CTSA Consortiums: WESTRN James F. Holmes, MD, MPH Professor, Department of EM UC Davis School of Medicine.

CTSA Consortiums: WESTRN

• James F. Holmes, MD, MPH

Professor, Department of EM

UC Davis School of Medicine

CTSA Consortia

• NIH wants CTSA consortia to develop

• Strategic Goal Committee 3: enhancing Consortium-Wide Collaborations

– August 26, 2011

– https://www.ctsacentral.org/best%20practices/research%20networking

– Implement research networking tools

– Data available on people in each CTSA

– Monitor collaborations

• 15 regional consortia listed on NIH CTSA website– https://www.ctsacentral.org/regional-consortia

West Coast Emergency Services Translational Research Network

(WESTRN)• Oregon Health & Science University

• Harborview/University of Washington

• University of California at Davis

• San Francisco General Hospital/UC San Francisco

• Stanford University

• Denver Health/University of Colorado

• University of Utah

• University of California at Irvine

• University of Southern California

• University of New Mexico

WESTRN: Timeline• February 2008: 1st meeting of west coast CTSA leaders

• May 2008: 1st meeting of EM investigators– 7 sites

• Oct 2008: 2nd meeting of EM investigators– Developed process for protocol submission/approval

• May 2009: 3rd meeting and planned project

• July 2009: Protocol for 1st project

• Feb 2010: Protocol for 2nd project

• May 2012: 1st meeting of the 10 current sites

WESTRN: Grants

• Funded:– RWJ Foundation: PI Newgard

– CTSC site grants for initial project: multiple sites

– CDC R01: PI Newgard

– UC Davis CTSA site grant for 2nd project: PI Nishijima

– NIGMS F32: PI – Jody Vogel

• Submitted:– NICHD R01

– NIGMS T32

WESTRN: Projects

• 1st Project: Link prehospital trauma data with outcomes data

– 7 sites

– Multiple projects within the database

• 2nd Project: Variability of admission in patients with TBI– 8 sites

• 3rd Project: Validation of Denver trauma MOF score– Part of a F32 training grant

– 3 sites

WESTRN: Publications

• Abstracts: 12 at meetings from 2010 to 2013– ACEP, SAEM, AAST, and American Heart Association –

Resuscitation Symposium

• Manuscripts: 7– Initial project: 6 (JACS, Annals of EM, AEM, J Trauma, Prehospital

EM Care)

– 2nd project: 1 (Annals of EM)

Thematic Special Interest GroupsConsortia

• Self-developed consortia– 10 listed on NIH website: https://www.ctsacentral.org/tsig

• Developing collaborations with existing networks, societies and organizations

• Identifying specific research proposals for collaboration

• Obtaining support from NIH Institutes and Centers, research institutions, and societies

• Organizing workshops and meetings with support from NIH ICs, research institutions, and NIH conference grants

• Meeting regularly in informal settings (teleconferences and at other pre-existing meetings) to share and collaborate

ECTRC: National EM CTSA research network

• National EM CTSA research network– https://www.ctsacentral.org/committee/emergency-

care-researchers

• May 2010 first meeting – Meetings each May at SAEM

• Massive numbers of patients within network• Process, however, has been slow

Conclusion

• NIH wants consortiums among its CTSAs

• Facilitate studies needing large numbers of

subjects• Several existing consortia (see NIH website)

– Regional and thematic

• Challenges with large consortia