CURRICULUM VITAE BIOGRAPHICAL Business Address: Business ...training.cvrc.virginia.edu/events/942resume.pdf · ST. HILAIRE | October 8, 2020 | 1 CURRICULUM VITAE University of Pittsburgh

ST. HILAIRE | October 8, 2020 | 1

CURRICULUM VITAE University of Pittsburgh

School of Medicine

BIOGRAPHICAL

Name: Cynthia St. Hilaire, PhD

Business Address: BST 1744.1 200 Lothrop Street Pittsburgh, PA 15261

Home Address: 121 S. Highland Ave #807 Pittsburgh, PA 15206

Business Phone: 412-648-9441

Home Phone: 202-320-1397 Email: [email protected]

Webpage: www.sthilairelab.pitt.edu

EDUCATION and TRAINING

UNDERGRADUATE

1997 – 2001 University of Vermont BS, 2001 Molecular Genetics Burlington, VT

GRADUATE 2003 – 2008 Boston University PhD, 2008 Biochemistry, School of Medicine Program in Cell and Boston, MA Molecular Biology

POSTGRADUATE

2008 – 2009 NCI, National Institutes of Health, Bethesda, MD

Angiogenesis

2009 – 2015 NHLBI, National Institutes of Health, Bethesda, MD

Vascular Disease & Biology

APPOINTMENTS and POSITIONS

2015 – current 2015 – current 2015 – current

Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA Pittsburgh Heart, Lung, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, P Department of Pathology, Graduate Training Program in Cell and Molecular Pathology, University of Pittsburgh, Pittsburgh, PA

Assistant Professor of Medicine VMI Scholar Member


2018 – current 2019 – current

Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA Aging Institute University of Pittsburgh, Pittsburgh, PA

Assistant Professor of Bioengineering – Secondary Appointment Associate Member

MEMBERSHIP in PROFESSIONAL and SCIENTIFIC SOCIETIES

2000 – current Sigma Xi – Scientific Research Society 2011 – current North American Vascular Biology Organization 2014 – 2016 American Society for Biochemistry and Molecular Biology 2015 – 2016 Women in Bio – Pittsburgh Chapter 2013 – current

American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)

2016 – current International Society for Applied Cardiovascular Biology (ISACB) 2019 – current

American Heart Association, Council on Basic Cardiovascular Sciences (BCVS)

HONORS

2008 Henry I. Russek Student Achievement Day Boston University School of Medicine

2010 Best Postdoctoral Poster Presentation 8th NHLBI Division of Intramural Research Scientific Retreat, Baltimore, MD

2010 NHLBI Star Awards, Excellence in Laboratory Basic and Clinical Research, NIH, Bethesda, MD

2011 Fellows Award for Research Excellence, Vascular Disease & Biology Section, NIH, Bethesda, MD

2011

Outstanding Poster Award, North American Vascular Biology Organization, Vascular Matrix Biology and Bioengineering Workshop, Hyannis, MA

2011

Best Peripheral Artery Disease Research Award in Epidemiology/Preventative Medicine, Peripheral Arterial Disease Coalition, Vascular Disease Foundation, Severna Park, MD

2012

Orloff Science Award for Outstanding Scientific Contributions, NHLBI, NIH, Bethesda, MD

2013

NHLBI Director’s Award – Outstanding Translational Science, NHLBI, NIH, Bethesda, MD


2015

Orloff Science Award for Outstanding Scientific Contributions, NHLBI, NIH, Bethesda, MD

2018

North American Vascular Biology Organization Lab of the Month (July)

2018 2020

Outstanding New PI, New PI Slack – a community for new faculty (December) Fellow of the American Heart Association, ATVB Council

Honors to Trainees

2017 Luis Hortells, PhD Vascular Matrix Biology and Bioengineering Workshop 10th Anniversary Travel Award

2018 Pouya Joolharzadeh, Medical Student Longitudinal Research Project Certificate of Merit for Excellence

PUBLICATIONS

ORCID: 0000-0003-1871-6915 Web of Science Research Stats as of July 2020:

Researcher ID: R-8205-2017 h-index: 17 citations: 2069

PEER REVIEWED PUBLICATIONS

1. Al-Baradie R, Yamada K, St Hilaire C, Chan WM, Andrews C, McIntosh N, Nakano M, Martonyi EJ, Raymond WR, Okumura S, Okihiro MM, Engle EC. Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family. Am J Hum Genet. 2002 Nov; 71(5):1195-9. PMC385096.

2. Nagata Y, Jones MR, Nguyen HG, McCrann DJ, St. Hilaire C, Schreiber BM, Hashimoto A,

Inagaki M, Earnshaw WC, Todokoro K, Ravid K. Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle. Exp Cell Res. 2005 May 1;305(2):277-91. PMID: 15817153.

3. Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR, St.

Hilaire C, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest 2006 July;116(7):1913-1923. PMC1483170.


Commentary: Linden J. (2006) New insights into the regulation of inflammation by adenosine. J Clin Invest. 2006;116(7):1835–1837

4. Hazony Y, Lu J, St. Hilaire C, Ravid K. Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res. 2006 34(16):4416-28. PMC1636359.

5. Yang D, McCrann DJ, Nguyen H, St. Hilaire C, DePinho RA, Jones MR, Ravid K. Increased

polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell. 2007 Apr;6(2):257-60. PMC3303600.

6. Hurtado PA, Vora S, Sume SS, Yang D, St. Hilaire C, Guo Y, Palamakumbura AH,

Schreiber BM, Ravid K, Trackman PC. Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun. 2008 Feb 1;366(1):156-61. PMC2211633.

