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CURRICULUM VITAE
A. Personal Details
Full Name SEOW Heng Fong
Title: Professor
Designation
Professor of Molecular Immunology
Research interest: cancer immunology and molecular biology for
cancer diagnostics and therapeutics
Administrative Appointment Deputy Dean, School of Graduate Studies (2010-2013)
Current Address Contact number and email
Immunology Unit,
Department of Pathology,
Faculty of Medicine and Health Sciences,
Universiti Putra Malaysia, Serdang,
Selangor 43400, Malaysia
Tel: 603-8947 2387
Mobile: +6012 248 9396
Fax:603-8946 4232
[email protected]
[email protected]
B. Academic Qualification
Certificate / Qualification
obtained
Name of School /
Institution
Year
obtained
Area of Specialization
PhD University of Auckland
New Zealand
1986 Biochemistry
BSc (Hons) Chelsea College,
University of London,
United Kingdom
1982 Biomedical Sciences
C. Scientific experience and Specialisation
Organization Position Start
Date
End
Date
Specialisation
Postdoctoral fellow
(Peter Parham’s lab)
Stanford
University,
California, USA
1986 1987 Molecular Cloning and Gene
Sequencing
Institute of Molecular and Cell
Biology, National University
of Singapore
Senior Research
Fellow
1987 1990 Cloning and gene expression
CSIRO Australia Senior Scientist
Project Leader,
Cytokines Group
1990 1995 Cytokines in nfectious
disease and vaccine
development
Macfarlane Burnet Institute Acting Head
Hepatitis Unit
1996 1997 Hepatitis E diagnostics and
vaccine development;
Hepatitis B antivirals
Washington State University,
Pullman, USA
Visiting Scientist May
1993
Sept
1993
Flow cytometry &
Γδ T cell identification
Centenary Institute, University
of Sydney, Australia
Visiting Scientist April
2003
Dec
2003
Genetics, Gene and Stem cell
therapy
Cancer Centre, Prince Alfred
Hospital, South Western
Health, Sydney, Australia
Research
administrator
August
2007
Dec
2007
Cancer
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D. Current research projects
Title of project StartingDate
Influence of cross talk between polarized macrophages and cancer stem-like cells on
tumorigenicity, metastasis and immune responses
March 2015
Effects of exosomes on angiogenesis March 2015
Identification of microRNAs associated with colon cancer metastasis and effects of
antagomirs on colon cancer cell invasion and metastasis in SW480
Sept 2013
Effects of silencing disheveled 1, 2 and 3 on cancer cell invasion, migration and
canonical WNT pathway-mediated TCF-LEF transcriptional activity
Sept 2012
Aberrations in WNT and NOTCH signaling pathways in primary colorectal carcinoma
tissues
Sept 2011
Relationship between M1/M2 macrophages with TGF-β and IL-17 expression in
primary colorectal carcinoma tissues
Sept 2011
E. Honours and Awards Name of awards Title Award Authority Award Type Year
Academic Awards Dean’s Fellowship Stanford
University
University 1986 & 1987
Non-Academic Awards
Fellowship Ministry of
Commerce ,
Australia
National 1993
Awards of Merit
Detection of medically
important Candida
species by semi-nested
PCR
A Molecular
Diagnostic Kit to
Monitor Response to
Standard
Chemotherapy.
Generation of Human
Umbilical Cord derived
Mesenchymal Stem
Cells: A Tool for Stem
Cell Therapy, 2010
Mesenchymal Stem
Cells Mediated Tumour
Cell Suppression: A
Potential Therapy for
Cancer
Generation and
Characterisation of
Mesenchymal stem
Cells Derived from
Myocardiac Tissues: A
potential Pool of
Cardiac Stem Cells
The Effect of Human
Universiti Putra
Malaysia
Universiti Putra
Malaysia
Malaysian
Technology
Expo (MTE)
Universiti Putra
Malaysia
UPM
UPM
Gold Medal,
Pameran Reka
Cipta, PRPI
2012
UPM
Gold Medal,
Pameran Reka
Cipta, PRPI
2010 UPM
SILVER Medal
National
GOLD Medal
Pameran Reka
Cipta, PRPI
2009
GOLD Medal
Pameran Reka
Cipta, PRPI
2009
UPM
SILVER Medal
Pameran Reka
Cipta, PRPI
2009
UPM
17-19 July
2012
20-22 July
2010
4-6 February
2010, Putra
Word Trade
Centre (PWTC)
28 July 2009
28 July 2009
28 July 2009
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Mesenchymal Stem
Cells on the
Proliferation and
Cytotoxicity of Natural
Killer Cells
F. List of publications
Papers relating to work on microRNA and qPCR
Pei Yuan He, Wai Kien Yip, Boon Lee Chai, Boon Yean Chai, Mohd Faisal Jabar , Noraini
Mohd Dusa, Norhafizah Mohtarrudin, Heng Fong Seow. Inhibition of cell migration and
invasion by miR-29a-3p in a colorectal cancer cell line through suppression of CDC42BPA
mRNA expression (manuscript in preparation)
Pei Yuan He, Wai Kien Yip, Mohd Faisal Jabar, Heng Fong Seow. miR-96-5p inhibitor blocks
migration but has no influence on cell invasion in colorectal cancer. (manuscript in preparation)
P.Y. He, W.K. Yip, H.F. Seow. Are miR-29 and miR-96 oncomirs or tumour suppressors?
20th World Congress on Advances in Oncology and 18th International Symposium on Molecular
Medicine, Metropolitan Hotel, Athens, Greece, October 8-10, 2015, A283.
Ng CT, Yip WK, Seow HF. Inhibition of MEK-ERK and PI3K-Akt pathways differentially
affects angiogenesis and microRNA expression. RNAi 2014: Short and long noncoding RNAs, 9
th International Conference RNAi 2014, 25-27 Mac 2014 , St Hilda’s College, Oxford, United
Kingdom. http://libpubmedia.co.uk/rnai-2014/speakers-agenda/
Other publications:
Seow HF, Yip WK, Fifis T. Advances in targeted and immunobased therapy for colorectal cancer.
OncoTargets and Therapy 2016, 9:2565-2574.
