., Simeone, DM. “Gastric Ulcer.” In Bland, K, et al (eds): General Surgery: Principles and

International Practice. Springer, U.K. 2008. 20. Heidt DG, Lubman DM, Simeone, DM. “Incorporation of Genomics and Proteomics in Drug

Development.” In, Lowy, A. et al (eds): Pancreatic Cancer. MD Anderson Solid Tumor Oncology Series 2008.

21. Lin J, Simeone DM. “Chronic Pancreatitis.” In Doherty G. (ed). Current Surgical Procedures. McGraw Hill 2008.

22. Welling, TH and Simeone DM. “Gallbladder and Biliary Tract: Anatomy and Structural Anomalies.” In Yamada’s Textbook of Gastroenterology, 5th Edition, 2009.

23. Welling, TH and Simeone DM. “Gallbladder and Biliary Tract: Anatomy and Structural Anomalies.” In Yamada’s Atlas of Gastroenterology, 4th Edition, 2009.

24. Heidt, D.G., Mulholland MW and Simeone DM: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al (eds): Textbook of Gastroenterology, 5th Edition. Philadelphia, PA, JB Lippincott Co. 2009.

25. Heidt DG, Mulholland MW, and Simeone DM: “Pancreas: Anatomy and Structural Anomalies.” In Yamada, T., et al (eds): Atlas of Gastroenterology, 4th Edition. Philadelphia, PA, JB Lippincott Co. 2009.


Page 19 26. Lee CJ, Li C, Simeone DM. “Pancreatic Cancer Stem Cells.” In Yu J, et al. (eds). Methods in Molecular

Biology: Cancer Stem Cells. Humana Press 2009. 27. Lee CJ, Heidt DG, Simeone DM. “Pancreatic Cancer Stem Cells.” In Schwab M (ed). Encyclopedia of

Cancer (2nd edition). Springer Press 2009. 28. Dosch J, Lee CJ, and Simeone DM. “Cancer Stem Cells- Pancreatic Cancer.” In “Stem Cells and Cancer”.

(1st Edition), Humana Press 2009. 29. Sonnenday C and Simeone DM. “Disorders of the Exocrine Pancreas”. In the 6th Edition of

“Pathophysiology of Disease: An Introduction to Clinical Medicine”, McGraw-Hill, 2010. 30. Patwa TH, Qiu Y, Zhao J, Simeone DM, Lubman DM. All-Liquid Separations, Protein Microarrays, and

Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics”. In Tainsky, M.A., Methods of Molecular Biology, Tumor Biomarker Discovery, Vol 520, Springer Science 2009.

31. Simeone, DM. “Complications of Pancreatic Surgery”. In Mulholland, MW et al. Complications in Surgery. 2nd Edition, Lippincott Williams and Wilkens (in press).

32. Simeone, DM. “Total Pancreatectomy”. In Adams, R. ed. Atlas of Hepatobiliary and Pancreatic Surgery. Elsevier Publishers. (in press)

SCIENTIFIC PRESENTATIONS 1. Simeone DM, Mulholland MW: “Dual pathways regulate outgrowth in enteric neurons.”American College

of Surgeons 78th Clinical Congress, October, 1992. 2. Simeone DM, Mulholland MW: “Bombesin stimulates cholinergic neurotransmission in the myenteric

plexus.” 26th Annual Meeting, The Association for Academic Surgery, November,1992. 3. Simeone DM, Mulholland MW: “Mechanisms of growth regulation in the enteric nervous system.”

Frederick A. Coller Society Meeting, October, 1992. 4. Simeone DM, Mulholland MW: “Calcium signaling in myenteric neurons.” The Society of University

Surgeons 54th Annual Meeting, February, 1993. 5. Simeone DM, Mulholland MW: “Acetylcholine induces calcium transients in myenteric neurons.

Michigan Chapter American College of Surgeons, May, 1993. 6. Simeone DM, Mulholland MW: “Acetylcholine induces calcium transients in single myenteric neurons.”

American Gastroenterological Association Meeting, May, 1993. 7. Simeone DM, Mulholland MW: “Bombesin mediates calcium fluxes in myenteric neurons via a

phospholipase C-dependent mechanism.” American College of Surgeons 80th Clinical Congress, October, 1994.

8. Simeone DM, Sandelin K, Thompson NW: “The undescended superior parathyroid gland: a potential cause of failed cervical exploration for hyperparathyroidism. 16th Annual Meeting , American Association of Endocrine Surgeons, April, 1995.

9. Simeone DM: Support of House Bill 5000: “The importance of the primary seatbelt enforcement issue and its impact on the care of the trauma patient.” Meeting of the Michigan Safety Belt Coalition, Ann Arbor, MI, January, 1996.

10. Few J, Thompson NW, Angelos P, Simeone DM, Giordano T, Reeve T: “Riedel’s thyroiditis: treatment with tamoxifen.” 17th Annual Meeting, American Association of Endocrine Surgey

11. Simeone DM, Cascarelli A, Logsdon C: “Defining TGF signaling pathways in pancreatic cancer.” University of Michigan Gastrointestinal Peptide Center Retreat, January, 1997.

12. Simeone DM, Cascarelli A, Logsdon C: “Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumor cell proliferation.” 58th Annual Meeting, Society of University Surgeons, February, 1997.