7. St. Hilaire C, Yang D, Schreiber BM, Ravid K. B-Myb regulates the A(2B) adenosine

receptor in vascular smooth muscle cells. J Cell Biochem. 2008 Apr 15;103(6):1962-74. PMC3303598.

8. St Hilaire C, Koupenova M, Carroll SH, Smith BD, Ravid K. TNF-alpha upregulates the A2B

adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Commun. 2008 Oct 24;375(3):292-6. PMC2583397.

9. Nguyen HG, Makitalo M, Yang D, Chinnappan D, St. Hilaire C, Ravid K. Deregulated

Auroa-B induced tetraploidy promotes tumorigenesis. FASEB J. 2009 Aug; 23(8):2741-8. PMC2717782.

10. St. Hilaire C, Carroll SH, Chen H, Ravid K. Mechanisms of induction of adenosine receptor genes and its functional significance. J Cell Physiol. 2009 Jan; 218(1):35-44. PMC 3265330.

11. Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St. Hilaire C, Boehm M. Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J Clin Invest. 2010 Jan;120(1):303-14. PMC2798694.

Commentary: Hla T and Oo ML. Ramping up RANTES in the acute response to arterial injury J Clin Invest. 2010 Jan;120(1):90–92.

12. St. Hilaire C, Ziegler SG, Markello T, Bruscs A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Krishna Chaganti R, Nussbaum R, Kleta R, Gahl WA, Boehm M. NT5E Mutations and Arterial Calcifications. N Engl J Med. 2011 Feb 3;364(5):432-42. PMC3049958.

This paper was highlighted in >20 articles, including:

• Medical Detectives Find Their First New Disease. New York Times, February 3, 2011, page A3


• Solution to medical mystery offers treatment hope. Nature, February 2, 2011, doi:10.1038/news.2011.65

13. Markello TC, Pak LK, St. Hilaire C, Dorward H, Ziegler SG, Chen MY, Chaganti K,

Nussbaum RL, Boehm M, Gahl WA. Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab. 2011 May; 103:44-50. PMC3081917.

14. Cooley BC, Nevado J, Mellad J, Yang D, St. Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF-b Signaling Mediates Endothelial-to-Mesenchymal Transition (EndMT) During Vein Graft Remodeling. Sci Transl Med. 2014 Mar 12;6(227):227ra34. PMC4181409.

Commentary: James D, Rafii S. Maladapted Endothelial Cells Flip the Mesenchymal Switch. Sci Transl Med. 2014 Mar 12;6(227):227fs12.

15. Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, St. Hilaire C, Shanahan C. Medial vascular calcification revisited: review and perspectives. Eur Heart J. 2014 Jun 14; 35(23):1515-1525. PMC4072893.

16. Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Montealegre Sanchez GA, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee C-CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St. Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz HC , Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R. Activated STING in a Vascular and Pulmonary Syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18. PMC4174543.

17. Garland BT, Boehm M, Grayson PC, St. Hilaire C, Brofferio A, and Starnes BW. Abnormal molecular response to Takayasu arteritis causing extensive large-vessel calcification. Journal of Vascular Surgery Cases and Innovative Techniques. 2016 2(4):190-2. PMC5523942.

18. St. Hilaire C*, Liberman M*, Miller JD*. Bidirectional Translation in Cardiovascular Calcification. Arterioscler Thromb Vasc Biol. 2016;36(3):e19-24. PMC4770569. * denotes co-corresponding author

19. Jin H*, St. Hilaire C*, Huang Y*, Yang D, Dmitrieva NI, Negro A, Schwartzbeck R, Liu Y, Yu Z, Walts A, Davaine JM, Lee DY, Donahue D, Hsu KS, Chen J, Cheng T, Gahl W, Chen G, Boehm M. Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. Science Signaling. 2016 Dec;9(458):ra121-ra. PMC5489239. * denotes equal contribution


20. Xue YF, St. Hilaire C, Hortells L, Phillippi JA, Sant V, Sant S. Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture. Cellular and Molecular Bioengineering. 2017;10(5):483-500. doi: 10.1007/s12195-017-0495-6. PMC6178984.

21. Gomez D, Baylis R, Durgin B, Newman A, Alencar G, Mahan S, St. Hilaire C, Müller W,

Waisman A, Francis S, Pinteaux E, Randolph G, Gram H, Owens G. Interleukin-1b promotes atheroprotective changes of advanced atherosclerotic lesions in mice. Nature Medicine. 2018 Sep;24(9):1418-1429 doi:10.1038/s41591-018-0124-5. PMC6130822.

22. Hortells L, Sur S, and St Hilaire C. Cell Phenotype Transitions in Cardiovascular Calcification. Front Cardiovasc Med. 2018; 5, 27. PMC5879740.

23. Carlsten M, Namazi A, Reger R, Levy E, Berg M, St. Hilaire C, and Childs RW. Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5. Oncoimmunology 2019 8(2) doi:10.1080/2162402X.2018.1534664 PMC6343814.

24. Joolharzadeh P, St. Hilaire C. CD73 and the differences between mice and humans. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):339-348. doi: 10.1161/ATVBAHA.118.311579. PMC6446586.

25. Moorhead WJ 3rd, Chu CC, Cuevas RA, Callahan J 4th, Wong R, Regan C, Boufford CK, Sur S, Liu M, Gomez D, MacTaggart JN, Kamenskiy A, Boehm M, St. Hilaire C. Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020;40:1680–1694. PMC7310306

Commentary: Sutton NR, Hofmann Bowman MA. Reining in Peripheral Arterial Calcification. Arterioscler Thromb Vasc Biol. 2020;40:1614-1616

OTHER PEER REVIEWED PUBLICATIONS Invited Editorials

26. Roman BL and St. Hilaire C. Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 Nov 1;194(9):1047-8. PMC5114453.

27. St Hilaire, C. "Retinoids: Dissolving the Calcification Paradox." Arterioscler Thromb Vasc Biol (2020) 40(3): 503-505. PMC7101021.