Yip WK, He PY, M Abullah, Yusof, Seow HF. Increased expression of phosphatidylinositol 3-kinase
p110α and gene amplification of PIK3CA in nasopharyngeal carcinoma. Path Oncol Res (2016), 2(2):413-
419.
Peyman Amini , Maha Abdullah, Lee Sing Seng, Thanusha Karunakaran, Norzhafarina Hani, Saraiza Abu
Bakar, Amir Hamzah Abdul Latiff, Seow Heng Fong and Yap Yoke Yeow. Ethnicity influences disease
characteristics and symptom severity in allergic rhinitis patients in Malaysia. International Forum of
Allergy & Rhinology. (2016) DOI: 10.1002/alr.21442.
Ayunidra, Yip WK, Seow HF. Combinatorial Treatments Targeting IGF-1R, PI3K, mTOR, or MEK
Signaling Pathways Synergize to Inhibit Cell Growth, Induce Apoptosis, and Arrest Cell at G1 Phase in
MDA-MB-231 cell line. Biomedicine and Pharmacotherapy (2015), 75, 40-50.
Ng CT, Yip WK, Seow HF. Comparison of endothelial cell invasion by SV40 large antigen and
telomerase- immortalized human microvascular endothelial cell lines in response to VEGF and bFGF in a
three-dimensional (3D) cell culture system. Malaysian J Path (2015) 37(3): 219 – 225.
Goh IWL, Yip WK, Seow HF. Characterization of tumorspheres generated from nasopharyngeal
carcinoma cell line, TW06 and chemoresistance to docetaxel and oxaliplatin. Malaysian J Med Health Sc
(2015) 11 (2): 9-20.
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SY Chew, YK Cheah, HF Seow, D Sandai, LTL Than. In vitro modulation of probiotic bacteria on the
biofilm of Candida glabrata. Anaerobe 34, 132-138.
SY Chew, YK Cheah, HF Seow, D Sandai, LTL Than. Probiotic Lactobacillus rhamnosus GR‐1 and
Lactobacillus reuteri RC‐14 exhibit strong antifungal effects against vulvovaginal candidiasis‐causing
Candida glabrata isolates. Journal of applied microbiology 118 (5), 1180-1190.
Koh RY, Lim CL, Ho CC, Uhal BD, Maha A, Vidyadaran S, Heng Fong Seow Inhibition of
transforming growth factor-β receptor via the activin 5 receptor- like kinase-5 inhibitor attenuates
pulmonary fibrosis. Molecular Medicine Reports (2015) 11: 3808-3813.
Than L, KP Ng, Chong PP, Seow HF. Detection of medically important Candida species by absolute real
time quantitative PCR. Jundisphapur J Med Microbiol (2015), 8 (1):e14940.
Kasi R, Koh RY, Lim CL, Yip YK, Seow HF and MM Ching. para-Phenylenediamine-induces apoptosis
via a pathway dependent on PTK-Ras-Raf-JNK activation but independent on PI3K/Akt pathway in
NRK-52E cells. Molecular Medicine Reports (2015), 11: 2262-2268.
Ooi SC, Ho CC, Seow HF. Isolation of a potential anticancer agent with protein phosphatase inhibitory
activity from soil-derived Penicillium sp. strain H9318. J Trop Pharm Res (2015), in press.
Koh RY, Lim CL, Ho CC, Uhal BD, Maha A, Vidyadaran S, Seow HF. Metabolites from
Actinomyces strain H6552 extract inhibit transforming growth factor-mediated pulmonary fibrosis. J Trop
Pharm Res (2014)13 (11):1815-1823.
Seow HF. Tumour immunology. Malaysian J Pathol 2014; 36(3) :226
Yip WK, Choo W, Leong PP, Leong V, Jabar F, Seow HF. (2013) Molecular alterations of Ras Raf
mitogen-activated protein kinase and phosphatidylinositol 3 kinase Akt signaling pathways in colorectal
carcinoma from a tertiary hospital in Kuala Lumpur Malaysia. Acta Pathologica Microbiologica e
Immunologica Scandinavica (APMIS),121: 954–966, IF 2.068, (Q1 Pathology)
Davoodi H, Hasemi SR, Seow HF. 5-Fluorouracil induce the expression of TLR4 on HCT116 colorectal
cancer cell line expressing different variants of TLR4. Iranian J Pharm Res (2013) 12, 453-460, IF 0.674,
ISSN: 17350328
Chye SM, Tiong YL, Yip WK, Koh RY, Len YW, Seow HF, Ng KY, Ranjit DA, Chen SC., Apoptosis
induced by para-phenylenediamine involves formation of ROS and activation of p38 and JNK in chang
liver cells. Environmental Toxicology (2012) 13, online: 22 NOV 2012. IF: 2.708.ISN 1522-7278
Yip WK and Seow HF. Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates
membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal carcinoma cells Cancer
Letters (2012), 318, 115-234.(10 citations in Scopus)
Fonseka M, Ramasamy R, Yip WK, Tan BC and Seow HF. Human Umbilical Cord Blood-Derived
Mesenchymal Stem Cells (hUCB-MSC) Inhibits the Proliferation of K562 (Human Erythromyeloblastoid
Leukemic Cell Line). Internat. Cell Biol. (2012) 36, 793-801
Ramasamy R, Tong CK, Yip WK, Vellasamy S, Tan BC and Seow HF. bFGF modulate growth kinetic
of MSC Basic Fibroblast Growth Factor Modulates the Cell Cycle of Human Umbilical Cord Derived
Mesenchymal Stem Cells (2012) Cell Proliferation, 45, 132-139.
Than, L, Chong PP, Ng KP and Seow HF. Application of seminested PCR method for detection of ten
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medically important Candida species. Diagnostic Microbiology and Infection (2012) 72 (2) , pp. 196-198.
