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Curriculum Vitae
David G. Harrison
Business Address: 2220 Pierce Avenue, Room 536 RRB
Nashville, TN 37232-6602 Business Phone: (615) 875-3049
Cell Phone: (404) 290-0904 Fax: (615) 875-3297
E-mail: [email protected] EDUCATION:
Undergraduate: Oklahoma State University, 1966-1970 Medical School:
Oklahoma University School of Medicine 1970-1974 TRAINING:
1974-75 Medical Internship Duke Hospital, Durham, NC James
Wyngaarden (Chairman) 1975-77 Medical Residency Duke Hospital,
Durham, NC James Wyngaarden (Chairman) 1977-79 Cardiology Fellow
Duke University Medical Center, Durham, NC James Wyngaarden
(Chairman) 1980-82 Cardiovascular Cardiovascular Center, University
of Iowa, Research Fellowship University of Iowa, Iowa City,
Iowa
Francois M. Abboud (Chairman) LICENSURE/CERTIFICATION: State of
Georgia Medical License, # 033348
State of Tennessee Medical License # 46911 Certified in Internal
Medicine, 1977 #62864
Certified in Cardiovascular Diseases, 1979 # 62864 ACADEMIC
APPOINTMENTS: Betty and Jack Bailey Professor of Medicine Director,
Division of Clinical Pharmacology Vanderbilt University School of
Medicine HOSPITAL APPOINTMENTS: Vanderbilt University Hospital and
Medical Center OTHER EMPLOYMENT: (optional) None HONORS AND AWARDS:
1974 Alpha Omega Alpha, University of Oklahoma 1974 Benjamin Rush
Award for Outstanding Student in Psychiatry, University of Oklahoma
1977 Haskel Schiff Award for Outstanding Medical House Officer,
Duke University Department of
Medicine 1980 Outstanding Attending, Department of Medicine
Charlotte Memorial Hospital 1980 Individual National Research
Service Award, National Institute of Health 1981 Clinical
Investigator Award, NIH, August 1982 - July 1987 1981 Clinician
Scientist Award, American Heart Association (Awarded, but not
accepted) 1987-92 Established Investigator, American Heart
Association 1995 George E. Brown Memorial Lecture, American Heart
Association Scientific Sessions 1998 Wellcome Visiting Professor in
the Basic Medical Sciences, New York Medical College, May 10,
1998 2001 Pfizer Visiting Professorship, Temple University,
Philadelphia
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February 14-16, 2001 2001 Robert Furchgott Lecture for the 8th
Symposium on Mechanisms of Vasodilatation, Boston, Massachusetts
2001 Bernard Marcus Chair of Cardiovascular Medicine
2002 Robert M. Berne Award for Cardiovascular Research,
Cardiovascular Section, American Physiological Society
2002 Sir George Pickering Lecture, British Hypertension Society
Annual Scientific Meeting, Queens’ College, Cambridge, UK,
September 2002
2003 2003 Distinguished Achievement Award (AHA Council on Basic
Sciences) 2004 J. Willis Hurst Internal Medicine Residency Program
Mentorship Award 2004 Novartis Award for Hypertension Research,
American Heart Association Council of High Blood
Pressure 2008 Outstanding Basic Science Research Citation Award,
Emory University Department of Medicine 2010 Carl J. Wiggers Award,
Cardiovascular Section, American Physiological Society 2010
Distinguished Scientist Award, American Heart Association 2012
Distinguished Scientist Award, American Society of Hypertension
2013 Fellow, American Association for the Advancement of
Science
PROFESSIONAL ORGANIZATIONS: 1985 Member, Central Society for
Clinical Research 1984 Member, American Federation of Clinical
Research, Midwest Section 1987 Member, American Physiological
Society 1988 Fellow, Cardiovascular Section, American Physiological
Society 1992 Member, American Society for Clinical Investigation
1993 Member, Society for Vascular Medicine and Biology
1994 Member, American Association of University Cardiologists
1996 Member, Oxygen Society 2001 Fellow, Basic Science Council,
American Heart Association 2002 Fellow, American College of
Cardiology 2002 Member, Association of American Physician 2012
Fellow, American Association for the Advancement of Science 2012
Member, American Clinical and Climatological Association
PROFESSIONAL ACTIVITIES:
INSTITUTIONAL SERVICE 1983-84 Medical Student Advisory
Committee, University of Iowa
1983-90 University Animal Care Committee, University of Iowa
1983-90 House Staff Advisory Committee, Dept. of Medicine, Univ. of
Iowa 1986-90 House Staff Evaluation Committee, Dept. of Medicine,
Univ. of Iowa 1986-1989 Service Chief, Veterans Administration
Hospital, Iowa City, IA 1988-89 Promotions Committee, University of
Iowa (to Associate Professor) 1997-2000 Service Chief, Veterans
Administration Hospital, Atlanta, GA 1997 Committee for Research
Planning, Emory Univ. Health Sciences Center 2000 Department of
Medicine Research Strategic Planning Committee 2000-2009 Director,
Division of Cardiology, Emory University
2002-2009 Heart Center Steering Committee, Emory Heart Center
2003-2004 Proteomics, Chemical and Structural Biology Strategic
Planning Committee 2003-2009 Member, Governing Board for Carlyle
Frazier Heart Center, Crawford Long Hospital 2011- Present
Director, Division of Clinical Pharmacology, Vanderbilt
University
2011-present Executive committee, Mouse physiology core
facility, Vanderbilt University Medical Center 2011-Present
Director, Vascular Biology Center, Vanderbilt University Medical
Center
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2011-2012 Member – Biochemistry Chair search committee 2011-2012
Chair – Search committee for Oates Chair of Translational Research
TEACHING (past and present) Medical Student Teaching: 1994-2010
Pathophysiology lectures on Endothelial function and dysfunction,
Emory Medical School 1995-2009 Sophomore Electives, Emory
University Hospital. 2001-2009 Director, Bench to Bedside,
Cardiology Sophomore Clinical Methods, Emory University Hospital
1990-2010 Attending Physician, Cardiology Service, Atlanta VA
Hospital, 2.5 months per year
2001-2010 Attending Physician, R. Bruce Logue Cardiology
Service, Emory University Hospital, 2-3 months per year
2011-Present Attending Physician, Harrison Cardiology Service,
Vanderbilt University, 1 month per year
Graduate Program: Training programs:
Faculty Member, Molecular and Systems Pharmacology Program,
Emory University. 1992-2010 Lecture Series on nitric oxide/cGMP
biology to MSP graduate students every other year Emory
University
2011 – present: Member Pharmacology faculty and mentor,
Vanderbilt University 2013- present: Member Molecular Physiology
and Biophysics faculty and mentor, Vanderbilt University
TRAINEES a. Ph.D. students directly supervised:
Years in Name Current position/Institution Training 1995-1998
Steven Presnell, Ph.D. Research Associate, Univ. of Kentucky
Medical Center,
Department of Pathology 1998-2003 Linda Cai, M.D., Ph.D.,
Professor, UCLA 1999-2003 Michael E. Davis, Ph.D., Associate
Professor, Emory University 2002-2005 Scott McNally, M.D., Ph.D
Assistant Professor, University of Utah 2003-2008 Nyssa E. Hoch,
Ph.D Medical Writer, San Francisco, CA 2006- 2011 Li Li Life
Sciences Specialist, L.E.K. Consulting 2010 – present Jing Wu 2013
– present Allison Norlander 2013 – present Roxana Loprena
b. Post-doctoral fellows directly supervised:
Years in Training Name Current position/Institution 1984-1987
Paul Freiman, MD Cardiologist, Private Practice 1985-1986 Gordon
Mitchell, MD Cardiologist, Private Practice 1985-1987 Darrel C.
Gumm, MD Cardiologist, Private Practice 1986-1989 Rich Guerra, MD
Cardiologist, Private Practice 1987-1988 Peter Banitt, MD
Cardiologist, Private Practice 1987-1989 R. Paul Myers, MD, PhD
Cardiologist, Private Practice 1988-1989 Frank Sellke, MD,
Professor and Director Cardiothoracic Surgery, Brown University
1988-1990 Kevin Peters, M.D. Chief Scientific Officer and VP
Research and Development, Akebia Therapeutics
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1989-1990 James Quillen, MD Cardiologist, Private Practice
1989-1990 Rob Minor, MD Cardiologist, Private Practice 1989-1990
Maurizio Cappelli-Bigazzi, MD Specialist, Pediatric Cardiology,
University of Naples 1990-1992 Robert M. Wheatley, MD Cardiologist,
Private Practice 1991-1993 Jorge Navas, MD Cardiologist, Private
Practice 1991-1995 Yuichi Ohara, MD Assistant Professor, Kyushu
University 1992-1995 Hassan S. Sayegh, MD Cardiologist, Private
Practice 1993-1995 Natalie James, PhD Research Scientist,
Ventassist Corporation, Australia 1993-1995 Thomas Münzel, MD
Professor and Director of Cardiology, University of Mainz, Germany
1993-1995 Richard Venema, Ph.D Professor of Pharmacology and
Toxicology, Georgia Health
Sciences University 1993-1995 Nobutaka Inoue, MD Professor, Kobe
University 1993-1994 Jean-Francois Arnal, MD, PhD Faculty, INSERM,
France 1994-1996 Sanjay Rajagopalan, MD Professor of Medicine and
Radiology, Ohio State University 1994-1996 Sabine Kurz, MD
Cardiologist, Private Practice 1995-1996 Georg Kojda, PhD Faculty
Member, Pharmacology Department, Univ. of Dusseldorf, Germany
1995-1996 Jørn-Bech Laursen, MD Cardiologist, Private Practice,
Denmark 1995-1999 Tohru Fukai, MD Associate Professor of Medicine
and Pharmacology, University of Illinois Chicago 1995-1999 Jonathan
D. Kent, PhD Research Scientist, Bayer Pharma 1995-1997 Charles
Searles, MD Assistant Professor, Emory University 1996-1997 Ascan
Warnholtz, MD Cardiologist, University of Mainz 1996-1999 Mark
Somers, MD Cardiologist, Private Practice 1997-1999 Martin
Siegfried, MD Cardiologist, Private Practice 1997-1999 Grant
Drummond, PhD NHMRC RD Associate Professor, Monash University,
Australia 1997-2000 Yoichi Miwa, MD, PhD Physician, Kobe University
1998-2000 Hans Ulrich Hink, MD Cardiologist, University of Mainz
1998-2001 David Schultz, MD, PhD Cardiologist, Private Practice
1998-2003 Hua (Linda) Cai, MD, Ph.D. Associate Professor of
Anesthesiology, Cardiovascular Research Laboratories, University of
California at Los Angeles 2000-2002 Ulf Landmesser, MD Director of
translational research, Klinik für Kardiologie,
HerzKreislaufZentrum UniversitätsSpital, Zürich, Switzerland
2000-2002 Kenji Kanazawa, MD, PhD Physician, Kyushu University
2002-2003 Quinton Gradek, MD Cardiologist, Private Practice
2002-2004 Cornelius Mueller, M.D. Cardiologist, University of Bonn,
Germany 2002-2004 Karine Laude, Ph.D. Faculti de
Medicine-Pharmacie, France 2002-2004 Isabella Grumbach, M.D., Ph.D.
Assistant Professor, University of Iowa 2003-2006 Julian Widder,
M.D. 2nd Uberartz, Medizinische Hochschule Hannover, Germany
2004-2008 Wei Chen, Ph.D. Assistant Professor, Vanderbilt
University 2005-2011 Maria Carolina Gongora Cardiology Fellow,
Emory University 2005-2008 Tomasz Guzik, M.D., Ph.D Professor,
University of Cracow, Poland Department Chairman, Internal Medicine
2005-2007 Kathryn Brown, Ph.D. Manager, Medical Affairs, Imedex
2007-2008 Petra Gratze, M.D. Cardiology Fellow, University of
Berlin 2007-2009 Klaudia Budzyn, Ph.D. Post-doctoral fellowship,
NHMRC 2008-2009 Thomas Jansen, M.D. Research Fellow, Karolinska
Institute 2007-2010 Meena Madhur, M.D., Ph.D. Assistant Professor,
Vanderbilt University 2008-2010 Antony Vinh, Ph.D. Faculty member,
Monash University, Australia 2006-2011 Paul Marvar, Ph.D. Marie
Curie International Research Fellow
School of Physiology & Pharmacology, Bristol Heart
Institute, University of Bristol, England
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2006-2011 Heinrich Lob, Ph.D. Research Scientist, Cornell
University 2008-2012 Salim Thabet, M.D. Cardiology Fellow, Emory
University
Current Trainees Years in Laboratory Name Support
2010-Present Jing Wu (pre-doctoral) NIH 2011-Present Daniel
Trott, Ph.D. NIH T32 training grant 2011-Present Annett Kirabo,
DVM, PhD AHA Fellowship 2012-Present Mohamed Saleh, Ph.D. NIH
2012-Present Liang Xiao, Ph.D. NIH 2012-Present Hanaa Itani, Ph.D.