Page 20 13. Simeone DM, Cascarelli A, Logsdon C: Regulation of mob-1 chemokine gene expression in isolated

pancreatic acinar cells.” Annual Meeting, American Gastroenterological Association, May, 1997. 14. Simeone DM, Hassan A, Schiman J: “Giant peptic ulcer: a surgical or medical disease?”Annual Meeting,

The Society for Surgery of the Alimentary Tract, May, 1997. 15. Simeone DM, Cascarelli A, Pham T, Logsdon C: “Disruption of the transforming growth factor beta

(TGF) signaling pathway in human pancreatic cancer cells.” American College of Surgeons 83rd Clinical Congress, October, 1997.

16. Simeone DM, Scheiman J: “Giant peptic ulcer: current management .” Annual Meeting, Frederick A. Coller Surgical Society, October, 1997.

17. Taheri P, Michaels A, Simeone DM, Iteld L, Garner G, Wahl W, Wang S, Nyachowe P, Griffes L, Greenfield L: “Trauma service cost: the real story.” 109th Annual Session, Southern Surgical Association, December, 1997.

18. Simeone DM, Pham T, Schaefer C, Logsdon CD: “MAP kinases are activated by transforming growth factor beta in rat pancreas in vitro.” Annual Meeting, Michigan Gastrointestinal Peptide Research Center, January, 1998.

19. Simeone DM, Pham T, Logsdon CD: “Altered TGF signaling pathways in pancreatic cancer cells: role of Smad proteins.” Annual Meeting, Michigan Gastrointestinal Peptide Research Center, January, 1998.

20. Simeone DM, Pham T, Schaefer C, Nicke B, Logsdon CD: “Transforming growth factor activates mitogen-activated (MAP) kinase in pancreatic acinar cells.” 99th Annual Meeting of the American Gastroenterological Association, May, 1998.

21. Simeone DM, Pham T, Schaefer C, Nicke B, Logsdon CD: “Transforming growth factor signaling pathways in pancreatic acinar cells.” 12th International Symposium on Regulatory Peptides, September, 1998.

22. Simeone DM, Pham T, Logsdon CD. “The role of Smad4 in TGF signaling pathways in human pancreatic cancer cells.” 100th Annual Meeting of the American Gastroenterological Association, May, 1999.

23. Simeone DM. “Pancreatic growth regulation: TGF and Smads. Department of Surgery Monthly Research Conference, University of Michigan Medical Center, October, 1999.

24. Zhang L, Pham T, Logsdon CD, Simeone DM. “Adenovirus-mediated dominant negative DPC4 blocks TGF inhibition of pancreatic acinar cell growth.” Annual Meeting of the American Pancreatic Association, November, 1999.

25. van Leeuwen K, Zhang L, Logsdon CD, Simeone DM. Transcription factor activation by TGFb in pancreatic acinar cells: role of DPC4 and MAP kinases. Annual Meeting of the Michigan Chapter of the American College of Surgeons, May, 2000.

26. Zhang L, Logsdon CD, Simeone DM. TGF-mediated growth inhibition and induction of p21 in pancreatic acinar cells is blocked by adenoviral gene transfer of dominant negative DPC4. Annual Meeting of the American Gastroenterological Association, May, 2000.

27. vanLeeuwen K, Zhang L, Logsdon CD, Simeone DM. Transcriptional factor regulation by TGF in pancreatic acinar cells: Role of DPC4 and MAP kinases. Annual Meeting of the American Gastroenterological Association, May, 2000.

28. Han B, Simeone DM, Logsdon CD. -cyclodextrins enhance efficiency of adenoviral-mediated gene delivery to the pancreas in vivo without inducing pancreatitis. Annual Meeting of the American Gastroenterological Association, May, 2000.

29. Simeone DM. TGF signaling in the pancreas: the role of Smads and MAP kinases. University of Michigan Gut Peptide Center Annual Symposium- invited talk. June, 2000.

30. Cowles RA, Moyer CA, Sonnad SS, Simeone DM, Knol JA, Eckhauser FE, Mulholland MW,


Page 21

Colletti LA. Patients’ attitudes and expectations regarding involvement and education of surgical residents. Association for Academic Surgery Annual Meeting, November, 2000.

31. Chen X, Ji B, Ernst SA, Simeone DM, Logsdon CD. Acute pancreatitis and systemic inflammatory response induced by NFkB activation in the pancreas. University of Michigan Gut Peptide Center Annual Retreat, January, 2001.

32. Logsdon CD, Simeone DM, Greenson J, Misek D, Hanash S. Microarray analysis of genes over-expressed in pancreatic cancer. University of Michigan Gut Peptide Center Annual Retreat, January, 2001.

33. Ji B, Simeone DM, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. University of Michigan Gut Peptide Center Annual Retreat, January, 2001.

34. Zhang L, vanLeeuwen K, Logsdon CD, Simeone DM. Expression of dominant negative Smad4 targeted to pancreatic acinar cells in transgenic mice results in islet cell hyperplasia. Society of University Surgeons Annual Meeting, February, 2001.

35. Zhang L, Graziano K, Logsdon, CD, Simeone, DM. TGF activation of cAMP responsive element binding protein (CREB) is dependent on PKA and Smads in pancreatic acinar cells. Annual Meeting of the American Gastroenterological Association, May, 2001.