Yong, P.V.C., Seow, H.F., Rosli, R., Sidik, S.M., Chong, P.P. (2012). Histopathological Characteristics of
Experimental Candida tropicalis Induced Acute Systemic Candidiasis in BALB/c Mice. International
Journal of Zoological Research. (ePUB)
Davoodi H and Seow HF. (2011) Variant Toll-Like Receptor4 (Asp299Gly and Thr399Ile Alleles) and
Toll-Like Receptor2 (Arg753Gln and Arg677Trp Alleles) in Colorectal Cancer. Iran J Allergy Asthma
Immunol. 10(2): 91-99. (16 citations in Scopus)
Cheenpracha, S, Borris RP, Tran TT, Jee JM, Seow, HF, Cheah HY Ho CC and Chang LC. 2. Three
New Amides from Streptomyces sp. H7372 J. Braz. Chem. Soc., 2011, vol.22, n.2, pp. 223-229
Leong PP, Rohaizak M, Naqiyah, Cheong SK and Seow HF. (2011) HLA-A and breast cancer in West
Peninsular Malaysia. Medical Oncology 28, (1): 51-56
Seow HF. Molecular diagnostics for tumour genotyping in selecting cancer targeted therapies. Malaysian
Society of Genetics Jan-July 2011, 7-9.
Lim CSY, Rozita R, Seow HF, Chong PP. Candida and invasive candidiasis: back to basics. European
Journal of Clinical Microbiology, 2011, 1-11.
Tong CK, Vellasamy S, Tan BC, Abdullah M, Vidyadaran S, Seow HF and Ramasamy R. Generation
of mesenchymal stem cell from human umbilical cord tissue using a combination enzymatic and
mechanical disassociation method. Cell Biology International (2011) 35, 221–226
Abdullah M, Chai PS, Loh C-Y , Chong MY, Quay HW, Vidyadaran S, Seman Z, Kandiah M, Seow,
HF. Carica papaya increases regulatory T cells and reduces IFN- +CD4+ T cells in healthy human
subjects. Molecular Nutrition & Food Research 2011, 55 (5) , pp. 803-806
Lim CSY, Rozita R Seow HF, Chong PP. Transcriptome profiling of endothelial cells during
infections with high and low densities of C. albicans cells. International Journal of Medical
Microbiology, 2011 (online March) 301 (6) , pp. 536-546
1. Cheenpracha, S, Borris RP, Tran TT, Jee JM, Seow, HF, Cheah HY Ho CC and Chang LC. 2. Three
New Amides from Streptomyces sp. H7372 J. Braz. Chem. Soc., 2011, vol.22, n.2, pp. 223-229
2.
3. Seow, H.F., Yip W.K,. Loh H.W., Ithnin H., Por P. and Rohaizak M. Immunohistochemical Detection of
Phospho-Akt, Phospho-BAD, HER2 and Oestrogen Receptors alpha and beta in Malaysian Breast Cancer
Patients. Pathology Oncology Research 2010, 16:239-248.
4. Leong PP, Rohaizak M, Naqiyah, Cheong SK and Seow HF. HLA-A and breast cancer in West
Peninsular Malaysia. Medical Oncology, published online 13 Jan 2010.
5. Chong, P.P., Yong, P.V.C., Seow, H.F., Rosli, R. (2010). Gene expression profiling of mouse host
response to Candida tropicalis infection. International Journal of Infectious Diseases 14 Supplement 1,
e189.
6. Yip WK, Cheenpracha S, Chang LC, Ho CC, Seow HF. 2010. Anti-proliferative and anti-invasive
properties of a purified fraction from Streptomyces sp. H7372. Int J Oncol 2010, 37:1229-1241.
7.
8. Cheenpracha S., Zhang H., Mar A.M., Foss A.P., Foo S.H., Lai N.S., Jee J.M., Seow H.F. , Ho C.C. and
Chang L.C. Yeast glycogen synthase kinase-3beta pathway inhibitors from an organic extract of
Streptomyces sp. Journal of Natural Products. 2009; 72(8): 1520-1523
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9. Lim C.S., Wong W.F., Rosli R., Ng K.P., Seow H.F. and Chong P.P. 2-dodecanol (decyl methyl
carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology.
2009; 49 (6): 579-583.
10. Yong, P.V.C., Ong, K.W., Seow, H.F., Rosli, R., Sidik, S., Chong, P.P. (2009). A modified in situ RT-
PCR method for localizing fungal-specific gene expression in Candida-infected mice renal cells. Journal
of Microbiological Methods. 2009, 79:242-245.
11. Vidyadaran S., Ooi Y.Y. Subramaiam H., Badiei A., Abdullah M., Ramasamy R., Seow H.F. Effects of
macrophage colony-stimulating factor on microglial responses to lipopolysaccharide and beta amyloid.
Cellular Immunology. 2009; 259 (1): 105-110.
12. Yip W.K., Abdullah M.A., Yusoff S.M. and Seow H.F. Increase in tumour-infiltrating lymphocytes with
regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma
patients. Clinical Experimental Immunology. 2009; 155( 3): 412-422.
13. Ching-Shian Leong V, Jabal MF, Leong PP, Abdullah MA, Gul YA, Seow HF. PIK3CA gene mutations
in breast carcinoma in Malaysian patients. Cancer Genet Cytogenet. 2008 ;187(2):74-9.
14. Tong CK, Seow HF, Ramasamy R. Cord blood-derived mesenchymal stem cell does not stimulate nor
inhibits T lymphocytes activation. Med J Malaysia. 2008;63 Suppl A:77-8.
15. Maha A, Cheong SK, Leong CF, Seow HF. Cell viability of acute myeloid leukaemia blasts in culture
correlates with treatment outcome. Hematology. 2008;13(1):13-20
16. Ramasamy R, Tong CK, Seow HF, Vidyadaran S, Dazzi F. The immunosuppressive effects of
human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector
function. Cell Immunol. 2008;251(2):131-6. (84 citations in Scopus)
17. See HS, Yap YY, Yip WK, Seow HF. Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp
deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia. World J Surg
Oncol. 2008;6:18.
18. Yip WK, Leong VC, Abdullah MA, Yusoff S, Seow HF. Overexpression of phospho-Akt correlates
with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma.Oncol Rep.
2008;19(2):319-28. (37 citations in Scopus)
19. Seow, HF. Biomarkers in cancer: an update (a review), Malaysian J of Medical and Health Sciences,
2008, 4: 23-32.