Book Chapters

28. Negro A, St. Hilaire C, Boehm M. Cell-Based Regenerative Therapies: Role of Major Histocompatibility Complex-1 Antigen. In: Hayat MA, ed. 2014. Book chapter in Stem Cells and Cancer Stem Cells, Volume 3: Springer Netherlands; p173-8.


29. Boehm M, St. Hilaire C. Vascular Genetics. In: Lanzer P. (Ed.) Pan Vascular Medicine, 2nd edition, vol.x, pp 53-88. Springer Heidelberg New York Dordrecht London, 2015. DOI: 10.1007/978-3-642-37393-0_4-1

Published Abstracts

1. Engle EC, Al-Baradie R, St. Hilaire C, Moy R, Xu PX, Maas R. Linkage mapping and candidate gene analysis of Duane syndrome with radial ray anomalities (Okihiro syndrome). Journal of The Neurological Sciences 2002 199, S98-S99

2. St. Hilaire C, Yang D, Ravid, K. The A2b adenosine receptor gene is regulated by the cellular proliferation state: the role of Myb protein. The FASEB Journal 2006 20 (5), LB69

3. St. Hilaire C, Ravid, K. Stress-induced regulation of the A2B adenosine receptor gene: implications for vascular function. Journal of Interferon & Cytokine Research 2008 28 (11), 769-770

4. St. Hilaire C, Kyaw MT, Boehm M. Modulation of IGF2-mediated PI3K/MEK signaling is implicated in the vascular calcification of a rare monogenetic disease. Angiogenesis 2013 16 (1), 245-277

5. St. Hilaire C, Jin J, Huang Y, Yang D, Negro A, Walts A, Liu Y, Davaine J-M, Schwartzbeck R, Yu Z, Dmitrieva N, Donahue D, Chen G, Boehm M. In Vitro and in vivo Disease Modeling Using Patient Derived iPSCs to Characterize the Calcification Phenotype in Arterial Calcification Due to Deficiency of CD73 ATVB 2016 36 (Suppl 1), A518-A518

6. St. Hilaire C. Autophagy in Vascular Calcification ATVB 2017 37 (Suppl 1), A330-A330

7. Satoh T, Wang L, McTiernan CF, Levine A, Hahn S, Baust J, Wyman S, Salamacha N, Wu YL, St. Hilaire C, Goncharova D, Goncharova E, Straub AC, Lai YC, Gladwin MT. Novel Rodent Model of Exercise-induced Pulmonary Hypertension (EIPH) in Heart Failure With Preserved Ejection Fraction. Circulation. 2019;140:A11249

8. Hortells L, Boufford C, Regan C, Chu C, Moorhead MJ, Doyon G, Bruemmer D, St. Hilaire C. A Novel Role for Telomerase in Calcific Aortic Valve Disease. Circulation Research. 2019; 125 Suppl_1 A480

9. Chu C, Moorhead WJ, Callahan J, Boufford CK, Sur S, MacTaggart JN, Kamenskiy A, St. Hilaire C. CD73 Deficiency and Peripheral Artery Calcification. 2019 ATVB 39 (Suppl_1), A135-A135

Other Non-peer Reviewed Publications

Correspondence

1. Boehm M., St. Hilaire C., Gahl W.A. NT5E mutations and Arterial Calcifications. N Engl J Med. 2011 364: 1577-1580. 10.1056/NEJMc1102515

2. Markello T., Pak L.K., St. Hilaire C., Ziegler S., Nussbaum R., Boehm M., Gahl W.A. Reply to Professor Leftheriotis et al. Molecular Genetics and Metabolism. 2011 July;103(3): 305


Invited Commentary

1. St. Hilaire C. Lessons Learned. NewsBeat – Monthly Newsletter of the North American Vascular Biology Organization. 2019 May

PROFESSIONAL ACTIVITIES

TEACHING

Medical Student and Fellows Teaching

2016 Proctor, MSTP Research Basics of Medical Knowledge (MS2 2016), University of Pittsburgh School of Medicine, Approximately 5 medical students, 1 hour

2017, 2017, 2019, 2020

Lecturer, Fundamentals of Bench Research (CLRES2700) – Introduction to Cell Biology Lecture, University of Pittsburgh, Pittsburgh, PA. 15-20 Research/Clinical Fellows, 1 Hour/Year

2016, 2017, 2018, 2020

Lecturer, Molecular Genetics of Rare Monogenic Disorders: Insights into Complex Disease Phenotypes (CLRES 2700), University of Pittsburgh School of Medicine, Pittsburgh, PA, Approximately 20 Clinical Fellows, 1 hour

Undergraduate and Graduate Student Teaching

2001 Laboratory Teaching Assistant, Intro to Molecular Genetics (MG102), University of Vermont, Department of Molecular Genetics, Burlington, VT, 15-20 undergraduate students, 2 session per week

2002, 2003 Lecturer, General Biology Laboratory (BI210), Boston College, Department of Biology, Chestnut Hill, MA, 15 15-20 undergraduate students, 2 session per week

2006 Instructor, Introduction of Biomedical Laboratory Sciences (BT-110), Boston University, Metropolitan College, Boston, MA, 15-20 pre-baccalaureate students, 2 session per week

2016, 2017, 2018 Lecturer, AHA Summer Undergraduate Research Program (SURP) in Cardiovascular Sciences, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 5 undergraduate students, 1 hour