NIH T32 training grant 2013-Present William McMaster, M.D. NIH T32
training grant 2013-Present Daniele Michell, PhD NIH 2013-Present
Allison Norlander (pre-doctoral) NIH T32 training grant
2013-Present Roxanna Loperena (pre-doctoral) APS 2014-Present Kim
Montaniel (pre-doctoral)
EXTRAMURAL ACTIVITIES National and International: 1982-1985 Iowa
Affiliate Study Section, American Heart Association 1983-1988 Great
Plains Regional Review Committee Study Section, AHA
1987-1988 Chairman, Great Plains Regional Review Committee Study
Section, American Heart Association
1987-1988 Committee for Regional and National Research, AHA
1987-1990 National Review Committee Study Section, AHA 1990-1994 VA
Merit Review, Cardiovascular Study Section 1991-1992 Chairman, VA
Merit Review Cardiovascular Study Section 1991-1994 Vascular Wall
Biology Study Section, American Heart Association 1992-1994
Chairman, Credentials Committee, Council on Circulation, AHA
1992-1995 National Study Section on Vascular Biology, AHA
1992-1997 Member, Experimental Cardiovascular Sciences Study
Section, Division of Research Grants, National Institutes of
Health
1993-1995 Chairman, Scientific Conference Planning Committee,
AHA 1993-1995 Chairman, Marcus Selection Committee, AHA 1993-1995
Member, Executive Committee, Council on Circulation, AHA 1994-1997
Chairman, Experimental Cardiovascular Sciences Study Section,
Division of Research Grants, National Institutes of Health
1995-1998 Vice Chairman, Executive Committee, Council on
Circulation, AHA 1998-1999 Chairman, Executive Committee, Council
on Circulation, AHA 1999-2000 Program Committee, Council Basic
Cardiovascular Sciences, AHA 2000-2001 Member, American Heart
Association Research Planning and
Evaluation Committee 2002-2004 Member, American Heart
Association Research Committee 2005-present Member, Novartis Award
Selection Committee of the Council for High Blood Pressure
Research (AHA) 2010 Organizer and Chair, American Physiological
Conference on Inflammation, Immunity and
Cardiovascular Disease 2011 Organizer and Chair, North American
Vascular Biology Organization. Session on
Immunology and Vascular Biology 2011-2012 Organizer, Vasculata
Conference of North American Vascular Biology Organization
2012-2014 Chair – Research program for American Society of
Hypertension 2014 Chair – Distinguished Scientist Award Selection
Committee for American Society of
Hypertension 2014 Chair, NHLBI Workshop on Salt, Immunity and
Hypertension
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Consultantships: External Advisory Committee - Louisiana State
University COBRE grant. External Advisory Committee – T32 Training
Grant, University of Alabama Birmingham External Advisory Committee
– T32 Training Grant, Physiology University of Virginia Other
administrative appointments:
Organizer, American Heart Association Winter Conference on
Vascular Biology, 1992 Organizer, American Heart Association Winter
Conference on Vascular Biology, 1995 American Heart Association
Scientific Sessions Planning Committee, 1998 Chair, Basic
Cardiovascular Research Council, American Heart Association,
1997-1998 Secretary/Treasurer, Association of University
Cardiologists 2003-2006
Vice President, Association of University Cardiologists
2006-2007 President, Association of University Cardiologists,
2007-2008 Organizer and Chair, Inflammation, Immunity and
Cardiovascular Disease Symposium, American Physiological Society,
2008-2010. Meeting Held August 2010 Co-chair for Basic
Pathophysiology, American Society of Hypertension Meeting, May
2011. Chair and Organizer, Vascular Inflammation and Immunity
Session. North American Vascular Biology Organization Symposium.
October 2011 Chair and Organizer, Vasculata Conference held in
Nashville, TN July 2012
Patents: US patent #5498539, “Endothelial Nitric Oxide
Synthase,” Issued: 3/12/96,
EDITORIAL RESPONSIBILITIES
Editorships and Editorial Boards: 1990-1994 Editorial Board,
Circulation 1991-present Editorial Board, Journal of Cardiovascular
Pharmacology 1992-1993 Editorial Board, Trends in Cardiovascular
Medicine 1992-1996 Editorial Board, Endothelium 1993-1998 Editorial
Board, Journal of Vascular Medicine and Biology 1995-present
Editorial Board, Circulation Research 1997-2006 Editorial Board,
Journal of Clinical Investigation 1999-present Editorial Board,
Arteriosclerosis, Thrombosis, and Vascular Biology 2000-present
Editorial Board, Hypertension 2005-2008 Editorial Board,
Circulation 2005-2010 Editorial Board, Journal of the
CardioMetabolic Syndrome 2010-present Editorial Board, American
Journal of Physiology, Renal physiology
Manuscript reviewer:
1982-present Circulation 1984-present American Journal of
Physiology 1984-present Circulation Research 1988-present Journal
of American College of Cardiology 1988-present Journal of Clinical
Investigation
1990-present Journal of Pharmacological Exp. Therapeutics
1990-present Journal of Cardiovascular Pharmacology 1992-present
Trends in Cardiovascular Medicine 1992-present Endothelium
1992-present Arteriosclerosis, Thrombosis, and Vascular Biology
1992-present American Journal of Medical Sciences 1992-present
Journal of Cardiovascular Pharmacology 1992-present Nature
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1993-present Journal of Biological Chemistry 1993-1998 Journal
of Vascular Medicine and Biology 1993-present American Journal of
Cardiology 1995-present Proceedings of the National Academy of
Sciences, USA 1996-present Molecular Pharmacology 1996-present
Biochemical Pharmacology 1997-present Diabetes 1997-present Journal
of Cell Physiology 1998-present Journal of Free Radicals in
Medicine and Biology 2000-present Nature Medicine 2008-Present
Atherosclerosis 2009-Present Lab Investigation 2011-Present
Blood
GRANT AWARDS:
1. Principal Investigator; NIH R01 HL39006-24; Immunity,
Inflammation and Hypertension; $325,000/yr; 08/01/87 to 11/31/2017.
(Funded since 1997).
2. Principal Investigator, American Heart Association
Strategically Focused Research Network; $750,000/year.
Basic Science Project Director, Meena Madhur Co-Director;
$250,000/year.
3. Project Director, NIH P01 GM015431-46, Research Center for
Pharmacology & Drug Toxicology. Principal investigator: L.
Jackson Roberts. Project 4 – Therapeutic Modulation of Endothelial
Cell Tetrahydrobiopterin. Period: 07/01/2011-06/31/2016.
$250,000/year.
4. Co-Principal Investigator, NIH 1R01HL108701-01, Vascular
Oxidative Stress in Obesity. Multi-investigator grant with Hua Cai,
UCLA Medical School. Period 2/24/12 – 12/31/2015. Total project
$499,562/year. Funding to Dr. Harrison $250,000
5. Co-Investigator, NIH Vascular Interventions and Therapeutic
Advances. Period 1/1/14 -12/30/17. Total project $250,000 per
year
6. Principal Investigator, Bristol Meyers Squibb industry grant;
Use of Abatacept to Treat Patients with Resistant Hypertension.
5/1/14 – 4/30/16. Total project $375,000
Past Awards:
1. Veterans Administration Merit Award, 1984-2009. 2.
Collaborating Investigator, NIH BAA-HV-10-08 Program of Excellence
in Nanotechnology (PEN): Center for
Translational Cardiovascular Nanomedicine. $30,000/yr (Salary
support). Principal Investigator Gang Bao
3. Collaborating Investigator, NIH R01DA030996-01 Cocaine,
HIV/AIDS, and Antiretrovirals, $72,968/yr. (salary and
post-doctoral support). Principal Investigator William Lewis
4. Principal Investigator & Preceptor; NIH; Research
Training in Academic Cardiology; T32 HL07745; $495,092/yr (no
salary); 7/1/04-12/3102010. (Funded since 1997)
PUBLICATIONS: A. Published and accepted research articles
(clinical, basic science, other) in refereed journals: 1. Koyanagi
S, Eastham CL, Harrison DG, Marcus ML. Transmural Variation in the
Relationship Between Myocardial
Infarct Size and Risk Area. Am J Physiol 1982; 242:H867-874.
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2. Koyanagi S, Eastham CL, Harrison DG, Marcus ML. Increased
Size of Myocardial Infarction in Dogs with Chronic Hypertension and
Left Ventricular Hypertrophy. Circ Res 1982; 50:55-62.
3. Palmeri ST, Harrison DG, Cobb FR, Morris KG, Ideker RE,
Harrell FE, Selvester RH, Wagner GS. A QRS Scoring
System for Assessing Left Ventricular Function After Myocardial
Infarction. N Eng J Med 1982; 306:4-9. 4. Baker JT, Bramlet DA,
Lester RM, Harrison DG, Roe CR, Cobb FR. Myocardial Infarct
Extension: Incidence and
Relationship to Survival. Circulation1982; 65:918-923. 5.
Anderson CI, Harrison DG, Stack NC, Hindman NB, Ideker RE, Palmeri
ST, Selvester RH, Wagner GS. Evaluation of
Serial QRS Changes During Acute Inferior Myocardial Infarction
Using a QRS Scoring System. Am J Cardiol 1983; 52:252-256.
6. Harrison DG, White CW, Hiratzka LF, Doty DB, Eastham CL,
Marcus ML. The Value of Lesion Cross-Sectional Area
Determined by Quantitative Coronary Angiography in Assessing the
Physiologic Significance of Proximal Left Anterior Descending
Coronary Arterial Stenoses. Circulation 1984; 69:1111-1119.
7. Harrison DG, Ferguson DW, Collins SM, Skorton DJ, Ericksen
EE, Kioschos JM, Marcus ML, White CW. Rethrombosis
After Reperfusion with Streptokinase: Importance of Geometry of
Residual Lesions. Circulation 1984; 69:991-999. 8. White CW, Wright
CB, Doty DB, Hiratzka LF, Eastham CL, Harrison DG, Marcus ML. Does
Visual Interpretation of the
Coronary Arteriogram Predict the Physiologic Importance of a
Coronary Stenosis? N Engl J Med 1984; 310:819-824. 9. Harrison DG,
Barnes DH, Hiratzka LF, Eastham CL, Kerber RE, Marcus ML. The
Effect of Cardiac Hypertrophy on the
Coronary Collateral Circulation. Circulation 1985; 71:1135-1145.
10. Roberts N, Harrison DG, Reimer KA, Crain BS, Wagner GS. Right
Ventricular Infarction with Shock but Without
Significant Left Ventricular Infarction: A New Clinical
Syndrome. Am Heart J 1985; 110:1047-1053. 11. Chilian WM, Harrison
DG, Haws CW, Snyder WD, Marcus ML. Adrenergic Coronary Tone During
Submaximal
Exercise in the Dog is Produced by Circulating Catecholamines:
Evidence for Adrenergic Denervation Supersensitivity in the
Myocardium But Not in Coronary Vessels. Circ Res 1986;
58:68-82.
12. Harrison DG, Chilian WM, Marcus ML. Absence of Functioning
�-Adrenergic Receptors in Mature Canine Coronary
Collaterals. Circ Res 1986; 59:133-142. 13. Freiman PC, Mitchell
GG, Heistad DD, Armstrong ML, Harrison DG. Atherosclerosis Impairs
Endothelium-Dependent
Vascular Relaxation to Acetylcholine and Thrombin in Primates.
Circ Res 1986; 58:783-789. 14. Harrison DG, Chapman MP, Christy JP,
Marcus ML. Studies of Functional Site of Origin of Native Coronary
Collaterals.
Am J Physiol 1986; 251:H1217-1224. 15. Johnson MR, Brayden GP,
Ericksen EE, Collins SM, Skorton DJ, Harrison DG, Marcus ML, White
CW. Changes in
Cross-Sectional Area of the Coronary Lumen in the Six Months
After Angioplasty: A Quantitative Analysis of the Variable Response
to Percutaneous Transluminal Angioplasty. Circulation 1986;
73:467-475.
16. Marcus ML, Harrison DG, Chilian WM, Koyanagi S, Inou T,
Tomanek RJ, Martins JB, Eastham CL, Hiratzka LF.
Alterations in the Coronary Circulation in Hypertrophied
Ventricles. Circulation 1987; 75:I19-25. 17. Harrison DG, Armstrong
ML, Freiman PC, Heistad DD. Restoration of Endothelium-Dependent
Relaxation by Dietary
Treatment of Atherosclerosis. J Clin Invest 1987; 80:1808-1811.
18. Harrison DG, Freiman PC, Armstrong ML, Marcus ML, Heistad DD.
Alterations of Vascular Reactivity in
Atherosclerosis. Circ Res 1987; 61:II74-80. 19. Inou T, Lamberth
WC Jr, Koyanagi S, Harrison DG, Eastham CL, Marcus ML. Relative
Importance of Hypertension
After Coronary Occlusion in Chronic Hypertensive Dogs with LVH.
Am J Physiol 1987; 253:H1148-158.
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20. Heistad DD, Harrison DG, Armstrong ML. Serotonin and
Experimental Vascular Disease. Int J Cardiol 1987; 14:205-
212. 21. Gumm DC, Cooper SM, Thompson SB, Marcus ML, Harrison
DG. Influence of Risk Area Size and Location on Native
Collateral Resistance and Ischemic Zone Perfusion. Am J Physiol
1988; 254:H473-480. 22. Harrison DG, Florentine MS, Brooks LA,
Cooper SM, Marcus ML. The Effect of Hypertension and Left
Ventricular
Hypertrophy on the Lower Range of Coronary Autoregulation.