V.C. Yong, R. Rozita, H.F. Seow, P.P. Chong Identification of Candida tropicalis Immunoreactive
Proteins by Immunoproteomics International Journal of Infectious Diseases . December 2008 (Vol.
12Supplement 1, Pages e175-e176)
20. Chong PP, Abdul Hadi SR, Lee YL, Phan CL, Tan BC, Ng KP, Seow HF. Genotyping and drug
resistance profile of Candida spp. in recurrent and one-off vaginitis, and high association of non-albicans
species with non-pregnant status. Infect Genet Evol. 2007, 7(4), 449-456 (28 citations in Scopus)
21. Tan GH, Yusoff K, Seow HF, Tan WS. A phage-displayed single chain variable fragment that interacts
with hepatitis B core antigen: library construction, selection and diagnosis. J Clin Virol. 2007
Jan;38(1):49-56. Epub 2006 Oct 30. [impact factor = 2.63]
22. Leong PP, Rohaizak, Natiquah, H. Ithnin, Maha A., Davis W., Seow HF. Phenotyping of
lymphocytes in infiltrating ductal breast carcinoma. Immunol. Letts., 2006, 102:229-236.
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[impact factor = 3.049]
23. Khor Tin Oo, Hairuszah Ithnin, Yunus Gul A. Gul, Heng Fong Seow. A comparative study of the
expression of Wnt-1, WISP-1, survivin and cyclin D1 in colorectal carcinoma. Internat. J
Colorectal Disease. (2006) 55 (4): 423-428. ( 28 citations in Scopus)
24. Chong PP, Chieng DC, Low LY, Hafeez A, Shamsudin MN, Seow HF, Ng KP. Recurrent candidaemia in
a neonate with Hirschsprung's disease: fluconazole resistance and genetic relatedness of eight Candida
tropicalis isolates. J Med Microbiol. 2006 Apr;55(Pt 4):423-8.
25. 26. Leong PP and Seow HF. Cancer Immunotherapy. Malaysian J of Medicine and Health Sciences. 2006, 2:
1-26.
27. 28. Yong, P.V.C., Chew, L.M., Kwan, C.L., Ng, K.P., Seow, H.F., Chong, P.P. (2006). Transcriptional and
sequencing analysis of CtCDR1, CtMDR1 and CtERG11 genes in fluconazole-resistant Candida
tropicalis isolates from candidemia patients. Journal of Medical Sciences 6(5):713-723
Ong HT, Duraisamy G, Ng KP, Tan WS and Seow HF. Genotyping of hepatitis B virus in Malaysia based on the nucleotide sequence of preS and S genes. Microbes and Infection (2005) 7: 494-500.[ impact factor = 3.154] factttor =3.154]
Looi CY, D' Silva EC, Seow HF, Rosli R, Ng KP and Chong PP. Increased expression and hotspot
mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from
vaginitis patients. FEMS Microbiol Lett. 2005, 249(2):283-289.
Ng KP, Soo-Hoo TS, Na S, Tay ST, Hamimah H, Lim PC, Chong PP, Seow HF, Chavez AJ and Messer
SA. The mycological and molecular study of Hortaea werneckii isolated from blood and splenic abscess.
Mycopathologia. 2005, 159(4):495-500.
Tan, GH, Yusoff, K, Seow, HF and Tan, WS. Antigenicity and immunogenicity of the
immunodominant region of hepatitis B surface antigen displayed on bacteriophage T7. J Med Virol.
2005, 77(4):475-80.
Tan, WS, Tan, GH, Yusoff, K. and Seow, HF. A phage-displayed cyclic peptide that interacts tightly
with the immunodominant region of hepatitis B surface antigen. J Clin Virol. 2005, 34(1):35-41.
Heng F Seow, Stefan Bröer, Angelika Bröer, Charles G Bailey, Simon J Potter, Juleen A
Cavanaugh, John E J Rasko Hartnup disorder is caused by mutations in the gene encoding the
neutral amino acid transporter SLC6A19. (2004) Nature Genetics 36, 1003 – 1007. [impact factor
=25.277], 110 citations in Scopus.
KHOR, T.O., YUNUS A. G., HAIRUSZAH I. and SEOW, H.F. 2004. Positive correlation of pBAD
with pAkt-Ser 473 but not pAKT-Thr 308 expression in colorectal carcinoma. Cancer Letters
210: 139-150. [impact factor = 3.049]
Ban KC, Harjit Singh, R. Krishnan and Seow HF. Comparison of beta catenin expression in
hepatocellular carcinoma from areas of high and low aflatoxin exposure. J. Surgical Oncology 2004, 86,
Issue 3, 2004. Pages 157-163.
HONG, S.K., YUNUS ALIF GUL, HAIRUSZAH I., ARNI T. and SEOW, H.F. Expression of β-catenin,
COX-2 and iNOS in colorectal cancer – implications of the relevance of COX-2 and iNOS inhibitors for
treatment in Malaysia?’ Asian Journal of Surgery, 2004, 27, 10-17.
Kong LL, Omar AR, Hair-Bejo M, Aini I, Seow HF 2004. Comparative analysis of viral RNA and
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apoptotic cells in bursae following infection with infectious bursal disease virus. Comp.Immunol.
Microbiol. Infect. Dis 27(6) 433-443.
Kong, LL, Omar AR, Hair-Bejo M, Aini I, Seow HF. Sequence analysis of both genome segments of
two very virulent infectious bursal disease virus field isolates with distinct pathogenicity. Arch
Virol. 2004 Feb;149(2):425-34.
HO, K.L., YUSOFF, K., SEOW, H.F., TAN, W.S. Selection of high affinity ligands to hepatitis B core
antigen from a phage-displayed cyclic peptide library. J Med Virol. 2003 Jan; 69(1):27-32. [impact factor
= 2.3]
BAN K.C., HARJIT S., R. KRISHNAN2, SEOW, H.F. GSK-3β Phosphorylation and Alteration of
β-Catenin in Hepatocellular Carcinoma Cancer Letters (2003), 1999: 201-208.[impact
factor=3.049], 44 citations in Scopus.
CHIA, C.S., BAN K., HAIRUSZAH I., HARJIT, S., KRISHNAN, R., SURYATI M., MALIHAN, N.,
SEOW, H.F. Expression of IFN-γ, IL-18 and IL-10 in hepatocellular carcinoma. Immunology Letts.