36. Zhang L., Logsdon CD, Simeone DM. TGF activation of CREB is dependent on the physical interaction of an activated Smad complex and the regulatory subunit of PKA. Annual Meeting of the Americal Pancreatic Association, November, 2001.

37. Ji B, Chen X, Simeone DM, Mortensen R, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Annual Meeting of the Americal Pancreatic Association, November, 2001.

38. Zhang L, Duan CJ, Binkley C, Logsdon CD, Simeone DM. Raf-1 kinase inhibitor protein (RKIP) is an important regulator of beta cell proliferation. Annual Meeting of the Society of University Surgeons, February, 2002.

39. Binkley C, Zhang L, Duan CJ, Logsdon CD, Simeone DM. Pancreatic adenocarcinoma cDNA microarray analysis reveals marked overexpression of the novel gene ATDC. Annual Meeting of the Society of University Surgeons, February, 2002.

40. Allen AM, Zalupski MM, Eckhauser FE, Robertson JR, Simeone DM, Hejna G, Brown D, Normolle D, Lawrence TS, McGinn CJ. A phase 1 trial of radiation (RT) dose escalation with concurrent full dose gemcitabine (GEM) following resection of pancreatic cancer. Proceedings of the 38th Annual Meeting of the American Society of Clinical Oncology, 2002.

41. Binkley C, Zhang L, Lawrence T, Logsdon CD, Simeone DM. The ATDC gene is overexpressed in human pancreatic adenocarcinoma. Annual Meeting of the American Gastroenterological Association, May, 2002.

42. Logsdon CD, Simeone DM, Arumugam T, Binkley C, Ji B, Greenson J, Misek D, Kuick R, Hanash S. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Annual Meeting of the American Gastroenterological Association, May, 2002.

43. Allen AM, Zalupski MM, Eckhauser FE, Roberston JM, Simeone DM, Hejna D, Brown D, Normolle D, Lawrence TS, McGinn CJ. A phase I trial of radiation (RT) dose escalation with concurrent weekly full dose gemcitabine (GEM) following surgical resection for pancreatic cancer. Annual Meeting of the American Society of Clinical Oncology.

44. Binkley C, Logsdon CD, Simeone DM. The role of ATDC in radiation resistance in pancreatic adenocarcinoma. Annual Meeting of the Coller Society, October, 2002.

45. Binkley CE, Zhang L, Logsdon C, Simeone DM. Identification of common molecular determinants of pancreatic fibrosis in chronic pancreatitis and pancreatic adenocarcinoma. Association for Academic Surgery Annual Meeting, November, 2002.

46. Binkley CE, Zhang, L, Lawrence T, Logsdon CD, Simeone DM. ATDC expression in pancreatic adenocarcinoma: a molecular model of radiation resistance. American Pancreatic Association Annual Meeting, November, 2002.

47. Zhang L, Binkley CE, Duan CJ, Uhler M, Logsdon CD, Simeone DM. A TGF-induced Smad complex directly activates PKA. American Pancreatic Association Annual Meeting, November, 2002.

48. Binkley CE, Davis MA, Zhang L, Lawrence TS, Logsdon CD, Simeone DM. ATDC expression in pancreatic adenocarcinoma: the basis of radiation resistance. Society of University Surgeons Annual Meeting, February, 2003.

49. Okami J, Arumugam T, Simeone DM, Logsdon CD. Genes downregulated in pancreatic cancer: reintroduction of pro-apoptotic BNIP3 leads to cancer cell death. Plenary Presentation at the Annual Meeting of the American Gastroenterological Association, May, 2003.

50. Arumugam T, Simeone DM, Logsdon CD. S100P is highly expressed in pancreatic adenocarcinoma and stimulates cell proliferation and survival. Annual Meeting of the American Gastroenterological Association, May, 2003.

51. Arumugam T, Simeone DM, Logsdon CD. S100P is an autocrine growth and survival factor for pancreatic adenocarcinoma. American Pancreatic Association Annual Meeting, November, 2003.

52. Okami J, Arumugam T, Simeone DM, Logsdon CD. Genes downregulated in pancreatic adenocarcinoma affect cell survival: reintroduction of proapoptotic BNIP3 leads to pancreatic cancer cell death. American Pancreatic Association Annual Meeting, November, 2003.

53. Binkley CE, Davis MA, Zhang L, Lawrence TS, Logsdon CD, Simeone DM. ATDC confers a growth advantage and radiation resistance in pancreatic adenocarcinoma. American Pancreatic Association Annual Meeting, November, 2003.

54. Binkley CE, Davis MA, Zhang L, Lawrence TS, Logsdon CD, Simeone DM. The ataxia telangiectasia group D associated gene promotes a cellular survival advantage in pancreatic adenocarcinoma. Association of Academic Surgeons Annual Meeting, November, 2003.

55. Zhang L, Logsdon CD, Simeone DM. Rap1Gap in Pancreatic Cancer Progression. Society of University Surgeons Annual Meeting, February, 2004.


Page 22 56. Zhang L, Mahmood R, van Golen K, Greenson J, Logsdon CD, Simeone DM. Identification of a new tumor suppressor gene Rap1GAP in pancreatic cancer.