2016 Lecturer, Insights into Vascular Biology Through Rare Disease (HUGEN 2025), Department of Genetics, University of Pittsburgh, Pittsburgh, PA, 25-30 graduate students, 1 hour


2016, 2017, 2018, 2019, 2020

Lecturer, Translational Research in Heart Failure: Vascular Calcification & Atherosclerosis (MSCMP 2740), Cell and Molecular Pathology, University of Pittsburgh, Pittsburgh, PA, 3-5 graduate students, 1 hour/yr

2017 Proctor, K-Grant Writing Workshop, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, Approximately 10 graduate students, 1 hour

2017 Lecturer, PSTP PD II Mock Study Section, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, Approximately 5 graduate students, 2 hours

2017 Lecturer, Molecular Mechanisms of Cardiovascular Disease, Boston University School of Medicine, Boston, MA, Approximately 20 graduate students, 1 hour

2017, 2018, 2019 Instructor, Grant Writing for Graduate Students (INTBP 3240), Interdisciplinary Biomedical Sciences (INTBP), University of Pittsburgh School of Medicine, Pittsburgh, PA, Approximately 12 graduate students, five 2-hour sessions/year

2018, 2020 Instructor, Integrated Systems Biology Bench to Bedside, Cardiology Block (ISB 2020), University of Pittsburgh School of Medicine, Pittsburgh, PA, Approximately 10 graduate students, 2 – 4 hours

Curriculum Development/Teaching Products/Media Products

2017 "MSCs in Cardiovascular Health & Disease: The Role of CD73 and Adenosine", ISACB Live & Interactive Webinar, 60 minutes. ISACB members including PIs, postdoctoral fellows, students, and staff

2018 Organized and moderated the live webcast of VASCUATA, a 3 1/2-day course offered by the North American Vascular Biology Organization that introduces the basics of cardiovascular biology and cardiovascular disease

2019 Host of Discover Circ Res, the monthly podcast series for the journal Circulation Research http://circresearch.libsyn.com/

2020 “Career Navigation in a Time of COVID”, ISACB Zoom Discussion

MENTORING Undergraduate Mentorship 2016 Camille Klimas Boufford, B.S. Summer Undergraduate Research

Volunteer, University of Pittsburgh, Pittsburgh, PA

2016 Taylor Maurer, B.S. Summer Undergraduate Research Volunteer, University of Pittsburgh, Pittsburgh, PA


2016 – 2017 Sreya Addanki, B.S. Undergraduate Research Student, University of

Pittsburgh, Pittsburgh, PA

2017 Laura Garcia, Summer Undergraduate Research Technician, Pittsburgh Undergraduate Research Diversity Program, University of Pittsburgh, Pittsburgh, PA

2017 – 2020 Jack Callahan, Undergraduate Research Student, Class of 2020, University of Pittsburgh, Pittsburgh, PA

2018 – 2020

Cailyn Regan, Undergraduate Research Student, Class of 2020 University of Pittsburgh, Pittsburgh, PA

2018 – current Ryan Wong, Undergraduate Research Student, Class of 2021 University of Pittsburgh, Pittsburgh, PA

2019 – current

Angela Le, Undergraduate Research Student, Class of 2022 University of Pittsburgh, Pittsburgh, PA

Graduate and Medical Student Mentorship 2016 – 2019 Pouya Esmaeil Joolharzadeh, Medical Student, Scholarly Research

Project University of Pittsburgh School of Medicine, Pittsburgh, PA

2017 – 2018 Rachel Wolfe, Medical Student, PTSP Program Rotation University of Pittsburgh School of Medicine, Pittsburgh, PA

2018 Pooja Pardeshi, Graduate Student Rotation, Human Genetics, School of Public Health University of Pittsburgh, Pittsburgh, PA

2019 Junru Wu, Xiangya Scholar Rotation, University of Pittsburgh, Pittsburgh, PA

2020 Wenxi An, Graduate Student Rotation, Interdisciplinary Biomedical Graduate Program, University of Pittsburgh, Pittsburgh, PA

Thesis Committee Service Local 2017 – 2019 Bijun Li, Masters’s Graduate Student

Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Laboratory of Beth Roman, PhD Title: Zebrafish bmp10 mutants as a model for hereditary hemorrhagic telangiectasia-associated high output heart failure.

2018 Teresa Capasso, Phd Qualifying Exam Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Laboratory of Beth Roman, PhD


International 2019 Maria Bogdanova, PhD Graduate Student, University of

Oslo, Oslo, Norway. Laboratory of Jarle Vaage, MD Title: Cellular and molecular mechanisms of human aortic valve calcification Role: 1st Opponent (lead external reviewer of thesis)

2019

Iván Parra Izquierdo, PhD Graduate Student, University of Valladolid, Valladolid, Spain. Laboratory of Carmen Garcia-Rodríguez, PhD Title: Effects of interferons and their interactions with other ligands in human aortic valve cells Role: Expert evaluator (external reviewer of thesis)

Postgraduate Mentorship 2015 – 2016 Hanna Pulaski (nee Valli), Ph.D. Postdoctoral Fellow. University of

Pittsburgh, Pittsburgh, PA

2016 – 2017 Swastika Sur, Ph.D. Postdoctoral Fellow, University of Pittsburgh, Pittsburgh, PA

2016 – 2017 Luis Hortells, DVM, Ph.D. Postdoctoral Fellow. University of Pittsburgh, Pittsburgh, PA

2020 – current

Rolando Cuevas, Ph.D. Postdoctoral Fellow. University of Pittsburgh, Pittsburgh, PA