(2002) 84:3 163-72 [impact factor=2.3]
HO, K.L., TAN, W.S., SEOW, H.F. and KHATIJAH, Y. Identification of peptides that bind Hepatitis B
core proteins by phage display library (Patent filed-Nov 2001).
LEONG C.O. and SEOW H.F. Telomere and telomerase: useful as prognostic factor and targets for
cancer therapy? Clinical BiochemReviews (2001), 23: 39-51.
LI FAN, MICHAELA A. RIDDELL, HENG-FONG SEOW, NAOKAZU TAKEDA, TATSUO
MIYAMURA, and DAVID A. ANDERSON Recombinant subunit ORF2.1 antigen induces antibody
against immunodominant epitopes in the hepatitis E virus capsid protein. J Med Virol. 2000, 60: 379-
386.
RIFFKIN M. C., H-F. SEOW, P. R. WOOD, L. E. BROWN, D. C. JACKSON and J.-P. Y.
SCHEERLINCK. Trichostrongylus colubriformis extract up-regulates TNF-a receptor expression and
enhances TNF-a mediated lysis of L929 cells. Immunol. Cell Biol. 2000 , 78:6, 575-579
BAN K. and SEOW H.F. Molecular Events associated with hepatocellular carcinoma. International
Journal for Medical Research (2000) , 4: 7-21.
SEOW HF, NIZAM MBM, MAK JW, RIDDELL, M., LI F and ANDERSON D. Seroprevalence of
antibodies to Hepatitis E Virus in the normal blood donor population and two aboriginal communities in
Malaysia. J. Med. Virol. 1999, 59:164-168.
ANDERSON DA, LI F, RIDDELL M, HOWARD T, SEOW HF, TORRESI J, PERRY G,
SUMARISIDI D, SHRESTHA SM, SHRESTHA IL. ELISA for IgG-class antibody to hepatitis E
virus based on a highly conserved conformational epitope expressed in Escherichia coli. J. Virol
Methods. 1999, 81, 131-142. (49 citations in Scopus)
WONG GW, MANAF A and SEOW HF. Cloning, expression of human interleukin-18 expression and
the effects of chemical stimuli. Asian Pacific J Biotech and Mol Biol, 1999, 7(2): 1-11.
SEOW, H.F. Cytokines and the immune response. Malaysian Journal of Clinical Biochemistry, 1999, 2:
42-46.
SEOW HF. Hepatitis B and C in pregnancy. Current Obstetrics and Gynaecology, 1999, 9, 216-223.
ROTHEL, J.S., CORNER, L.A., LIGHTOWLERS, M.W., SEOW, H.F., McWATERS, P., ENTRICAN,
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G. and WOOD, P.R. Antibody and cytokine responses in efferent lymph following vaccination with
different adjuvants. Vet. Immunol. Immunopath. 1998, 63: 167-183.
ROTHEL, J.S., SEOW, H-F., LIGHTOWLERS, M.W., PARRY, B., GAUCI, C., HURST, L., MUCHA,
M-J., CORNER, L.A. and WOOD, P.R. The use of recombinant ovine IL- -
adjuvants and their physiological effects in vivo. Immunol. Cell Biol., 1998, 76:2, 167-172.
SEOW, H-F. Pathogen interactions with cytokines and host defense: an overview. Vet, Immunol.
Immunopath., 1998, 63, 139-148.
PERSSON K., COLDITZ I.G., FLAPPER P. and SEOW H-F. Leukocyte and cytokine accumulation in
the ovine teat and udder during endotoxin-induced inflammation. Veterinary Research Communications,
1997, 21:2, 101-115.
PERSSON K., COLDITZ I.G. and SEOW H-F Accumulation of leukocyte and cytokine in the lactating
ovine udder during Staphylococcus aureus and Escherichia coli mastitis. Research in Veterinary Science
1997, 62, 63-66.
WONG, C.W., SEOW, H-F., LIU, A.H., HUSBAND, A..J., SMITHERS, G.W. and WATSON, D.L.
Effects of purified bovine whey factors on cellular immune functions in ruminants. Vet. Immunol.
Immunopath., 1997, 56, 85-96.
ROTHEL, J.S., WATERKEYN, J., STRUGNELL, R.A., WOOD, P.R. SEOW, H-F. and
LIGHTOWLERS, M.W. Nucleic acid vaccination of sheep: use in combination with a conventional
adjuvanted vaccine against Taenia ovis. Immunol. Cell Biol., 1997, 75:41-46.
SEOW, H-F., DAVID, M-J., HURST, L., ROTHEL, J.S. and WOOD, P.R. Expression of ovine
interleukin-2 cDNA in Escherichia coli. Vet. Immunol. Immunopath. 1997, 56: 107-117.
ROTHEL, J.S., HURST, L., PEPIN, M., CORNER, L.A., BERTHON, P., SEOW, H-F., and WOOD,
P.R. Analysis of ovine IL-1ß production in vivo and in vitro by ELISA and immunohistochemistry. Vet.
Immunol. Immunopath. 1997 , 57, 267-278.
PEPIN, M, SEOW, H-F., CORNER, L.A., ROTHEL, J.S. HODGSON, A.L.M and WOOD, P.R.
Cytokine gene expression in sheep following experimental infection with various strains of
Corynebacterium pseudotuberculosis differing in virulence. Veterinary Research., 1997, 28 (2), 149-163.
ROTHEL, J.S., WOOD, P.R., SEOW, H-F. and LIGHTOWLERS, M.W. Urea/DTT solubilization of a
recombinant 45W-GST fusion protein results in enhanced protective immune response to the 45W moiety.
Vaccine, 1997, 15, 469-472.
LECHNER, F., MACHADO, J., BERTONI, G., SEOW, H-F., DOBBELAERE, D.A.E. and
PETERHANS, E. Caprine arthritis encephalitis virus dysregulates the expression of cytokines in
macrophages. J. Virol. 1997, 71: 7488-7497.