Circulation 1988; 77:1108-1115.
23. Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD.
Responsiveness of Iliac Collateral Vessels to Constrictor Stimuli
in Atherosclerotic Primates. Circ Res 1988; 63:1020-1028.
24. Peters KG, Marcus ML, Harrison DG. Vasopressin and the
Mature Coronary Collateral Circulation. Circulation 1989;
79:1324-1331. 25. Myers PR, Guerra R Jr, Harrison DG. Release of
NO and EDRF from Cultured Bovine Aortic Endothelial Cells. Am J
Physiol 1989; 256:H1030-1037. 26. Myers PR, Banitt PF, Guerra R
Jr, Harrison DG. Characteristics of Canine Coronary Resistance
Arteries: Importance of
the Endothelium. Am J Physiol 1989; 257:H603-610. 27. Feldman
RD, Christy JP, Paul ST, Harrison DG. ß-Adrenergic Receptors on
Canine Coronary Collateral Vessels:
Characterization and Function. Am J Physiol 1989;257:H1634-1639.
28. Guerra R Jr, Brotherton AFA, Goodwin PJ, Clark CR, Armstrong
ML, Harrison DG. Mechanisms of Abnormal
Endothelium-dependent Vascular Relaxation in Atherosclerosis:
Implications for Altered Autocrine and Paracrine Functions of EDRF.
Blood Vessels 1989; 26:300-314.
29. Tomanek RJ, Schalk KA, Marcus ML, Harrison DG. Coronary
Angiogenesis During Long-Term Hypertension and Left
Ventricular Hypertrophy in Dogs. Circ Res 1989; 65:352-359. 30.
Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD.
Vascular Responses to Leukocyte Products in
Atherosclerotic Primates. Circ Res 1989; 65:1078-1086. 31.
Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of Vessel
Size on the Sensitivity of Porcine Microvessels to
Nitroglycerin. Am J Physiol 1990; 258:H515-520. 32. Sellke FW,
Armstrong ML, Harrison DG. Endothelium-Dependent Vascular
Relaxation is Abnormal in the Coronary
Microcirculation of Atherosclerotic Primates. Circulation 1990;
81:1586-1593. 33. Sellke FW, Quillen JE, Brooks LA, Harrison DG.
Endothelial Modulation of the Coronary Vasculature in Vessels
Perfused Via Mature Collaterals. Circulation 1990; 81:1938-1947.
34. Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of Vessel
Size on the Sensitivity of Porcine Microvessels to
Nitroglycerin. Am J Physiol 1990; 258:H515-20. 35. Myers PR,
Minor RL Jr, Guerra R Jr, Bates JN, Harrison DG. Vasorelaxant
Properties of the Endothelium-Derived
Relaxing Factor More Closely Resemble S-Nitrosocysteine than
Nitric Oxide. Nature 1990; 345:161-163. 36. Murphy S, Minor RL Jr,
Welk G, Harrison DG. Evidence for an Astrocyte-Derived Vasorelaxing
Factor with Properties
Similar to Nitric Oxide. J Neurochem 1990; 55:349-351. 37.
Cappelli-Bigazzi M, Lamping KG, Nuno DW, Harrison DG. Leukocyte and
Platelet-Derived Factors Augment Canine
Coronary Constriction to Serotonin. Am J Physiol 1990;
259:H1161-170.
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38. Quillen JE, Sellke FW, Brooks LA, Harrison DG.
Ischemia-Reperfusion Impairs Endothelium-Dependent Relaxation of
Coronary Microvessels but Does Not Affect Large Arteries.
Circulation 1990; 82:586-594.
39. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG.
Diet-Induced Atherosclerosis Increases the Release of
Nitrogen Oxides from Rabbit Aorta. J Clin Invest 1990;
86:2109-2116. 40. Mügge A, Harrison DG. L-Arginine Does Not Restore
Endothelial Dysfunction in Atherosclerotic Rabbit Aorta In
Vitro.
Blood Vessels 1991; 28:354-357. 41. Myers PR, Banitt PF, Guerra
R Jr, Harrison DG. Role of the Endothelium in Modulation of the
Acetylcholine
Vasoconstrictor Response in Porcine Coronary Microvessels.
Cardiovasc Res 1991; 25:129-137. 42. Rubanyi G, Johns, Wilcox D,
Bates JN, Harrison DG. Evidence That a S-Nitrosothiol, But Not
Nitric Oxide, may be
Identical with Endothelium-Derived Relaxing Factor. J Cardiovasc
Pharmacol 1991; 17:S41-S45. 43. Mügge A, Elwell JH, Peterson TE,
Harrison DG. Release of Intact Endothelium-Derived Relaxing Factor
Depends on
Endothelial Superoxide Dismutase Activity. Am J Physiol 1991;
260:C219-225. 44. Kurz MA, Lamping KG, Bates JN, Eastham CL, Marcus
ML, Harrison DG. Mechanisms Responsible for the
Heterogeneous Coronary Microvascular Response to Nitroglycerin.
Circ Res 1991; 68:847-855. 45. Mügge A, Peterson TE, Harrison DG.
Release of Nitrogen Oxides from Cultured Bovine Endothelial Cells
Is Not
Impaired by Calcium Channel Antagonists. Circulation 1991;
83:1404-1409. 46. Harrison DG, Treasure CB, Mügge A, Dellsperger
KC, Lamping KG. Hypertension and the Coronary Circulation. With
Special Attention to Endothelial Regulation. Am J Hypertens
1991; 4:454S-459S. 47. Harrison DG, Marcus ML, Dellsperger KC,
Lamping KG, Tomanek RJ: Pathophysiology of Myocardial Perfusion
in
Hypertension. Circulation 1991; 83:III14-18 48. Sellke FW,
Tomanek RJ, Harrison DG. L-Cysteine Selectively Potentiates
Nitroglycerin-Induced Dilation of Small
Coronary Microvessels. J Pharmacol Exp Ther 1991; 258:365-369.
49. Bates JN, Harrison DG, Myers PR, Minor RL. EDRF Nitrosylated
Compound or Authentic Nitric Oxide. Basic Res
Cardiol 1991; 86:17-26. 50. Tomanek RJ, Wessel TJ, Harrison DG.
Capillary Growth and Geometry During Long-Term Hypertension and
Myocardial Hypertrophy in Dogs. Am J Physiol 1991; 261:H1011-8.
51. Bates JN, Baker MT, Guerra R Jr, Harrison DG. Nitric Oxide
Generation from Nitroprusside by Vascular Tissue.
Evidence that Reduction of the Nitroprusside Anion and Cyanide
Loss are Required. Biochem Pharmacol 1991; 42:S157-165.
52. Mügge A, Elwell JH, Peterson TE, Hofmeyer TG, Heistad DD,
Harrison DG. Chronic Treatment with Polyethylene-
Glycolated Superoxide Dismutase Partially Restores
Endothelium-Dependent Vascular Relaxations in Cholesterol-Fed
Rabbits. Circ Res 1991; 69:1293-1300.
53. Komaru T, Lamping KG, Eastham CL, Harrison DG, Marcus ML,
Dellsperger KC. Effect of an Arginine Analogue on
Acetylcholine-Induced Coronary Microvascular Dilation in Dogs.
Am J Physiol 1991; 261:H2001-2007. 54. Quillen JE, Sellke FW,
Armstrong ML, Harrison DG. Long-Term Cholesterol Feeding Alters the
Reactivity of Primate
Coronary Microvessels to Platelet Products. Arterioscler Thromb
Vasc Biol 1991; 11:639-644. 55. Murphy S, Minor RL Jr, Welk G,
Harrison DG. Central Nervous System Astroglial Cells Release
Nitrogen Oxide(s) with
Vasorelaxant Properties. J Cardiovasc Pharm 1991; 17:S265-S268.
56. Harrison DG, Simonetti I: Neurohumoral Regulation of Collateral
Perfusion. Circulation 1991; 83:III62-III67
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57. Quillen JE, Sellke FW, Banitt P, Harrison DG. The Effect of
Norepinephrine on the Coronary Microcirculation. J Vasc
Res 1992; 29:2-7. 58. Harrison DG. Kurz MA. Quillen JE. Sellke
FW. Mugge A: Normal and pathophysiologic considerations of
endothelial
regulation of vascular tone and their relevance to nitrate
therapy. Am J Cardiol 1992; 70:11B-17B. 59. Quillen JE, Harrison
DG. Vasomotor Properties of Porcine Endocardial and Epicardial
Microvessels. Am J Physiol 1992;
262:H1143-1148. 60. Fuji M, Nuno DW, Lamping KG, Dellsperger KC,
Eastham CL, Harrison DG. Effect of Hypertension and Hypertrophy
on Coronary Microvascular Pressure. Circ Res 1992; 71:120-126.
61. Myers PR, Guerra R, Jr, Harrison DG. Release of Multiple
Endothelium-Derived Relaxing Factors from Porcine
Coronary Arteries. J Cardiovasc Pharmacol 1992; 20:392-400. 62.
Nishida K, Harrison DG, Navas JP, Fisher AA, Dockery SP, Uematsu M,
Nerem RM, Alexander RW, Murphy TJ.
Molecular Cloning and Characterization of the Constitutive
Bovine Aortic Endothelial Cell Nitric Oxide Synthase. J Clin Invest
1992; 90:2092-2096.
63. Harrison DG, Kurz MA, Quillen JE, Sellke FW, Mügge A. Normal
and Pathophysiologic Considerations of Endothelial
Regulation of Vascular Tone: Relevance to Nitrate Therapy. Am J
Cardiol 1992;70:11B-17B. 64. Münzel T, Mulsch A, Holtz J, Just H,
Harrison DG, Bassenge E. Mechanisms of Interaction Between the
Sulfhydryl
Precursor L-Methionine and Glyceryl Trinitrate. Circulation
1992; 86:995-1003. 65. Harrison DG, Bates JN. The
Nitrovasodilators: New Ideas About Old Drugs. Circulation 1993;
87:1461-1467. 66. Kurz MA, Boyer TD, Harrison DG. Nitroglycerin
Metabolism in Vascular Tissue: Role of
Glutathione-S-Transferases
and the Relationship Between NO· and NO2¯ Formation. Biochem J
1993; 292:545-550. 67. Ohara Y, Peterson TE, Harrison DG.
Hypercholesterolemia Increases Endothelial Superoxide Anion
Production. J Clin
Invest 1993; 91:2546-2551. 68. Delafontaine P, Lou H, Harrison
DG, Bernstein KE. Sequence of a cDNA Encoding Dog Insulin-Like
Growth Factor I.
Gene 1993; 130:305-306. 69. Wheatley RM, Dockery SP, Kurz MA,
Harrison DG. Interactions of Nitroglycerin and Sulfhydryl Donating
Compounds
in Canine Coronary Microvessels. Am J Physiol 1994;
266:H291-297. 70. Lamping KG, Bloom EN, Harrison DG. Regulation of
Native Collateral Vessel Dilation Following Coronary Occlusion
in the Dog. Am J Physiol 1994; 266:H769-778. 71. Ohara Y,
Peterson TE, Zheng B, Kuo JF, Harrison DG. Lysophosphatidylcholine
Increases Vascular Superoxide Anion
Production Via Protein Kinase C Activation. Arterioscler Thromb
Vasc Biol 1994; 14:1007-1013. 72. Venema RC, Nishida K, Alexander
RW, Harrison DG, Murphy TJ. Organization of the Bovine Gene
Encoding the
Endothelial Nitric Oxide Synthase. Biochim Biophys Acta 1994;
1218:413-420. 73. Arnal J-F, Yamin J, Dockery SP, Harrison DG.
Regulation of Endothelial Nitric Oxide Synthase mRNA, Protein
and
Activity during Cell Growth. Am J Physiol 1994; 267:C1381-1388.
74. Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison, DG.
Evidence for Enhanced Vascular Superoxide Anion
Production in Nitrate Tolerance: A Novel Mechanism Underlying
Tolerance and Cross Tolerance. J Clin Invest 1995; 95:187-194.
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75. Harrison DG, Venema RC, Arnal J-F, Inoue Y, Ohara Y, Sayegh
H, Murphy TJ. The Endothelial Cell Nitric Oxide Synthase: Is It
Really Constitutively Expressed? Agents Actions Suppl 1995;
45:107-117.
76. Supari F, Ungerer T, Harrison DG, Williams JK. Fish Oil
Treatment Decreases Superoxide Anions in the Myocardium
and Coronary Arteries of Atherosclerotic Monkeys. Circulation
1995; 91:1123-1128. 77. Ohara Y, Sayegh HS, Yamin JJ, Harrison DG.
Regulation of Endothelial Constitutive Nitric Oxide Synthase by
Protein
Kinase C. Hypertension 1995; 25:415-420. 78. Inoue N, Venema RC,
Sayegh HS, Ohara Y, Murphy TJ, Harrison DG. Molecular Regulation of
the Bovine Endothelial
Cell Nitric Oxide Synthase by Transforming Growth Factor beta-1.
Arterioscler Thromb Vasc Biol 1995; 15:1255-1261. 79. Arnal J-F,
Münzel T, Venema RC, James NL, Bay C-L, Mitch W, Harrison DG.
Interactions Between L-arginine and L-
glutamine Modulate Endothelial NO Production: An Effect
Independent of NO Synthase Substrate Availability. J Clin Invest
1995;95:2565-72.