2020 – current Michael Bashline, MD. Cardiology Fellow. University of Pittsburgh, Department of Medicine, Pittsburgh, PA

Advisory Mentorship

2015 – current Dharendra Thapa, Ph.D. Postdoctoral Fellow in Iain Scott Laboratory, VMI, University of Pittsburgh, Pittsburgh, PA

2018 – current Theresa Capasso, M.S. PhD Graduate Student in Beth Roman Laboratory, Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA

Funding Awarded to Mentees

2016 Taylor Maurer, Undergraduate Student University of Pittsburgh, Cell and Molecular Pathology Summer Undergraduate Research $1,700

2016 Pouya Joolharzadeh, Medical Student University of Pittsburgh, Klionsky Summer Research Fellowship in Pathology


$3,000

2019 Jack Callahan, Undergraduate Student University of Pittsburgh, Honors College HEAL Research Fellowship $4,000

2020 Ryan Wong, Undergraduate Student University of Pittsburgh Summer Undergraduate Research Program (SURP) $3,500 (canceled due to COVID)

RESEARCH Current Grant Support R01 HL142932 The Role of Telomerase in

Calcific Aortic Valve Disease PI (65%)

08/2018 – 07/2023 NIH/NHLBI $1,499,670 directs + $824,840 indirects = $2,324,510

R01 GM122091 Altered Biosynthesis and Function of Abcc6 In Systemic Mineralization Disorders

co-I (10%)

07/2019 – 08/2021 NIH/NIGMS $66,572 directs to St. Hilaire

Pending Grant Support 20IPA35260111 *scored 11 percentile

NETs and Calcific Aortic Valve Disease

PI (10%)

07/2020 – 06/2022 (funding announcments delayed due to COVID)

AHA $180,000 directs + $20,000 indirects = $200,000

Completed Grant Support T32HL007969 NHLBI Institutional

Research Training Grant, Boston University School of Medicine

Student 7/2004 – 6/2007

NIH/NHLBI $162,359 direct to St. Hilaire

Sallie Rosen Kaplan Fellowship for Women Scientists

Fellow 2008 NIH/NCI $10,000 directs to St. Hilaire

Claude Lenfant Biomedical Fellowship

Fellow 2011 NIH/NHLBI


$10,876 directs to St. Hilaire

Mechanical Stress in Calcific Aortic Valve Disease: The Role of CD73 Activity and Adenosine Receptor Signaling in Disease Initiation

PI (1%)

7/2016 –6/2017 Samuel and Emma Winters Foundation $10,000 directs to St. Hilaire

Role of Mechanical Stress in Ectonucleotidase Activity and Adenosine Receptor Signaling in Calcific Aortic Valve Disease

PI (1%)

7/2016 –6/2017 VMI-HVI University of Pittsburgh $25,000 directs to St. Hilaire

A Role for Telomerase in Calcific Aortic Valve Disease

PI (1%)

7/2017 –6/2018 Samuel and Emma Winters Foundation $10,300 directs to St. Hilaire

K22 HL117917 Regulation of Vascular Calcification by Adenosine Signaling

PI (75%)

07/2015 –06/2018 NIH/NHLBI $679,464 directs + $51,957 indirects = $731,421

Non-Funded Research

Clinical Treatment Protocol/Clinical Trial

NCT01585402 Protocol 12-H-0110 An open-label, non-randomized, single-arm pilot study to evaluate the effectiveness of etidronate treatment for Arterial Calcifications due to Deficiency in CD73 (ACDC)

Associate Investigator IRB Approved: March, 2012 Start Date: August, 2012 Final Collection: August, 2020

Other Research-Related Activities

Patents


2013 Patent Application (Retired)

Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders. United States patent application 13/582,035

2017 Patent Application Genetically Modified Mesenchymal Stem Cells for Use in Decellularized Valve Prosthetics. United States Patent Number 62/572,709. International Patent Number PCT/US 2018/055908

Editorial Boards

2016 – current Journal of the American Heart Association; Associate Editor 2019 – current Circulation Research; Section Editor 2020 – current Associate Editor; Board of Heart Valve Disease – Frontiers in

Cardiovascular Medicine Manuscript Review (year indicates first invitation to review)

Acta Biomaterialia (2020) American Journal of Respiratory Critical Care Medicine (2015) Arteriosclerosis, Thrombosis, and Vascular Biology (2018) BBA – Molecular Basis of Disease (2019) BMJ – Case Reports (2020) BMC Surgery (2017) Cardiovascular Research (2019) Cellular Signaling (2019) Circulation (2019) Circulation: Cardiovascular Imaging (2019) Circulation Research (2017) Differentiation (2019) FASEB (2020) Frontiers in Physiology (2017) Hypertension (2019) International Journal of Molecular Sciences (2018) JCI Insights (2016) Journal of Biomechanics (2020) Journal of Clinical Rheumatology (2014) Journal of the American Heart Association (2018) Journal of Molecular Medicine (2019) Journal of Structural Biology (2020) Molecular Aspects of Medicine (2018) PLOS One (2014) Science Advances (2016) Scientific Reports (2019) Trends in Endocrinology and Metabolism (2019) Vascular Medicine (2019)


Approximately 15-20 manuscripts reviewed per year Study Section Membership

2019 - 2020 SGE Member of the Federal Advisory Committee, Department of Veterans Affairs. Scientific Review Group, Subcommittee for Cardiology – B

Ad Hoc Grant Review

Local

2016, 2017, 2018, 2020

Pilot Project Program in Hemostasis and Vascular Biology

Vascular Medicine Institute, University of Pittsburgh

2016, 2017, 2018, AHA Summer Undergraduate Research Program (SURP) in Cardiovascular Sciences