LECHNER, F., VOGT, H.R., SEOW, H.F., BERTONI, G., CHEEVER, W.P., voN BODUNGEN, U.,
ZUBRIGGEN, and PETERHANS, E. Expression of cytokine mRNA in lentivirus-induced arthritis.
American J. Pathology, 1997, 151: 1053-1065.
WOOD, P.R. and SEOW, H-F. T cell cytokines and disease prevention. Vet. Immunol. Immunopath.,
1997, 54, 33-44.
NASH, A., ANDREWS A., MARTIN, H., COLDITZ, I.G., WOOD, P. and SEOW, H-F .Methods for
detection and assay of ovine cytokines. In: Immunology Methods, Academic Press, 1997, Chapter 31.13,
edited by Ivan Lefkovits
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SEOW H-F., DAVID, M-J., MCWATERS, P, HURST, L. and P.R. WOOD. Cloning of ovine
interleukin-5 cDNA. DNA Sequence. J. of Sequencing and Mapping, 1996, 6, 331-335.
HAIG, D., DEANE D., PERCIVAL, A., MYATT, N., THOMSON, J., INGLIS, L., ROTHEL, J.S.,
SEOW H-F., WOOD, P.R., MILLER, H.R.P. and REID, H.W. The cytokine response of efferent lymph
following orf virus reinfection of sheep. Veterinary Dermatology, 1996, 7, 11-20.
HAIG, D.M., MCINNES, C., DEANE,D., LEAR, A., MYATT, N., REID, H., ROTHEL, J., SEOW, H-
F., WOOD, P., LYTTLE, D. and MERCER, A. Cytokines and their inhibitors in orf virus infection. Vet.
Immunol. Immunopath., 1996, 54: 261-267.
LECHNER, F., VOGT., HR., BERTONI, F., SEOW, H.F., ZUBRIGGEN, A. and PETERHANS, E.
Expression of TNF- Vet. Immunol. Immunopath., 1996, 54: 281-289.
ROTHEL, J.S., LIGHTOWLERS, M., SEOW, H-F. and WOOD, P.R., HEATH, D. and HARRISON, G.
Immune response associated with protection is sheep vaccinated with a recombinant antigen from Taenia
ovis, Parasite Immunology, 1996, 18: 201-208.
ROTHEL, J.S., CORNET, L.A., SEOW, H-F., WOOD, P.R. AND LIGHTOWLERS, M.W. Antigen-
specific IgA-secreting cells induced by peripheral vaccination. Immunology and Cell Biology, 1996, 74,
298-300.
WONG, C.W., SEOW,H-F., LIU, A.H.,HUSBAND, A.J., SMITHERS, G.W. AND WATSON,
D.L. Modulation of immune responses by bovine -casein. Immunol. Cell Biol.,1996, 74, 323-329.
MERTENS, B. and SEOW, H-F. The nucleotide sequence of bovine interleukin-5 cDNA. Gene,
1996, 176, 273-274.
PERSSON K., COLDITZ I.G., FLAPPER P., FRANKLIN N.A.F., SEOW H-F. Cytokine-
induced inflammation in the ovine teat and udder.Vet. Immunol. and Immunopath.1996, 53, 73-85.
EGAN, P.J., KIMPTON, W., SEOW, H-F., BOWLES, V.M., BRANDON, M.R. and NASH, A.D.
Inflammation-induced changes in the phenotype and cytokine profile of cells migrating through skin and
afferent lymph. Immunology, 1996, 89: 539-546.
HAIG, D.M., MCINNES, C.J., HUTCHISON, G., SEOW, H-F. And REID, H.W. Cyclosporin A
abrogates the acquired immunity to cutaneous reinfection with parapoxvirus orf virus. Immunology, 1996,
89: 524-531.
RIFFKIN, M., SEOW, H-F., BROWN, L., JACKSON,D. AND WOOD, P.R. Defense against immune
barrage: evasive strategies of helminth parasites. Immunol. Cell Biol. 1996 , 74: 564-574.
EGAN P.J., ROTHEL J.S., ANDREWS A.E., SEOW H-F., WOOD P.R. and NASH A.D.
Characterization of monoclonal antibodies to ovine tumor necrosis factor-10
sensitive immunoassay. Veterinary Immunology & Immunopathology, 1994, 41, 259-274.
SEOW H-F., YOSHIMURA T., WOOD P.R. and COLDITZ I.G. Cloning, sequencing, expression and
inflammatory activity in skin of ovine interleukin-8. Immunology and Cell Biology, 1994, 72, 398-405.
SEOW H-F., ROTHEL J.S. and WOOD P.R. Expression and purification of recombinant ovine
interleukin-1ß from Escherichia coli. Veterinary Immunology and Immunopathology, 1994, 41, 229-239.
ELHAY M.J., HANRAHAN, C.F., BOWLES, V.M., SEOW, H-F., ANDREWS, A.E. and NASH, A.D.
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Cytokine mRNA expression in skin in response to ectoparasite infection. Parasite Immunology, 1994, 16,
451-461.
HAIG D.M., McINNES C.J., WOOD P.R. and SEOW H.F. The cytokines: origin, structure and function.
In: Cell Mediated Immunity in Ruminants, pp. 75-92. (Eds. B. Goddeeris and I. Morrison). Boca Raton,
Fla., CRC Press, 1994.
WOOD P.R., SEOW H-F., ROTHEL, J.S. Cytokines and the regulation of immune response. In:
Vaccines in Agriculture: Immunological Applications to Animal Health and Production, pp. 49-56 (eds.
Wood,P.R., Willadsen, P., Vercoc, J.E., Hoskinson, R.M., Denmeyer, D.), East Melbourne, Victoria,
CSIRO, 1994
Patents filed (1)
ROTHEL J.S., SEOW, H-F, CORNER L.A., WOOD, P.R. International Patent Application No.
PM5438/94 on An Adjuvant.
SEOW H-F., ROTHEL J.S. and WOOD P.R. Cloning and sequencing an ovine interleukin-4-encoding
cDNA. Gene, 1993, 124, 291-293.
SEOW H.F., ROTHEL J.S., CORNER L.A. and WOOD P.R. Cloning of cervine interferon-gamma
cDNA by polymerase chain reaction. New Zealand Veterinary Journal, 1993, 41, 91-95.