Annual Meeting of the American Association of Cancer Research, March, 2004. 57. Arumugam T, Simeone DM, Logsdon CD. S100P Stimulates Pancreatic Cancer Growth, Survival and Motility. Annual Meeting of the American

Gastroenterological Association, May, 2004. 58. Okami J, Simeone DM, Logsdon CD. Silencing of the Hypoxia Inducible Cell death Protein BNIP3 in Pancreatic Cancer. Annual Meeting of the American

Gastroenterological Association, May, 2004. 59. Anderson M, Ji B, Simeone DM, Weinman B, Scheiman J, Logsdon CD. Pancreatic Cancer Associated Gene Expression from FNA Samples Differentiates

Neoplastic Pancreatic Masses from Normal and Chronic Pancreatitis. Annual Meeting of the American Gastroenterological Association, May, 2004. 60. Ji B, Simeone DM, Ramachandran V, Arumugam T, Hanash S, Greenson J, Taylor J, Bamberger AM, Logsdon CD. CEACAM1 is a Biomarker for Pancreatic

Cancer. Annual Meeting of the American Gastroenterological Association, May, 2004. 61. Ramachandran V, Arumugam T, Li G, Zhang L, Logsdon CD, Simeone DM. Adrenomedullin is over-expressed in pancreatic cancer and stimulates cell growth,

migration and invasion. Annual Meeting of the American Gastroenterological Association, May, 2004. 62. Li G, Zhang L, Hu D, Ramachandran V, Uhler M, Logsdon CD, Simeone DM. A TGF-Induced Smad3/Smad4 Complex Directly Activates Protein Kinase A:

Determining the Interaction Domains of the Trimeric Complex. Plenary Session, Annual Meeting of the American Gastroenterological Association, May, 2004. 63. Simeone DM, Zhang L, Treutelaar MK, Zhang L, Burant C. Adult Islet Size Regulation by TGF-Family Signaling in a Periductal Islet Precursor Cell. Annual

Meeting of the American Diabetes Association, June, 2004. 64. Ramachandran V, Arumugam T, Logsdon CD, Simeone DM. Adrenomedullin is over-expressed in pancreatic cancer and stimulates cell growth and invasion.

Annual Meeting of the American Pancreatic Association, November, 2004. 65. Arumugam T, Simeone DM, Logsdon CD. S100P increases pancreatic growth and invasion. Annual Meeting of the American Pancreatic Association,

November, 2004. 66. Li C, Zhang L, van Golen K, Logsdon CD, Simeone DM. Identification of a new tumor suppressor gene Rap1GAP1 in pancreatic cancer. Annual Meeting of the

American Pancreatic Association, November, 2004. 67. Li G, Zhang L, Ramachandran V, Hu D, Uhler M, Logsdon CD, Simeone DM. A TGF-Induced Smad3/Smad4 complex directly activates protein kinase A: the

interaction domains of the trimeric complex. Annual Meeting of the American Pancreatic Association, November, 2004. 68. Ji B, Simeone DM, Ramachandran V, Arumugam T, Hanash S, Giordano T, Greenson J, Bannerjee M, Logsdon CD. CAECAM1 is a biomarker for pancreatic

cancer. Annual Meeting of the American Pancreatic Association, November, 2004. 69. Ji B, Anderson M, Song J, Simeone DM, Weinman B, Scheiman J, Logsdon CD. Pancreatic cancer associated gene expression from FNA samples differentiates

neoplastic from benigh pancreatic diseases. Annual Meeting of the American Pancreatic Association, November, 2004. 70. Ramachandran V, Arumugam T, Li G, Logsdon CD, Simeone DM. Adrenomedullin stimulates pancreatic cancer cell growth and invasion. AACR Annual

Meeting, April, 2005. 71. Cleary MJ, Simeone DM, Scheiman JM. Surgical decision making in the treatment of cystic pancreatic lesions: what is the role of EUS + FNA? Society of

Surgeons of the Alimentary Tract (SSAT) Annual Meeting, May, 2005. 72. Anderson MA, Ji B, Simeone DM, Weinman B, Korneffel M, Song J, Logsdon CD, Scheiman JM. EUS-FNA detection of select biomarkers for the diagnosis of

pancreatic cancer. AGA Annual Meeting, May, 2005. 73. Wang L, Logsdon CD, Simeone DM. ATDC is overexpressed in pancreatic cancer and may play a role in DNA repair. AGA Annual Meeting, May, 2005. 74. Anderson MA, Ji B, Scheiman JM, Simeone DM, Weinman B, Korneffel M, Song J, and Logsdon CD. Molecular markers from EUS fine needle specimens can

differentiate pancreatic neoplasia requiring surgery from chronic pancreatitis and other benign conditions of the pancreas. ASGE Annual Meeting, May, 2005. 75. Chen J, Simeone DM, Lubman DM. Exploring serum biomarkers for pancreatic cancer by prefractionation, 2D-LC separation and mass spectrometry

identification. 53th American Society for Mass Spectrometry Conference, June 2005. 76. D.Heidt, J.D. Birkmeyer, Y. Sun, E. Ben-Josef, and D.M. Simeone. Effect of adjuvant radiation treatment on survival following pancreaticoduodenectomy for

pancreatic cancer: a population-based study. Annual Meeting of the American Pancreatic Association, Nov., 2005.