Vascular Medicine Institute, University of Pittsburgh

2018 CRISP: CTSI's Research Initiative for Special Populations

CTSI, University of Pittsburgh

2018 HVI-VMI Innovator Award Vascular Medicine Institute, University of Pittsburgh

2019 HVI Fellows Grant UPMC Heart and Vascular Institute, University of Pittsburgh

National

2018 Fellowship CV Dev BSc1 Study Group American Heart Association

2018, 2019, Fellowship Vascular Wall Biology Basic 1 American Heart Association

American Heart Association

2018 Somatosensory and Pain Systems (SPS) NIH 2018, 2019 (June & Dec)

Special Emphasis Panel/Scientific Review Group 2019/01 ZRD1 CARB-R (01) Cardiology – B

Department of Veterans Affairs

2020

Atherosclerosis and Inflammation of the Cardiovascular System (AICS)

NIH

International

2014 Development of Innovative Therapeutic Approaches for Rare Diseases

E-Rare Joint Transnational (JTC2014)

2019

Council Reference: MR/T032332/1

Medical Research Council, United Kindom


2020 Special Project British Heart Foundation, United Kindom

LIST of CURRENT RESEARCH INTERESTS

1. Vascular Calcification 2. Calcific Aortic Valve Disease 3. Vascular Remodeling 4. Arteriosclerosis 5. Vascular Cell Differentiation 6. Cell Phenotype Switching 7. Genetic Disease with Vascular Phenotypes

INVITED ORAL SEMINARS AND LECTURESHIPS

Local

2009 NIH Undiagnosed Disease Program, Bethesda, MD.

2010 National Institutes of Health Office of Intramural Training and Education hosting Morehouse College students, Bethesda, MD

2011 9th Annual NHLBI Division of Intramural Research Retreat, Cambridge, MD

2011 NIH Undiagnosed Diseases Program, Bethesda MD

2011 NIH Research Festival - Advances in Rare Diseases Research, Bethesda, MD

2014 12th Annual NHLBI Division of Intramural Research Retreat, Bethesda, MD

2015 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA

2016 Molecular Medicine Research Seminar, Children’s Hospital of Pittsburgh, Pittsburgh, PA

2017 Cardiology Grand Rounds, UPMC Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA

2018 Pittsburgh Center for Bone and Mineral Research Seminar Series, Pittsburgh, PA

2019 Vascular Medicine Institute and Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA

2019 Honors College HEAL Fellowship, University of Pittsburgh, Pittsburgh, PA

National

2007 15th Annual Meeting, North East Smooth Muscle Society, Providence, RI

2011 Seminars in Clinical Research Series, The Rockefeller University, New York, NY

2011 Nephrology Seminar Series, New York University Medical School, New York, NY

2011 Vascular Matrix Biology and Bioengineering Workshop, NAVBO Workshops in Vascular Biology 2011, Hyannis, MA (Declined)


2011 Vascular Disease Foundation Annual Meeting, Tyson’s Corner, VA

2012 Genetics and Genomics of Vascular Disease, NAVBO Workshops in Vascular B Biology, Monterey, CA

2012 Cardiology Grand Rounds, Stanford University School of Medicine, Stanford, CA

2014 Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC

2014 Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH

2014 Institute for Integrative Physiology, University of Chicago, Chicago, IL

2014 Vascular Medicine Institute and Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, PA

2015 Department of Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL.

2016 Cardiovascular Biology Seminar, Emory University Department of Medicine, Atlanta, GA

2017 Stem Cells for Drug Discovery and Toxicity Screening 2017, Boston, MA (Declined)

2017 10th Annual NIH Career Symposium, Bethesda, MD

2017 Vascular Biology 2017, Vascular Matrix Biology and Bioengineering Workshop, Monterey, CA

2017 Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston MA

2018 Orloff Awards Ceremony, NHLBI Office of the Scientific Director, NIH, Bethesda, MD

2018 Round-table Panelist, ATVB Early Career Training Session I, ATVB |PVD Scientific Sessions, San Francisco, CA

2018 ATVB Early Career Training Session II, ATVB |PVD Scientific Sessions, San Francisco, CA

2019 Vascular Discovery: From Genes to Medicine Scientific Sessions 2019, ATVB Early Career Training Session – Difficult Conversations, Boston, MA

2019 Vascular Discovery: From Genes to Medicine Scientific Sessions 2019, Translational Science in Vascular Medicine: Vascular Dysfunction, Boston, MA

2019 Vascular Biology 2019 - Vascular Matrix Biology and Bioengineering Workshop, A Novel Role for Telomerase in Calcific Aortic Valve Disease, Monterey, CA

2020 ATVB Early Career Training Round Table Discussion, Vascular Discovery: From Genes to Medicine Scientific Sessions (virtual session due to COVID-19)


2020 Cardiovascular Working Group Seminar Series, University of Massachusetts Medical School, Boston, USA (virtual session due to COVID-19)

2020 Cardiovascular Research Center Seminar Speaker, University of Virginia, Charlottesville, VA, USA (virtual session due to COVID-19)

2021 UCLA Cardiovascular Theme Research Seminar Series, University of California Los Angeles, Los Angeles, CA (virtual session due to COVID-19)

2021 NAVBO Workshop on Vascular Matrix Biology and Bioengineering, Asilomar Conference Grounds, Pacific Grove, California (virtual session due to COVID-19)

International

2010 16th International Vascular Biology Meeting, Los Angeles, CA. (invited due to a cancellation)