80. Ohara Y, Peterson T, Sayegh SH, Harrison DG. Dietary
Correction of Hypercholesterolemia in the Rabbit Normalizes
Endothelial Superoxide Anion Production. Circulation 1995;
92:898-903. 81. Münzel T, Giaid A, Kurz S, Stewart DJ, Harrison DG.
Evidence for a Role of Endothelin-1 and Protein Kinase C in
Nitroglycerin Tolerance. Proc Natl Acad Sci USA 1995;
92:5244-5248. 82. Venema RC, Sayegh HS, Arnal J-F, Harrison DG.
Role of the Enzyme Calmodulin-Binding Domain in Membrane
Association and Phospholipid Inhibition of Endothelial Nitric
Oxide Synthase. J Biol Chem 1995; 270:14705-11411. 83. Uematsu M,
Navas JP, Nishida Y, Ohara Y, Murphy TJ, Alexander RW, Nerem RM,
Harrison DG. Regulation of
Endothelial Cell Nitric Oxide Synthase Expression by Shear
Stress. Am J Physiol 1995; 269:C1371-1378. 84. James NL, Harrison
DG, Nerem RM. Effects of Shear on Endothelial Cell Calcium in the
Presence and Absence of ATP.
FASEB J 1995; 9:968-973. 85. Khan BV, Harrison DG, Olbrych MT,
Alexander RW, Medford RM. Nitric Oxide Regulates VCAM-1 Gene
Expression
and Redox-sensitive Transcriptional Events in Human Vascular
Endothelial Cells. Proc Natl Acad Sci USA 1996; 93:9114-9119.
86. Venema RC, Sayegh HS, Kent, JD, Harrison DG. Identification,
Characterization, and Comparison of the Calmodulin-binding Domains
of the Endothelial and Inducible Nitric Oxide Synthases. J Biol
Chem 1996; 271:6435-6440.
87. Rajagopalan S, Kurz S, Münzel T,Tarpey M, Freeman B,
Griendling KK, Harrison DG. Angiotensin II Mediated Hypertension in
the Rat Increases Vascular Superoxide Production via Membrane
NADH/NADPH Oxidase Activation: Contribution to Alterations of
Vasomotor Tone. J Clin Invest 1996; 97:1916-1923.
88. Münzel T, Heitzer T, Kurz S, Harrison DG, Luhman C, Pape L,
Olschewski M, Just H. Dissociation of Coronary Vascular Tolerance
and Neurohormonal Adjustments During Long-term Nitroglycerin
Therapy in Patients with Stable Coronary Artery Disease. J Am Coll
Cardiol 1996; 27:297-303.
89. Furukawa K, Harrison DG, Saleh D, Shennib H, Chagnon FP,
Giaid A. Expression of Nitric Oxide Synthase in the Human Nasal
Mucosa. Am J Respir Crit Care Med 1996;153:847-850.
90. Inoue N, Ramasamy S, Fukai T, Nerem R, Harrison DG. Shear
Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human
Aortic Endothelial Cells. Circ Res 1996; 79:32-37.
91. Wang S, Feelisch M, Harrison DG, Sellke F. Preferential
Dilation of Large Coronary Microvessels by the Mononitrates
SPM-4744 and SPM-5185. J Cardiovasc Pharmacol 1996; 27:587-593.
92. Münzel T, Kurz S, Rajagopalan S, Bennington W R, Thompson A,
Freeman B, Harrison DG. Hydralazine Prevents Nitroglycerin
Tolerance by Inhibiting Activation of a Membrane-bound NADH
Oxidase: A New Action for an Old Drug. J Clin Invest 1996;
98:1465-1470.
93. Corson M, James N, Latta S, Nerem R, Berk B, Harrison DG.
Phosphorylation of Endothelial Nitric Oxide Synthase in Response to
Fluid Shear Stress. Circ Res 1996; 79:984-991.
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94. Rajagopalan S, Meng X-P, Ramasamy S, Harrison DG, Galis Z.
Reactive Oxygen Species Produced by Macrophage-derived Foam Cells
Regulate the Activity of Vascular Matrix Metalloproteinases in
vitro: Implications for Atherosclerotic Plaque Stability. J Clin
Invest 1996; 98:2572-2579.
95. Harrison DG. Cellular and Molecular Mechanisms of
Endothelial Cell Dysfunction. J Clin Invest 1997;
100:2153-2157.
96. Fukui T, Rajagopalan S, Ishizaka N, Capers Q, Taylor WR,
Harrison DG, de Leon H, Wilcox JN, Griendling KK. p22phox mRNA
expression and NADPH oxidase activity are increased in aortas from
hypertensive rats. Circ Res 1997; 80:45-51.
97. Bech Laursen J, Rajagopalan S, Tarpey M, Freeman B, Harrison
DG. A Role of Superoxide in Angiotensin II - but not
Catecholamine-induced Hypertension. Circulation 1997;
95:588-593.
98. Rajagopalan S, Bech Laursen J, Borthayre A, Kurz S, Keiser
J, Haleen S, Giaid A, Harrison DG. A Role for Endothelin-1 in
Angiotensin II-Mediated Hypertension. Hypertension 1997;
30:29-34.
99. Capers QT, Laursen JB, Fukui T, Rajagopalan S, Mori I, Lou
P, Freeman BA, Berrington WR, Griendling KK, Harrison DG, Runge MS,
Alexander RW, Taylor WR. Vascular Thrombin Receptor Regulation in
Hypertensive Rats. Circ Res 1997; 80:838-844
100. Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock
JS, Harrison DG, Marsden PA. Expression of Multiple Isoforms of
Nitric Oxide Synthase in Normal and Atherosclerotic Vessels.
Arterioscler Thromb Vasc Biol 1997; 17:2479-2488.
101. Ramasamy S, Parthasarathy S, Harrison DG. Regulation of
Endothelial Nitric Oxide Synthase Gene Expression by Oxidized
Linoleic Acid. J Lipid Res 1998; 39:268-276.
102. Inoue N, Ohara Y, Fukai T. Harrison DG. Nishida K. Probucol
Improves Endothelial-dependent Relaxation and
Decreases Vascular Superoxide Production in Cholesterol-fed
Rabbits. Am J Med Sci 1998; 315:242-247. 103. Fukai T, Galis ZS,
Meng XP, Parthasarathy S, Harrison, DG. Vascular Expression of
Extracellular Superoxide Dismutase
in Atherosclerosis. J Clin Invest 1998; 101:2101-2111. 104.
Vejlstrup NG, Bouloumie A, Boesgaard S, Anderson CB, Nielsen-Kudsk
JE, Mortensen SA, Kent JD, Harrison DG,
Busse R, Aldershvile J. Inducible Nitric Oxide Synthase (iNOS)
in the Human Heart: Expression and Localization in Congestive Heart
Failure. J Mol Cell Cardiol 1998; 30:1215-1223.
105. Zafari AM, Ushio-Fukai M, Akers M, Yin Q, Shah A, Harrison
DG, Taylor WR, Griendling KK. Role of NADH/NADPH
Oxidase-derived H2O2 in Angiotensin II-induced Vascular
Hypertrophy. Hypertension 1998; 32:488-495. 106. Skatchkov MP,
Sperling D, Hink U, Mulsch A, Harrison DG, Sindermann I, Meinertz
T, Munzel T. Validation of
Lucigenin as a Chemiluminescent Probe to Monitor Vascular
Superoxide as well as Basal Vascular Nitric Oxide Production.
Biochem & Biophys Res Commun 1999; 254:319-324.
107. Huraux C, Makita T, Kurz S, Yamaguchi K, Szlam F, Tarpey
MM, Wilcox JN, Harrison DG, Levy JH. Superoxide
Production, Risk Factors, and Endothelium-dependent Relaxations
in Human Internal Mammary Arteries. Circulation 1999;99:53-9.
108. Fukai T, Siegfried M, Ushio-Fukai M, Griendling KK,
Harrison DG. Modulation of Extracellular Superoxide Dismutase
Expression by Angiotensin II and Hypertension. Circ Res 1999;
85:23-28. 109. Ramasamy S, Drummond GR, Ahn J, Storek M, Pohl J,
Parthasarathy S, Harrison DG. Modulation of Expression of
Endothelial Nitric Oxide Synthase by Antioxidants in Cultured
Endothelial Cells. Mol Pharmacol 1999; 56:116-123. 110. Kurz S,
Hink U, Nickenig G, Borthayre AB, Harrison DG, Munzel T. Evidence
for a Causal Role of the Renin
Angiotensin System in Nitrate Tolerance. Circulation 1999;
99:3181-3187. 111. Kojda G, Laursen JB, Ramasamy S, Kent JD, Kurz
S, Burchfield J, Shesely EG, Harrison DG. Protein Expression,
Vascular Reactivity and Soluble Guanylate Cyclase Activity in
Mice Lacking the Endothelial Cell Nitric Oxide Synthase:
Contributions of NOS Isoforms to Blood Pressure and Heart Rate
Control. Cardiovasc Res 1999; 42:206-213.
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112. Warnholtz A, Nickenig G, Schulz E, Macharzina R, Brasen JH,
Skatchkov M, Heitzer T, Stasch JP, Griendling KK, Harrison DG, Bohm
M, Meinertz T, Munzel T. Increased NADH-oxidase-mediated Superoxide
Production in the Early Stages of Atherosclerosis: Evidence for
Involvement of the Renin-angiotensin System. Circulaiton 1999;
99:2027-2033.
113. Kojda G, Harrison DG. Interactions Between NO and Reactive
Oxygen Species: Pathophysiological Importance in
Atherosclerosis, Hypertension, Diabetes and Heart Failure.
Cardiovasc Res 1999; 43:562-571. 114. Tummala PE, Chen XL, Sundell
CL, Laursen JB, Hammes CP, Alexander RW, Harrison DG, Medford RM.
Angiotensin
II Induces Vascular Cell Adhesion Molecule-1 Expression in Rat
Vasculature: A Potential Link between the Renin-Angiotensin System
and Atherosclerosis. Circulation 1999; 100:1223-1229.
115. Munzel T. Hink U. Yigit H. Macharzina R. Harrison DG.
Mulsch A. Role of Superoxide Dismutase in in vivo and in
vitro Nitrate Tolerance. Br J Pharmacol 1999; 127:1224-1230.
116. Gallis B, Corthals GL, Goodlett DR, Ueba H, Kim F, Presnell
SR, Figeys D, Harrison DG, Berk BC, Aebersold R, and
Corson MA. Identification of Flow-dependent Endothelial Nitric
Oxide Synthase Phosphorylation Sites by Mass Spectrometry and
Regulation of Phosphorylation and Nitric Oxide Production by the
Phosphatidylinositol 3-Kinase Inhibitor LY294002. J Biol Chem 1999;
274: 30101-30108.
117. Searles CD. Miwa Y, Harrison DG, Ramasamy S.
Posttranscriptional Regulation of Endothelial Nitric Oxide
Synthase
during Cell Growth. Circ Res 1999; 85:588-595. 118. Drummond GR,
Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and
Posttranscriptional Regulation of
Endothelial Nitric Oxide Synthase Expression by Hydrogen
Peroxide. Circ Res 2000; 86:347-354. 119. Somers MJ, Mavromatis K,
Galis ZS, Harrison DG. Vascular Superoxide Production and Vasomotor
Function in
Hypertension Induced by Deoxycorticosterone Acetate-Salt.
Circulation 2000; 101:1722-1728. 120. Fukai T, Siegfried M,
Ushio-Fukai M, Cheng Y, Kojda G, Harrison DG. Regulation of
Extracellular Superoxide
Dismutase by Nitric Oxide and Exercise Training. J Clin Invest
2000; 105:1631-1639. 121. Kleschyov AL. Mollnau H. Oelze M.
Meinertz T. Huang Y. Harrison DG. Munzel T. Spin Trapping of
Vascular Nitric
Oxide using Colloid Fe(II)-diethyldithiocarbamate. Biochem
Biophys Res Commun 2000; 275:672-677.
122. Somers MJ, Burchfield JS, Harrison DG. Evidence for a
NADH/NADPH Oxidase in Human Umbilical Vein Endothelial Cells using
Electron Spin Resonance. Antioxid Redox Signal 2000; 2:779-787.
123. Bech Laursen J, Somers M, Kurz S, McCann L, Warnholtz A,
Freeman BA, Tarpey M, Fukai T, Harrison DG.
Endothelial Regulation of Vasomotion in Apo(E)-deficient Mice:
Implications for Interactions Between Peroxynitrite and
Tetrahydrobiopterin. Circulation 2001; 103:1282-1288.
124. Sorescu D, Somers MJ, Lassegue B, Grant S, Harrison DG,
Griendling KK. Electron Spin Resonance Characterization of
the NAD(P)H Oxidase in Vascular Smooth Muscle Cells. Free Radic
Biol & Med 2001; 30:603-612. 125. Kojda G, Cheng Y, Burchfield
J, Harrison DG. Dysfunctional Regulation of eNOS Expression in
Response to Exercise in
Mice Lacking One eNOS Gene. Circulation 2001; 103:2839-2844.
126. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M,
Skatchkov M, Thaiss F, Stahl RAK, Warnholtz A, Meinertz
T, Griendling KK, Harrison DG, Forstermann U, Munzel T.