77. L. Wang, M. Davis, C.D. Logsdon, T.S. Lawrence and D.M. Simeone. ATDC is overexpressed in pancreatic cancer and may function as a novel DNA

repair gene. Annual Meeting of the American Pancreatic Association, Nov., 2005. 78. C. Li, D.G Heidt, N. Mollenberg, M. Clarke, D.M. Simeone. Identification of pancreatic cancer stem cells. Annual Meeting of the American Pancreatic

Association, Nov., 2005. 79. S. Khayyata, D.M. Simeone, L. Zhang, C. Li, O. Basturk, N.V. Adsay. Rap1GAP expression in pancreatic ductal adenocarcinoma: correlation with

clinicopathological parameters. Annual Meeting of the American Pancreatic Association, Nov., 2005. 80. L. Zhang, D.G. Heidt, D.M. Simeone, C. F. Burant. Prospective identification of adult pancreatic stem/progenitor cells. Annual Meeting of the American

Pancreatic Association, Nov., 2005. 81. D. G. Heidt, C. Li, N. Mollenberg, M. Clarke, D.M. Simeone. Identification of pancreatic cancer stem cells. Annual Meeting of the Society of University

Surgeons, Feb., 2006. 82. C.J. Lee, L. Zhang, M. D. Uhler, D.M. Simeone. A TGF-induced Smad complex directly activates PKA in pancreatic acinar cells and regulates pancreatic

acinar cell growth. Annual Meeting of the Society of University Surgeons, Feb., 2006. 83. S. Khayyata, D. M. Simeone, L. Zhang, C. Li, O. Basturk, E. Levi, N.V. Adsay. Loss of rap1GAP expression in pancreatic ductal adenocarcinoma and its

association with decreased survival. Annual Meeting of the International Academy of Pathology, Feb., 2006. 84. Chen J, Simeone DM, Lubman DM. Serum protein profiling for detection of pancreatic cancer. 54th American Society for Mass Spectrometry Conference, June

2006. 85. Desai SP, Ben-Josef E, Lawrence TS, Chang AE, Colletti LM, Simeone DM, Normolle DP, Zalupski MM A Phase I Study of Oxaliplatin and Full-dose

Gemcitabine with Concurrent Radiation Therapy in Patients with Pancreatic Cancer. Annual Meeting of ASCO-GI, 2006. 86. S. Chen, D. Hamelinck, T. LaRoche, D.E. Brenner, J. Marrero, M. Anderson, D. M. Simeone, R.E. Brand, B.B. Haab. Antibody-lectin microarrays reveal altered

glycosylation on secreted proteins in pancreatic cancer patients. Annual Meeting of the American Association of Cancer Research, April, 2006. 87. Lee CJ, Scheiman J, Simeone DM. Risk of Malignancy in Resected Cystic Tumors of the Pancreas < 3 Cm in Size: Is it Safe to Observe Asymptomatic Patients?

Annual Meeting of the Society of University Surgeons, Feb, 2007. 88. Heidt DG, Li, C, Lee, CJ, Simeone DM. BMI-1 is upregulated in pancreatic adenocarcinoma and pancreatic cancer stem cells and confers a malignant

phenotype. Annual Meeting of the Society of University Surgeons, Feb 2007. 89. Chandra M, Heidt D, Simeone DM, McKenna B, Scheiman J, Mycek M-A. Pancreatic tissue assessment using fluorescence and reflective spectroscopy.

European Biomedical Optics Meeting, Spring, 2007.


Page 23 90. Basturk O, Simeone DM, Wang L, Greenson J, Levi E, Thirabanjasak, D, Adsay NV. Overexpression of Ataxia Telangiectasia Group D Complement Gene

(ATDC) in pancreatic cancer. Annual Meeting of United States and Canadian International Academy of Pathology, San Diego, March, 2007. 91. Zolotarevsky E, Simeone DM, Anderson MA. Dose-dependent effects of alcohol and tobacco on age of presentation in pancreatic cancer. Annual Meeting of the

American Gastroenterological Association, May, 2007. 92. Wang L, Yang H, Davis M, Lawrence TS, Ljungman ME, Simeone DM. ATDC, a novel DNA damage response protein highly expressed in pancreatic cancer, is

a phosphorylation target of ATM. Annual Meeting of the American Gastroenterological Association, May, 2007. 93. Pausawasdi N, Heidt DG, Simeone DM, Kwon R, Subramanian S, Scheiman J. Long Term Follow- up of Patients With Incidentally Discovered Pancreatic

Cystic Neoplasm Evaluated by EUS. Annual Meeting of the American Gastroenterological Association, May, 2007). 94. Lee CJ, Anderson MA, Hines OJ, Reber HA, Kochman ML, Foley PJ, Drebin J, Oh D, Ginsberg G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Scheiman J,

Simeone DM. Risk of Malignancy in Resected Cystic Tumors of the Pancreas < 3 Cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-Institutional Report. Annual Meeting of the American Gastroenterological Association, May, 2007.

95. Haab BB, Bergsma D, Shafer M, Heidt DG, Anderson MA, Simeone DM. A Glyco-Proteomic Approach to Differentiate Mucin-Producing and Serous Cystic Neoplasms of the Pancreas Using Antibody Microarrays. Annual Meeting of the American Gastroenterological Association, May, 2007.

96. Kim H, Li C, Simeone DM , Misek DE, Lubman DM. Analysis of pancreatic cancer cell protein expression using micro-separation techniques. Annual HUPO Conference, Korea, October, 2007.