2012 Renal Research Institute 14th International Conference on Dialysis, Advances in CKD, Tarpon Springs, FL (Declined)

2013 Vascular Disease: Biology and Clinical Science, Core 7. AHA Scientific Sessions. Dallas, TX

2016 Keystone Symposia on Purinergic Signaling. Vancouver, BC, Canada

2016 15th Biennial International Society for Applied Cardiovascular Biology. Banff, AB, Canada

2017 Faculty Invitation, Frontiers in Vascular and Valvular Calcification, AHA Scientific Sessions, Anaheim, CA

2017 International Society for Applied Cardiovascular Biology, Cape Town, South Africa

2018 International Society for Applied Cardiovascular Biology, Bordeaux, France

2019 Heart Valve Society Annual Meeting, Sitges, Spain

2019 Invited Faculty Invitation, Genetic Influences on Cardiovascular Calcification, AHA Scientific Sessions, Philadelphia, PA

2019 Invited Faculty Invitation, Leveraging Social Media for Learning/Networking/Advocating in Cardiovascular Science, AHA Scientific Sessions, Philadelphia, PA

2019 Invited Faculty Invitation, Circulation and Circulation Research: Pulling Back the Scientific Publishing Curtain, AHA Scientific Sessions, Philadelphia, PA

2020 Invited Panelist, ISACB Roundtable: Career navigation in a time of COVID-19. Virtual Seminar due to COVID-19 pandemic

Poster Abstract Presentations


Local

2016 University of Pittsburgh Department of Medicine Research Day. Rapamycin is involved in inhibition of calcification in CD73 deficient human smooth muscle cells

2016 University of Pittsburgh Department of Medicine Research Day. Role of KLFs in the modulation of alkaline phosphatase in the disease Arterial Calcification due to Deficiency of CD73

2018 McGowan Institute Retreat, University of Pittsburgh, Pittsburgh, PA. A Role for Telomerase in Calcification Aortic Valve Disease

2018 Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA. Increased TGF-b signaling and elastin production in CD73-deficient vascular smooth muscle cells

2019 Science 2019, University of Pittsburgh School of Medicine, Pittsburgh, PA. FOXO1 is involved in the upregulation of TNAP in CD73 deficient cells

2020 Department of Medicine Research Day, University of Pittsburgh, Pittsburgh, PA. Role of CD73-mediated Adenosine Signaling in Elastin Expression in Vascular Smooth Muscle Cells

2020 Honors College Research Fair, University of Pittsburgh, Pittsburgh, PA. Role of CD73-mediated Adenosine Signaling in Elastin Expression in Vascular Smooth Muscle Cells

2020 Honors College Research Fair, University of Pittsburgh, Pittsburgh, PA. FOXO1 is involved in the upregulation of TNAP in CD73-deficient cells.

National

2016 ATVB|PVD Scientific Sessions, Nashville, TN. In Vitro And In Vivo Disease Modeling Using Patient-Derived iPSCs to Characterize the Calcification Phenotype in Arterial Calcification Due to Deficiency of CD73

2017 NAVBO Asilomar, CA. A Role for Telomerase in Calcification Aortic Valve Disease

2017 ATVB|PVD Scientific Sessions, Minneapolis, MN. Autophagy in Vascular Calcification

2019 BCVS Scientific Sessions, Boston, MA. A Novel Role for Telomerase in Calcific Aortic Valve Disease.

2020 Society for Vascular Surgery - Vascular Research Initiatives Conference (VRIC). Chicago, IL. Reduced CD73 Activity Increases Elastin and Contractility in Vascular Smooth Muscle Cells (invited and scheduled, however canceled secondary to the COVID19 Pandemic)

2020 Vascular Discoveries: From Genes to Medicine, meeting made virtual due to COVID19 pandemic. FOXO1 Promotes Peripheral Medial Arterial Calcification


International

2016 Keystone Symposia Conference, Purinergic Signaling, Vancouver, BC, Canada. In Vivo Disease Modeling Using Patient-Derived iPSCs: CD73-Deficiency Promotes Osteogenic Differentiation and Calcification

2016 19th International Vascular Biology Meeting, Boston, MA. The Compensatory Role of Tissue Non-Specific Alkaline Phosphatase Leads to Ectopic Calcification in Patients with Inactivating Mutations in the NT5E/CD73 gene

2018 International Society for Applied Cardiovascular Biology, Bordeaux, France. Intersection between CD73/Adenosine signaling and the TGF-b pathway in VSMCs

2019 International Society for Applied Cardiovascular Biology, Zurich, Switzerland. CD73 deficiency and peripheral artery calcification.

SERVICE

University of Pittsburgh Service

2016 Poster Judge, Biomedical Graduate Student Association Annual Symposium, University of Pittsburgh 2016 – 2019 Member, Genomics Research Core Advisory Committee, University of Pittsburgh 2016 – 2019 Member, Steering Committee, AHA Summer Undergraduate Research Program (SURP) in Cardiovascular Sciences, University of Pittsburgh 2016 – current Poster Judge, AHA Research Fellows Day at University of Pittsburgh (annual) 2017 – current Poster Judge, Annual University of Pittsburgh Department of Medicine Research Day 2018 Poster Judge, McGowan Institute for Regenerative Medicine Retreat, University of Pittsburgh 2018 – current Reviewer, Vascular Medicine Institute Grant Review Core, University of Pittsburgh

2019 – current Deputy Judge, Annual University of Pittsburgh Department of Medicine Research Day

2020 Screener for applicants to the Physician Scientist Training Program

2021 Chair, AHA Fellows Research Day, University of Pittsburgh

Previous Academic Service

2006 – 2008 Graduate School Admissions Committee, Boston University School of Medicine, Department of Biochemistry. Graduate Student Representative