Mechanisms Underlying Endothelial Dysfunction in Diabetis Mellitus.
Circ Res 2001; 88:14-22.
127. Uemura S, Matsushita H, Li W, Glassford AJ, Asagami T, Lee
KH, Harrison DG, Tsao PS. Diabetes Mellitus Enhances
Vascular Matrix Metalloproteinase Activity: Role of Oxidative
Stress. Circ Res 2001; 88:1291-1298. 128. Cai H, Davis ME, Drummond
GR, Harrison DG. Induction of Endothelial Nitric Oxide Synthase by
Hydrogen Peroxide
via a Ca2+/CaM Kinase II/JAK2-dependent Pathway. Arterioscler
Thromb Vasc Biol 2001; 21:1571-1576.
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129. Davis ME, Cai H, Drummond GR, Harrison DG. Shear Stress
Regulates Endothelial Nitric Oxide Synthase Expression through
c-Src by Divergent Signaling Pathways. Circ Res 2001;
89:1073-1080.
130. Fukai T, Folz RJ, Landmesser U, Harrison DG. Extracellular
Superoxide Dismutase and Cardiovascular Disease.
Cardiovascular Res 2002; 55:239-249. 131. Dikalov S, Landmesser
U, Harrison DG. Geldanamycin Leads to Superoxide Formation by
Enzymatic and Non-
enzymatic Dedox Cycling: Implications for Studies of Hsp90 and
eNOS. J Biol Chem 2002; 277:25480-25485. 132. Landmesser U, Cai H,
Dikalov S, MccAnn L, Hwang J, Jo H, Holland SM, Harrison DG. Role
of p47phox in Vascular
Oxidative Stress and Hypertension caused by Angiotensin II.
Hypertension 2002; 40:511-515. 133. Cai H, Li Z, Dikalov S, Holland
SM, Hwang J, Jo H, Dudley SC Jr, Harrison DG. NAD(P)H
Oxidase-derived Hydrogen
Peroxide Mediates Endothelial Nitric Oxide Production in
Response to Angiotensin II. J Biol Chem 2002; 277:48311-48317.
134. Nickenig G, Harrison DG. The AT(1) Angiotensin Receptor in
Oxidative Stress and Atherogenesis: Part I: Oxidative
Stress and Atherogenesis. Circulation 2002; 105:393-396. 135.
Nickenig G, Harrison DG. The AT(1)-Type Angiotensin Receptor in
Oxidative Stress and Atherogenesis: Part II: AT(1)
Receptor Regulation. Circulation 2002; 105:530-536. 136. Hink
HU, Santanam N, Dikalov S, McCann L, Nguyen AD, Parthasarathy S,
Harrison DG, Fukai T. Peroxidase
Properties of Extracellular Superoxide Dismutase: Role of Uric
Acid in Modulating in vivo Activity. Arterioscler Thromb Vasc Biol
2002; 22:1402-1408.
137. Munzel T, Afanas’ev IB, Kleschyov AL, Harrison DG.
Detection of Superoxide in Vascular Tissue. Arterioscler Thromb
Vasc Biol 2002; 11:1761-1768. 138. Cai H, Li Z, Goette A, Mera
F, Honeycutt C, Feterik K, Wilcox JN, Dudley SC, Harrison DG,
Langberg JJ.
Downregulation of Endocardial Nitric Oxide Synthase Expression
and Nitric Oxide Production in Atrial Fibrillation: Potential
Mechanisms for Atrial Thrombosis and Stroke. Circulation 2002;
106:2854-2858.
139. Braddon LG, Karoyli D, Harrison DG, Nerem RM. Maintenance
of a Functional Endothelial Cell Monolayer on a
Fibroblast/Polymer Substrate under Physiologically Relevant
Shear Stress Conditions. Tissue Eng 2002; 8:695-708. 140.
Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C,
Harrison DG, Hornig B, Drexler H. Vascular
Oxidative Stress and Endothelial Dysfunction in Patients with
Chronic Heart Failure: Role of Xanthine-Oxidase and Extracellular
Superoxide Dismutase. Circulation 2002; 106:3073-3078.
141. Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Sudley SC Jr.
Akt-dependent Phosphorylation of Serine 1179 and
Mitogen-activated Protein Kinase Kinase/Extracellular
Signal-regulated Kinase 1/2 Cooperatively Mediate Activation of the
Endothelial Nitric Oxide Synthase by Hydrogen Peroxide. Mol
Pharmacol 2003; 63:325-331.
142. Davis ME, Cai H, McCann L, Fukai T, Harrison DG. Role of
c-Src in Regulation of Endothelial Nitric Oxide Synthase
Expression During Exercise Training. Am J Physiol Heart Circ
Physiol 2003; 284:H1449-1453. 143. Spiekermann S, Landmesser U,
Dikalov S, Bredt M, Gamez G, Tatge H, Reepschlager N, Hornig B,
Drexler H, Harrison
DG. Electron Spin Resonance Characterization of Vascular
Xanthine and NAD(P)H Oxidase Activity in Patients with Coronary
Artery Disease: Relation to Endothelin-dependent Vasodilation.
Circulation 2003;107:1383-1389.
144. Landmesser U, Dikalov S, Price R, McCann L, Fukai T,
Holland SM, Mitch WE, Harrison DG. Oxidation of
Tetrahydrobiopterin Leads to Uncoupling of Endothelial Cell
Nitric Oxide Synthase in Hypertension: Role of the NADPH Oxidase. J
Clin Invest 2003; 111:1201-1209.
145. Harrison DG, Cai H, Landmesser U, Griendling KK.
Interactions of angiotensin II with NAD(P)H oxidase, oxidant
stress
and cardiovascular disease. J Renin Angiotensin Aldosterone Syst
2003;4:51-61.
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146. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S.
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic
Acid
and Thiols: Implications for Uncoupling Endothelial Nitric Oxide
Synthase. J Biol Chem 2003; 278:22546-22554. 147. Boo YC, Sorescu
GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo H.
Endothelial NO Synthase
Phosphorylated at Ser635 Produces NO Without Requiring
Intracellular Calcium Increase. Free Radic Biol Med
2003;35:729-41.
148. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland
SM, Dikalov S, Giddens DP, Griendling KK, Harrison DG,
Jo H. Oscillatory Shear Stress Stimulates Endothelial Production
of O2•- from p47phox-dependent NAD(P)H Oxidases Leading to Monocyte
Adhesion. J Biol Chem 2003; 278:47291-47298.
149. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov
S, Jo H, Harrison DG. Role of Xanthine Oxidoreductase
and the NAD(P)H Oxidase in Endothelial Superoxide Production in
Response to Oscillatory Shear Stress. Am J Physiol Heart Circ
Physiol 2003; 285:H2290-2297.
150. Cai H, Griendling KK, Harrison DG. The Vascular NAD(P)H
Oxidases as Therapeutic Targets in Cardiovascular
Diseases. Trends Pharmacol Sci 2003; 24:471-478. 151. Khatri JJ,
Johnson C, Magid R, Lessner S, Laude K, Dikalov S, Harrison DG,
Galis ZS. Vascular Oxidant Stress
Enhances Progression and Angiogenesis of Experimental Atheroma.
Circulation 2004;109:520-5. 152. Davis ME, Grumbach IM, Fukai T,
Cutchins A, Harrison DG. Shear Stress Regulates Endothelial Nitric
Oxide Synthase
Promoter Activity through Nuclear Factor Kappa-B Binding. J Biol
Chem 2004; 279:163-8. 153. Wyche KE, Wang SS, Griendling KK,
Dikalov SI, Austin H, Rao S, Fink B, Harrison DG, Zafari AM. C242T
CYBA
Polymorphism of the NADPH Oxidase is Associated with Reduced
Respiratory Burst in Human Neutrophils. Hypertension 2004;
43:1246-1251.
154. Ridker PM, Brown NJ, Vaughan DE, Harrison DG, Mehta JL.
Established and Emerging Plasma Biomarkers in the
Prediction of First Atherothrombotic Events. Circulation 2004;
109:6-19. 155. Cai H, McNally JS, Weber M, Harrison DG. Oscillatory
Shear Stress Upregulation of Endothelial Nitric Oxide Synthase
Requires Intracellular Hydrogen Peroxide and CaMKII. J Mol Cell
Cardiol 2004; 37:121-125. 156. Fink B, Laude K, McCann L, Doughan
A, Harrison DG, Dikalov S. Detection of Intracellular Superoxide
Formation in
Endothelial Cells and Intact Tissues Using Dihydroethidium and
an HPLC-based Assay. Am J Physiol Cell Physiol 2004;
287:C895-902.
157. Weber DS, Rocic P, Mellis AM, Laude K, Lyle AN, Harrison
DG, Griendling KK. Angiotensin II-induced Hypertrophy
is Potentiated in Mice Overexpressing p22phox in Vascular Smooth
Muscle. Am J Physiol Heart Circ Physiol 2005; 288:H37-42.
158. Laude K, Cai H, Fink B, Hoch N, Weber DS, McCann L, Kojda
G, Fukai T, Schmidt HH, Dikalov S, Ramasamy R,
Gamez G, Griendling KK, Harrison DG. Hemodynamic and Biochemical
Adaptations to Vascular Smooth Muscle Overexpression of p22phox in
Mice. Am J Physiol Heart Circ Physiol 2005; 288:H7-H12.
159. Abramson JL, Hooper WC, Jones DP, Ashfaq CS, Rhodes SD,
Weintraub WS, Harrison DG, Quyyumi AA, Vaccarino V.
Association Between Novel Oxidative Stress Markers and
C-reactive Protein Among Adults Without Clinical Coronary Heart
Disease. Atherosclerosis 2005; 178:115-21.
160. Lauer N, Suvorava T, Ruther U, Jacob R, Meyer W, Harrison
DG, Kojda G. Critical Involvement of Hydrogen Peroxide
in Exercise-Induced Upregulation of Endothelial NO Synthase.
Cardiovasc Res 2005; 65:254-262. 161. Jeney V, Itoh S, Wendt M,
Gradek Q, Ushio-Fukai M, Harrison DG, Fukai T. Role of
Antioxidant-1 in Extracellular
Superoxide Dismutase Function and Expression. Circ Res, 2005;
96:723-729.
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162. Weber M, Hagedorn CH, Harrison DG, Searles CD. Laminar
Shear Stress and 3’ Polyadenylation of eNOS mRNA. Circ Res, 2005;
96:1161-8.
163. McNally JS, Saxena A, Cai H, Dikalov S, Harrison DG.
Regulation of Xanthine Oxidoreductase Protein Expression by
Hydrogen Peroxide and Calcium. Arterioscler Thromb Vasc Biol,
2005;25:1623-8. 164. Kuzkaya N, Weissmann N, Harrison DG, Dikalov
S. Interactions of Peroxynitrite with Uric Acid in the Presence
of
Ascorbate and Thiols: Implications for Uncoupling Endothelial
Nitric Oxide Synthase. Biochem Pharmacol, 2005; 70:343-54.
165. Grumbach IM, Chen W, Mertens SA, Harrison DG. A Negative
Feedback Mechanism Involving Nitric Oxide and
Nuclear Factor Kappa-B Modulates Endothelial Nitric Oxide
Synthase Transcription. J Mol Cell Cardiol, 2005; 39:595-603.
166. Dudley SC, Hoch NE, McCann LA, Honeycutt C, Diamandopoulos
L, Fukai T, Harrison DG, Dikalov SI, Langberg J.
Atrial Fibrillation Increases Production of Superoxide by the
Left Atrium and Left Atrial Appendage: Role of the NADPH and
Xanthine Oxidases. Circulation, 2005; 112:1266-1273.
167. Mueller CFH, Widder JD, McNally JS, McCann L, Jones DP,
Harrison DG. The Role of the Multidrug Resistance
Protein-1 in Modulation of Endothelial Cell Oxidative Stress.
Circ Res 2005; 97:637-644. 168. Modlinger P, Chabrashvili T, Gill
PS, Mendonca M, Harrison DG, Griendling KK, Li M, Raggio J,
Wellstein A, Chen Y,
Welch WJ, Wilcox CS. RNA Silencing In Vivo Reveals Role of
p22phox in Rat Angiotensin Slow Pressor Response. Hypertension,
2006; 47:238-244.
169. Guzik TJ, Sadowski J, Guzik B, Jopek A, Kapelak B,
Przybylowski P, Wierzbicki K, Harrison DG, Rorbut R, Channon
KA. Coronary Artery Superoxide Production and Nox Isoform
Expression in Human Coronary Artery Disease. Arterioscler Thromb
Vasc Biol, 2005;26:333-339.
170. Ashfaq S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS,
Hooper WC, Vaccarino V, Harrison DG, Quyyumi AA.
The relationship between plasma levels of oxidized and reduced
thiols and early atherosclerosis in healthy adults. J Am Coll
Cardiol, 2006; 47:1005-1011.
171. Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov
S, Harrison DG, Jo H. Bone Morphogenic Protein-4
Induces Hypertension in Mice. Role of Noggin, Vascular NADPH
Oxidases, and Impaired Vasorelaxation. Circulation,
2006;113:2818-2825.