O'BRIEN, SEOW, H-F., ROTHEL, J.S. and WOOD, P.R. Cloning and sequencing of an ovine
granulocyte-colony stimulating factor cDNA. DNA Sequence: J. Sequencing and Mapping, 1995, 4, 339-
342.
SEOW H-F., ROTHEL J.S., M. PEPIN, DAVID, M.J. and WOOD, P.R. Expression, biological activity
and kinetics of expression of ovine TNF- Veterinary Immunology and Immunpathology, 1995, 44, 279-
291.
O'BRIEN P.M., SEOW H.F., COUPAR, B., ENTRICAN G., WOOD, P.R. Production and
characterisation of ovine GM-CSF expressed in bacterial and mammalian cells. Vet. Immunol.
Immunopathol., 1995, 48, 287-298.
WOOD, P.R. AND SEOW, H-F. Ruminant cytokines and regulation of the immune system. Bulletin de
la Societe Franco-Japonaise des Sciences Veterinaaires, Tome 6, No.2 December , 1995, 50-52.
PERSSON, K., COLDITZ, I. and SEOW, H-F. Role of cytokines in inflammatory responses in the ovine
udder. Proceedings of the Third IDF International Mastitis Seminar, (1995) pp. 35-38
Patents (1)
Seow, H-F. and Wood, P.R. Immune response modulators and uses therefor. Provisional filed 14 June
1995
O'BRIEN P.M., ROTHEL J.S., SEOW H-F. and WOOD P.R. Cloning and sequencing of the cDNA for
ovine granulocyte- macrophage colony-stimulating factor (GM-CSF). Immunology and Cell Biology,
1991, 69, 51-55.
SEOW H-F., ROTHEL J.S., DAVID M-J. and WOOD P.R. Nucleotide sequence of ovine macrophage
interleukin-1 beta cDNA. J. DNA Sequence and Mapping, 1991, 1, 423-426.
Patents
Wood P.R., Seow H-F. and Rothel J.S.Ovine cytokine genes. International Patent Application No.
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PCT/AU91/00419 filed 12/9/91.
SEOW H-F., ROTHEL J.S., RADFORD A.J. and WOOD P.R. The molecular cloning of ovine
interleukin 2 gene by the polymerase chain reaction. Nucleic Acids Research, 1990, 18, 7175.
SEOW H-F., GOH C.R., KRISHNAN L. and PORTER A.G. Bacterial expression, facile purification and
properties of recombinant human lymphotoxin (tumor necrosis factor beta). Bio/technology, 1989, 7, 363-
368.
.SCOTT G.K., SEOW H.F. and TSE C.A.. Investigations into the nature of growth-related proteolysis in
human fibroblasts. Biochimica et Biophysica Acta, 1989, 1010, 160-165.
JACKSON A.P., SEOW H.F., HOLMES N., DRICKAMER K. and PARHAM P. Clathrin light
chains contain brain-specific insertion sequences and a region of homology with intermediate
filaments. Nature, 1987, 326, 154-159.
BRODSKY F.M., GALLOWAY C.J., BLANK G.S., JACKSON A.P., SEOW H-F., DRICKAMER K.
and PARHAM P.. Localization of clathrin light-chain sequences mediating heavy- chain binding and
coated vesicle diversity. Nature, 1987, 326, 203-205.
SCOTT G.K. and SEOW H.F. Does a fibroblast membrane proteinase affect the binding, uptake and
metabolism of epidermal growth factor? Comparative Biochemistry and Physiology, 1986, 84B, 595-599.
SCOTT G.K. and SEOW H.F. Further evidence for a cell surface proteinase essential to the growth of
cultured fibroblasts. Experimental Cell Research, 1985, 158, 41-52
HARPER L., SCOTT G.K. and SEOW H.F. Antibody affinity chromatography of human proteinases and
related proteins. Comparative Biochemistry and Physiology, 1984, 78B, 231-235
Books/Monographs Are there “Magic Bullets” for Cancer Therapy, UPM Press, 2011.
Chapter in book Immunomodulatory potential of mesenchymal stem cells on microglia
Recent Invited
Oral presentations
Tumour Immunology, Immunology Symposia, 15-16th October 2014,
Faculty of Medicine and Health Sciences, UPM.
Role of polarised macrophages in the tumour microenvironment. Cancer
Treatment: beyond a microscopic view. Taylor’s University 2-3rd
September 2014.
Are tumorspheres relevant as in vitro models for studying chemoresistance
by cancer stem cells? 3rd Universiti Tunku Abdul Rahman Stem Cell and
iPCS Seminar, 2nd December 2013.
Role of EGFR (epidermal growth factor receptor) and PI3K (phosphatidyl-
inositide-3-kinase)/Akt Signal Pathway in Nasopharyngeal Cancer Cell
Adhesion and Invasion. 6th Annual Conference of the Malaysian Society
for Biochemistry and Molecular Biology Society, 27-28 July 2011, Eastin
Hotel, Petaling Jaya, Selangor.
Research Ethics and Integrity. Postgraduate International Symposium. 16th
September 2011, Petronas University.