2008 – 2009 Member, National Cancer Institute, Center for Cancer Research, Fellows and Young Investigators Association


2008 – 2009 Member, NIH Fellows Committee, NCI-Frederick Representative

2009 – 2010 Co-Chair, 2011 Steering Committee, Fellows Award for Research Excellence, National Institutes of Health

2009 – 2010 Member At Large, NIH Fellows Committee, National Institutes of Health

2012 Abstract Judge, NIH Fellows Award for Research Excellence 2013, Vascular Disease & Biology study section, National Institutes of Health

2013 Steering Committee for 2014 NIH Career Symposium

2013 Abstract Judge, NIH Fellows Award for Research Excellence 2014, Biochemistry- General & Lipids study section

2014 Alternate Judge, NIH Fellows Award for Research Excellence 2015, Molecular Biology - Eukaryotic study section

2015 Member, NHLBI Fellows Advisory Committee

Professional Service

2014 – 2018 Member, Early Career Committee - American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) 2015 Co-Chair, North American Vascular Biology Origination (NAVBO) Vascular

Biology 2015, Vascular Matrix Calcification Session 2015 Co-Chair, American Heart Association Scientific Sessions, ATVB Early Career Investigator Award Finalists Session 2016 Co-Chair, ATVB|PVD Scientific Sessions. Succeeding at Every Stage: Insights from the Early Career Committee – The importance of mentoring and being mentored 2016 – 2018 Liaison, ATVB Early Career Committee liaison to the ATVB Women’s Leadership Committee 2016 – 2018 Member, ATVB Nomination and Awards Committee 2016 – current Chair, Women’s Leadership Committee, International Society of Applied Cardiovascular Biology 2017 Invited Moderator, BCVS/ATVB Joint Early Career Programming, AHA Scientific

Sessions, Anaheim, CA

2018 Abstract Judge, ATVB Early Career Investigator Award, AHA 2018 – 2020 Member, ATVB Women’s Leadership Committee 2018 – 2020 Vice Chair, Early Career Committee, American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)


2019 Invited Moderator, Vascular Research Initiatives Conference, Society for

Vascular Surgery. Boston, MA

2019 – 2022 Councilor, North American Vascular Biology Organization 2019 – 2022 Poster Judge, Vascular Biology 2019, Asilomar, CA 2019 Invited Moderator, Russell Ross Memorial Lectureship in Vascular Biology, AHA

Scientific Sessions, Philadelphia, PA

2019 Invited Moderator, Elaine W. Raines Early Career Investigator Award, AHA Scientific Sessions, Philadelphia, PA

2020 Moderator & Judge, ATVB Women’s Leadership Committee’s Junior Investigator Award for Women, Vascular Discovery: From Genes to Medicine Scientific Sessions 2020 (meeting made virtual due to COVID19 pandemic)

2020 – 2022 Chair, Early Career Committee, American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) 2020 – 2022 Member, Vascular Discoveries Program Committee, American Heart Association,

Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) 2020 – 2022 Member, Leadership Committee, American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)

Local Community Service

2017 Panelist, STEM Careers Achievement Night, American Association of University Women – Fox Chapel Branch, Fox Chapel, PA

2019 Invited Speaker, R.A.R.E (Raising Awareness for the Rare Epidemic) Club, University of Pittsburgh, Pittsburgh, PA

2020 Invited Speaker, DOM PhD Virtual Retreat. Introducing Twitter and Why You Need It: A Guided Tour and Q & A for Getting Started. University of Pittsburgh, Pittsburgh, PA

Professional Training and Development

2006 The Grant Institute: 5-Day Professional Program Development and Grant Communication Workshop, Harvard Medical School, Boston, MA. 08/14/06- 08/18/06

2008 BIO-TRAC 28: Analytical Techniques for the Quantitation of Angiogenesis and Lymphangiogenesis. FAES/NIH, Bethesda, MD. 10/27/08-10/30/08

2012 Research Mentor Training, NIH Office of Intramural Training and Education. Bethesda, MD. 06/04/12-07/23/12


2012 Leadership Training: Workplace Dynamics I-V: Self-Awareness; Communication, Learning, & Influencing Others; Conflict & Feedback; Team Skills; Diversity in a Multicultural Society. NIH Office of Intramural Training and Education, Bethesda, MD. Series of 5 workshops, July – November

2013 NHLBI Rodent Survival Surgery Technique Training Animal Surgery and Resources Core, NHLBI, Bethesda, MD. 06/21/13

2013 BIO-TRAC 47: iPSC II: Human Induced Pluripotent Stem Cells (hiPSC), FAES/NIH, Bethesda, MD. 03/11/12-03/15/13

2013 Leadership Training: Management Boot Camp, NIH Office of Intramural Training and Education, Bethesda, MD. 01/31/13-02/01/13

2015 CRISPR-Cas9 Genome Editing Bootcamp, ATVB|PVD 2016, Nashville, TN

2015 – 2016 Springboard 2015, University of Pittsburgh, Office of the Senior Vice Chancellor for the Health Sciences

2016 Scientifically Speaking: A Public Engagement Workshop, University of Pittsburgh School of Medicine

2016 – 2017 Career Mentoring Program, University of Pittsburgh School of Medicine

2018 – 2019 Faculty Leadership Academy for Early Career Faculty, University of Pittsburgh Schools of the Health Sciences

Other

2018 Featured Artist, University of Pittsburgh SCIENCE 2018 “Scientists as Artists” exhibit.

Primordial Soup, 2018 – alcohol ink on yupo paper Edelweiss, 2018 – alcohol ink on yupo paper

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