172. Gongora MC, Qin Z, Laude K, Kim HW, McCann L, Folz JR,
Dikalov S, Fukai T, Harrison DG. Role of Extracellular
Superoxide Dismutase in Hypertension. Hypertension, 2006;
48:473-481. 173. Boulden BM, Widder JD, Allen JC, Smith DA,
Al-Baldawi RN, Harrison DG, Dikalov SI, Jo H, Dudley SC Jr..
Early
Determinants of H202-induced Endothelial Dysfunction. Free Radic
Biol Med, 2006;41:810-817.
174. Ramchandran R, Takezako T, Saad Y, Stull L, Fink B, Yamada
H, Dikalov S, Harrison DG, Moravec C, Karnik SS. Angiotensinergic
Stimulation of Vascular Endothelium in Mice Causes Hypotension,
Bradycardia, and Attenuated Angiotensin Response. Proc Natl Acad
Sci USA, 2006; 103:19087-19092.
175. Widder JD, Guzik TJ, Mueller CF, Clempus RE, Schmidt HH,
Dikalov SI, Griendling KK, Jones DP, Harrison DG. Role of the
multidrug resistance protein-1 in hypertension and vascular
dysfunction caused by angiotensin II. Arterioscler Thromb Vasc
Biol. 2007; 27:762-768.
176. San Martin A, Du P, Dikalova A, Lassegue B, Aleman M,
Gongora MC, Brown K, Joseph G, Harrison DG, Taylor WR,
Jo H, Griendling KK. Reactive Oxygen Species-selective
Regulation of Aortic Inflammatory Gene Expression in Type 2
Diabetes. Am J Physiol Heart Circ Physiol, 2007;
292:H2073-2082.
177. Widder JD, Chen W, Li L, Dikalov S, Thöny B, Hatakeyama K,
Harrison DG. Regulation of Tetrahydrobiopterin
Biosynthesis by Shear Stress. Circ Res. 2007;101:830-838.
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178. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov
S, Goronzy J, Weyand C, Harrison DG. Role of the T-Cell in the
Genesis of Angiotensin II-Induced Hypertension and Vascular
Dysfunction. J Exp Med, 2007; 204:2449-2460.
179. Dikalov S, Griendling KK, Harrison DG. Measurement of
reactive oxygen species in cardiovascular studies.
Hypertension. 2007; 49:717-727. 180. Doughan, AK, Harrison DG,
Diklov SI. Molecular Mechanisms of Angiotensin II-Mediated
Mitochondrial Dysfunction:
linking mitochondrial oxidative damage and vascular endothelial
dysfunction. Cir Res, 2007; 102:488-496 181. Cai H, Dikalov S,
Griendling KK, Harrison DG. Detection of reactive oxygen species
and nitric oxide in vascular cells
and tissues: comparison of sensitivity and specificity. Methods
Mol Med. 2007;139:293-312. 182. Chen W, Bacanamwo M, Harrison DG.
Activation of p300 histone acetyl-transferase activity is an early
endothelial
response to laminar shear stress and is essential for
stimulation of eNOS mRNA transcription. J Biol Chem. 2008;
283:16293-16298.
183. S, Abramson JL, Jones DP, Rhodes SD, Weintraub WS, Hooper
WC, Vaccarino V, Alexander RW, Harrison DG,
Quyyumi AA. Endothelial Function and Aminothiol Biomarkers of
Oxidative Stress in Healthy Adults. Hypertension, 2008;
52:80-85
184. Porkert M, Sher S, Reddy U, Cheema F, Niessner C, Kolm P,
Jones DP, Hooper C, Taylor WR, Harrison DG, Quyyumi
AA. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum
Hypertens. 2008; 22:401-407. 185. Gongora MC, Lob HE, Landmesser U,
Guzik TJ, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N,
Gravanis M,
Fukai T, Harrison DG. Loss of extracellular superoxide dismutase
leads to acute lung damage in the presence of ambient air: a
potential mechanism underlying adult respiratory distress syndrome.
Am J Pathol. 2008; 173:915-926.
186. Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M,
Harrison DG, Fukai T. Role of Menkes ATPase in
Angiotensin II-Induced Hypertension. A key modulator for
extracellular superoxide dismutase function. Hypertension. 2008;
52:945-951.
187. Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Mangalat D,
Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski
J, Harrison DG. Calcium-dependent NOX5 nicotinamide adenine
dinucleotide phosphate oxidase contributes to vascular oxidative
stress in human coronary artery disease. J Am Coll Cardiol. 2008;
52:1803-1809.
188. Hoch NE, Guzik TJ, Chen W, Deans T, Maalouf SA, Gratze P,
Weyand C, Harrison DG. Regulation of T cell function by
endogenously produced angiotensin II. Am J Physiol Regul Integr
Comp Physiol. 2008; 296:R208-216. 189. Jones R, Baker MB, Weber M,
Harrison DG, Bao G, Searles CD. Molecular Beacons Can Assess
Changes in Expression
and 3' Polyadenylation of Human eNOS mRNA. Am J Physiol Cell
Physiol. 2009; 296:C498-504. 190. Collins AR, Lyon CJ, Xia X, Liu
JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Praticò D,
Harrison DG, Hsueh
WA. Age-accelerated atherosclerosis correlates with failure to
upregulate antioxidant genes. Circ Res. 2009; 104:e42-54. 191.
Shuvaev VV, Chistofidou-Solomidou M, Bhora F, Laude K, Cai H,
Dikalov S, Arguiri E, Solomides CC, Albelda SM,
Harrison DG, Muzykantiv VR. Targeted detoxification of selected
reactive oxygen species in the vascular endothelium. J Pharm Exp
Ther. 2009; 331:404-411.
192. Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison
DG, Giddens D, Jo H. Partial carotid ligation is a model
of acutely induced disturbed flow, leading to rapid endothelial
dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol.
2009; 297:H1535-1543.
193. Silberman GA, Fan TH, Liu H, Jiao Z, Xiao HD, Lovelock JD,
Boulden BM, Widder J, Fredd S, Bernstein KE, Wolska
BM, Dikalov S, Harrison DG, Dudley SC Jr. Uncoupled cardiac
nitric oxide synthase mediates diastolic dysfunction. Circulation.
2010; 121:519-528.
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194. Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, Guzik
TJ, Harrison DG. Interleukin 17 promotes angiotensin II-induced
hypertension and vascular dysfunction. Hypertension. 2010;
55:500-507.
195. Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C,
Gordon FJ, Harrison DG. Induction of hypertension
and peripheral inflammation by reduction of extracellular
superoxide dismutase in the central nervous system. Hypertension.
2010; 55:277-283.
196. Li L, Rezvan A, Salerno JC, Husain A, Kwon K, Jo H,
Harrison DG, Chen W. GTP cyclohydrolase i phosphorylation and
interaction with GTP cyclohydrolase feedback regulatory protein
provide novel regulation of endothelial tetrahydrobiopterin and
nitric oxide. Circ Res. 2010; 106:328-336.
197. Bonsall JM, Hughes R, Mosunjac M, Harrison DG, Samady H. A
rare case of squamous cell carcinoma of the bladder presenting as a
metastatic right ventricular mass. Case Reports in Med. 2010;
ePUB
198. Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N,
Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB,
Kritchevsky SB, Harris TB, Butler J, Health ABC Study
Investigators; Inflammatory markers and incident heart failure risk
in older adults: the Health ABC (Health, Aging, and Body
Composition) study. J Am Coll Cardiol. 2010; 55:2129-2137.
199. Dikalova AE, Bikineyeva AT, Budzyn K, Nazarewicz RR, McCann
L, Lewis W, Harrison DG, Dikalov SI. Therapeutic Targeting of
Mitochondrial Superoxide in Hypertension. Circ Res. 2010,
107:106-116
200. Schneider MP, Sullivan JC, Wach PF, Boesen EI, Yamamoto T,
Fukai T, Harrison DG, Pollock DM, Pollock JS.
Protective role of extracellular superoxide dismutase in renal
ischemia/reperfusion injury. Kidney Int., 2010, 78:374-378 201.
Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon
FJ, Harrison DG. Central and Peripheral
Mechanisms of T-Lymphocyte Activation and Vascular Inflammation
Produced by Angiotensin II-Induced Hypertension. Circ Res. 2010,
107:263-270
202. Nam D, Ni CW, Rezvan A, Suo J, Budzyn K, Llanos A, Harrison
DG, Giddens DP, Jo H. A model of disturbed flow-
induced atherosclerosis in mouse carotid artery by partial
ligation and a simple method of RNA isolation from carotid
endothelium. J Vis Exp. 2010, pii: 1861
203. Dikalova AE, Gongora MC, Harrison DG, Lambeth JD, Dikalov
S, Griendling KK. Upregulaiton of Nox1 in vascular
smooth muscle leads to impaired endothelium-dependent relaxation
via eNOS uncoupling. Am J Physiol Heart Circ Physiol. 2010,
299:H673-679.
204.
VinhA,ChenW,BlinderY,WeissD,TaylorWR,GoronzyJJ,WeyandCM,HarrisonDG,GuzikTJ.Inhibitionand
geneticablationoftheB7/CD28T‐cellcostimulationaxispreventsexperimentalhypertension.Circulation.2010;122:2529‐2537.
205.
ChenW,LiL,BrodT,SaeedO,ThabetS,JansenT,DikalovS,WeyandC,GoronzyJ,HarrisonDG.Theroleof
increasedguanosinetriphosphatecyclohydrolase‐1expressionandtetrahydrobiopterinlevelsuponTcellactivation.JBiolChem.2011,286:13846‐13851.
206.
McDanielMC,GalbraithEM,JeroudiAM,KashlanOR,EshtehardiP,SuoJ,DhawanS,VoeltzM,DevireddyC,Oshinski
J,HarrisonDG,GiddensDP,SamadyH.LocalizationofculpritlesionsincoronaryarteriesofpatientswithST‐segmentelevationmyocardialinfarctions:Relationtobifurcationsandcurvatures..AmHeartJ.2011,161:508‐515.
207.
MadhurMS,FuntSA,LiL,VinhA,ChenW,LobHE,IwakuraY,BlinderY,RahmanA,QuyyumiAA,HarrisonDG..
RoleofInterleukin17inInflammation,Atherosclerosis,andVascularFunctioninApolipoproteinE‐DeficientMice.ArteriosclerThrombVascBiol.2011.31:1565‐1572.
208.
LiL,ChenW,RezvanA,JoH,HarrisonDG.TetrahydrobiopterinDeficiencyandNitricOxideSynthase.Uncoupling
ContributetoAtherosclerosisInducedbyDisturbedFlow.ArteriosclerThrombVascBiol.2011.31:1547‐1554.209.
LiL,DuY,ChenW,FuH,HarrisonDG.ANovelHigh‐ThroughputScreeningAssayforDiscoveryofMoleculesThat
IncreaseCellularTetrahydrobiopterin.JournalofBiomolecularScreening.2011.16:836‐844.
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210.
LobHE,VinhA,LiL,BlinderY,OffermannsS,HarrisonDG.Roleofthevascularextracellularsuperoxidedismutaseinhypertension.Hypertension.2011.58:232‐239.
211.
ErezA,SandeshNagamaniSCS,ShchelochkovOA,PremkumarMH,CampeauPM,ChenY,GargHK,LiL,MianA,
BertinTK,BlackJO,ZengH,TangY,ReddyAK,MarshallSummarM,O’BrienWE,HarrisonDG,MitchWE,MariniJC,AschnerJL,BryanNS,andLeeB.RequirementofArgininosuccinateLyaseforSystemicNitricOxideProduction.NatureMedicine,2011.17:1619‐626.
212.
MarvarPJ,VinhA,ThabetS,LobHE,GeemD,ResslerKJ,HarrisonDG.TLymphocytesandVascularInflammationContributetoStress‐DependentHypertension.BiologicalPsychiatry,2012.71:774‐782.
213.
YounJY,WangT,BlairJ,LaudeKM,OakJH,McCannLA,HarrisonDG,CaiHL.Endothelium‐specificSepiapterinReductaseDeficiencyinDOCA‐saltHypertension.AmJPhysiolHeartCircPhysiol.2012:H2243‐2249.
214.
FelgerJC,LiL,MarvarPJ,WoolwineBJ,HarrisonDG,RaisonCL,MillerAH.Tyrosinemetabolismduringinterferon‐alphaadministration:AssociationwithfatigueandCSFdopamineconcentrations.BrainBehavImmun.2012,Inpress.
215.
LobHE,SchultzD,Marvar,PM,DavissonRL,HarrisonDG.RoleoftheNADPHOxidasesintheSubfornicalOrganinAngiotensinII‐InducedHypertension.Hypertension,2013,
61:382-387.
216. Pech V, Thumova M, Dikalov SI, Hummler E, Rossier BC,
Harrison DG, Wall SM. Nitric Oxide reduces Cl- absorption in the
mouse cortical collecting duct through an ENaC-dependent mechanism.
Am J Physiol Renal Physiol. 2013, In Press
217.
ChowK,FesselJP,KaoriihidaS,SchmidtEP,GaskillC,AlvarezD,GrahamB,HarrisonDG,WagnerDH,Jr.,Nozik‐GrayckE,WestJD,KlemmDJ,MajkaSM.Dysfunctionalresidentlungmesenchymalstemcellscontributetopulmonarymicrovascularremodeling.PulmCirc.2013;3:31‐49.
218.