97. Yue T, Chen S, Goldstein I, Hollingsworth MA, Simeone DM, Brand RE, Haab BB.

Profiling glycan structures on mucins in the sera of pancreatic cancer patients using antibody arrays: cancer-associated variation and potential disease markers. Annual Meeting of the American Pancreatic Association, November, 2007.

98. C.J. Lee CJ, Spalding A, Li C, Wang L, Simeone DM. In-vivo Imaging of Radiated Orthotopic Pancreatic Xenografts in NOD-SCID Mice: a Novel Method for Assaying Clinical Efficacy of Ionizing Radiation. Annual Meeting of the American Pancreatic Association, November, 2007.

99. Wang L, Lee CJ, Heidt DG, Ljungman ME, Simeone DM. ATDC, a Highly Expressed Protein in Pancreatic Cancer, Contributes to Tumorigenicity by Upregulating Wnt/-Catenin Signaling. Annual Meeting of the American Pancreatic Association, November, 2007.

100. Lee CJ, Li C, Ljungman ME, Simeone DM. Pancreatic cancer stem cells are resistant to ionizing radiation and the chemotherapeutic agent gemcitabine. Annual meeting of the Society of University Surgeons, February, 2008.

101. Barnes D, Wang L, Ljungman M, Simeone DM. ATDC, a novel DNA damage response protein, is highly expressed in pancreatic cancer. Plenary talk, Annual meeting of the Society of University Surgeons, February, 2008.

102. Zolotarevsky E, Wamsteker E, Kwon R, Piraka C, Simeone DM, Scheiman J, Anderson MA. Fluid CEA level is more influential than the PathFinderTG® test in guiding clinical management of pancreatic cystic lesions. Annual Meeting of the American Gastroenterological Association, May, 2008.

103. Wilson RH, , Chandra M, Scheiman J, Heidt D, Simeone DM, McKenna B, Mycek M-A. Modeling reflectance and fluorescence spectra of human pancreatic tissues for cancer diagnostics. Optical Society of America Meeting, October, 2008).

104. Haab BB, Porter A, Schmidt C, Lee CJ, Barnes D, Simeone, DM. Glycosylation variants on mucins as candidiate markers for the diagnosis of pancreatic cystic neoplasms. Annual Meeting of the American Pancreatic Association, November, 2008.

105. Wang L, Davis M, Xu, L, Ljungman ME, Simeone DM. ATDC participates in the radiation –induced damage response. Annual Meeting of the American Pancreatic Association, November, 2008.

106. Yang H and Simeone DM. TGF-Induced PKA activation regulates Smad4 nuclear trafficking. Annual Meeting of the American Pancreatic Association, November, 2008.

107. Lee CJ, Dosch J, Wang L, Xu L, Ljungman M, and Simeone DM. Expression of ATDC in Pancreatic Cancer Stem Cells Confers Resistance to DNA Damage. SUS Plenary talk, Academic Surgical Congress, February, 2009.

108. Morgan MA, Parsels LA, Parsels JD, Davis MA, Hylander-Gans, Zabludoff SD, Simeone DM, Maybaum J, and Lawrence TS. Targeting Chk1 to enhance gemcitabine-radiation therapy efficiacy in pancreatic cancer. AACR National Conference, April, 2009.


Page 24 109. Chandra M, Wilson RH, Scheiman J, Simeone DM, McKenna B, Purdy J, Mycek M-A. Optical

spectroscopy for clinical detection of pancreatic cancer. European Conferences on Biomedical Optics, April, 2009.

110. Brown D, Boyd A, Hendrickson C, Hampton J, Almani F, Ben-Josef E, Zalupski M, Simeone DM, Taylor J, Armitage R, Riba M. Prevalence of depression, sleep related disturbances and anxiety and their effect on quality of life in patients with adenocarcinoma of the pancreas. American Society of Clinical Oncology, May, 2009.

111. Krishnaswami S, Perkins S, Frost M, Nwomeh B, Simeone DM, Nadler E, Orloff S. International Surgical Efforts within U.S. Academic Institutions: results of a Survey by the AAS/SUS joint committee on international surgery. Annual Meeting of the Academic Surgical Congress, February, 2010.

112. Li C, Hynes M, Dosch J, Wu JJ, Sarkar B, Pasca di Magliano M, Simeone DM. c-Met: a new cancer stem cell marker and therapeutic target for pancreatic cancer. AACR Meeting, April, 2010. 113. Wang L, Wilkerson JE, Kumju P, Kumar C, Liebert M, Simeone DM. Novel transgenic model of bladder cancer. 10th Annual Michigan Urological Oncology Research Symposium. June11, 2010. INVITED PRESENTATIONS (UNIV OF MICHIGAN) 2006 University of Michigan Department of Radiology Grand Rounds, “An approach to Cystic Pancreatic Lesions”, January 18, 2006. 2006 Center For Organogenesis Seminar, “ATDC is Overexpressed in Pancreatic Cancer and Functions as a Novel DNA Repair Protein”, March 29, 2006. 2006 Hematology Oncology Research Conference, UMCC, “Pancreatic Cancer: Clinical/Translational Research Program”, September 25, 2006. 2007 Univ. of Michigan Translational Research Program, “Biomarkers for Pancreatic Cancer, February 13, 2007. 2008 University of Michigan Comprehensive Cancer Center Update on Cancer, “Update on the Diagnosis and Treatment of Pancreatic Adenocarcinoma”, July 11, 2008. 2008 University of Michigan Comprehensive Cancer Center Update on Cancer, “Pancreatic Cancer Stem Cells”, July 11, 2008. INVITED PRESENTATIONS (NATIONAL)

1) “Mechanisms of agonist-induced Ca2+

signaling in myenteric neurons. “Invited lecture, Harvard Medical School, Deaconess Hospital, November, 1994.