H. GRANTS APPROVED Project No. Project Title Role Year Source of Status
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fund
GP-IPS/2014/9433958 Identification of potential therapeutic
targets for metastastic colon cancer by
inhibition of microRNA expression
Project
leader/Principal
Investigator
Sept
2014-
Aug
2016
Geran
Putra
Siswazah
Ongoing
04-01-14-1455 Cross talk between polarized
macrophages and cancer
stem-like cells influences
tumorigenicity, metastasis
and immune responses
Project
leader/Principal
Investigator
July
2014-
June
2016
FRGS Ongoing
02-01-04-SF1312
Cell migration and
angiogenesis inhibition by
targeting Wnt as a potential
cancer treatment strategy
Project
leader/Principal
Investigator
2012-
2014
MOSTI Completed
02-01-04-SF0347 Discovering signal
transduction inhibitors from
Actinomycetes for potential
anticancer drugs
Project leader/
Principal
Investigator
2007
&
2008
MOSTI Completed
04-01-07-104FR Characterisation of the mode
of action of signal
transduction inhibitors from
Actinomycetes extracts
Project leader
/Principal
Investigator
2007-
2008
MOHE Completed
04/01/07/0113RU
Immunomodulatory effects of
mesenchymal stem cells:
implications for cancer
therapy
Project leader/
Principal
Investigator
2007-
2009
RUGS Completed
(06-02-01-0000-
PR0054/06-04)
Identification of
nasopharyngeal carcinoma
specific Epstein-Barr virus
antigens towards the
development of
cytotoxic T lymphocyte-
based immunotherapy
Project Leader/
Principal
Investigator
2003-
2007
MOSTI Completed
(06-02-
04-005 BTK/ER/023)
Molecular Approaches to the
Diagnosis and Management
of Systemic Fungal
Infections
Program
Leader/
Principal
Investigator
2003-
2007
MOSTI Completed
(06-02-04-0373-
PR002/07-07)
Identification of novel
therapeutic targets for
treatment of breast cancer
Project Leader/
Principal
Investigator
2002-
2004
MOSTI Completed
(06-05-01-
003BTK/ER018)
Molecular studies on disease
biomarkers and pathogenesis
of cancer: colorectal
carcinoma as a model
Project Leader/
Principal
Investigator
2003-
2005
MOSTI Completed
( 09-02-04-0449-
EA001)
Comparison of tumour
markers from various
biological fluids
Project Leader/
Principal
Investigator
2004-
2006
MOSTI Completed
(06-04-02-0083) Characterisation of cytokines
and apoptotic/anti-apoptotic
molecule expression in acute
myeloid leukemia
Project Leader/
Principal
Investigator
2000-
2002
MOSTI Completed
I. TEACHING EXPERIENCE
Role Course/Module
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2
Lecturer (1997-2001)
Module Co-ordinator/Lecturer
(1997-2001)
Lecturer
Module Co-ordinator/Lecturer
(1997-2003)
Course Co-ordinator/Lecturer
Lecturer (2004-2007)
Lecturer (2010-present)
Biochemistry II (MDP 3202; 4 credit hours) – Taught the topics in the
area of metabolism
Medical Microbiology I (MDL 3001; 3 credit hours) – Basic features of
DNA and RNA viruses; clinical diagnostics including serological and
molecular detection methods; antiviral drugs for treatment of viral
infections.
Immunology (MDL 3401; 2 credit hours)
Immunology (SPM 3200)- all 14 lectures; 5 tutorials and 1 practical)
Virology component of Medical Microbiology and Parasitology (SPM
3300)
Molecular Medicine (SPD 3104) – mechanism of cytokine action
Genetic Engineering for biomedical students (2 credits): realtime
quantitative PCR lecture
Immunology for Medical students. (35 contact hours per semester)
Immunology (BMS 3070) for BSc (Hons) Biomedical Sciences. (42
hours per semester)
Immunobiology (SMK5600) for Masters of Science Students.
Immunology in Biotechnology (3 credits: contact hours = 42 h per
semester)
Immunology for Medical Students ; problem-based learning sessions
Immunology for Medical Students
Nutritional Immunology for Nutrition and Dietetics Program
Masters of Medicine (Pathology)
Deputy Dean,
Learning Support Programme,
School of Graduate Studies
UPM (2010-2013)
Created the learning support program is designed with five clusters
towards the development of academic skills such as ethics, scholarly
integrity, writing for publishing and thesis, skills in software application
such as SPSS, SEM and also in soft skills such as in leadership,
communication and team building. In addition, the program includes
activities which involve engagement with the community and schools.
This program is designed to enhance the student experience and acquire
academic skills and emotional intelligence as well as awareness in the
importance of contributions to social and community activities.
Examples of seminars include “Enhancing the Postgraduate Student
Experience”, “Scientific Writing” and “Presentation Skills”. A total of
1300 students have attended these seminars.
Deputy Dean,
Thesis Unit
Oversee the examination process and conduct of the viva voce. Manage
the administration of the Graduate on Time and thesis submission and
conflict resolution. Involved in the preparation of the documents for
accreditation of postgraduate programs according to the MQF
requirements.
J. CONTRIBUTION TO UNIVERSITY
Member of grant evaluation panel for FRGS, eSc, Grant Putra
Member of Human Ethics Committee (2010-2012)
Chairperson of UPM Postgraduate Thesis Examination Committee Appointments (2011-2013)
Chairperson for UPM Thesis Titles (2011-2013)
Committee Member for University Postgraduate Studies (2010-2013)
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2
Member of UPM School of Graduate Studies Management (2010-2013)
Chairperson for Course Evaluation Committee (2004-2006);
Head of Internal Audit for Quality Management System ISO 9001:2000 (2004-2007) : duties include
organizing internal audits at least three times a year with university auditors and staff members;
Committee member of the QMS ISO 9001:2000 to prepare documentation as required by ISO standards;
Committee Member for Faculty Research Committee (2004-2007);
Committee member involved in curriculum development for Master of Pathology postgraduate
programme for medical doctors. The first intake is in 2008;
Committee Member of Equipment Committee, Faculty of Medicine and Health Science, UPM (1997-
2000);
Member of the interviewing panel for new intake of medical students (Year 2000);
Committee member for the student project examination board (1998-1999);
Administrative contract officer responsible for the purchase of all equipment for the Immunology unit
and the Cancer Research Lab, Institute of Bioscience in the year 2000.
K. MEMBER OF EDITORIAL BOARD
Journal of Nasopharyngeal Carcinoma
Malaysian Journal of Pathology
L. REVIEWER OF MANUSCRIPTS FOR JOURNALS
Stem Cells
Clinical Cancer Research
Tumour Biology
International Journal of Cancer
International J. of Science Monitoring
Journal of Immunological Methods
International Immunopharmacology
Medical Journal of Malaysia
Diabetologia
Diabetes
M. EXTERNAL DUTIES
Reviewer of Malaysian Ministry of Science, Innovation and Technology Grants(Technofund, eScience
Fund, eSc grants)
External Examiner for UCSI Biotechnology Program
Member of Assessor Panel for Higher Education Centres of Excellence
N. MEMBERSHIP OF SOCIETIES
i. Australasian Society of Immunology
ii. Who’s Who of the Historical Society