WiigH,SchroderA,NeuhoferW,JantschJ,KoppC,KarlsenTV,BoschmannM,GossJ,BryM,RakovaN,DahlmannA,BrennerS,TenstadO,NurmiH,MervaalaE,WagnerH,BeckFX,MullerDN,KerjaschkiD,LuftFC,HarrisonDG,AlitaloK,TitzeJ.Immunecellscontrolskinlymphaticelectrolytehomeostasisandbloodpressure.JClinInvest.2013,123:2803-15
219.
FengQ,VickersKC,AndersonMP,LevinMG,ChenW,HarrisonDG,WilkeRA.AcommonfunctionalpromotervariantlinksCNR1geneexpressiontoHDLcholesterollevel.NatCommun.2013;4:1973.
220. Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L,
Lassegue B, Griendling KK, Harrison DG, Dikalova AE. Nox2-Induced
Production of Mitochondrial Superoxide in Angiotensin II-Mediated
Endothelial Oxidative Stress and Hypertension. Antioxid Redox
Signal. 2014;20:281-294.
221. Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L,
Madhur MS, Chen W, and Harrison DG. Inflammation and Mechanical
Stretch Promote Aortic Stiffening in Hypertension Through
Activation of p38 Mitogen-Activated Protein Kinase. Circ Res 114:
616-625, 2014.
222. Youn JY, Siu KL, Lob H, Itani H, Harrison DG, and Cai H.
Role of Vascular Oxidative Stress in Obesity and Metabolic
Syndrome. Diabetes 2014.
223.
TrottDW,ThabetSR,KiraboA,SalehM,ItaniH,NorlanderAE,WuJ,GoldsteinA,ArendshorstWJ,LiCL,ShyrY,ChenW,MadhurMS,HarrisonDG.OligoclonalCD8+Tcellsplayacriticalroleinthedevelopmentofhypertension.Hypertension.2014;InPress
224.
KiraboA,FontanaV,deFariaAPC,LoperenaR,GalindoCL,WuJ,BikineyevaAT,DikalovS,XiaoL,ChenW,SalehMA,D.W.T,ItaniHA,VinhA,AmarnathV,AmarnathK,GuzikTJ,Bernstein.KE,ShenXZ,ShyrY,ChenSC,MernaughRL,LafferCL,ElijovichF,DaviesSL,MorenoLH,MadhurMS,RobertsIIJ,HarrisonDG.Dendriticcellisoketal‐modifiedproteinsactivateTcellsandpromotehypertension.JournalofClinicalInvestigation.2014;Inpress
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B. Reviews,CaseReports,Letters,Editorials
1.
WhiteCW,HiratzkaLF,EasthamCL,HarrisonDG,MarcusML:ArteriogramandthePhysiologicalSignificanceofCoronaryStenoses.CardiologyBoardRev1984;1:118‐123
2.
MarcusML,HarrisonDG,WhiteCW,HiratzkaLF:AssessingthePhysiologicalSignificanceofCoronaryObstructioninMan.CanJCardiol1986;195A‐199A
3.
MarcusML,HiratzkaLF,DotyDB,WrightCB,HarrisonDG,WhiteCW:CoronaryObstructiveLesions:AssessingTheirPhysiologicalSignificanceinHumans.AnnThoracSurg1986;42:S5‐S8
4.
MarcusML,HiratzkaLF,WhiteCW,HarrisonDG,EasthamCL,KerberRE:ApplicationofDopplerTechnologytoStudiesoftheCoronaryCirculation.CardiovascClin1986;17:33‐43
5.
HeistadDD,HarrisonDG,ArmstrongML:SerotoninandExperimentalVascularDisease.IntJCardiol1987;14:205‐212
6.
MarcusML,SkortonDJ,JohnsonMR,CollinsSM,HarrisonDG,KerberRE:VisualEstimatesofPercentDiameterCoronaryStenosis:“ABatteredGoldStandard.”JAmCollCardiol1988;11:882‐885
7.
MarcusML,HarrisonDG,WhiteCW,McPhersonDD,WilsonRF,KerberRE:AssessingthePhysiologicSignificanceofCoronaryObstructionsinPatients:ImportanceofDiffuseUndetectedAtherosclerosis.ProgCardiovascDis1988;31:39‐56
8.
HarrisonDG:FromIsolatedVesselstotheCatheterizationLaboratory.StudiesofEndothelialFunctionintheCoronaryCirculationofHumans.Circulation1989;80:703‐706.
9.
HarrisonDG,SellkeFW,QuillenJE:NeurohumoralRegulationofCoronaryCollateralVasomotorTone.BasicResinCardiol1990;85:121‐12
10.
ArmstrongML,HeistadDD,MeganMB,LopezJA,HarrisonDG:ReversibilityofAtherosclerosis.CardiovascClin1990;20:113‐126
11.
HarrisonDG:EndothelialModulationofVascularTone:RelevancetoCoronaryAngioplastyandRestenosis.JAmCollCardiol1991;17:71B‐76B
12.
HarrisonDG,TreasureCB,MüggeA,DellspergerKC,LampingKG:HypertensionandtheCoronaryCirculation:WithSpecialAttentiontoEndothelialRegulation.AmJHypertension1991;4:454S‐459S
13.
HarrisonDG:TheEndothelialCell.HeartDiseaseandStroke1992;2:95‐9914.
HarrisonDG:EndothelialDysfunctioninAtherosclerosis.BasicResCardiol1993;88:87‐10215.
NeremRM,HarrisonDG,TaylorWR,AlexanderRW:Hemodynamicsandvascularendothelialbiology.Journalof
CardiovascularPharmacology.1993;21:Suppl1:S6‐10.16.
HarrisonDG:EndothelialDysfunctionintheCoronaryMicrocirculation:ANewClinicalEntityoranExperimental
Finding?JClinInvest1993;1:1‐217.
HarrisonDG:EndogeneundTherapeutischeNitrateinGesundenundArterioskleroischenGefässen.Schweiz.
RundschauMedPrax1993;82:1172‐117618.
HarrisonDG:EndothelialRegulationofVasomotion:AlterationsinAtherosclerosis.CanJCardiol1993;9:1A‐6A19.
HarrisonDG:PhysiologicalAspectsofVascularEndothelialCellInteractionsinHypertensionand
Atherosclerosis.ActaAnaesthesiolScand1993;37:10‐1520.
HarrisonDG,MünzelT:Nitroglycerin:WhatCausesNitroglycerinTolerance?PrimaryCardiology1994;20:30‐4721.
ArnalJ‐F,MichelJ‐B,HarrisonDG:NitricOxideinthePathogenesisofHypertension.CurrOpinNephroland
Hypertens1995;4:182‐18822.
HarrisonDG:EndothelialDysfunctioninAtherosclerosis.BasicResCardiol1994;1:87‐10223.
HarrisonDG:AlterationsofVasomotorRegulationinAtherosclerosis.CardiovascularDrugsandTherapy1994;
9:55‐63
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24.
HarrisonDG,OharaY.Physiologicconsequencesofincreasedvascularoxidantstressesinhypercholesterolemiaandatherosclerosis:implicationsforimpairedvasomotion.AmJCardiol1995;75:75B‐81B
25.
HarrisonDG.EndothelialControlofVasomotionandNitricOxideProduction:APotentialTargetforRiskFactorManagement.CardiolClin1996;14:1‐15
26.
Rajagopalan,S,HarrisonDG.ReversingEndothelialDysfunctionwithACEInhibitors:AnewTREND?Circulation1996;94:240‐243
27.
MünzelT,KurzS,HeitzerT,HarrisonDG.Newinsightsintomechanismsunderlyingnitratetolerance.AmJCardiol1996;77:24C‐30C.
28.
HarrisonDG,SayeghHypertension,OharaY,InoueN,VenemaRC.RegulationofExpressionoftheEndothelialCellNitricOxideSynthase.ClinExpPharmacolPhysiol1996;23:251‐255.
29.
BechLaursenJ,HarrisonDG.ModulationofMyocardialOxygenConsumptionthroughACEInhibitors:NOEffect?Circulation1997;95:14‐6.
30.
KurzS,HarrisonDG.InsulinandtheArginineParadox.JClinInvest1997;99:369‐370.31.
HarrisonDG.EndothelialFunctionandOxidantStress.ClinCardiol1997;20:1‐17.32.
MunzelT,HarrisonDG.EvidenceforaRoleofOxygen‐derivedRadicalsandProteinKinaseCinNitrate
Tolerance.JMolMed1997;75:891‐900.33.
HarrisonDG.EndothelialFunctionandOxidantStress.ClinCardiol1997;20:11‐17.34.
DrummondGR,HarrisonDG.eNOS‐overexpressingMice:TooMuchNOMakestheBloodPressureLow.JClin
Invest1998;102:2033‐4.35.
HarrisonDG.OxidativeStressandCoronaryArteryDisease.CanadianJournalofCardiology1998;14Suppl
D:30D‐32D.36.
HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.OxidativeStressandHypertension.HypertensionPrimer,
Baltimore:Lippincott,Williams&Wilkins,1999,pp163‐166.37.
GriendlingKK,HarrisonDG.DualRoleofReactiveOxygenSpeciesinVascularGrowth.CircRes1999;85:562‐
563.38.
MunzelT,HarrisonDG.IncreasedSuperoxideinHeartFailure:ABiochemicalBaroreflexGoneAwry.Circulation
1999;100:216‐218.39.
SearlesCD.HarrisonDG.Theinteractionofnitricoxide,bradykinin,andtheangiotensinIItype2receptor:
lessonslearnedfromtransgenicmice.JClinInvest1999;104:1013‐1014.40.
SomersMJ,HarrisonDG.ReactiveOxygenSpeciesandtheControlofVasomotorTone.CurrHypertensRep1999;
1:102‐110.41.
ShahAM,VallanceP,HarrisonDG.NOinthecardiovascularsystem.CardiovascRes1999;43:507‐508.42.
LauerN.HarrisonDG.KojdaG.Nitricoxide(NO)andvascularoxidativestress.Newpathologicmechanismsand
bloodvesseldiseases.[German]MedMonatsschrPharm1999;22:382‐387.43.
SchultzD,HarrisonDG.QuestforFire:SeekingtheSourceofPathogenicOxygenRadicalsinAtherosclerosis.
ArteriosclerThrombVascBiol2000;20:1412‐1413.44.
WeintraubWS,HarrisonDG.C‐reactiveprotein,inflammationandatherosclerosis:dowereallyunderstandit
yet?EuropeanHeartJournal2000;21:958‐960.45.
CaiH,HarrisonDG.EndothelialDysfunctioninCardiovascularDiseases:TheRoleofOxidantStress.Circulation
2000;87:840‐844.46.
WeberM,HarrisonDG.KojdaG.Nitricoxide(NO)andvascularoxidativestress.Importanceincoronarydisease,
hypertension,diabetesmellitusandheartfailure.[German]MedMonatsschrPharm2000;23:12‐17.47.
GriendlingKK,HarrisonDG.Out,DamnedDot:StudiesoftheNADPHOxidaseinAtherosclerosis.JClinInvest
2001;108:1423‐1424(editorial).
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48.
DavisMandHarrisonDG.CrackingDownonCaveolin:ARoleofHMGCoAReductaseInhibitorsinModulatingEndothelialCellNitricOxideProduction.Circulation2001;103:2‐4.
49.
LandmesserUandHarrisonDG.Oxidativestressandvasculardamageinhypertension.CoronaryArteryDisease2001;12:455‐461.
50.
LandmesserU,HarrisonDG.Oxidantstressasamarkerforcardiovascularevents:Oxmarksthespot.Circulation2001;104:2638‐40.
51.
ZafariAM,HarrisonDG.FreeRadicalsinHeartFailure:TherapeuticTargetsforOldandNewDrugs.CongestHeartFail2002;8:129‐30.
52.
FukaiT,FolzRJ,LandmesserU,HarrisonDG.ExtracellularSuperoxideDismutaseandCardiovascularDisease.CardiovascularRes2002;239‐249.
53.
HarrisonDG,CaiH.EndothelialControlofVasomotionandNitricOxideProduction.CardiolClin2003;21:289‐302.
54.
SonSM,WhalinMK,HarrisonDG,TaylorWR,GriendlingKK.OxidativeStressandDiabeticVascularComplications.CurrDiabRep2004;4:247‐52.
55.
MuellerCF,LaudeK,McNallyJS,HarrisonDG.RedoxMechanismsinBloodVessels.ArteriosclerThrombVascBiol2005;25:274‐278.
56.
WidderJD,HarrisonDG.CanvitaminEpreventcardiovasculareventsandcancer?NatClinPractCardiovascMed.2005;10:510‐1.
57.
HarrisonDG.Theshearstressofkeepingarteriesclear.NatMed.2005;4:375‐6.58.
LandmesserJ,HarrisonDG,DrexlerH.OxidantStress–AMajorCauseofReducedEndothelialNitricOxide
AvailabilityinCardiovascularDisease.EurJClinPharmacol2006;13‐9.59.
Harrison,DG,WidderJ.GrumbachI,ChenW,WeberM,SearlesC.Endothelialmechanotransduction,nitricoxide
andvascularinflammation.JInternMed2006;259:351‐63.60.
GuzikTG,Harrison,DG.VascularNADPHoxidasesasdrugtargetsfornovelantioxidantstrategies.DrugDiscov
Today2006;11:524‐33.61.