2) Society of University Surgeons. Surgical Oncology Scientific Session Moderator. Houston, Texas, February, 2003. 3) “Update on Pancreatic Adenocarcinoma.” Invited lecture, Cancer Update 2003: Highlighting recent advances in the prevention,

diagnosis, and treatment of breast cancer, melanoma, and gastrointestinal cancers. Mackinac Island, MI., July, 2003. 4) Moderator, Plenary Session, Society of Surgeons of the Alimentary Tract, May, 2004. 5) Moderator, AGA Research Forum (Oral Session): Pancreatic inflammation and fibrogenesis.

Digestive Diseases week, May, 2004. 6) “Serum CEACAM1: a Novel Biomarker for Early Detection of Pancreatic Cancer”. Invited Lecture,

American Association of Cancer Research/Lustgarden Foundation Meeting “Pancreatic Cancer 2004”, San Francisco, CA, 2004.

7) “New Advances in Pancreatic Cancer Research”. Invited Lecture, University of Michigan Comprehensive Cancer Center Frontiers in Gastrointestinal Malignancies Conference, Dearborn, MI, 2004.

8) “Pancreatic Cancer: Conflicting Data for Adjuvant/Neoadjuvant Therapy”. Invited Lecture, American College of Surgeons Post-graduate Course on Diseases of the Liver, Biliary Tract, and Pancreas. October, 2004.


Page 25

9) “Novel TGF Signaling Mechanisms- Relevance to Pancreatic Biology and Disease”. Invited Lecture, Surgical Biology Club, New Orleans, LA, October, 2004.

10) “Identification of Novel Early Detection Biomarkers for Pancreatic Cancer: CEACAM1”. Invited Lecture, The National Cancer Institute Early Detection Research Network (EDRN) Workshop on Pancreatic Cancer Early Detection Biomarkers., Norfolk, VA, September, 2004.

11) Invited Moderator, American Pancreatic Association Oral Session “Pancreatic Cancer-Clinical”. Annual Meeting of the American Pancreatic Association, November, 2004.

12) Invited Lecture, M.D. Anderson Cancer Center Grand Rounds, “Novel TGF Signaling Mechanisms: Relevance to Pancreatic Biology and Oncogenesis”, January, 2005.

13) Invited Lecture, M.D. Anderson Cancer Center Pancreatic Cancer Club, “Rap1GAP: a Novel Tumor Suppressor Gene at 1 p36 in Pancreatic Cancer”, January, 2005.

14) Invited Lecture, “How to Get Out of Trouble in the OR: Problems During GI Surgery”. American College of Surgeons 33rd Annual Spring Meeting, April, 2005.

15) Invited Lecture, Karmanos Cancer Center, “Identification of Rap1GAP, a Novel Tumor Suppressor in Pancreatic Cancer”, April, 2005.

16) Invited Lecture, “Transition to the R01”, Fundamentals of Surgical Research Course and AAS Career Development Course, San Francisco, CA, October 2005.

17) Invited Lecture, “Stem Cells and Pancreatic Cancer”, Annual Meeting of the American Hepato-Pancreato-Biliary Association, Miami, March, 2006.

18) Invited Chair of Session, “Pancreatic Disorders: Stellate Cells”. Annual Meeting of the American Gastroenterological Association, Los Angeles, May, 2006.

19) Invited Chair of Session, “Basic Science Studies in Pancreatic Cancer”. Annual Meeting of the Pancreas Club, UCLA Medical Center, May, 2006.

20) Invited Lecture, “Developmental Biology: Pancreatic Stem Cells”. Annual Meeting of the American Pancreatic Association”, Chicago, IL., November, 2006.

21) Invited Lecture, “Why is pancreatic cancer so difficult to treat? Stem cell resistance in pancreas cancer”. Gastrointestinal Cancers Symposium (Combined meeting of ASCO, ASTRO, AGA, and SSO), Orlando, FL, January, 2007.

22) Invited Moderator, “Gastrointesinal III: Inflammation”. Annual Meeting of the Academic Surgical Congress, February, 2007 23) Invited Lecture, “Identification and Characterization of Pancreatic Cancer Stem Cells”. M.D. Anderson Cancer Center Pancreatic

Cancer Club, February, 2007. 24) Invited Lecture, “Pancreatic Cancer Stem Cells”. Keystone Symposia on Cancer Stem Cells, March, 2007. 25) Invited Lecture, “Hedgehog signaling and Pancreatic Cancer Stem Cells”. Infinity Pharmaceuticals, Boston, MA, March, 2007. 26) Invited Chair of Session, “Total Pancreatectomy: Indications, Technique, and Metabolic Sequelae”. Annual Meeting of the

AHPBA, Las Vegas, Nevada, April, 2007. 27) Invited Lecture, “Pancreatic Cancer Stem Cells: Implications for Treatment”. Mayo Clinic Cancer Center, May, 2007. 28) Invited Chair of Session, “SSAT State-of-the-Art Conference: Controversies in Surgical Management of Cystic Neoplasms of the