GuzikTG,Harrison,DG.EndothelialNF‐kBasamediatorofkidneydamage:Themissinglinkbetweensystemic
vascularandrenaldisease.CircRes2007;101:227‐9.62.
GuzikTJ,Harrison,DG.EndothelialNF‐kappaBasamediatorofkidneydamage:themissinglinkbetween
systemicvascularandrenaldisease?CircRes.2007;101:268‐76.63.
GongoraMC,Harrison,DG.SadheartfromnoSOD.Hypertension.2008;51:19‐25.64.
Harrison,DG,BrownWV,RaggiP.EnhancedHype.AmericanJournalofCardiology.2008;102:368‐9.65.
DaiberA,HarrisonDG,MunzelT.Doubtaboutanessentialroleforconstitutivenitricoxidesynthasein
nitroglycerin‐mediatedvasodilation.ProcNatlAcadSciUSA.2008,105:E92;authorreplyE93.66.
HarrisonDG,GuzikTJ,GoronzyJ,WeyandC.Ishypertensionanimmunologicdisease?CurrCardiolRep.2008,
10:464‐469.67.
MarvarPJ,GordonFJ,HarrisonDG.Bloodpressurecontrol:saltgetsunderyourskin.NatMed.200915:487‐488.68.
GongoraMC,HarrisonDG.NOsolutionforaradicalproblem:Atalstory.AmJPhysiolRenalPhysiol.2010;2010,
298:F883‐884.69.
RichMW,MensahGAandPriceVInvestigators.Fifthpivotalresearchincardiologyintheelderly(PRICE‐V)
symposium:Preventivecardiologyintheelderly‐‐executivesummary.Partii:Afternoonsession.PrevCardiol.2010;13:42‐47.
70.
RichMW,MensahGAandPriceVInvestigators.Fifthpivotalresearchincardiologyintheelderly(PRICE‐V)symposium:Preventivecardiologyintheelderly‐executivesummary.Parti:Morningsession.PrevCardiol.2009;12:198‐204.
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71.
HarrisonDG,VinhA,LobH,MadhurMS.Roleoftheadaptiveimmunesysteminhypertension.CurrOpinPharmacol.2010,10:203‐207.
72.
HarrisonDG,Chen,W,DikalovS,LiL.RegulationofEndothelialCellTetrahydrobiopterin:Pathophysiologicalandtherapeuticimplications.AdvancesinPharmacology.2010,60:107‐132.
73.
HarrisonDG,GuzikTJ,LobH,MadhurM,MarvarPJ,ThabetS,VinhA,WeyandC.Inflammation,Immunity,andHypertension.Hypertension.2011,57:132‐140.
74.
MarvarPJ,LobH,VinhA,ZarreenF,HarrisonDG.Thecentralnervoussystemandinflammationinhypertension.CurrOpinPharmacol.2011,11:156‐161.
75.
HarrisonDG.JustNotHimselfTheseDays:AninvitationtosubmitpapersonthetopicofInflammationandImmunityinOrganSystemsPhysiologyandPathophysiology.AmJPhysiolRegulIntegrCompPhysiol.2011,300:R1263‐1265.
76.
MajorAS,HarrisonDG.Whatfansthefire:insightsintomechanismsofinflammationinatherosclerosisanddiabetesmellitus.Circulation.201,124:2809‐2811.
77.
CowleyAWJr,NadeauJH,BaccarelliA,BerecekK,FornageM,GibbonsGH,HarrisonDG,LiangM,NathanielszPW,O'ConnorDT,OrdovasJ,PengW,SoaresMB,SzyfM,TolunayHE,WoodKC,ZhaoK,GalisZS.ReportoftheNationalHeart,Lung,andBloodInstituteWorkingGrouponEpigeneticsandHypertension.Hypertension.2012,
59:899-905
78.
RoleoftheRenin‐AngiotensinSysteminthePathogenesisofIntimalHyperplasia:TherapeuticPotentialforPreventionofVeinGraftFailure?OsgoodMJ,HarrisonDG,SextonKW,HockingKM,VoskresenskyIV,KomalavilasP,Cheung‐FlynnJ,GuzmanRJ,BrophyCM.AnnVascSurg.2012,
26:1130-1144
79.
HarrisonDG,MarvarPJ,TitzeJM.VascularInflammationinHypertension.FrontPhysiol.2012,3:1‐8.80.
HarrisonDG,GuzikTJ.StudiesoftheT‐cellAngiotensinreceptorusingcre‐loxtechnology:anunan‐T‐cellpated
result.CircRes.2012,110:1543‐1545.81.
MarvarPJ,HarrisonDG.Stress‐dependenthypertensionandtheroleofTlymphocytes.ExpPhysiol.2012,
22:1161‐116782. Dikalov SI, Harrison DG. Methods for detection
of mitochondrial and cellular ROS. Antioxid Redox Signal. 2012
in
press
83. Hasty AH, Harrison DG. Endoplasmic reticulum stress and
hypertension - a new paradigm? J Clin Invest. 2012,
122:3859-3861
84. Madhur MS, Harrison DG. Synapses, Signals, CDs, and
Cytokines: Interactions of the Autonomic Nervous System and
Immunity in Hypertension. Circ Res. 2012, 111:1113-1116
85. Harrison DG. The Mosaic Theory revisited: common molecular
mechanisms coordinating diverse organ and cellular events in
hypertension. Journal of the American Society of Hypertension.
2013, 7:68-74
86. Itani HA, Dikalov S, Harrison DG. Knock, knock: Who’s there?
Nox1: Circulation. 2013, 127:1850-1852
87.
MadhurMS,HarrisonDG.SenescentTCellsandHypertension:NewIdeasAboutOldCells.Hypertension.2013,62:13-15
88. Harrison DG. From ST segments to endothelial
pathophysiology: hypercholesterolemia and endothelial superoxide
production. J Clin Invest. 2014;124:473-475.
89. Trott DW, and Harrison DG. The immune system in
hypertension. Adv Physiol Educ. 2014;38:20-24.
C. Symposiumcontributions:
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1.
HarrisonDG.Interactionsofnitricoxide,superoxideandsuperoxidedismutaseinthevesselwall:contributionstoregulationofvasomotion.1997,CoronaryMicrocirculationduringIschemiaandReperfusion,AlfredBenzonSymposium41:173‐188.
D. BooksandBookchapters:
1.
MarcusML,KoyanagiS,HarrisonDG,HiratzkaLF,WrightCD,DotyDB,EasthamCL.Abnormalitiesinthe
CoronaryCirculationSecondarytoCardiacHypertrophy.In:PerspectivesinCardiovascularResearch,Tarai,RC.andDunbar,JB.(Eds.),RavenPress,NewYork,Vol,8,1983,pp.273‐285.
2.
HarrisonDG,MarcusML.TheClinicalDiagnosisofRightVentricularInfarction.In:AcuteMyocardialInfarction,
MartinusNijhoff.
3.
HarrisonDG.PostThrombolyticCare.In:AcuteCoronaryCare,Wagner,GS.(Ed.),MartinusNijhoffPublishing,Boston,1986.
4.
HeistadDD,HarrisonDG,ArmstrongML.SerotoninandExperimentalVascularDisease.In:InternationalJournal
ofCardiology,Frye,RL(Ed.),ElsevierSciencePublisher,Amsterdam,1987,pp.205‐212.
5.
HarrisonDG,GuerraR,FreimanPC,ArmstrongML.ImpairedEndothelium‐DependentMechanismsinAtherosclerosis.In:ResistanceArteries,HalpernW,PegramBL,BraydenJE,MackeyK,McLaoughlinMK,andOsolG(Eds),PerinatologyPress,Ithaca,NewYork,1988,pp.54‐67.
6.
HeistadDD,ArmstrongML,BrownB,HarrisonDG.ResponsivenesstoSerotonininAtheroscleroticBlood
Vessels.In:Vasodilatation:VascularSmoothMuscle,Peptides,AutonomicNerves,andEndothelium,VanhoutteP(Ed.),RavenPress,NewYork,1988,pp.245‐259.
7.
HarrisonDG.AtherosclerosisAltersEndothelium‐DependentResponsestoaVarietyofNeurohumoralAgents:
PotentialMechanismsandPathophysiologicConsequences.In:Vasodilatation:VascularSmoothMuscle,Peptides,AutonomicNerves,andEndothelium,VanhoutteP(Ed.),RavenPress,NewYork,1988,pp.517‐521.v.
8.
HarrisonDG,GuerraRJr.,FreimanPC,ArmstrongML.In:ImpairedEndothelium‐DependentMechanismsin
Atherosclerosis.ProceedingoftheSymposiumonResistanceVessels,PerinatologyPress,Ithaca,NewYork,1988,pp.54‐58.
9.
ArmstrongML,HeistadDD,MeganMB,LopezJAG,HarrisonDG.ReversibilityofAtherosclerosis.In:Preventive
AspectsofCoronaryHeartDisease,Frohlich,Ed.,andBrest,AN.(Eds.),F.A.DavisCompany,1990,pp.113‐126.
10.
HarrisonDG,MinorRL,GuerraR,QuillenJE,SellkeFW.EndothelialDysfunctioninAtherosclerosis.In:CardiovascularSignificanceofEndothelium‐DerivedVasoactiveFactors.Editor,RubanyiR,263‐280,FuturaPublishingCo.,1990.
11.
HarrisonDG.EndothelialRegulationofVasomotorToneinAtherosclerosis.In:Atherosclerosis:Cellularand
MolecularInteractionsintheArteryWall.Editors,GotliebAI,LangilleBL,FedoroffS,pp.153‐160,PlenumPress,1990.
12.
HarrisonDG.NeurohumoralandPharmacologicRegulationofCollateralPerfusion.In:CollateralCirculation.
Editors,SchaperWandSchaperJ,pp.329‐343,KluwerAcademicPublishers,1993.
13.
HarrisonDG.EndothelialDysfunctioninAtherosclerosis.In:Arteriosclerosis.JustH,HortW,ZeiherAM(Eds.),SteinkipffVerlagDarmstadt,1994,pp.87‐102.
14.
HarrisonDG,KurzS,TarpeyM,FreemanB,andMünzelT.IncreasedVascularSuperoxideProduction:ANovel
MechanismUnderlyingNitrateTolerance.In:NitratesinCardiovascularDisease.
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15.
HarrisonDG.Interactionsofnitricoxide,superoxideandsuperoxidedismutaseinthevesselwall:contributionstoregulationofvasomotion.CoronaryMicrocirculationDuringIschemiaandReperfusion.HaunsøS,AldershvileJ,SvendsenJ(Eds.).Munksgaard,Copenhagen1997,pp.173‐194.
16.
GriendlingKK,HarrisonDG.AngiotensinII,oxidativestressandnitricoxide.In:Levin,E.R.andNadler,J.,eds.
EndocrinologyofCardiovascularFunction,Norwell:KluwerAcademicPublishers,1998,pp79‐98.17.
HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.Oxidativestressandhypertension.HypertensionPrimer,
Baltimore:Lippincott,Williams&Wilkins,1999,pp163‐166.
18.
ZafariAM,HarrisonDG,GriendlingKK.VascularOxidantStressandNOBioactivity.In:RichardO.CannonandJulioA.Panza,eds.,Endothelium,NitricOxide,andAtherosclerosis,FuturaPublishingCompany,1999,pp133‐144.
19.
SomersMJ,GriendlingKK,HarrisonDG.Theroleofoxidativestressinhypertension.Keaney,JF,Jr.,ed.
OxidativeStressandVascularDisease,Norwell:KluwerAcademicPublishers,1999.
20.
GriendlingKK,HarrisonDG,AlexanderRW.Molecularandcellularbiologyofbloodvessels.In:FusterV,AlexanderRW,andO’RourkeRA,eds.Hurst’sTheHeart,NewYork:McGraw‐Hill,2001,Chapter6.
21.
HarrisonDG,GalisZ,ParthasarathyS,GriendlingKK.Oxidativestressandhypertension.HypertensionPrimer,
Baltimore:Lippincott,WilliamsandWilkins,2003,pp185‐188.22.
GriendlingKK,HarrisonDG,AlexanderRW.Biologyofthevesselwall.In:FusterV,AlexanderRW,andO’Rourke
RA,eds.Hurst'sTheHeart,NewYork:McGraw‐Hill,2004,pp135‐154.
23.
GriendlingKK,HarrisonDG,AlexanderRW.Molecularandcellularbiologyofbloodvessels.In:FusterV,AlexanderRW,andO’RourkeRA,eds.Hurst’sTheHeart,NewYork:McGraw‐Hill,2005,Chapter7.
24.
HarrisonDG,DoughanAR,SellkeFW.PhysiologyoftheCoronaryCirculation.In:SellkeFrank,delNidoPedroJ,
SwansonScottJ,eds.SurgeryoftheChest,NewYork:ElsevierSaunders,2005,pp753‐765.
25.
VoisineP,WykrzykowskaJJ,BoodhwaniM,HarrisonDG,LahamRJ,SellkeFW.In:LahamR,BaimD,eds.TheCoronaryMicrocirculationandAngiogenesis,Totowa,NJ:HumanaPress,2005,Chapter4,pp..065‐106.
26.
DikalovS,HarrisonDG.PharmacologicalCompoundswithAntioxidantActivity.In:Bourassa,MartialG.;Ta