Pancreas”, Annual Meeting of the Society of Surgeons of the Alimentary Tract, May, 2007. 29) Invited Chair of Session, Pancreatic Disorders: Biomarker Discovery for Pancreatic Cancer, Annual Meeting of the American

Gastroenterological Association, May, 2007. 30) Visiting Professor, University of Alabama at Birmingham, Resident Research Day, Invited Talk, “Human Pancreatic Cancer

Stem Cells: Identification and Implications for Treatment”, June, 2007. 31) Invited Lecture, “Pancreatic Cancer Stem Cells”. The PanCAN Summit on Pancreatic Cancer, August 3, 2007, La Jolla, CA. 32) Invited Speaker, Annual Langer Lecture, “Human Pancreatic Cancer Stem Cells: Implications for How We Treat Pancreatic

Cancer”. September 7, 2007, University of Toronto, Toronto, Ontario. 33) Invited Speaker, Jointly Sponsored Conference by the American Pancreatic Association and Lustgarten Foundation. “Isolation

and Characterization of Pancreatic cancer Stem Cells”. November 2, 2007, Chicago, IL. 34) Invited Speaker, Jointly Sponsored Conference by the American Pancreatic Association and Lustgarten Foundation.

“Point/Counterpoint: Stem Cell Theory”. November 3, 2007, Chicago IL. 35) Invited Speaker, Van Andel Research Institute. “Pancreatic Cancer Stem Cells and the Treatment of Pancreatic Cancer”.

November 21, 2007, Grand Rapids, MI. 36) Invited Speaker, NCI State of the Clinical Science Meeting on Pancreatic Cancer. “Tumor and Host factors Contributing to

Pancreatic Cancer”. November, 2007, Bethesda, Md. 37) Invited Speaker, NIH Cancer Stem Cell Workshop, 2008. “Human Cancer Stem Cells in Pancreatic Cancer”. January 17, 2008,

Bethesda, Md.


Page 26 38) Invited Speaker, Vanderbilt GI Spore Monthly Seminar, “Pancreatic Cancer Stem Cells: Implications for How We Treat Cancer.

Nashville, Tn. March, 2008. 39) Invited Speaker, University of Minnesota Surgery Grand Rounds, “Evolving Management of Cystic Tumors of the Pancreas”.

April, 2008. 40) Invited Speaker, University of Minnesota Cancer Center Grand Rounds, “Pancreatic Cancer Stem Cells and Treatment of

Pancreatic Cancer.” April, 2008 41) Invited Speaker, Virginia Surgical Society, “ Pancreatic Cancer Stem Cells and Pancreatic Cancer Treatment”, May 2, 2008,

Fairfax, VA. 42) Invited Speaker, Virginia Surgical Society, “State-of-the-Art Management of Cystic Tumors of the Pancreas”, May 2, 2008,

Fairfax, VA. 43) Invited Speaker, NCI CTEP Early Drug Development Meeting, “Disease Specific Identification of Cancer Stem Cells: Pancreas”.

September, 23, 2008, Besthesda, Maryland. 44) Invited Speaker, American College of Surgeons Clinical Congress, “Cancer Stem Cells in Gastrointestinal Malignancies”,

October 13, 2008, San Francisco, CA. 45) Invited participant, “Controversies on Cancer and Stem Cells- A Think Tank Meeting”, October 18, 2008, Saint-Jean-Cap-Ferrat,

France. 46) Invited Speaker, American Pancreatic Association, “Optimal Pre-Clinical Models to Study Pancreatic Cancer- Primary Human

Pancreatic Cancer Xenografts”, November 7, 2008. 47) Invited Speaker, ASCO GI, “Pancreatic Cancer Stem Cells: Implications for Therapy”, Friday, January 16th, 2009, San

Franscisco, CA. 48) Invited Chair of Session, “Basic and Translational Advances in Pancreatic Cancer Treatment: New Concepts in Organ Site

Research”, AACR Annual Meeting, April 20, 2009. 49) Invited Speaker, “Targeting Pancreatic Cancer Stem Cells”. AACR Annual Meeting”. April 20, 2009. 50) Invited Keynote Speaker, “Therapeutic Advances for Pancreatic Cancer: the Impact of Cancer Stem Cells”. University of

Wisconsin Regenerative Medicine Summit, May 22, 2009. 51) Invited Speaker, “Adjuvant Therapy for Pancreatic Cancer: Making the Case for Chemoradiation”. Joint Meeting of the

American Pancreatic Association and Japanese Pancreas Society, November 07, 2009. 52) Invited Visiting Professor, UCLA Department of Surgery Grand Rounds, “Novel Therapeutic Approaches to Target Pancreatic

Cancer”, January 6, 2010. 53) Plenary Speaker, NIH-ACS Surgical Investigators Conference: “Finding a Path to Success in Academic Surgery”. Besthesda,

Maryland, March 6, 2010. 54) Keynote Speaker, “Novel Therapeutic Approaches to Pancreatic Adenocarcinoma”. Society of Surgeons of Southern Africa, East

London, South Africa, July 15, 2010.

CURRICULUM VITAE Diane Marie Simeone … Department_of...Diane M. Simeone, M.D. Curriculum Vitae Page 4 24. “Adrenomedullin Overexpression in Pancreatic Cancer.” Frederick A. Coller

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